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First published online January 25, 2008

Development 135, 403e (2008)
© The Company of Biologists Limited
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In this issue

Polo kinase: a polarity player


Figure 1

Polo kinases regulate diverse processes during cell division, including mitotic onset and centrosomal duplication. Rueyling Lin's lab now reports a novel role for the polo kinases PLK-1 and PLK-2 in regulating the polarity of C. elegans embryos (see p. 687). In the one-cell C. elegans embryo, various proteins, including the PAR proteins and the maternal proteins MEX-5 and MEX-6, asymmetrically localize along the AP axis, determining the position of the first mitotic spindle and thus of the first asymmetric division. PLK-1 and PLK-2, Lin's team report, also asymmetrically localize at this stage, in a MEX-5/6-dependent manner, with which they also co-localize. PLK-1/2 interact with MEX-5/6 via the PLK-1/2 polo box domain and also via an amino acid site (T186) on MEX-5, which is primed for PLK-dependent phosphorylation by another developmentally regulated kinase, MBK-2. This priming by MBK-2, the authors report, allows the interaction between PLK-1/2 and MEX-5/6, and also the onset of MEX-5/6 function, to be temporally regulated during the crucial oocyte to embryo transition.


Related articles in Development:

Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6
Yuichi Nishi, Eric Rogers, Scott M. Robertson, and Rueyling Lin
Development 2008 135: 687-697. [Abstract] [Full Text]  




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