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Figure 8


Fig. 8. A model of Nkx2.2 activity in the developing pancreas. Nkx2.2 functions as a repressor to specify and differentiate the glucagon-producing {alpha}-cell population. Nkx2.2 also functions as a repressor to specify the early insulin-positive population and/or the immature Pdx1low, Nkx6.1+, MafA-, Glut2- insulin-producing ß-cells, but this activity is not sufficient to produce a fully differentiated mature Pdx1high, Nkx6.1+, MafA+, Glut2+ ß-cell. We propose that Nkx2.2-activator function will be required for this later differentiation step.





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