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First published online January 26, 2007

Development 134, 405e (2007)
© The Company of Biologists Limited
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In this issue

SRF: muscling in on ectoderm


Figure 1

The inhibition of Activin/Nodal signalling during germ layer formation is essential for ectodermal specification and for correctly positioning the endoderm and mesoderm. As serum response factor (SRF)-deficient mice die in early embryonic development, Yun et al. turned to Xenopus embryos, where mesodermal induction is better characterised, to investigate the contribution that SRF makes to mesoderm development, They reveal, on p. 769, that the ectopic expression of SRF RNA suppresses mesoderm induction in the marginal zone (where animal and vegetal hemispheres meet) of frog embryos, and also in cultured animal caps, by inhibiting Activin/Nodal signals. Activin signalling induces the binding of FAST-1 and Smad2 to each other. Since XSRF competes with FAST-1 to bind Smad2, it thus terminates Activin signalling. The authors demonstrate how the inhibition of XSRF function by antisense morpholinos causes the expression domain of mesodermal genes to expand within ectodermal territory, and how this enhances the inducing activity of Activin signalling. Thus, SRF ensures that correct germ layer specification occurs by regulating Activin signalling.


Related articles in Development:

Negative regulation of Activin/Nodal signaling by SRF during Xenopus gastrulation
Chang-Hyun Yun, Sun-Cheol Choi, Eunjoo Park, Seong-Jin Kim, An-Sik Chung, Hyeong-Kyu Lee, Ho-Jae Lee, and Jin-Kwan Han
Development 2007 134: 769-777. [Abstract] [Full Text]  




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