A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain

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				C. Koike, A. Nishida, S. Ueno, H. Saito, R. Sanuki, S. Sato, A. Furukawa, S. Aizawa, I. Matsuo, N. Suzuki, et al. Functional Roles of Otx2 Transcription Factor in Postnatal Mouse Retinal Development Mol. Cell. Biol., December 1, 2007; 27(23): 8318 - 8329. [Abstract] [Full Text] [PDF]

				Q. Zhou, H. Chipperfield, D. A. Melton, and W. H. Wong A gene regulatory network in mouse embryonic stem cells PNAS, October 16, 2007; 104(42): 16438 - 16443. [Abstract] [Full Text] [PDF]

				H. H. Kim, A. Wolfe, R. N. Cohen, S. C. Eames, A. L. Johnson, C. N. Wieland, and S. Radovick In Vivo Identification of a 107-Base Pair Promoter Element Mediating Neuron-Specific Expression of Mouse Gonadotropin-Releasing Hormone Mol. Endocrinol., February 1, 2007; 21(2): 457 - 471. [Abstract] [Full Text] [PDF]

				D. Kurokawa, Y. Sakurai, A. Inoue, R. Nakayama, N. Takasaki, Y. Suda, T. Miyake, C. T. Amemiya, and S. Aizawa Evolutionary constraint on Otx2 neuroectoderm enhancers-deep conservation from skate to mouse and unique divergence in teleost PNAS, December 19, 2006; 103(51): 19350 - 19355. [Abstract] [Full Text] [PDF]

				B. Enkhmandakh, A. V. Makeyev, and D. Bayarsaihan The role of the proline-rich domain of Ssdp1 in the modular architecture of the vertebrate head organizer PNAS, August 1, 2006; 103(31): 11631 - 11636. [Abstract] [Full Text] [PDF]

				Z. Lin, R. Cantos, M. Patente, and D. K. Wu Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling Development, May 15, 2005; 132(10): 2309 - 2318. [Abstract] [Full Text] [PDF]

				B. Vernay, M. Koch, F. Vaccarino, J. Briscoe, A. Simeone, R. Kageyama, and S.-L. Ang Otx2 Regulates Subtype Specification and Neurogenesis in the Midbrain J. Neurosci., May 11, 2005; 25(19): 4856 - 4867. [Abstract] [Full Text] [PDF]

				I. Oda-Ishii, V. Bertrand, I. Matsuo, P. Lemaire, and H. Saiga Making very similar embryos with divergent genomes: conservation of regulatory mechanisms of Otx between the ascidians Halocynthia roretzi and Ciona intestinalis Development, April 1, 2005; 132(7): 1663 - 1674. [Abstract] [Full Text] [PDF]

				T. Akagi, M. Mandai, S. Ooto, Y. Hirami, F. Osakada, R. Kageyama, N. Yoshimura, and M. Takahashi Otx2 Homeobox Gene Induces Photoreceptor-Specific Phenotypes in Cells Derived from Adult Iris and Ciliary Tissue Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4570 - 4575. [Abstract] [Full Text] [PDF]

				A. Ohtoshi and R. R. Behringer Neonatal Lethality, Dwarfism, and Abnormal Brain Development in Dmbx1 Mutant Mice Mol. Cell. Biol., September 1, 2004; 24(17): 7548 - 7558. [Abstract] [Full Text] [PDF]

				D. Kurokawa, N. Takasaki, H. Kiyonari, R. Nakayama, C. Kimura-Yoshida, I. Matsuo, and S. Aizawa Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm Development, July 15, 2004; 131(14): 3307 - 3317. [Abstract] [Full Text] [PDF]

				F. Gao, H. Y. Shi, C. Daughty, N. Cella, and M. Zhang Maspin plays an essential role in early embryonic development Development, April 1, 2004; 131(7): 1479 - 1489. [Abstract] [Full Text] [PDF]

				C. Kimura-Yoshida, K. Kitajima, I. Oda-Ishii, E Tian, M. Suzuki, M. Yamamoto, T. Suzuki, M. Kobayashi, S. Aizawa, and I. Matsuo Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification Development, January 1, 2004; 131(1): 57 - 71. [Abstract] [Full Text] [PDF]

				F. Hirth, L. Kammermeier, E. Frei, U. Walldorf, M. Noll, and H. Reichert An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila Development, June 1, 2003; 130(11): 2365 - 2373. [Abstract] [Full Text] [PDF]

				W. Chen, Y. Liang, W. Deng, K. Shimizu, A. M. Ashique, E. Li, and Y.-P. Li The zinc-finger protein CNBP is required for forebrain formation in the mouse Development, April 1, 2003; 130(7): 1367 - 1379. [Abstract] [Full Text] [PDF]

				T. Hide, J. Hatakeyama, C. Kimura-Yoshida, E Tian, N. Takeda, Y. Ushio, T. Shiroishi, S. Aizawa, and I. Matsuo Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice Development, March 11, 2003; 129(18): 4347 - 4357. [Abstract] [Full Text] [PDF]

				M. Mukhopadhyay, A. Teufel, T. Yamashita, A. D. Agulnick, L. Chen, K. M. Downs, A. Schindler, A. Grinberg, S.-P. Huang, D. Dorward, et al. Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation Development, February 1, 2003; 130(3): 495 - 505. [Abstract] [Full Text] [PDF]

				C. G. Kelley, M. L. Givens, N. Rave-Harel, S. B. Nelson, S. Anderson, and P. L. Mellon Neuron-Restricted Expression of the Rat Gonadotropin-Releasing Hormone Gene Is Conferred by a Cell-Specific Protein Complex that Binds Repeated CAATT Elements Mol. Endocrinol., November 1, 2002; 16(11): 2413 - 2425. [Abstract] [Full Text] [PDF]

				A. Dohmoto, K. Shimizu, Y. Asada, and T. Maeda Quantitative Trait Loci on Chromosomes 10 and 11 Influencing Mandible Size of SMXA RI Mouse Strains J. Dent. Res., July 1, 2002; 81(7): 501 - 504. [Abstract] [Full Text] [PDF]

				C. Roberts, H. F. Sutherland, H. Farmer, W. Kimber, S. Halford, A. Carey, J. M. Brickman, A. Wynshaw-Boris, and P. J. Scambler Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality Mol. Cell. Biol., April 1, 2002; 22(7): 2318 - 2328. [Abstract] [Full Text] [PDF]

				F. C. Wardle, D. H. Wainstock, and H. L. Sive Cement gland-specific activation of the Xag1 promoter is regulated by co-operation of putative Ets and ATF/CREB transcription factors Development, January 10, 2002; 129(19): 4387 - 4397. [Abstract] [Full Text] [PDF]

				J. Y. H. Li and A. L. Joyner Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression Development, December 15, 2001; 128(24): 4979 - 4991. [Abstract] [Full Text] [PDF]

				D. Acampora, P. P. Boyl, M. Signore, J. P. Martinez-Barbera, C. Ilengo, E. Puelles, A. Annino, H. Reichert, G. Corte, and A. Simeone OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation Development, December 1, 2001; 128(23): 4801 - 4813. [Abstract] [Full Text] [PDF]

				K. D. Tremblay, N. R. Dunn, and E. J. Robertson Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation Development, September 15, 2001; 128(18): 3609 - 3621. [Abstract] [Full Text] [PDF]

				P. P. Boyl, M. Signore, D. Acampora, J. P. Martinez-Barbera, C. Ilengo, A. Annino, G. Corte, and A. Simeone Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR Development, August 1, 2001; 128(15): 2989 - 3000. [Abstract] [Full Text] [PDF]

				M. Yamamoto, C. Meno, Y. Sakai, H. Shiratori, K. Mochida, Y. Ikawa, Y. Saijoh, and H. Hamada The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse Genes & Dev., May 15, 2001; 15(10): 1242 - 1256. [Abstract] [Full Text]

				P. A. Hoodless, M. Pye, C. Chazaud, E. Labbé, L. Attisano, J. Rossant, and J. L. Wrana FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse Genes & Dev., May 15, 2001; 15(10): 1257 - 1271. [Abstract] [Full Text]

				A Perea-Gomez, K. Lawson, M Rhinn, L Zakin, P Brulet, S Mazan, and S. Ang Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo Development, January 3, 2001; 128(5): 753 - 765. [Abstract] [PDF]