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First published online January 10, 2007

Development 134, 303e (2007)
© The Company of Biologists Limited
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In this issue

LRP6: axing axin


Figure 1

The LDL receptor-related protein 6 (LRP6) was first identified as a Wnt co-receptor in mice. However, the precise role that LRP6 plays in Wnt signalling has remained unclear. On p. 503, Janet Heasman's group now reveal that LRP6 degrades axin - an essential event in the Wnt11-activated formation of the dorsal axis in Xenopus embryogenesis. They also reveal that LRP6 regulates axin levels in the oocyte and maintains ß-catenin expression in a low steady state - Wnt signalling has previously been believed to exist in either an on or off state. Axin is a negative regulator of Wnt signalling that targets ß-catenin for degradation, so preventing Wnt target gene activation. LRP6 depletion in the embryo, in this study, led to increased axin and decreased ß-catenin levels. In wild-type oocytes, exogenous ß-catenin degradation was prevented by the co-injection of LRP6 mRNA, whereas in axin-depleted oocytes, ß-catenin levels increased. This study reveals a novel role for LRP6 in axin degradation and highlights the complexity of Wnt signalling.


Related articles in Development:

Wnt11/ß-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin
Matt Kofron, Bilge Birsoy, Douglas Houston, Qinghua Tao, Christopher Wylie, and Janet Heasman
Development 2007 134: 503-513. [Abstract] [Full Text]  




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