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Fig. 5. Fins regenerate faster in fish heterozygous for a loss-of-function
mutation in axin1. (A) Average length of regenerating tail
fins at 7 dpa is increased in fish heterozygous for an axin1
loss-of-function mutation (mbltm013) compared with
wild-type siblings. Results of one representative experiment of three are
shown. To determine the length of the regenerate for individual fish, the
average length of the third, fourth and fifth dorsal regenerating fin ray was
calculated. n=12 wild-type fish and 9 mbl heterozygous fish;
error bars represent the s.e.m. of the average regenerate lengths;
***, P=0.0009 (one-tailed). (B) The number of fin
rays (in percent of the total number counted) is plotted against the length of
the regenerate (in 0.1 mm intervals) for wild-type (upper bar graph) and
axin1 heterozygous fish (lower bar graph). The curves represent a
fifth-order polynomial trendline. The average regenerate length is marked by
black bars at the x-axis. 148 fin rays were counted (combined results
from three experiments) in 19 wild-type fish and 94 rays were counted in 10
axin1+/- fish.
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