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Figure 3


Fig. 3 . Anchorage of synaptic nuclei is abolished in Syne-1-/- mice. (A-A''') Representative Syne-1+/- muscle fiber with four nuclei (synaptic nuclei) clustered under the NMJ. (B-C''') No nuclei were observed under the NMJ of Syne-1-/- mice. (D,E) Statistical analyses of synaptic nuclei based on anti-SUN2 signals. Synaptic nuclei disappeared in Syne-1-/- mice (4.7 in Syne-1+/+ and Syne-1+/- vs 0.0 in Syne-1-/-, n=140 for Syne-1+/? and 210 for Syne-1-/-, P<0.0001); the number of perisynaptic nuclei was slightly increased in Syne-1-/- mice (0.0 in control vs 0.8 in KO, P<0.0001). Blue, DAPI; Green, anti-SUN2-labeled myonuclei; Red, BTX. Scale bar: 25 µm.





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