|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 6. Predicted shifts in the cortex of PAX77 mice. (A) Pax6 levels
are about three times higher in the anterior cortex than in the posterior
cortex. In PAX77 mice, Pax6 expression is still graded, but is increased by
1.5- to 3-fold (shown here as an average of approximately 2-fold). Thus, in
PAX77 embryos, cells in posterior regions of the cortex express levels of Pax6
that are normally found in anterior regions. (B-D) Dorsal views of
mouse neocortex. (B) In the wild-type, Pax6 is expressed in a
rostro-lateralhigh to caudo-mediallow gradient, while
(C) Emx2 is expressed in an opposite gradient. We predicted that the
overexpression of Pax6 would result in a downregulation of
Emx2 expression and (D) in a caudal shift of rostral areas at the
expense of caudal areas. M, motor area; S, somatosensory area; V, visual
area.
|
