patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Johnson, R. L.
	Articles by Scott, M. P.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Johnson, R. L.
	Articles by Scott, M. P.

Basler, K. and G. Struhl (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.[Medline]

Bellen, H. J., C. O'Kane, C. Wilson, U. Grossniklaus, R. K. Pearson and W. J. Gehring (1989). P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev 3, 1288-1300.[Abstract/Free Full Text]

Brand, A. H. and N. Perrimon (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.[Abstract]

Capdevila, J., M. P. Estrada, E. S\207nchez-Herrero and I. Guerrero (1994). The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J 13, 71-82.[Medline]

Capdevila, J. and I. Guerrero (1994). Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J 13, 4459-4468.[Medline]

Capdevila, J., F. Pariente, J. Sampedro, J. L. Alonso, and I. Guerrero (1994). Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos. Development 120, 987-998.[Abstract]

Chang, D. T., A. Lopez, D. P. von Kessler, C. Chiang, B. K. Simandl, R. Zhao, M. F. Seldin, J. F. Fallon and P. A. Beachy (1994). Products, genetic linkage, and limb patterning activity of a murine hedgehog gene. Development 120, 3339-3353.[Abstract]

Cubas, P., J. F. de Celis, S. Campuzano and J. Modolell (1991). Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev 5, 996-1008.[Abstract/Free Full Text]

Eaton, S. and T. B. Kornberg (1990). Repression of ci-D in posterior compartments of Drosophila by engrailed. Genes Dev 4, 1068-1077.[Abstract/Free Full Text]

Fausto-Sterling, A (1978). Pattern formation in the wing veins of the fused mutant ( Drosophila melanogaster ). Dev. Biol 63, 358-369.[Medline]

Felsenfeld, A. L. and J. A. Kennison (1995). Positional signaling by hedgehog in Drosophila imaginal disc development. Development 121, 1-10.[Abstract]

Forbes, A. J., Y. Nakano, A. M. Taylor and P. W. Ingham (1993). Genetic analysis of hedgehog signalling in the Drosophila embryo. Development 1993, 115-124.

Garcia-Bellido, A., P. Ripoll and G. Morata (1973). Developmental compartmentalisation of the wing disk of Drosophila. Nature New Biol 245, 251-253.[Medline]

Hinz, U., B. Giebel and J. A. Campos-Ortega (1994). The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 76, 77-87.[Medline]

Hooper, J. E. and M. P. Scott (1989). The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 59, 751-765.[Medline]

Huang, F., C. Dambly-Chaudiere and A. Ghysen (1991). The emergence of sense organs in the wing disc of Drosophila. Development 111, 1087-1095.[Abstract/Free Full Text]

Ingham, P. W. and M. J. Fietz (1995). Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing. Curr. Biol 5, 432-440.[Medline]

Ingham, P. W., A. M. Taylor and Y. Nakano (1991). Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187.[Medline]

Jiang, J. and G. Struhl (1995). Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80, 563-572.[Medline]

Kojima, T., T. Michiue, M. Orihara and K. Saigo (1994). Induction of a mirror-image duplication of anterior wing structures by localized hedgehog expression in the anterior compartment of Drosophila melanogaster wing imaginal discs. Gene 148, 211-217.[Medline]

Kornberg, T., I. Siden, P. O'Farrell and M. Simon (1985). The engrailed locus of Drosophila: In situ localization of transcripts reveals compartment-specific expression. Cell 40, 45-53.[Medline]

Lee, J. J., D. P. von Kessler, S. Parks and P. A. Beachy (1992). Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71, 33-50.[Medline]

Lepage, T., S. M. Cohen, F. J. Diaz-Benjumea and S. M. Parkhurst (1995). Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373, 711-715.[Medline]

Li, W., J. T. Ohlmeyer, M. E. Lane and D. Kalderon (1995). Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553-562.[Medline]

Lin, D. M. and C. S. Goodman (1994). Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance. Neuron 13, 507-523.[Medline]

Mathies, L. C., S. Kerridge and M. P. Scott (1994). Roles of the teashirt gene in Drosophila midgut morphogenesis: Secreted proteins mediate the combinatorial action of homeotic genes. Development 120, 2799-2809.[Abstract]

Mohler, J. and K. Vani (1992). Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development 115, 957-971.[Abstract]

Nakano, Y., I. Guerrero, A. Hidalgo, A. Taylor, J. R. S. Whittle and P. W. Ingham (1989). A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature 341, 508-513.[Medline]

Orenic, T. V., D. C. Slusarski, K. L. Kroll and R. A. Holmgren (1990). Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev 4, 1053-1067.[Abstract/Free Full Text]

Padgett, R. W., R. D. St Johnston and W. M. Gelbart (1987). A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-beta family. Nature 325, 81-84.[Medline]

Pan, D. and G. M. Rubin (1995). cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543-552.[Medline]

Patel, N. H., B. Schafer, C. S. Goodman and R. Holmgren (1989). The role of segment polarity genes during Drosophila neurogenesis. Genes Dev 3, 890-904.[Abstract/Free Full Text]

Phillips, R. G., I. J. H. Roberts, P. W. Ingham and J. R. S. Whittle (1990). The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs. Development 110, 105-114.[Abstract]

Posakony, L. G., L. A. Raftery and W. M. Gelbart (1991). Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary. Mech. Dev 33, 69-82.

Preat, T., P. Therond, C. Lamour-Isnard, B. Limbourg-Bouchon, H. Tricoire, I. Erk, M. C. Mariol and D. Busson (1990). A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila. Nature 347, 87-89.[Medline]

Riddle, R. D., R. L. Johnson, E. Laufer and C. Tabin (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Sampedro, J. and I. Guerrero (1991). Unrestricted expression of the Drosophila gene patched allows a normal segment polarity. Nature 353, 187-190.[Medline]

Sanicola, M., J. Sekelsky, S. Elson and W. M. Gelbart (1995). Drawing a stripe in Drosophila imaginal disks: Negative regulation of decapentaplegic and patched expression by engrailed. Genetics 139, 745-756.[Abstract]

Schmucker, D., A. L. Su, A. Beermann, H. Jackle and D. G. Jay (1994). Chromophore-assisted laser inactivation of patched protein switches cell fate in the larval visual system of Drosophila. Proc. Natl. Acad. Sci. USA 91, 2664-2668.[Abstract/Free Full Text]

Schuske, K., J. E. Hooper and M. P. Scott (1994). patched overexpression causes loss of wingless expression in Drosophila embryos. Dev. Biol 164, 300-311.[Medline]

Slusarski, D. C., C. K. Motzny and R. Holmgren (1995). Mutations that alter the timing and pattern of cubitus interruptus expression in Drosophila melanogaster. Genetics 139, 229-240.[Abstract]

Speicher, S. A., U. Thomas, U. Hinz and E. Knust (1994). The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: Control of cell proliferation. Development 120, 535-544.[Abstract]

Spradling, A. C. and G. M. Rubin (1982). Transposition of cloned P elements into Drosophila germ line chromosomes. Science 218, 341-7.[Abstract/Free Full Text]

Tabata, T., S. Eaton and T. B. Kornberg (1992). The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev 6, 2635-2645.[Abstract/Free Full Text]

Tabata, T. and T. B. Kornberg (1994). Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102.[Medline]

Tashiro, S., T. Michiue, S. Higashijima, S. Zenno, S. Ishimaru, F. Takahashi, M. Orihara, T. Kojima and K. Saigo (1993). Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication. Gene 124, 183-189.[Medline]

Taylor, A. M., Y. Nakano, J. Mohler and P. W. Ingham (1993). Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo. Mech. Dev 42, 89-96.[Medline]

Therond, P., D. Busson, E. Guillement, B. Limbourg-Bouchon, T. Preat, R. Terracol, H. Tricoire and C. Lamour-Isnard (1993). Molecular organization and expression pattern of the segment polarity gene fused of Drosophila melanogaster. Mech. Dev 44, 65-80.[Medline]

This article has been cited by other articles:

T. Sasamura, H. O. Ishikawa, N. Sasaki, S. Higashi, M. Kanai, S. Nakao, T. Ayukawa, T. Aigaki, K. Noda, E. Miyoshi, et al.
The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila
Development, April 1, 2007; 134(7): 1347 - 1356.
[Abstract] [Full Text] [PDF]

P. J. Neuburger, K. J. Saville, J. Zeng, K.-A. Smyth, and J. M. Belote
A Genetic Suppressor of Two Dominant Temperature-Sensitive Lethal Proteasome Mutants of Drosophila melanogaster Is Itself a Mutated Proteasome Subunit Gene
Genetics, July 1, 2006; 173(3): 1377 - 1387.
[Abstract] [Full Text] [PDF]

D. Kent, E. W. Bush, and J. E. Hooper
Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.
Development, May 1, 2006; 133(10): 2001 - 2010.
[Abstract] [Full Text] [PDF]

S. K. Pallavi and L. S. Shashidhara
Signaling interactions between squamous and columnar epithelia of the Drosophila wing disc
J. Cell Sci., August 1, 2005; 118(15): 3363 - 3370.
[Abstract] [Full Text] [PDF]

G. M. Guild, P. S. Connelly, L. Ruggiero, K. A. Vranich, and L. G. Tilney
Actin Filament Bundles in Drosophila Wing Hairs: Hairs and Bristles Use Different Strategies for Assembly
Mol. Biol. Cell, August 1, 2005; 16(8): 3620 - 3631.
[Abstract] [Full Text] [PDF]

K. S. Ho, K. Suyama, M. Fish, and M. P. Scott
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused
Development, March 15, 2005; 132(6): 1401 - 1412.
[Abstract] [Full Text] [PDF]

C. Zhang, E. H. Williams, Y. Guo, L. Lum, and P. A. Beachy
Inaugural Article: Extensive phosphorylation of Smoothened in Hedgehog pathway activation
PNAS, December 28, 2004; 101(52): 17900 - 17907.
[Abstract] [Full Text] [PDF]

K. Hori, M. Fostier, M. Ito, T. J. Fuwa, M. J. Go, H. Okano, M. Baron, and K. Matsuno
Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling
Development, November 15, 2004; 131(22): 5527 - 5537.
[Abstract] [Full Text] [PDF]

L. S. Collier, K. Suyama, J. H. Anderson, and M. P. Scott
Drosophila Costal1 Mutations Are Alleles of Protein Kinase A That Modulate Hedgehog Signaling
Genetics, June 1, 2004; 167(2): 783 - 796.
[Abstract] [Full Text] [PDF]

C. Torroja, N. Gorfinkiel, and I. Guerrero
Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction
Development, May 15, 2004; 131(10): 2395 - 2408.
[Abstract] [Full Text] [PDF]

L. K. MacDougall, M. E. Gagou, S. J. Leevers, E. Hafen, and M. D. Waterfield
Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent Effects on Patterning and Interactions with Receptor Signaling Pathways
Mol. Cell. Biol., January 15, 2004; 24(2): 796 - 808.
[Abstract] [Full Text] [PDF]

D. J. Emlen and C. E. Allen
Genotype to Phenotype: Physiological Control of Trait Size and Scaling in Insects
Integr. Comp. Biol., November 1, 2003; 43(5): 617 - 634.
[Abstract] [Full Text] [PDF]

J. E. Hooper
Smoothened translates Hedgehog levels into distinct responses
Development, September 1, 2003; 130(17): 3951 - 3963.
[Abstract] [Full Text] [PDF]

F. Janody, Z. Martirosyan, A. Benlali, and J. E. Treisman
Two subunits of the Drosophila mediator complex act together to control cell affinity
Development, August 15, 2003; 130(16): 3691 - 3701.
[Abstract] [Full Text] [PDF]

A. J. Zhu, L. Zheng, K. Suyama, and M. P. Scott
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
Genes & Dev., May 15, 2003; 17(10): 1240 - 1252.
[Abstract] [Full Text] [PDF]

K. Matsuno, M. Ito, K. Hori, F. Miyashita, S. Suzuki, N. Kishi, S. Artavanis-Tsakonas, and H. Okano
Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling
Development, March 4, 2003; 129(4): 1049 - 1059.
[Abstract] [Full Text] [PDF]

J. J. Chern and K.-W. Choi
Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc
Development, September 1, 2002; 129(17): 4005 - 4013.
[Abstract] [Full Text] [PDF]

D. ten Berge, A. Brouwer, J. Korving, M. J. Reijnen, E. J. van Raaij, F. Verbeek, W. Gaffield, and F. Meijlink
Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis
Development, August 1, 2001; 128(15): 2929 - 2938.
[Abstract] [Full Text] [PDF]

P Aza-Blanc, H. Lin, A Ruiz i Altaba, and T. Kornberg
Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities
Development, January 10, 2000; 127(19): 4293 - 4301.
[Abstract] [PDF]

Q. Wang and R. Holmgren
Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation
Development, January 7, 2000; 127(14): 3131 - 3139.
[Abstract] [PDF]

H. Park, C Bai, K. Platt, M. Matise, A Beeghly, C. Hui, M Nakashima, and A. Joyner
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
Development, January 4, 2000; 127(8): 1593 - 1605.
[Abstract] [PDF]

G. Wang, B. Wang, and J. Jiang
Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
Genes & Dev., November 1, 1999; 13(21): 2828 - 2837.
[Abstract] [Full Text]

A. A. Kiger, S. Gigliotti, and M. T. Fuller
Developmental Genetics of the Essential Drosophila Nucleoporin nup154: Allelic Differences Due to an Outward-Directed Promoter in the P-Element 3' End
Genetics, October 1, 1999; 153(2): 799 - 812.
[Abstract] [Full Text] [PDF]

I. D. Louro, P. McKie-Bell, H. Gosnell, B. C. Brindley, R. P. Bucy, and J. M. Ruppert
The Zinc Finger Protein GLI Induces Cellular Sensitivity to the mTOR Inhibitor Rapamycin
Cell Growth Differ., July 1, 1999; 10(7): 503 - 516.
[Abstract] [Full Text]

H Matakatsu, R Tadokoro, S Gamo, and S Hayashi
Repression of the wing vein development in Drosophila by the nuclear matrix protein plexus
Development, January 12, 1999; 126(23): 5207 - 5216.
[Abstract] [PDF]

Q. Wang and R. Holmgren
The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels
Development, January 11, 1999; 126(22): 5097 - 5106.
[Abstract] [PDF]

M. Price and D Kalderon
Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A
Development, January 10, 1999; 126(19): 4331 - 4339.
[Abstract] [PDF]

A Sato, T Kojima, K Ui-Tei, Y Miyata, and K Saigo
Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants
Development, January 10, 1999; 126(20): 4421 - 4430.
[Abstract] [PDF]

L Milenkovic, L. Goodrich, K. Higgins, and M. Scott
Mouse patched1 controls body size determination and limb patterning
Development, January 10, 1999; 126(20): 4431 - 4440.
[Abstract] [PDF]

Y Chen, J. Cardinaux, R. Goodman, and S. Smolik
Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
Development, January 8, 1999; 126(16): 3607 - 3616.
[Abstract] [PDF]

R Hays, K. Buchanan, C Neff, and T. Orenic
Patterning of Drosophila leg sensory organs through combinatorial signaling by hedgehog, decapentaplegic and wingless
Development, January 7, 1999; 126(13): 2891 - 2899.
[Abstract] [PDF]

K. Lewis, G Drossopoulou, I. Paton, D. Morrice, K. Robertson, D. Burt, P. Ingham, and C Tickle
Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway
Development, January 6, 1999; 126(11): 2397 - 2407.
[Abstract] [PDF]

M. Milán, F. J. Diaz-Benjumea, and S. M. Cohen
Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function
Genes & Dev., September 15, 1998; 12(18): 2912 - 2920.
[Abstract] [Full Text]

Y. Chen, N. Gallaher, R. H. Goodman, and S. M. Smolik
Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
PNAS, March 3, 1998; 95(5): 2349 - 2354.
[Abstract] [Full Text] [PDF]

K Lunde, B Biehs, U Nauber, and E Bier
The knirps and knirps-related genes organize development of the second wing vein in Drosophila
Development, January 11, 1998; 125(21): 4145 - 4154.
[Abstract] [PDF]

B Biehs, M. Sturtevant, and E Bier
Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs
Development, January 11, 1998; 125(21): 4245 - 4257.
[Abstract] [PDF]

Z Huang and S Kunes
Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly
Development, January 10, 1998; 125(19): 3753 - 3764.
[Abstract] [PDF]

P Rorth, K Szabo, A Bailey, T Laverty, J Rehm, G. Rubin, K Weigmann, M Milan, V Benes, W Ansorge, et al.
Systematic gain-of-function genetics in Drosophila
Development, January 3, 1998; 125(6): 1049 - 1057.
[Abstract] [PDF]

J. T. Ohlmeyer and D. Kalderon
Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila�embryos
Genes & Dev., September 1, 1997; 11(17): 2250 - 2258.
[Abstract] [Full Text] [PDF]

T. Von Ohlen, D. Lessing, R. Nusse, and J. E. Hooper
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding�protein
PNAS, March 18, 1997; 94(6): 2404 - 2409.
[Abstract] [Full Text] [PDF]

M Strigini and S. Cohen
A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
Development, January 11, 1997; 124(22): 4697 - 4705.
[Abstract] [PDF]

A Kopp, M. Muskavitch, and I Duncan
The roles of hedgehog and engrailed in patterning adult abdominal segments of Drosophila
Development, January 10, 1997; 124(19): 3703 - 3714.
[Abstract] [PDF]

D. Strutt and M Mlodzik
Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc
Development, January 9, 1997; 124(17): 3233 - 3240.
[Abstract] [PDF]

T. Heslip, H Theisen, H Walker, and J. Marsh
Shaggy and dishevelled exert opposite effects on Wingless and Decapentaplegic expression and on positional identity in imaginal discs
Development, January 3, 1997; 124(5): 1069 - 1078.
[Abstract] [PDF]

J. Mullor, M Calleja, J Capdevila, and I Guerrero
Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning
Development, January 3, 1997; 124(6): 1227 - 1237.
[Abstract] [PDF]

M. Sturtevant, B Biehs, E Marin, and E Bier
The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing
Development, January 1, 1997; 124(1): 21 - 32.
[Abstract] [PDF]

R Mo, A. Freer, D. Zinyk, M. Crackower, J Michaud, H. Heng, K. Chik, X. Shi, L. Tsui, S. Cheng, et al.
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
Development, January 1, 1997; 124(1): 113 - 123.
[Abstract] [PDF]

J Hepker, Q. Wang, C. Motzny, R Holmgren, and T. Orenic
Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes
Development, January 1, 1997; 124(2): 549 - 558.
[Abstract] [PDF]

J L Gomez-Skarmeta and J Modolell
araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing.
Genes & Dev., November 15, 1996; 10(22): 2935 - 2945.
[Abstract] [PDF]

C Alexandre, A Jacinto, and P W Ingham
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.
Genes & Dev., August 15, 1996; 10(16): 2003 - 2013.
[Abstract] [PDF]

B L Hogan
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.
Genes & Dev., July 1, 1996; 10(13): 1580 - 1594.
[PDF]

L V Goodrich, R L Johnson, L Milenkovic, J A McMahon, and M P Scott
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
Genes & Dev., February 1, 1996; 10(3): 301 - 312.
[Abstract] [PDF]

H Theisen, T. Haerry, M. O'Connor, and J. Marsh
Developmental territories created by mutual antagonism between Wingless and Decapentaplegic
Development, January 12, 1996; 122(12): 3939 - 3948.
[Abstract] [PDF]

V Marigo, M. Scott, R. Johnson, L. Goodrich, and C. Tabin,
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb
Development, January 4, 1996; 122(4): 1225 - 1233.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

				P. J. Neuburger, K. J. Saville, J. Zeng, K.-A. Smyth, and J. M. Belote A Genetic Suppressor of Two Dominant Temperature-Sensitive Lethal Proteasome Mutants of Drosophila melanogaster Is Itself a Mutated Proteasome Subunit Gene Genetics, July 1, 2006; 173(3): 1377 - 1387. [Abstract] [Full Text] [PDF]

				D. Kent, E. W. Bush, and J. E. Hooper Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. Development, May 1, 2006; 133(10): 2001 - 2010. [Abstract] [Full Text] [PDF]

				S. K. Pallavi and L. S. Shashidhara Signaling interactions between squamous and columnar epithelia of the Drosophila wing disc J. Cell Sci., August 1, 2005; 118(15): 3363 - 3370. [Abstract] [Full Text] [PDF]

				G. M. Guild, P. S. Connelly, L. Ruggiero, K. A. Vranich, and L. G. Tilney Actin Filament Bundles in Drosophila Wing Hairs: Hairs and Bristles Use Different Strategies for Assembly Mol. Biol. Cell, August 1, 2005; 16(8): 3620 - 3631. [Abstract] [Full Text] [PDF]

				K. S. Ho, K. Suyama, M. Fish, and M. P. Scott Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused Development, March 15, 2005; 132(6): 1401 - 1412. [Abstract] [Full Text] [PDF]

				C. Zhang, E. H. Williams, Y. Guo, L. Lum, and P. A. Beachy Inaugural Article: Extensive phosphorylation of Smoothened in Hedgehog pathway activation PNAS, December 28, 2004; 101(52): 17900 - 17907. [Abstract] [Full Text] [PDF]

				K. Hori, M. Fostier, M. Ito, T. J. Fuwa, M. J. Go, H. Okano, M. Baron, and K. Matsuno Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling Development, November 15, 2004; 131(22): 5527 - 5537. [Abstract] [Full Text] [PDF]

				L. S. Collier, K. Suyama, J. H. Anderson, and M. P. Scott Drosophila Costal1 Mutations Are Alleles of Protein Kinase A That Modulate Hedgehog Signaling Genetics, June 1, 2004; 167(2): 783 - 796. [Abstract] [Full Text] [PDF]

				C. Torroja, N. Gorfinkiel, and I. Guerrero Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction Development, May 15, 2004; 131(10): 2395 - 2408. [Abstract] [Full Text] [PDF]

				L. K. MacDougall, M. E. Gagou, S. J. Leevers, E. Hafen, and M. D. Waterfield Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent Effects on Patterning and Interactions with Receptor Signaling Pathways Mol. Cell. Biol., January 15, 2004; 24(2): 796 - 808. [Abstract] [Full Text] [PDF]

				D. J. Emlen and C. E. Allen Genotype to Phenotype: Physiological Control of Trait Size and Scaling in Insects Integr. Comp. Biol., November 1, 2003; 43(5): 617 - 634. [Abstract] [Full Text] [PDF]

				J. E. Hooper Smoothened translates Hedgehog levels into distinct responses Development, September 1, 2003; 130(17): 3951 - 3963. [Abstract] [Full Text] [PDF]

				F. Janody, Z. Martirosyan, A. Benlali, and J. E. Treisman Two subunits of the Drosophila mediator complex act together to control cell affinity Development, August 15, 2003; 130(16): 3691 - 3701. [Abstract] [Full Text] [PDF]

				A. J. Zhu, L. Zheng, K. Suyama, and M. P. Scott Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction Genes & Dev., May 15, 2003; 17(10): 1240 - 1252. [Abstract] [Full Text] [PDF]

				K. Matsuno, M. Ito, K. Hori, F. Miyashita, S. Suzuki, N. Kishi, S. Artavanis-Tsakonas, and H. Okano Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling Development, March 4, 2003; 129(4): 1049 - 1059. [Abstract] [Full Text] [PDF]

				J. J. Chern and K.-W. Choi Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc Development, September 1, 2002; 129(17): 4005 - 4013. [Abstract] [Full Text] [PDF]

				D. ten Berge, A. Brouwer, J. Korving, M. J. Reijnen, E. J. van Raaij, F. Verbeek, W. Gaffield, and F. Meijlink Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis Development, August 1, 2001; 128(15): 2929 - 2938. [Abstract] [Full Text] [PDF]

				P Aza-Blanc, H. Lin, A Ruiz i Altaba, and T. Kornberg Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities Development, January 10, 2000; 127(19): 4293 - 4301. [Abstract] [PDF]

				Q. Wang and R. Holmgren Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation Development, January 7, 2000; 127(14): 3131 - 3139. [Abstract] [PDF]

				H. Park, C Bai, K. Platt, M. Matise, A Beeghly, C. Hui, M Nakashima, and A. Joyner Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation Development, January 4, 2000; 127(8): 1593 - 1605. [Abstract] [PDF]

				G. Wang, B. Wang, and J. Jiang Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus Genes & Dev., November 1, 1999; 13(21): 2828 - 2837. [Abstract] [Full Text]

				A. A. Kiger, S. Gigliotti, and M. T. Fuller Developmental Genetics of the Essential Drosophila Nucleoporin nup154: Allelic Differences Due to an Outward-Directed Promoter in the P-Element 3' End Genetics, October 1, 1999; 153(2): 799 - 812. [Abstract] [Full Text] [PDF]

				I. D. Louro, P. McKie-Bell, H. Gosnell, B. C. Brindley, R. P. Bucy, and J. M. Ruppert The Zinc Finger Protein GLI Induces Cellular Sensitivity to the mTOR Inhibitor Rapamycin Cell Growth Differ., July 1, 1999; 10(7): 503 - 516. [Abstract] [Full Text]

				H Matakatsu, R Tadokoro, S Gamo, and S Hayashi Repression of the wing vein development in Drosophila by the nuclear matrix protein plexus Development, January 12, 1999; 126(23): 5207 - 5216. [Abstract] [PDF]

				Q. Wang and R. Holmgren The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels Development, January 11, 1999; 126(22): 5097 - 5106. [Abstract] [PDF]

				M. Price and D Kalderon Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A Development, January 10, 1999; 126(19): 4331 - 4339. [Abstract] [PDF]

				A Sato, T Kojima, K Ui-Tei, Y Miyata, and K Saigo Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants Development, January 10, 1999; 126(20): 4421 - 4430. [Abstract] [PDF]

				L Milenkovic, L. Goodrich, K. Higgins, and M. Scott Mouse patched1 controls body size determination and limb patterning Development, January 10, 1999; 126(20): 4431 - 4440. [Abstract] [PDF]

				Y Chen, J. Cardinaux, R. Goodman, and S. Smolik Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling Development, January 8, 1999; 126(16): 3607 - 3616. [Abstract] [PDF]

				R Hays, K. Buchanan, C Neff, and T. Orenic Patterning of Drosophila leg sensory organs through combinatorial signaling by hedgehog, decapentaplegic and wingless Development, January 7, 1999; 126(13): 2891 - 2899. [Abstract] [PDF]