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Fig. 7. Notch ligand density and N1::cre genetic mapping. A hypothetical
model to explain the relationship between the strength of Notch signaling and
fate mapping as a function of ligand concentration. The probability of
identifying a marked lineage in tissues within N1::cre mice is correlated with
Notch1 function as revealed by loss-of-function phenotypes and the ability to
detect activated Notch1 protein by immunostaining (see
Table 1).