Expression of the c-ret proto-oncogene during mouse embryogenesis

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Altman, J. and Bayer, S (1982). Development of the cranial nerve ganglia and related nuclei in the rat. Adv. Anat. Embryol. Cell Biol._Fb_74._Fb_Auffray, C. and Rougeon, F. (1980). Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur. J. Biochem 107, 303-314.

Baetge, G. and Gershon, M. D (1989). Transient catecholaminergic (TC) cells in the vagus nerves and bowel of fetal mice: relationship to the development of enteric neurons. Dev. Biol 132, 189-211.[Medline]

Baetge, G., Pintar, J. E. and Gershon, M. D (1990). Transiently catecholaminergic (TC) cells in the bowel of the fetal rat: precursors of noncatecholaminergic enteric neurons. Dev. Biol 141, 353-380.[Medline]

Bongarzone, I., Monzini, N., Borrello, M. G., Carcano, C., Ferraresi, G., Arighi, E., Mondellini, P., Della-Porta, G. and Pierotti, M. A (1993). Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A. Mol. Cell Biol 13, 358-366.[Abstract/Free Full Text]

Cantley, L., Auger, K., Carpenter, C. D., Duckworth, B., Graziani, A., Kapeller, R. and Soltoff, S. P (1991). Oncogenes and signal transduction. Cell 64, 281-302.[Medline]

Carnahan, J. F., Anderson, D. J. and Patterson, P. H (1991). Evidence that enteric neurons may derive from the sympathoadrenal lineage. Dev. Biol 148, 552-561.[Medline]

Carroll, S. L., Silos-Santiago, I., Frese, S. E., Ruit, K. G., Milbrandt, J. and Snider, W. D (1992). Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero. Neuron 9, 779-788.[Medline]

Dodd, J., Solter, D. and Jessell, T. M (1984). Monoclonal antibodies against carbohydrate differentiation antigens identify subsets of primary sensory neurons. Nature 311, 469-472.[Medline]

Dodd, J. and Jessell, T. M (1985). Lactoseries carbohydrates specify subsets of dorsal root ganglion neurons projecting to the superficial dorsal horn of rat spinal cord. J. Neurosci 5, 3278-3294.[Abstract]

Erickson, R. A (1968). Inductive interactions in the development of the mouse metanephros. J. Exp. Zool 169, 33-42.[Medline]

Fabien, N., Paulin, C., Santoro, M., Berger, N., Grieco, M., Galvain, D., Barbier, Y., Dubois, P. M. and Fusco, A (1992). Detection of RET oncogene activation in human papillary thyroid carcinomas by in situ hybridisation. Br. J. Cancer 66, 1094-1098.[Medline]

Gershon, M. D., Chalazonitis, A. and Rothman, T. P (1993). From neural crest to bowel: development of the enteric nervous system. J. Neurobiol 24, 199-214.[Medline]

Grieco, M., Santoro, M., Berlingieri, M. T., Melillo, R. M., Donghi, R., Bongarzone, I., Pierotti, M. A., Della-Porta, G., Fusco, A. and Vecchio, G (1990). PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60, 557-563.[Medline]

Grobstein, C (1953). Inductive epithelio-mesenchymal interaction in cultured organ rudiments of the mouse. Science 118, 52-55.[Free Full Text]

Grobstein, C (1955). Inductive interaction in the development of the mouse metanephros. J. Exp. Zool 130, 319-340.

Grobstein, C (1956). Trans-filter induction of tubules in mouse metanephrogenic mesenchyme. Exp. Cell Res 10, 424-440.[Medline]

Guillemot, F. and Cepko, C. L (1992). Retinal fate and ganglion cell differentiation are potentiated by acidic FGF in an in vitro assay of early retinal development. Development 114, 743-754.[Abstract]

Hafen, E. and Basler, K (1990). Role of receptor tyrosine kinases during Drosophila development. Ciba. Found. Symp 150, 191-204.[Medline]

Hunt, P., Wilkinson, D. and Krumlauf, R (1991). Patterning the vertebrate head: murine Hox-2 genes mark distinct subpopulations of premigratory and migrating cranial neural crest. Development 112, 43-50.[Abstract]

Ikeda, I., Ishizaka, Y., Tahira, T., Suzuki, T., Onda, M., Sugimura, T. and Nagao, M (1990). Specific expression of the ret proto-oncogene in human neuroblastoma cell lines. Oncogene 5, 1291-1296.[Medline]

Iwamoto, T., Taniguchi, M., Asai, N., Ohkusu, K., Nakashima, I. and Takahashi, M (1993). cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily. Oncogene 8, 1087-1091.[Medline]

Jhiang, S. M., Caruso, D. R., Gilmore, E., Ishizaka, Y., Tahira, T., Nagao, M., Chiu, I. M. and Mazzaferri, E. L (1992). Detection of the PTC/retTPC oncogene in human thyroid cancers. Oncogene 7, 1331-1337.[Medline]

Johnson, J. E., Birren, S. J. and Anderson, D. J (1990). Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors. Nature 346, 858-861.[Medline]

Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V. and Parada, L. F (1991). The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 252, 554-558.[Abstract/Free Full Text]

Kaplan, D. R., Martin-Zanca, D. and Parada, L. F (1991). Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350, 158-160.[Medline]

Kapur, R. P., Yost, C. and Palmiter, R. D (1992). A transgenic model for studying development of the enteric nervous system in normal and aganglionic mice. Development 116, 167-175.[Abstract]

Klein, R., Jing, S. Q., Nanduri, V., O'Rourke, E. and Barbacid, M (1991). The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65, 189-197.[Medline]

Klein, R., Nanduri, V., Jing, S. A., Lamballe, F., Tapley, P., Bryant, S., Cordon-Cardo, C., Jones, K. R., Reichardt, L. F. and Barbacid, M.V. Pachnis, B. Mankoo and F. Costantini1017Expression of c-retproto-oncogene in mouse (1991). The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66, 395-403.[Medline]

Lairmore, T. C., Howe, J. R., Korte, J. A., Dilley, W. G., Aine, L., Aine, E., Wells, S. A. J. and Donis-Keller, H (1991). Familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2B map to the same region of chromosome 10 as multiple endocrine neoplasia type 2A. Genomics 9, 181-192.[Medline]

Lamballe, F., Klein, R. and Barbacid, M (1991). trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66, 967-979.[Medline]

Le Douarin, N. and Teillet, M. A (1973). The migration of neural crest cells to the wall of the digestive tract in avian embryo. J. Embryol. exp. Morph 30, 31-48.[Medline]

Levi-Montalcini, R (1987). The nerve growth factor 35 years later. Science 237, 1154-1162.[Free Full Text]

Lillien, L. and Cepko, C (1992). Control of proliferation in the retina: temporal changes in responsiveness to FGF and TGF alpha. Development 115, 253-266.[Abstract]

Lo, L. C., Johnson, J. E., Wuenschell, C. W., Saito, T. and Anderson, D. J (1991). Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells. Genes Dev 5, 1524-1537.[Abstract/Free Full Text]

Lumsden, A., Sprawson, N. and Graham, A (1991). Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo. Development 113, 1281-1291.[Abstract]

Martinez, H. J., Dreyfus, C. F., Jonakait, G. M. and Black, I. B (1985). Nerve growth factor promotes cholinergic development in brain atrial cultures. Proc. Natl. Acad. Sci. USA 82, 7777-7781.[Abstract/Free Full Text]

Mulligan, L. M., Kwok, J. B. J., Healy, C. S., Elsdon, M. J., Eng, C., Gardner, E., Love, D. R., Mole, S. E., Moore, J. K., Papi, L., Ponder, M. A., Telenius, H., Tunnacliffe, A. and Ponder, B. A. J (1993). Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363, 458-460.[Medline]

Nichols, D (1981). Neural crest formation in the head of the mouse embryo as observed using a new histological technique. J. Embryol. Exp. Morph 64, 105-120.[Medline]

Nichols, D (1986). Formation and distribution of neural crest mesenchyme to the first pharyngeal arch region of the mouse embryo. Am. J. Anat 176, 221-231.[Medline]

Noden, D. M (1983). The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissue. Dev. Biol 96, 144-165.[Medline]

Noden, D. M (1988). Interactions and fates of avian craniofacial mesenchyme. Development 103, 121-140.

Pankratz, D. S (1931). The development of the suprarenal gland in the albino rat. Anat. Rec 49, 31-39.

Pawson, T. and Bernstein, A (1990). Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development. Trends Genet 6, 350-356.[Medline]

Ruit, K. G., Elliott, J. L., Osborne, P. A., Yan, Q. and Snider, W. D (1992). Selective dependence of mammalian dorsal root ganglion neurons on nerve growth factor during embryonic development. Neuron 8, 573-587.[Medline]

Santoro, M., Rosati, R., Grieco, M., Berlingieri, M. T., D'Amato, G. L., de-Franciscis, V. and Fusco, A (1990). The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas. Oncogene 5, 1595-1598.[Medline]

Serbedzija, G. N., Bronner-Fraser, M. and Fraser, S (1992). Vital dye analysis of cranial neural crest cell migration in the mouse embryo. Development 116, 297-307.[Medline]

Soppet, D., Escandon, E., Maragos, J., Middlemas, D. S., Reid, S. W., Blair, J., Burton, L. E., Stanton, B. R., Kaplan, D. R., Hunter, T., Nikolics, K. and Parada, L (1991). The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell 65, 895-903.[Medline]

Szentirmay, Z., Ishizaka, Y., Ohgaki, H., Tahira, T., Nagao, M. and Esumi, H (1990). Demonstration by in situ hybridization of ret proto-oncogene mRNA in developing placenta during mid-term of rat gestation. Oncogene 5, 701-705.[Medline]

Tahira, T., Ishizaka, Y., Sugimura, T. and Nagao, M (1988). Expression of proto-ret mRNA in embryonic and adult rat tissues. Biochem. Biophys. Res. Commun 153, 1290-1295.[Medline]

Tahira, T., Ishizaka, Y., Itoh, F., Sugimura, T. and Nagao, M (1990). Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line. Oncogene 5, 97-102.[Medline]

Tahira, T., Ishizaka, Y., Itoh, F., Nakayasu, M., Sugimura, T. and Nagao, M (1991). Expression of the ret proto-oncogene in human neuroblastoma cell lines and its increase during neuronal differentiation induced by retinoic acid. Oncogene 6, 2333-2338.[Medline]

Takahashi, M., Ritz, J. and Cooper, G. M (1985). Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 42, 581-588.[Medline]

Takahashi, M. and Cooper, G. M (1987). Ret transforming gene encodes a fusion protein homologous to tyrosine kinases. Mol. Cell Biol 7, 1378-1385.[Abstract/Free Full Text]

Takahashi, M., Buma, Y., Iwamoto, T., Inaguma, Y., Ikeda, H. and Hiai, H (1988). Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene 3, 571-578.[Medline]

Takahashi, M., Buma, Y. and Taniguchi, M (1991). Identification of the ret proto-oncogene products in neuroblastoma and leukemia cells. Oncogene 6, 297-301.[Medline]

Tucker, G., Ciment, G. and Thiery, J. P (1986). Pathways of avian neural crest cell migration in the developing gut. Dev. Biol 116, 439-450.[Medline]

Turner, D. L. and Cepko, C (1987). A common progenitor for neurons and glia persists in rat retina late in development. Nature 328, 131-136.[Medline]

Turner, D. L., Snyder, E. Y. and Cepko, C. L (1990). Lineage-independent determination of cell type in the embryonic mouse retina. Neuron 4, 833-845.[Medline]

Ullrich, A. and Schlessinger, J (1990). Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203-212.[Medline]

Wetts, R., Serbedzija, G. N. and Fraser, S. E (1989). Cell lineage analysis reveals multipotent precursors in the ciliary margin of the frog retina. Dev. Biol 136, 254-263.[Medline]

Yarden, Y. and Ullrich, A (1988). Growth factor receptor tyrosine kinases. Ann. Rev. Biochem 57, 443-478.[Medline]

Yntema, C. L. and Hammond, W. S (1954). The origin of intrinsic gagnlia of trunk viscera from vagal neural crest in the chick embryo. J. Comp. Neurol 101, 515-542.

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P. Wang, F. A. Pereira, D. Beasley, and H. Zheng
Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis
Development, October 15, 2003; 130(20): 5019 - 5029.
[Abstract] [Full Text] [PDF]

P Griseri, G Patrone, F Puppo, G Romeo, R Ravazzolo, and I Ceccherini
Rescue of human RET gene expression by sodium butyrate: a novel powerful tool for molecular studies in Hirschsprung disease
Gut, August 1, 2003; 52(8): 1154 - 1158.
[Abstract] [Full Text] [PDF]

A. Majumdar, S. Vainio, A. Kispert, J. McMahon, and A. P. McMahon
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
Development, July 15, 2003; 130(14): 3175 - 3185.
[Abstract] [Full Text] [PDF]

A. Maeshima, S. Yamashita, K. Maeshima, I. Kojima, and Y. Nojima
Activin A Produced by Ureteric Bud Is a Differentiation Factor For Metanephric Mesenchyme
J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1523 - 1534.
[Abstract] [Full Text] [PDF]

K. Niederreither, J. Vermot, I. L. Roux, B. Schuhbaur, P. Chambon, and P. Dolle
The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system
Development, June 1, 2003; 130(11): 2525 - 2534.
[Abstract] [Full Text] [PDF]

D. Lang and J. A. Epstein
Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer
Hum. Mol. Genet., April 15, 2003; 12(8): 937 - 945.
[Abstract] [Full Text] [PDF]

A. Popsueva, D. Poteryaev, E. Arighi, X. Meng, A. Angers-Loustau, D. Kaplan, M. Saarma, and H. Sariola
GDNF promotes tubulogenesis of GFR{alpha}1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase
J. Cell Biol., April 14, 2003; 161(1): 119 - 129.
[Abstract] [Full Text] [PDF]

L. Yip, G. J. Cote, S. E. Shapiro, G. D. Ayers, C. E. Herzog, R. V. Sellin, S. I. Sherman, R. F. Gagel, J. E. Lee, and D. B. Evans
Multiple Endocrine Neoplasia Type 2: Evaluation of the Genotype-Phenotype Relationship
Arch Surg, April 1, 2003; 138(4): 409 - 416.
[Abstract] [Full Text] [PDF]

D. Natarajan, C. Marcos-Gutierrez, V. Pachnis, and E. de Graaff
Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis
Development, March 13, 2003; 129(22): 5151 - 5160.
[Abstract] [Full Text] [PDF]

K. Huber, B. Bruhl, F. Guillemot, E. N. Olson, U. Ernsberger, and K. Unsicker
Development of chromaffin cells depends on MASH1 function
Development, March 12, 2003; 129(20): 4729 - 4738.
[Abstract] [Full Text] [PDF]

				K. Hamatani, H. Eguchi, R. Ito, M. Mukai, K. Takahashi, M. Taga, K. Imai, J. Cologne, M. Soda, K. Arihiro, et al. RET/PTC Rearrangements Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors Exposed to High Radiation Dose Cancer Res., September 1, 2008; 68(17): 7176 - 7182. [Abstract] [Full Text] [PDF]

				G. Williams, J. T. Fletcher, S. I. Alexander, and J. C. Craig Vesicoureteral Reflux J. Am. Soc. Nephrol., May 1, 2008; 19(5): 847 - 862. [Abstract] [Full Text] [PDF]

				N. Akeno-Stuart, M. Croyle, J. A. Knauf, R. Malaguarnera, D. Vitagliano, M. Santoro, C. Stephan, K. Grosios, M. Wartmann, R. Cozens, et al. The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells Cancer Res., July 15, 2007; 67(14): 6956 - 6964. [Abstract] [Full Text] [PDF]

				F. D'Autreaux, Y. Morikawa, P. Cserjesi, and M. D. Gershon Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia Development, June 15, 2007; 134(12): 2237 - 2249. [Abstract] [Full Text] [PDF]

				J. Mijatovic, M. Airavaara, A. Planken, P. Auvinen, A. Raasmaja, T. P. Piepponen, F. Costantini, L. Ahtee, and M. Saarma Constitutive Ret Activity in Knock-In Multiple Endocrine Neoplasia Type B Mice Induces Profound Elevation of Brain Dopamine Concentration via Enhanced Synthesis and Increases the Number of TH-Positive Cells in the Substantia Nigra J. Neurosci., May 2, 2007; 27(18): 4799 - 4809. [Abstract] [Full Text] [PDF]

				M. Narlis, D. Grote, Y. Gaitan, S. K. Boualia, and M. Bouchard Pax2 and Pax8 Regulate Branching Morphogenesis and Nephron Differentiation in the Developing Kidney J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1121 - 1129. [Abstract] [Full Text] [PDF]

				E. Hatton-Ellis, C. Ainsworth, Y. Sushama, S. Wan, K. VijayRaghavan, and H. Skaer From the Cover: Genetic regulation of patterned tubular branching in Drosophila PNAS, January 2, 2007; 104(1): 169 - 174. [Abstract] [Full Text] [PDF]

				J. C. Clarke, S. R. Patel, R. M. Raymond Jr, S. Andrew, B. G. Robinson, G. R. Dressler, and P. D. Brophy Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage Hum. Mol. Genet., December 1, 2006; 15(23): 3420 - 3428. [Abstract] [Full Text] [PDF]

				N. Asai, T. Fukuda, Z. Wu, A. Enomoto, V. Pachnis, M. Takahashi, and F. Costantini Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells Development, November 15, 2006; 133(22): 4507 - 4516. [Abstract] [Full Text] [PDF]

				H. Fan, J. Stefkova, and S. S. El-Dahr Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway Am J Physiol Renal Physiol, September 1, 2006; 291(3): F670 - F682. [Abstract] [Full Text] [PDF]

				J. W. B. de Groot, T. P. Links, J. T. M. Plukker, C. J. M. Lips, and R. M. W. Hofstra RET as a Diagnostic and Therapeutic Target in Sporadic and Hereditary Endocrine Tumors Endocr. Rev., August 1, 2006; 27(5): 535 - 560. [Abstract] [Full Text] [PDF]

				A. Cranston, C. Carniti, S. Martin, P. Mondellini, Y. Hooks, J. Leyland, S. Hodgson, S. Clarke, M. Pierotti, B. A. J. Ponder, et al. A Novel Activating Mutation in the RET Tyrosine Kinase Domain Mediates Neoplastic Transformation Mol. Endocrinol., July 1, 2006; 20(7): 1633 - 1643. [Abstract] [Full Text] [PDF]

				J. R. Cabrera, L. Sanchez-Pulido, A. M. Rojas, A. Valencia, S. Manes, J. R. Naranjo, and B. Mellstrom Gas1 Is Related to the Glial Cell-derived Neurotrophic Factor Family Receptors {alpha} and Regulates Ret Signaling J. Biol. Chem., May 19, 2006; 281(20): 14330 - 14339. [Abstract] [Full Text] [PDF]

				S. M. Ward, G. J. McLaren, and K. M. Sanders Interstitial cells of Cajal in the deep muscular plexus mediate enteric motor neurotransmission in the mouse small intestine J. Physiol., May 15, 2006; 573(1): 147 - 159. [Abstract] [Full Text] [PDF]

				T. A. Heanue and V. Pachnis From the Cover: Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes PNAS, May 2, 2006; 103(18): 6919 - 6924. [Abstract] [Full Text] [PDF]

				S. Fisher, E. A. Grice, R. M. Vinton, S. L. Bessling, and A. S. McCallion Conservation of RET Regulatory Function from Human to Zebrafish Without Sequence Similarity Science, April 14, 2006; 312(5771): 276 - 279. [Abstract] [Full Text] [PDF]

				C. Carniti, S. Belluco, E. Riccardi, A. N. Cranston, P. Mondellini, B. A.J. Ponder, E. Scanziani, M. A. Pierotti, and I. Bongarzone The RetC620R Mutation Affects Renal and Enteric Development in a Mouse Model of Hirschsprung's Disease Am. J. Pathol., April 1, 2006; 168(4): 1262 - 1275. [Abstract] [Full Text] [PDF]

				D. Grote, A. Souabni, M. Busslinger, and M. Bouchard Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney Development, January 1, 2006; 133(1): 53 - 61. [Abstract] [Full Text] [PDF]

				E. A. Grice, E. S. Rochelle, E. D. Green, A. Chakravarti, and A. S. McCallion Evaluation of the RET regulatory landscape reveals the biological relevance of a HSCR-implicated enhancer Hum. Mol. Genet., December 15, 2005; 14(24): 3837 - 3845. [Abstract] [Full Text] [PDF]

				A. Wong, S. Bogni, P. Kotka, E. de Graaff, V. D'Agati, F. Costantini, and V. Pachnis Phosphotyrosine 1062 Is Critical for the In Vivo Activity of the Ret9 Receptor Tyrosine Kinase Isoform Mol. Cell. Biol., November 1, 2005; 25(21): 9661 - 9673. [Abstract] [Full Text] [PDF]

				P. Gut, K. Huber, J. Lohr, B. Bruhl, S. Oberle, M. Treier, U. Ernsberger, C. Kalcheim, and K. Unsicker Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells Development, October 15, 2005; 132(20): 4611 - 4619. [Abstract] [Full Text] [PDF]

				S. J. Marx and W. F. Simonds Hereditary Hormone Excess: Genes, Molecular Pathways, and Syndromes Endocr. Rev., August 1, 2005; 26(5): 615 - 661. [Abstract] [Full Text] [PDF]

				K. M. Schmidt-Ott, J. Yang, X. Chen, H. Wang, N. Paragas, K. Mori, J.-Y. Li, B. Lu, F. Costantini, M. Schiffer, et al. Novel Regulators of Kidney Development from the Tips of the Ureteric Bud J. Am. Soc. Nephrol., July 1, 2005; 16(7): 1993 - 2002. [Abstract] [Full Text] [PDF]

				H. K.W. Tse, M. B.W. Leung, A. S. Woolf, A. L. Menke, N. D. Hastie, J. A. Gosling, C.-P. Pang, and A. S.W. Shum Implication of Wt1 in the Pathogenesis of Nephrogenic Failure in a Mouse Model of Retinoic Acid-Induced Caudal Regression Syndrome Am. J. Pathol., May 1, 2005; 166(5): 1295 - 1307. [Abstract] [Full Text] [PDF]

				M. Rossel, K. Loulier, C. Feuillet, S. Alonso, and P. Carroll Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons Development, March 15, 2005; 132(6): 1175 - 1185. [Abstract] [Full Text] [PDF]

				I. Plaza Menacho, R. Koster, A. M. van der Sloot, W. J. Quax, J. Osinga, T. van der Sluis, H. Hollema, G. M. Burzynski, O. Gimm, C. H.C.M. Buys, et al. RET-Familial Medullary Thyroid Carcinoma Mutants Y791F and S891A Activate a Src/JAK/STAT3 Pathway, Independent of Glial Cell Line-Derived Neurotrophic Factor Cancer Res., March 1, 2005; 65(5): 1729 - 1737. [Abstract] [Full Text] [PDF]

				M. A. Skinner, S. Kalyanaraman, S. D. Safford, R. O. Heuckeroth, W. Tourtellotte, D. Goyeau, P. Goodfellow, J. D. Milbrandt, and A. Freemerman A Human Yeast Artificial Chromosome Containing the Multiple Endocrine Neoplasia Type 2B Ret Mutation Does Not Induce Medullary Thyroid Carcinoma but Does Support the Growth of Kidneys and Partially Rescues Enteric Nervous System Development in Ret-Deficient Mice Am. J. Pathol., January 1, 2005; 166(1): 265 - 274. [Abstract] [Full Text] [PDF]

				G. Schuetz, M. Rosario, J. Grimm, T. M. Boeckers, E. D. Gundelfinger, and W. Birchmeier The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells J. Cell Biol., December 6, 2004; 167(5): 945 - 952. [Abstract] [Full Text] [PDF]

				M. Santoro, R. M. Melillo, F. Carlomagno, G. Vecchio, and A. Fusco Minireview: RET: Normal and Abnormal Functions Endocrinology, December 1, 2004; 145(12): 5448 - 5451. [Abstract] [Full Text] [PDF]

				O. H. Yu, I. J. Murawski, D. B. Myburgh, and I. R. Gupta Overexpression of RET leads to vesicoureteric reflux in mice Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1123 - F1130. [Abstract] [Full Text] [PDF]