Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development

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Barone, M. V., Pepperkok, R., Peverali, F. A. and Philipson, L (1994). Id proteins control growth induction in mammalian cells. Proc. Natl. Acad. Sci. USA 91, 4985-4988.[Abstract/Free Full Text]

Begley, C. G., Visvader, J., Green, A. R., Aplan, P. D., Metcalf, D., Kirsch, I. R. and Gough, N. M (1991). Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL. Proc. Natl. Acad. Sci. USA 88, 869-873.[Abstract/Free Full Text]

Blanar, M. A. and Rutter, W. J (1992). Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. Science 256, 1014-1018.[Abstract/Free Full Text]

Brown, L. and Baer, R (1994). HEN1 encodes a 20-kilodalton phosphoprotein that binds an extended E-box motif as a homodimer. Mol. Cell. Biol 14, 1245-1255.[Abstract/Free Full Text]

Buchberg, A. M., Brownell, E., Nagata, S., Jenkins, N. A. and Copeland, N. G (1989). A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics 122, 153-161.[Abstract/Free Full Text]

Bulmer, J. N (1989). Decidual cellular responses. Curr. Opin. Immunol 1, 1141-1147.[Medline]

Burdsal, C. A., Damsky, C. H. and Pedersen, R. A (1993). The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak. Development 118, 829-844.[Abstract]

Copeland, N. G. and Jenkins, N. A (1991). Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet 7, 113-118.[Medline]

Cross, J. C. and Roberts, R. M (1991). Constitutive and trophoblast-specific expression of a class of bovine interferon genes. Proc. Natl. Acad. Sci. USA 88, 3817-3821.[Abstract/Free Full Text]

Cross, J. C., Werb, Z., Fisher, S. J (1994). Implantation and the placenta: key pieces of the development puzzle. Science 266, 1508-1518.[Abstract/Free Full Text]

Ellenberger, T., Fass, D., Arnaud, M. and Harrison, S. C (1994). Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. Genes Dev 8, 970-980.[Abstract/Free Full Text]

Evans, S. M. and O'Brien, T. X (1993). Expression of the helix-loop-helix factor Id during mouse embryonic development. Dev. Biol 159, 485-499.[Medline]

Faria, T. N. and Soares, M. J (1991). Trophoblast cell differentiation: establishment, characterization and modulation of a rat trophoblast cell line expressing members of the placental prolactin family. Endocrinology 129, 2895-2906.[Abstract]

Freeman, M., Ashkenas, J., Rees, D. J., Kingsley, D. M., Copeland, N. G., Jenkins, N. A. and Krieger, M (1990). An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc. Natl. Acad. Sci. USA 87, 8810-8814.[Abstract/Free Full Text]

Garrell, J. and Campuzano, S (1991). The helix-loop-helix domain: a common motif for bristles, muscles and sex. BioEssays 13, 493-498.[Medline]

German, M. S., Blanar, M. A., Nelson, C., Moss, L. G. and Rutter, W. J (1991). Two related helix-loop-helix protein participate in separate cell-specific complexes that bind the insulin enhancer. Mol. Endocrinol 5, 292-299.[Abstract]

Gossen, M. and Bujard, H (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547-51.[Abstract/Free Full Text]

Guillemot, F., Nagy, A., Auerbach, A., Rossant, J. and Joyner, A. L (1994). Essential role of Mash-2 in extraembryonic development. Nature 371, 333-336.[Medline]

Hamlin, G. P., Lu, X.-J., Roby, K. F. and Soares, M. J (1994). Recapitulation of the pathway for trophoblast giant cell differentiation in vitro: stage-specific expression of members of the prolactin gene family. Endocrinology 134, 2390-2396.[Abstract]

Henthorn, P., Kiledjian, M. and Kadesch, T (1990). Two distinct transcription factors that bind the immunoglobulin enhancerE5/ E2 motif. Science 247, 467-470.[Abstract/Free Full Text]

Hu, J. S., Olson, E. N. and Kingston, R. E (1992). HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors. Mol. Cell. Biol 12, 1031-1042.[Abstract/Free Full Text]

Jan, Y. N. and Jan, L. Y (1993). Functional gene cassettes in development. Proc. Natl. Acad. Sci. USA 90, 8305-8307.[Free Full Text]

Jenkins, N. A., Copeland, N. G., Taylor, B. A. and Lee, B. K (1982). Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J. Virol 43, 26-36.[Abstract/Free Full Text]

Johnson, J. E., Birren, S. J. and Anderson, D. J (1990). Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors. Nature 346, 858-861.[Medline]

Ko, L. J., Yamamoto, M., Leonard, M. W., George, K. M., Ting, P. and Engel, J. D (1991). Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptorgene enhancer. Mol. Cell. Biol 11, 2778-2784.[Abstract/Free Full Text]

Kramer, K. K., Duffy, J. Y., Klemann, S. W., Bixby, J. A., Low, B. G., Pope, W. F. and Roberts, R. M (1994). Selective cloning of cDNA for secretory proteins of early embryos. Identification of a transiently expressed kunitz domain protein from preimplantation sheep trophoblast. J. Biol. Chem 269, 7255-7261.[Abstract/Free Full Text]

Kuo, S. S., Mellentin, J. D., Copeland, N. G., Gilbert, D. J., Jenkins, N. A. and Cleary, M. L (1991). Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. Oncogene 6, 961-968.[Medline]

Lawson, K. A., Meneses, J. J. and Pedersen, R. A (1991). Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113, 891-911.[Abstract]

Ma, P. C. M., Rould, M. A., Weintraub, H. and Pabo, C. O (1994). Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation. Cell 77, 451-459.[Medline]

McKenzie, A. N., Li, X., Largaespada, D. A., Sato, A., Kaneda, A., Zurawski, S. M., Doyle, E. L., Milatovich, A., Francke, U., Copeland, N. G., et al (1993). Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J. Immunol 150, 5436-5444.[Abstract]

Murre, C., Voronova, A. and Baltimore, D (1991). B-cell-and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. Mol. Cell. Biol 11, 1156-1160.[Abstract/Free Full Text]

Ng, Y.-K., George, K. M., Engel, J. D. and Linzer, D. I. H (1994). GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene. Development 120, 3257-3266.[Abstract]

Olson, E. N (1990). MyoD family: a paradigm for development?. Genes Dev 4, 1454-1461.[Free Full Text]

Olson, E. N (1992). Interplay between proliferation and differentiation within the myogenic lineage. Dev. Biol 154, 261-272.[Medline]

Robbins, J., Gulick, J., Sanchez, A., Howes, P. and Doetschman, T (1990). Mouse embryonic stem cells express the cardiac myosin heavy chain genes during development in vitro. J. Biol. Chem 265, 11905-11909.[Abstract/Free Full Text]

Roberts, R. M., Farin, C. E. and Cross, J. C (1990). Trophoblast proteins and maternal recognition of pregnancy. Oxford Rev. Reprod. Biol 12, 147-180.[Medline]

Roberts, R. M., Cross, J. C. and Leaman, D. W (1992). Interferons as hormones of pregnancy. Endocrine Rev 13, 432-452.[Medline]

Rothstein, J. L., Johnson, D., DeLoia, J. A., Skowronski, J., Solter, D. and Knowles, B (1992). Gene expression during preimplantation mouse development. Genes Dev 6, 1190-1201.[Abstract/Free Full Text]

Sasai, Y., Kageyama, R., Tagawa, Y., Shigemoto, R. and Nakanishi, S (1992). Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev 6, 2620-2634.[Abstract/Free Full Text]

Shida, M. M., Ng, Y. K., Soares, M. J. and Linzer, D. I. H (1993). Trophoblast-specific transcription from the mouse placental lactogen-I gene promoter. Mol. Endocrinol 7, 181-188.[Abstract]

Spindle, A (1980). An improved culture medium for mouse blastocysts. In Vitro 16, 669-674.[Medline]

Spindle, A (1982). Cell allocation in preimplantation mouse chimeras. J. Exp. Zool 219, 361-367.[Medline]

Sun, X. H., Copeland, N. G., Jenkins, N. A. and Baltimore, D (1991). Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol. Cell. Biol 11, 5603-5611.[Abstract/Free Full Text]

Tietze, K., Oellers, N. and Knust, E (1992). Enhancer of split D, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein. Proc. Natl. Acad. Sci. USA 89, 6152-6156.[Abstract/Free Full Text]

Vernet, M., Bonnerot, C., Briand, P. and Nicolas, J. F (1993). Application of LacZ gene fusions to preimplantation development. Methods Enzymol 225, 434-451.[Medline]

Wilcox, A. J., Weinberg, C. R., O'Connor, J. F., Baird, D. D., Schlatterer, J. P., Canfield, R. E., Armstrong, E. G. and Nisula, B. C (1988). Incidence of early loss of pregnancy. New Engl. J. Med 319, 189-194.[Abstract]

Wilcox, L. S., Peterson, H. B., Haseltine, F. P. and Martin, M. C (1993). Defining and interpreting pregnancy success rates for in vitro fertilization. Fert. Steril 60, 18-25.[Medline]

Wilkinson, D. G. and Nieto, M. A (1993). Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol 225, 361-373.[Medline]

Wolf, C., Thisse, C., Stoetzel, C., Thisse, B., Gerlinger, P. and Perrin-Schmitt, F (1991). The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes. Dev. Biol 143, 363-373.[Medline]

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Mol. Endocrinol., March 1, 1998; 12(3): 418 - 427.
[Abstract] [Full Text]

				P. Mattar, L. M. Langevin, K. Markham, N. Klenin, S. Shivji, D. Zinyk, and C. Schuurmans Basic Helix-Loop-Helix Transcription Factors Cooperate To Specify a Cortical Projection Neuron Identity Mol. Cell. Biol., March 1, 2008; 28(5): 1456 - 1469. [Abstract] [Full Text] [PDF]

				R. M. Rivera, P. Stein, J. R. Weaver, J. Mager, R. M. Schultz, and M. S. Bartolomei Manipulations of mouse embryos prior to implantation result in aberrant expression of imprinted genes on day 9.5 of development Hum. Mol. Genet., January 1, 2008; 17(1): 1 - 14. [Abstract] [Full Text] [PDF]

				F. D'Autreaux, Y. Morikawa, P. Cserjesi, and M. D. Gershon Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia Development, June 15, 2007; 134(12): 2237 - 2249. [Abstract] [Full Text] [PDF]

				C. A. Risebro, N. Smart, L. Dupays, R. Breckenridge, T. J. Mohun, and P. R. Riley Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart Development, November 15, 2006; 133(22): 4595 - 4606. [Abstract] [Full Text] [PDF]

				A. Hamik, B. Wang, and M. K. Jain Transcriptional Regulators of Angiogenesis Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 1936 - 1947. [Abstract] [Full Text] [PDF]

				D. R Arnold, V. Bordignon, R. Lefebvre, B. D Murphy, and L. C Smith Somatic cell nuclear transfer alters peri-implantation trophoblast differentiation in bovine embryos. Reproduction, August 1, 2006; 132(2): 279 - 290. [Abstract] [Full Text] [PDF]

				A. D. Gultice, K. L. Selesniemi, and T. L. Brown Hypoxia Inhibits Differentiation of Lineage-Specific Rcho-1 Trophoblast Giant Cells Biol Reprod, June 1, 2006; 74(6): 1041 - 1050. [Abstract] [Full Text] [PDF]

				K. Nadra, S. I. Anghel, E. Joye, N. S. Tan, S. Basu-Modak, D. Trono, W. Wahli, and B. Desvergne Differentiation of Trophoblast Giant Cells and Their Metabolic Functions Are Dependent on Peroxisome Proliferator-Activated Receptor {beta}/{delta} Mol. Cell. Biol., April 15, 2006; 26(8): 3266 - 3281. [Abstract] [Full Text] [PDF]

				D. Strumpf, C.-A. Mao, Y. Yamanaka, A. Ralston, K. Chawengsaksophak, F. Beck, and J. Rossant Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst Development, May 1, 2005; 132(9): 2093 - 2102. [Abstract] [Full Text] [PDF]

				D. G. McFadden, A. C. Barbosa, J. A. Richardson, M. D. Schneider, D. Srivastava, and E. N. Olson The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner Development, January 1, 2005; 132(1): 189 - 201. [Abstract] [Full Text] [PDF]

				J. Wilson-Rawls, J. M. Rhee, and A. Rawls Paraxis Is a Basic Helix-Loop-Helix Protein That Positively Regulates Transcription through Binding to Specific E-box Elements J. Biol. Chem., September 3, 2004; 279(36): 37685 - 37692. [Abstract] [Full Text] [PDF]

				Y. Morikawa and P. Cserjesi Extra-embryonic vasculature development is regulated by the transcription factor HAND1 Development, May 1, 2004; 131(9): 2195 - 2204. [Abstract] [Full Text] [PDF]

				M. Moser, Y. Li, K. Vaupel, D. Kretzschmar, R. Kluge, P. Glynn, and R. Buettner Placental Failure and Impaired Vasculogenesis Result in Embryonic Lethality for Neuropathy Target Esterase-Deficient Mice Mol. Cell. Biol., February 15, 2004; 24(4): 1667 - 1679. [Abstract] [Full Text] [PDF]

				K. J. Austin, B. M. Bany, E. L. Belden, L. A. Rempel, J. C. Cross, and T. R. Hansen Interferon-Stimulated Gene-15 (Isg15) Expression Is Up-Regulated in the Mouse Uterus in Response to the Implanting Conceptus Endocrinology, July 1, 2003; 144(7): 3107 - 3113. [Abstract] [Full Text] [PDF]

				T. Kamei, S. R. Jones, B. M. Chapman, K. L. MCGonigle, G. Dai, and M. J. Soares The Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Modulates the Endocrine Differentiation of Trophoblast Cells Mol. Endocrinol., July 1, 2002; 16(7): 1469 - 1481. [Abstract] [Full Text] [PDF]

				Y.-S. Dai and P. Cserjesi The Basic Helix-Loop-Helix Factor, HAND2, Functions as a Transcriptional Activator by Binding to E-boxes as a Heterodimer J. Biol. Chem., April 5, 2002; 277(15): 12604 - 12612. [Abstract] [Full Text] [PDF]

				D. G. McFadden, J. McAnally, J. A. Richardson, J. Charite, and E. N. Olson Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding Development, January 7, 2002; 129(13): 3077 - 3088. [Abstract] [Full Text] [PDF]

				H. J. Auman, T. Nottoli, O. Lakiza, Q. Winger, S. Donaldson, and T. Williams Transcription factor AP-2{gamma} is essential in the extra-embryonic lineages for early postimplantation development Development, January 6, 2002; 129(11): 2733 - 2747. [Abstract] [Full Text] [PDF]

				J. C. Cross, L. Anson-Cartwright, and I. C. Scott Transcription Factors Underlying the Development and Endocrine Functions of the Placenta Recent Prog. Horm. Res., January 1, 2002; 57(1): 221 - 234. [Abstract] [Full Text] [PDF]

				S. Parrinello, C. Q. Lin, K. Murata, Y. Itahana, J. Singh, A. Krtolica, J. Campisi, and P.-Y. Desprez Id-1, ITF-2, and Id-2 Comprise a Network of Helix-Loop-Helix Proteins That Regulate Mammary Epithelial Cell Proliferation, Differentiation, and Apoptosis J. Biol. Chem., October 12, 2001; 276(42): 39213 - 39219. [Abstract] [Full Text] [PDF]

				J.-H. Cho, H. Kimura, T. Minami, J. Ohgane, N. Hattori, S. Tanaka, and K. Shiota DNA Methylation Regulates Placental Lactogen I Gene Expression Endocrinology, August 1, 2001; 142(8): 3389 - 3396. [Abstract] [Full Text] [PDF]

				X.S. Ouyang, X. Wang, D.T.W. Lee, S.W. Tsao, and Y.C. Wong Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat Carcinogenesis, June 1, 2001; 22(6): 965 - 973. [Abstract] [Full Text] [PDF]

				D. M. Adelman, M. Gertsenstein, A. Nagy, M. C. Simon, and E. Maltepe Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses Genes & Dev., December 15, 2000; 14(24): 3191 - 3203. [Abstract] [Full Text]

				B. Jiang, A. Kamat, and C. R. Mendelson Hypoxia Prevents Induction of Aromatase Expression in Human Trophoblast Cells in Culture: Potential Inhibitory Role of the Hypoxia-Inducible Transcription Factor Mash-2 (Mammalian Achaete-Scute Homologous Protein-2) Mol. Endocrinol., October 1, 2000; 14(10): 1661 - 1673. [Abstract] [Full Text]

				I.-T. Hwang, Y.-H. Lee, B.-C. Moon, K.-Y. Ahn, S.-W. Lee, and J.-Y. Chun Identification and Characterization of a New Member of the Placental Prolactin-Like Protein-C (PLP-C) Subfamily, PLP-C{beta} Endocrinology, September 1, 2000; 141(9): 3343 - 3352. [Abstract] [Full Text] [PDF]

				M. Fernandez-Teran, M. E. Piedra, I. S. Kathiriya, D. Srivastava, J. C. Rodriguez-Rey, and M. A. Ros Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway Development, May 15, 2000; 127(10): 2133 - 2142. [Abstract] [PDF]

				C. Q. Lin, J. Singh, K. Murata, Y. Itahana, S. Parrinello, S. H. Liang, C. E. Gillett, J. Campisi, and P.-Y. Desprez A Role for Id-1 in the Aggressive Phenotype and Steroid Hormone Response of Human Breast Cancer Cells Cancer Res., March 1, 2000; 60(5): 1332 - 1340. [Abstract] [Full Text]

				N. Hattori, T. C. Davies, L. Anson-Cartwright, and J. C. Cross Periodic Expression of the Cyclin-dependent Kinase Inhibitor p57Kip2 in Trophoblast Giant Cells Defines a G2-like Gap Phase of the Endocycle Mol. Biol. Cell, March 1, 2000; 11(3): 1037 - 1045. [Abstract] [Full Text]

				I. C. Scott, L. Anson-Cartwright, P. Riley, D. Reda, and J. C. Cross The HAND1 Basic Helix-Loop-Helix Transcription Factor Regulates Trophoblast Differentiation via Multiple Mechanisms Mol. Cell. Biol., January 15, 2000; 20(2): 530 - 541. [Abstract] [Full Text]

				D. McFadden, J Charite, J. Richardson, D Srivastava, A. Firulli, and E. Olson A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart Development, January 12, 2000; 127(24): 5331 - 5341. [Abstract] [PDF]