Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation

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Bodmer, R (1993). The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118, 719-729.[Abstract]

Bodmer, R., Jan, L. Y. and Jan, Y. N (1990). A new homeobox-containing gene, msh-2 , is transiently expressed early during mesoderm formation of Drosophila. Development 110, 661-669.[Abstract/Free Full Text]

Chen, C. Y. and Schwartz, R. J (1995). Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, Nkx2. 5. J. Biol. Chem 270, 15628-15633.[Abstract/Free Full Text]

Chen, J.-N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F. J. M., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.-P., Jiang, Y.-J., Kane, D. A., Kelsh, R. N., Mullins, M. C. and Nusslein-Volhard, C (1996). Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123, 293-302.[Abstract]

Cleaver, O. B., Patterson, K. D. and Krieg, P. A (1996). Overexpression of the tinman-related genes XNkx2. 5 and XNkx2. 3 in Xenopus embryos results in myocardial hyperplasia. Development 122, 3549-3556.[Abstract]

Danos, M. C. and Yost, H. J (1995). Linkage of cardiac left-right asmmetry and dorsal-anterior development in Xenopus. Development 121, 1467-1474.[Abstract]

DeHaan, R. L (1959). Cardia bifida and the development of pacemaker function in the early chick heart. Dev. Biol 1, 586-602.

Detrich, H. W., Kieran, M. W., Chan, F. Y., Barone, L. M., Yee, K., Rundstadler, J. A., Pratt, S., Ransom, D. and Zon, L. I (1995). Intraembryonic hematopoietic cell migration during vertebrate development. Proc. Natl. Acad. Sci. USA 92, 10713-10717.[Abstract/Free Full Text]

Evans, S. M., Yan, W., Murillo, P., Ponce, J. and Papalopulu, N (1995). tinman , a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3 , a second vertebrate homologue of tinman. Development 121, 3889-3899.[Abstract]

Frasch, M (1995). Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo. Nature 374, 464-467.[Medline]

Graff, J. M., Thies, R. S., Song, J. J., Celeste, A. J. and Melton, D. A (1994). Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 79, 169-179.[Medline]

Joly, J. S., Joly, C., Schulte-Merker, S., Boulekbache, H. and Condamine, H (1993). The ventral and posterior expression of the zebrafish homeobox gene eve1 is perturbed in dorsalized and mutant embryos. Development 119, 1261-1275.[Abstract]

Kane, D. A. and Kimmel, C. B (1993). The zebrafish midblastula transition. Development 119, 447-456.[Abstract]

Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B. and Schilling, T. F (1995). Stages of embryonic development of the zebrafish. Dev. Dynam 203, 253-310.[Medline]

Kimmel, C. B., Warga, R. M. and Schilling, T. F (1990). Origion and organization of the zebrafish fate map. Development 108, 581-594.[Abstract/Free Full Text]

Lee, R. K. K., Stainier, D. Y. R., Weinstein, B. M. and Fishman, M. C (1994). Cardiovascular development in the zebrafishII. Endocardial progenitors are sequestered within the heart field. Development 120, 3361-3366.[Abstract]

Levin, M., Johnson, R. L., Stern, C. D., Kuehn, M. and Tabin, C (1995). A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 82, 803-814.[Medline]

Lin, S., Gaiano, N., Culp, P., Burns, J. C., Friedmann, T., Yee, J.-K. and Hopkins, N (1994). Integration and germ-line transmission of a psuedotyped retroviral vector in zebrafish. Science 265, 666-669.[Abstract/Free Full Text]

Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I. and Harvey, R. P (1993). Nkx-2. 5 : a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419-431.[Abstract]

Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Tobb, L. and Harvey, R. P (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 9, 1654-1666.[Abstract/Free Full Text]

Messersmith, E. K., Leonardo, E. D., Shatz, C. J., Tessier-lavigne, M., Goodman, C. S. and Kolodkin, A. L (1995). Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord. Neuron 14, 949-959.[Medline]

Nascone, N. and Mercola, M (1995). An inductive role for the endoderm in Xenopus cardiogenesis. Development 121, 515-523.[Abstract]

Olson, E. N (1993). Regulation of muscle transcription by the MyoD family: The heart of the Matter. Circulation Research 72, 1-6.[Abstract/Free Full Text]

Olson, E. N. and Srivastava, D (1996). Molecular pathways controlling heart development. Science 272, 671-676.[Abstract]

Oxtoby, E. and Jowett, T (1993). Cloning of the zebrafish Krox-20 gene ( krs-20 ) and its expression during hindbrain development. Nucl. Acids Res 21, 1087-1095.[Abstract/Free Full Text]

Schultheiss, T. M., Xydas, S. and Lassar, A. B (1995). Induction of avian cardiac myogenesis by anterior endoderm. Development 121, 4203-4214.[Abstract]

Srivastava, D., Cserjesi, P. and Olson, E. N (1995). A subclass of bHLH proteins required for cardiac morphogenesis. Science 270, 1995-1999.[Abstract/Free Full Text]

Staehling-Hampton, K., Hoffmann, F. M., Baylies, M. K., Rushton, E. and Bate, M (1994). dpp induces mesodermal gene expression in Drosophila. Nature 372, 783-786.[Medline]

Stainier, D. Y. R. and Fishman, M. C (1992). Patterning the zebrafish heart tube: Acquisition of anteroposterior polarity. Dev. Biol 153, 91-101.[Medline]

Tonissen, K. F., Drysdale, T. A., Lints, T. J., Harvey, R. P. and Krieg, P. A (1994). XNkx-2. 5 , a Xenopus gene related to Nkx-2. 5 and tinman : evidence for a conserved role in cardiac development. Dev. Biol 162, 325-328.[Medline]

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				X. Shu, J. Huang, Y. Dong, J. Choi, A. Langenbacher, and J.-N. Chen Na,K-ATPase {alpha}2 and Ncx4a regulate zebrafish left-right patterning Development, May 15, 2007; 134(10): 1921 - 1930. [Abstract] [Full Text] [PDF]

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				E. N. Olson Gene regulatory networks in the evolution and development of the heart. Science, September 29, 2006; 313(5795): 1922 - 1927. [Abstract] [Full Text] [PDF]

				M. Poulain, M. Furthauer, B. Thisse, C. Thisse, and T. Lepage Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling Development, June 1, 2006; 133(11): 2189 - 2200. [Abstract] [Full Text] [PDF]

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				A. D. Langenbacher, Y. Dong, X. Shu, J. Choi, D. A. Nicoll, J. I. Goldhaber, K. D. Philipson, and J.-N. Chen Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish PNAS, December 6, 2005; 102(49): 17699 - 17704. [Abstract] [Full Text] [PDF]

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				W. Rottbauer, S. Just, G. Wessels, N. Trano, P. Most, H. A. Katus, and M. C. Fishman VEGF-PLC{gamma}1 pathway controls cardiac contractility in the embryonic heart Genes & Dev., July 1, 2005; 19(13): 1624 - 1634. [Abstract] [Full Text] [PDF]

				E. M. Small, A. S. Warkman, D.-Z. Wang, L. B. Sutherland, E. N. Olson, and P. A. Krieg Myocardin is sufficient and necessary for cardiac gene expression in Xenopus Development, March 1, 2005; 132(5): 987 - 997. [Abstract] [Full Text] [PDF]

				H. Hashimoto, M. Rebagliati, N. Ahmad, O. Muraoka, T. Kurokawa, M. Hibi, and T. Suzuki The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish Development, April 15, 2004; 131(8): 1741 - 1753. [Abstract] [Full Text] [PDF]

				X. Shu, K. Cheng, N. Patel, F. Chen, E. Joseph, H.-J. Tsai, and J.-N. Chen Na,K-ATPase is essential for embryonic heart development in the zebrafish Development, December 22, 2003; 130(25): 6165 - 6173. [Abstract] [Full Text] [PDF]

				M. Gering, Y. Yamada, T. H. Rabbitts, and R. K. Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1 Development, December 22, 2003; 130(25): 6187 - 6199. [Abstract] [Full Text] [PDF]

				T. A. Westfall, R. Brimeyer, J. Twedt, J. Gladon, A. Olberding, M. Furutani-Seiki, and D. C. Slusarski Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/{beta}-catenin activity J. Cell Biol., September 1, 2003; 162(5): 889 - 898. [Abstract] [Full Text] [PDF]

				E. N. Olson and M. D. Schneider Sizing up the heart: development redux in disease Genes & Dev., August 15, 2003; 17(16): 1937 - 1956. [Full Text] [PDF]

				M. Dentice, C. Morisco, M. Vitale, G. Rossi, G. Fenzi, and D. Salvatore The Different Cardiac Expression of the Type 2 Iodothyronine Deiodinase Gene between Human and Rat Is Related to the Differential Response of the dio2 Genes to Nkx-2.5 and GATA-4 Transcription Factors Mol. Endocrinol., August 1, 2003; 17(8): 1508 - 1521. [Abstract] [Full Text] [PDF]

				T. Ueyama, H. Kasahara, T. Ishiwata, N. Yamasaki, and S. Izumo Csm, a Cardiac-specific Isoform of the RNA Helicase Mov10l1, Is Regulated by Nkx2.5 in Embryonic Heart J. Biol. Chem., August 1, 2003; 278(31): 28750 - 28757. [Abstract] [Full Text] [PDF]

				K. Hoshijima, J. E. Metherall, and D. J. Grunwald A protein disulfide isomerase expressed in the embryonic midline is required for left/right asymmetries Genes & Dev., October 1, 2002; 16(19): 2518 - 2529. [Abstract] [Full Text] [PDF]

				S. Zaffran and M. Frasch Early Signals in Cardiac Development Circ. Res., September 20, 2002; 91(6): 457 - 469. [Abstract] [Full Text] [PDF]

				H. Toko, W. Zhu, E. Takimoto, I. Shiojima, Y. Hiroi, Y. Zou, T. Oka, H. Akazawa, M. Mizukami, M. Sakamoto, et al. Csx/Nkx2-5 Is Required for Homeostasis and Survival of Cardiac Myocytes in the Adult Heart J. Biol. Chem., June 28, 2002; 277(27): 24735 - 24743. [Abstract] [Full Text] [PDF]

				C. Thisse and L. I. Zon Organogenesis--Heart and Blood Formation from the Zebrafish Point of View Science, January 18, 2002; 295(5554): 457 - 462. [Abstract] [Full Text] [PDF]

				B. R. Keegan, J. L. Feldman, D. H. Lee, D. S. Koos, R. K. Ho, D. Y. R. Stainier, and D. Yelon The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo Development, January 4, 2002; 129(7): 1623 - 1632. [Abstract] [Full Text] [PDF]

				B. Bisgrove, J. Essner, and H. Yost Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry Development, January 8, 2000; 127(16): 3567 - 3579. [Abstract] [PDF]

				D Yelon, B Ticho, M. Halpern, I Ruvinsky, R. Ho, L. Silver, and D. Stainier The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development Development, January 6, 2000; 127(12): 2573 - 2582. [Abstract] [PDF]

				F Reifers, E. Walsh, S Leger, D. Stainier, and M Brand Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar) Development, January 1, 2000; 127(2): 225 - 235. [Abstract] [PDF]

				J. F. Reiter, J. Alexander, A. Rodaway, D. Yelon, R. Patient, N. Holder, and D. Y.R. Stainier Gata5 is required for the development of the heart and endoderm in zebrafish Genes & Dev., November 15, 1999; 13(22): 2983 - 2995. [Abstract] [Full Text]

				I. Shiojima, I. Komuro, T. Oka, Y. Hiroi, T. Mizuno, E. Takimoto, K. Monzen, R. Aikawa, H. Akazawa, T. Yamazaki, et al. Context-dependent Transcriptional Cooperation Mediated by Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4 J. Biol. Chem., March 19, 1999; 274(12): 8231 - 8239. [Abstract] [Full Text] [PDF]

				R. Schwartz and E. Olson Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription Development, January 10, 1999; 126(19): 4187 - 4192. [Abstract] [PDF]