Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system

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Benowitz, L. I. and Routtenberg, A (1987). A membrane phosphoprotein associate with neural development, axonal regeneration, phospholipid metabolism, and synaptic plasticity. Trends in Neurosci 3, 527-532.

Benowitz, L. I., Apostolides, P. J., Perrone-Bizzozero, N., Finklestein, S. P. and Zwiers, H (1988). Anatomical distribution of the growth-associated protein GAP-43/B-50 in the adult rat brain. J. Neurosci 8, 339-352.[Abstract]

Caviness, V. S., Jr (1982). Neocortical histogenesis in normal and reeler mice: a developmental study based upon [3 H]thymidine autoradiography. Dev. Brain Res 4, 293-302.

Caviness, V. S. and Sidman, R. L (1973). Time of origin of corresponding cell classes in the cerebral cortex of normal and reeler mutant mice: an autoradiographic analysis. J. Comp. Neurol 148, 141-152.[Medline]

Cleveland, D. W., Fischer, S. G., Kirschner, M. W. and Laemmli, U. K (1977). Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. J. Biol. Chem 252, 1102-6.[Abstract/Free Full Text]

Dani, J. W., Armstrong, D. M. and Benowitz, L. I (1991). Mapping the development of the rat brain by GAP-43 immunocytochemistry. Neurosci 40, 277-287.[Medline]

Draetta, G (1990). Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends Biochem. Sci 15, 378-83.[Medline]

Draetta, G. and Beach, D (1988). Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54, 17-26.[Medline]

Drewes, G., Lichtenberg-Kraag, B., Doring, F., Mandelkow, E.-M., Biernat, J., Goris, J., Doree, M. and Mandelkow, E (1992). Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state. EMBO J 11, 2131-2138.[Medline]

Ducommun, B., Brambilla, P., Felix, M. A., Franza, B. J., Karsenti, E. and Draetta, G (1991). cdc2 phosphorylation is required for its interaction with cyclin. EMBO J 10, 3311-3319.[Medline]

Elledge, S. J. and Spottswood, M. R (1991). A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homologue of Xenopus Eg1. EMBO J 10, 2653-2659.[Medline]

Evans, T., Rosenthal, E. T., Youngblom, J., Distel, D. and Hunt, T (1983). Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 33, 389-396.[Medline]

Fang, F. and Newport, J. W (1991). Evidence that the G1 -S and G2 -M transitions are controlled by different cdc2 proteins in higher eukaryotes. Cell 66, 731-742.[Medline]

Goslin, K., Schreyer, D. J., Skene, J. H. P., and Banker, G (1988). Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones. Nature 336, 672-674.[Medline]

Gould, K. L., Moreno, S., Owen, D. J., Sazer, S. and Nurse, P (1991). Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function. EMBO J 10, 3297-3309.[Medline]

Gould, K. L. and Nurse, P (1989). Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature 342, 39-45.[Medline]

Hamaguchi, J. R., Tobey, R. A., Pines, J., Crissman, H. A., Hunter, T. and Bradbury, E. M (1992). Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210. J. Cell Biol 117, 1041-1053.[Abstract/Free Full Text]

Harlow, E., Franza, B. J. and Schley, C (1985). Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products. J. Virol 55, 533-546.[Abstract/Free Full Text]

Hellmich, M. R., Pant, H. C., Wada, E. and Battey, J. F (1992). Neuronalcdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression. Proc. Natl. Acad. Sci. USA 89, 10867-10871.[Abstract/Free Full Text]

Hisanaga, S.-I., Kusubata, M., Okumura, E. and Kishimoto, T (1991). Phosphorylation of neurofilament H subunit at the tail domain by cdc2 kinase dissociates the association to microtubules. J. Biol. Chem 266, 21798-21803.[Abstract/Free Full Text]

Hunt, T (1989). Maturation promoting factor, cyclin and the control of M-phase. Current Opinion in Cell Biology 1, 268-74.[Medline]

Hunt, T (1991). Cell biology. Cell cycle gets more cyclins [news; comment]. Nature 350, 462-3.[Medline]

Hunter, T. and Pines, J (1991). Cyclins and Cancer. Cell 66, 1071-1074.[Medline]

Jacobson, R. D., Virag, I. and Skene, J. H. P (1986). A protein associated with axon growth, GAP-43, is widely distributed and developmentally regulated in rat CNS. J. Neurosci 6, 1843-1855.[Abstract]

Koff, A., Cross, F., Fisher, A., Schumacher, J., Leguellec, K., Philippe, M. and Roberts, J. M (1991). Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell 66, 1217-28.[Medline]

Kosik, K. S (1993). The molecular and cellular biology of Tau. Brain Pathol 3, 39-43.[Medline]

Krek, W. and Nigg, E. A (1991). Differential phosphorylation of vertebrate p34cdc2 kinase at the G1 /S and G2 /M transitions of the cell cycle: Identification of major phosphorylation sites. EMBO J 10, 305-316.[Medline]

Krek, W. and Nigg, E. A (1991). Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: Evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J 10, 3331-3341.[Medline]

Laemmli, U. K (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.[Medline]

Lew, J., Beaudette, K., Litwin, C. M. E. and Wang, J. H (1992). Purification and characterization of a novel proline-directed protein kinase from bovine brain. J. Biol. Chem 267, 13383-13390.[Abstract/Free Full Text]

Lew, J., Winkfein, R. J., Paudel, H. K. and Wang, J. H (1992). Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. J. Biol. Chem 267, 25922-25926.[Abstract/Free Full Text]

Meyerson, M., Enders, G., Wu, C.-L., Su, L.-K., Gorka, C., Nelson, C., Harlow, E. and Tsai, L.-H (1992). A family of human cdc2-related protein kinases. EMBO J 11, 2909-2917.[Medline]

Meiri, K. F., Willard, M. and Johnson, M. I (1988). Distribution and phosphorylation of the growth associated protein GAP-43 in regenerating sympathetic neurons in culture. J. Neurosci 8, 2571-2581.[Abstract]

Misson, J-P., Austin, C. P., Takahashi, T., Cepko, C. L. and Caviness, V S. jr (1991). The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system. Cerebral Cortex 1, 221-229.[Abstract/Free Full Text]

Misson, J-P., Edwards, M. A., Yamamoto, M. and Caviness,V. S. Jr (1988). Identification of radial glial cells within the developing murine central nervous system: studies based upon a new immunochemical marker. Dev. Brain Res 44, 95-108.[Medline]

Misson, J.-P., Takahashi, T. and Caviness, V. S. Jr (1991). Ontogeny of radial and other astroglial cells in murine cerebral cortex. Glia 4, 138-148.[Medline]

Moya, K. L., Jhaveri, S., Schnieder, G. E. and Benowitz, L (1989). Immunohistochemical localization of GAP-43 in the developing hamster retinofugal pathway. J. Comp. Neurol 288, 51-58.[Medline]

Murray, A. W. and Kirschner, M. W (1989). Dominoes and clocks: the union of two views of the cell cycle. Science 246, 614-21.[Abstract/Free Full Text]

Ninomiya-Tsuji, J., Nomoto, S., Yasuda, H., Reed, S. I. and Matsumoto, K (1991). Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. Proc. Natl. Acad. Sci. USA 88, 9006-9010.[Abstract/Free Full Text]

Nixon, R. and Sihag, R. K (1991). Neurofilament phosphorylation: a new look at regulation and function. Trends in NeuroSci 14, 501-506.[Medline]

Norbury, C., Blow, J. and Nurse, P (1991). Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates. EMBO J 10, 3321-3329.[Medline]

Nurse, P (1990). Universal control mechanism regulating onset of M-phase. Nature 344, 503-508.[Medline]

Pagano, M., Pepperkok, R., Lukas, J., Baldin, V., Ansorge, W., Bartek, J. and Draetta, G (1993). Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J. Cell Biol 121, 101-111.[Abstract/Free Full Text]

Paris, J., Le, G. R., Couturier, A., Le, G. K., Omilli, F., Camonis, J., MacNeill, S. and Philippe, M (1991). Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2. Proc. Natl. Acad. Sci. USA 88, 1039-43.[Abstract/Free Full Text]

Pines, J. and Hunter, T (1990). p34cdc2 : the S and M kinase?. New Biologist 2, 389-401.[Medline]

Rakic, P (1972). Mode of cell migration to the superficial layers of fetal monkey neocortex. J. Comp. Neurol 45, 61-84.

Rakic, P (1988). Specification of cerebral cortical areas. Science 241, 170-176.[Abstract/Free Full Text]

Reed, S. I (1991). G1 specific cyclins: in search of an S-phase promoting factor. Trends in Genetics 7, 95-99.[Medline]

Riabowol, K., Draetta, G., Brizuela, L., Vandre, D. and Beach, D (1989). The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57, 393-401.[Medline]

Sidman, R L., Miale, I. L. and Feder, N (1959). Cell proliferation and migration in the primitive ependymal zone: an autoradiographic study of histogenesis in the nervous system. Exp. Neurol 1, 322-333.[Medline]

Skene, J. H. P (1989). Axonal growth-associated proteins. Ann. Rev. Neurosci 12, 127-156.[Medline]

Solomon, M. J., Glotzer, M., Lee, T. H., Phillipe, M. and Kirschner, M. W (1990). Cyclin activation of p34cdc2. Cell 63, 1013-1024.[Medline]

Takahashi, T., Misson, J.-P. and Caviness, V. S. Jr (1991). Glial process elongation and branching in the developing murine neocortex: a qualitative and quantitative immunohistochemical analysis. J. Comp. Neurol 302, 15-28.

Takahashi, T., Nowakowski, R. S. and Caviness, V. S. Jr (1992). BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone. J. Neurocytol 21, 185-197.[Medline]

Takahashi, T., Nowakowski, R. S. and Caviness, V. S. Jr (1993). Cell cycle parameters and patterns of nuclear movement in the neocortical proliferative zone of the fetal mouse. J. Neurosci 13, 820-833.[Abstract]

Th'ng, J. P., Wright, P. S., Hamaguchi, J., Lee, M. G., Norbury, C. J., Nurse, P. and Bradbury, E. M (1990). The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product. Cell 63, 313-24.[Medline]

Tsai, L.-H., Harlow, E. and Meyerson, M (1991). Isolation of the human cdk2 gene that encodes the cyclin A-and adenovirus E1A-associated p33 kinase. Nature 353, 174-177.[Medline]

Tsai, L.-H., Lees, E., Faha, B., Harlow, E. and Riabowol, K (1993). The cdk2 kinase is required for the G1 -to-S transition in mammalian cells. Oncogene 8, 1593-1602.[Medline]

Xiong, Y., Zhang, H. and Beach, D (1992). D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71, 505-514.[Medline]

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Cell Growth Differ., March 1, 1999; 10(3): 173 - 181.
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M Boxem, D. Srinivasan, and S van den Heuvel
The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase
Development, January 5, 1999; 126(10): 2227 - 2239.
[Abstract] [PDF]

G. Paglini, G. Pigino, P. Kunda, G. Morfini, R. Maccioni, S. Quiroga, A. Ferreira, and A. Caceres
Evidence for the Participation of the Neuron-Specific CDK5 Activator P35 during Laminin-Enhanced Axonal Growth
J. Neurosci., December 1, 1998; 18(23): 9858 - 9869.
[Abstract] [Full Text] [PDF]

G. N. Patrick, P. Zhou, Y. T. Kwon, P. M. Howley, and L.-H. Tsai
p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5�(Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway
J. Biol. Chem., September 11, 1998; 273(37): 24057 - 24064.
[Abstract] [Full Text] [PDF]

E. C. Gilmore, T. Ohshima, A. M. Goffinet, A. B. Kulkarni, and K. Herrup
Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex
J. Neurosci., August 15, 1998; 18(16): 6370 - 6377.
[Abstract] [Full Text] [PDF]

Z. Qi, D. Tang, X. Zhu, D. J. Fujita, and J. H. Wang
Association of Neurofilament Proteins with Neuronal Cdk5 Activator
J. Biol. Chem., January 23, 1998; 273(4): 2329 - 2335.
[Abstract] [Full Text] [PDF]

X. Wang, H. Luo, H. Chen, W. Duguid, and J. Wu
Role of Proteasomes in T Cell Activation and Proliferation
J. Immunol., January 15, 1998; 160(2): 788 - 801.
[Abstract] [Full Text]

				C. J. Strock, J.-I. Park, E. K. Nakakura, G. S. Bova, J. T. Isaacs, D. W. Ball, and B. D. Nelkin Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. Cancer Res., August 1, 2006; 66(15): 7509 - 7515. [Abstract] [Full Text] [PDF]

				K. E. Morris, L. M. Schang, and D. N. Brindley Lipid Phosphate Phosphatase-2 Activity Regulates S-phase Entry of the Cell Cycle in Rat2 Fibroblasts J. Biol. Chem., April 7, 2006; 281(14): 9297 - 9306. [Abstract] [Full Text] [PDF]

				P. D. Smith, M. P. Mount, R. Shree, S. Callaghan, R. S. Slack, H. Anisman, I. Vincent, X. Wang, Z. Mao, and D. S. Park Calpain-Regulated p35/cdk5 Plays a Central Role in Dopaminergic Neuron Death through Modulation of the Transcription Factor Myocyte Enhancer Factor 2 J. Neurosci., January 11, 2006; 26(2): 440 - 447. [Abstract] [Full Text] [PDF]

				S. Cicero and K. Herrup Cyclin-Dependent Kinase 5 Is Essential for Neuronal Cell Cycle Arrest and Differentiation J. Neurosci., October 19, 2005; 25(42): 9658 - 9668. [Abstract] [Full Text] [PDF]

				S. Luo, C. Vacher, J. E. Davies, and D. C. Rubinsztein Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity J. Cell Biol., May 23, 2005; 169(4): 647 - 656. [Abstract] [Full Text] [PDF]

				S. V. Griffin, K. Hiromura, J. Pippin, A. T. Petermann, M. J. Blonski, R. Krofft, S. Takahashi, A. B. Kulkarni, and S. J. Shankland Cyclin-Dependent Kinase 5 Is a Regulator of Podocyte Differentiation, Proliferation, and Morphology Am. J. Pathol., October 1, 2004; 165(4): 1175 - 1185. [Abstract] [Full Text] [PDF]

				S. Kesavapany, N. Amin, Y.-L. Zheng, R. Nijhara, H. Jaffe, R. Sihag, J. S. Gutkind, S. Takahashi, A. Kulkarni, P. Grant, et al. p35/Cyclin-Dependent Kinase 5 Phosphorylation of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) Mediates Rac-Dependent Extracellular Signal-Regulated Kinase 1/2 Activity, Altering RasGRF2 and Microtubule-Associated Protein 1b Distribution in Neurons J. Neurosci., May 5, 2004; 24(18): 4421 - 4431. [Abstract] [Full Text] [PDF]

				M. Hirasawa, T. Ohshima, S. Takahashi, G. Longenecker, Y. Honjo, Veeranna, H. C. Pant, K. Mikoshiba, R. O. Brady, and A. B. Kulkarni Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects PNAS, April 20, 2004; 101(16): 6249 - 6254. [Abstract] [Full Text] [PDF]

				V. Hammond, L.-H. Tsai, and S.-S. Tan Control of Cortical Neuron Migration and Layering: Cell and Non Cell-Autonomous Effects of p35 J. Neurosci., January 14, 2004; 24(2): 576 - 587. [Abstract] [Full Text] [PDF]

				J. L. Rosales, B.-C. Lee, M. Modarressi, K. P. Sarker, K.-Y. Lee, Y.-G. Jeong, R. Oko, and K.-Y. Lee Outer Dense Fibers Serve as a Functional Target for Cdk5{middle dot}p35 in the Developing Sperm Tail J. Biol. Chem., January 9, 2004; 279(2): 1224 - 1232. [Abstract] [Full Text] [PDF]

				J. L. Hallows, K. Chen, R. A. DePinho, and I. Vincent Decreased Cyclin-Dependent Kinase 5 (cdk5) Activity Is Accompanied by Redistribution of cdk5 and Cytoskeletal Proteins and Increased Cytoskeletal Protein Phosphorylation in p35 Null Mice J. Neurosci., November 19, 2003; 23(33): 10633 - 10644. [Abstract] [Full Text] [PDF]

				S. Takahashi, T. Saito, S.-i. Hisanaga, H. C. Pant, and A. B. Kulkarni Tau Phosphorylation by Cyclin-dependent Kinase 5/p39 during Brain Development Reduces Its Affinity for Microtubules J. Biol. Chem., March 14, 2003; 278(12): 10506 - 10515. [Abstract] [Full Text] [PDF]

				C. Gao, S. Negash, H. T. Guo, D. Ledee, H.-S. Wang, and P. Zelenka CDK5 Regulates Cell Adhesion and Migration in Corneal Epithelial Cells Mol. Cancer Res., November 1, 2002; 1(1): 12 - 24. [Abstract] [Full Text] [PDF]

				R. Dhavan, P. L. Greer, M. A. Morabito, L. R. Orlando, and L.-H. Tsai The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the alpha -Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and alpha -Actinin-1 in a Calcium-Dependent Manner J. Neurosci., September 15, 2002; 22(18): 7879 - 7891. [Abstract] [Full Text] [PDF]

				B. Bu, J. Li, P. Davies, and I. Vincent Deregulation of cdk5, Hyperphosphorylation, and Cytoskeletal Pathology in the Niemann-Pick Type C Murine Model J. Neurosci., August 1, 2002; 22(15): 6515 - 6525. [Abstract] [Full Text] [PDF]

				L. M. Schang, A. Bantly, and P. A. Schaffer Explant-Induced Reactivation of Herpes Simplex Virus Occurs in Neurons Expressing Nuclear cdk2 and cdk4 J. Virol., June 27, 2002; 76(15): 7724 - 7735. [Abstract] [Full Text] [PDF]

				L. Keshvara, S. Magdaleno, D. Benhayon, and T. Curran Cyclin-Dependent Kinase 5 Phosphorylates Disabled 1 Independently of Reelin Signaling J. Neurosci., June 15, 2002; 22(12): 4869 - 4877. [Abstract] [Full Text] [PDF]

				T. Ohshima, M. Ogawa, K. Takeuchi, S. Takahashi, A. B. Kulkarni, and K. Mikoshiba Cyclin-Dependent Kinase 5/p35 Contributes Synergistically with Reelin/Dab1 to the Positioning of Facial Branchiomotor and Inferior Olive Neurons in the Developing Mouse Hindbrain J. Neurosci., May 15, 2002; 22(10): 4036 - 4044. [Abstract] [Full Text] [PDF]

				S. Negash, H.-S. Wang, C. Gao, D. Ledee, and P. Zelenka Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells J. Cell Sci., May 15, 2002; 115(10): 2109 - 2117. [Abstract] [Full Text] [PDF]

				A. Fischer, F. Sananbenesi, C. Schrick, J. Spiess, and J. Radulovic Cyclin-Dependent Kinase 5 Is Required for Associative Learning J. Neurosci., May 1, 2002; 22(9): 3700 - 3707. [Abstract] [Full Text] [PDF]

				K. Tomizawa, J. Ohta, M. Matsushita, A. Moriwaki, S.-T. Li, K. Takei, and H. Matsui Cdk5/p35 Regulates Neurotransmitter Release through Phosphorylation and Downregulation of P/Q-Type Voltage-Dependent Calcium Channel Activity J. Neurosci., April 1, 2002; 22(7): 2590 - 2597. [Abstract] [Full Text] [PDF]

				H. Patzke and L.-H. Tsai Calpain-mediated Cleavage of the Cyclin-dependent Kinase-5 Activator p39 to p29 J. Biol. Chem., March 1, 2002; 277(10): 8054 - 8060. [Abstract] [Full Text] [PDF]

				S. Ross, A. Tienhaara, M.-S. Lee, L.-H. Tsai, and G. Gill GC Box-binding Transcription Factors Control the Neuronal Specific Transcription of the Cyclin-dependent Kinase 5 Regulator p35 J. Biol. Chem., February 1, 2002; 277(6): 4455 - 4464. [Abstract] [Full Text] [PDF]

				P. A. Stein, C. P. Toret, A. N. Salic, M. M. Rolls, and T. A. Rapoport A novel centrosome-associated protein with affinity for microtubules J. Cell Sci., January 9, 2002; 115(17): 3389 - 3402. [Abstract] [Full Text] [PDF]

				R. Graeser, J. Gannon, R. Y. C. Poon, T. Dubois, A. Aitken, and T. Hunt Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells J. Cell Sci., January 9, 2002; 115(17): 3479 - 3490. [Abstract] [Full Text] [PDF]

				E. C. Gilmore and K. Herrup Neocortical Cell Migration: GABAergic Neurons and Cells in Layers I and VI Move in a Cyclin-Dependent Kinase 5-Independent Manner J. Neurosci., December 15, 2001; 21(24): 9690 - 9700. [Abstract] [Full Text] [PDF]

				V. Frost, S. Delikat, S. Al-Mehairi, and A. J. Sinclair Regulation of p27KIP1 in Epstein-Barr virus-immortalized lymphoblastoid cell lines involves non-apoptotic caspase cleavage J. Gen. Virol., December 1, 2001; 82(12): 3057 - 3066. [Abstract] [Full Text] [PDF]

				F. Liu, X.-H. Ma, J. Ule, J. A. Bibb, A. Nishi, A. J. DeMaggio, Z. Yan, A. C. Nairn, and P. Greengard Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors PNAS, September 25, 2001; 98(20): 11062 - 11068. [Abstract] [Full Text] [PDF]

				J. Ko, S. Humbert, R. T. Bronson, S. Takahashi, A. B. Kulkarni, E. Li, and L.-H. Tsai p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment J. Neurosci., September 1, 2001; 21(17): 6758 - 6771. [Abstract] [Full Text] [PDF]

				C. Hall, G. J. Michael, N. Cann, G. Ferrari, M. Teo, T. Jacobs, C. Monfries, and L. Lim {alpha}2-Chimaerin, a Cdc42/Rac1 Regulator, Is Selectively Expressed in the Rat Embryonic Nervous System and Is Involved in Neuritogenesis in N1E-115 Neuroblastoma Cells J. Neurosci., July 15, 2001; 21(14): 5191 - 5202. [Abstract] [Full Text] [PDF]