The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Allard, J. D.
	Articles by Simon, M. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Allard, J. D.
	Articles by Simon, M. A.

Ahmad, S., Banville, D., Zhao, Z., Fischer, E. H. and Shen, S. H (1993). A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Natl. Acad. Sci. USA 90, 2197-2201.[Abstract/Free Full Text]

Ambrosio, L., Mahowald, A. P. and Perrimon, N (1989). Requirement of the Drosophila raf homologue for torso function. Nature 342, 288-291.[Medline]

Basler, K., Siegrist, P. and Hafen, E (1989). The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements. EMBO J 8, 2381-2386.[Medline]

Basler, K., Christen, B. and Hafen, E (1991). Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell 64, 1069-1081.[Medline]

Bennett, A. M., Tang, T. L., Sugimoto, S., Walsh, C. T. and Neel, B. G (1994). Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proc. Natl. Acad. Sci. USA 91, 7335-7339.[Abstract/Free Full Text]

Brunner, D., Ducker, K., Oellers, N., Hafen, E., Scholz, H. and Klambt, C (1994). The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370, 386-389.[Medline]

Brunner, D., Oellers, N., Szabad, J., Biggs, W. H., Zipursky, S. L. and Hafen, E (1994). A gain of function mutation in Drosophila MAP kinase activates multiple receptor kinase signalling pathways. Cell 76, 875-888.[Medline]

Dickson, B., Sprenger, F., Morrison, D. and Hafen, E (1992). Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature 360, 600-603.[Medline]

Farnsworth, C. L. and Feig, L. A (1991). Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP. Mol. Cell. Biol 11, 4822-4829.[Abstract/Free Full Text]

Feig, L. A. and Cooper, G. M (1988). Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol 8, 3235-3243.[Abstract/Free Full Text]

Feng, G. S. and Pawson, T (1994). Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. Trends. Genet 10, 54-58.[Medline]

Fortini, M. E., Simon, M. A. and Rubin, G. M (1992). Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature 355, 559-561.[Medline]

Freeman, R. M., Jr., Plutzky, J. and Neel, B. G (1992). Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc. Natl. Acad. Sci. USA 89, 11239-11243.[Abstract/Free Full Text]

Gaul, U., Mardon, G. and Rubin, G. M (1992). A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell 68, 1007-1019.[Medline]

Guan, K. L. and Dixon, J. E (1991). Eukaryotic proteins expressed in Escherichia coli : an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem 192, 262-267.[Medline]

Hortsch, M., Bieber, A. J., Patel, N. H. and Goodman, C. S (1990). Differential splicing generates a nervous system-specific form of Drosophila neuroglian. Neuron 4, 697-709.[Medline]

Kimmel, B. E., Heberlein, U. and Rubin, G. M (1990). The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes Dev 4, 712-727.[Abstract/Free Full Text]

Kunkel, T. A (1985). Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82, 488-492.[Abstract/Free Full Text]

Lechleider, R. J., Freeman, R. M.,Jr. and Neel, B. G (1993). Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2. J. Biol. Chem 268, 13434-13438.[Abstract/Free Full Text]

Lechleider, R. J., Sugimoto, S., Bennett, A. M., Kashishian, A. S., Cooper, J. A., Shoelson, S. E., Walsh, C. T. and Neel, B. G (1993). Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. J. Biol. Chem 268, 21478-21481.[Abstract/Free Full Text]

Li, W., Nishimura, R., Kashishian, A., Batzer, A. G., Kim, W. J., Cooper, J. A. and Schlessinger, J (1994). A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell Biol 14, 509-517.[Abstract/Free Full Text]

Lu, X., Chou, T. B., Williams, N. G., Roberts, T. and Perrimon, N (1993). Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila. Genes. Dev 7, 621-632.[Abstract/Free Full Text]

Milarski, K. L. and Saltiel, A. R (1994). Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. J. Biol. Chem 269, 21239-21243.[Abstract/Free Full Text]

Noguchi, T., Matozaki, T., Horita, K., Fujioka, Y. and Kasuga, M (1994). Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation. Mol. Cell Biol 14, 6674-6682.[Abstract/Free Full Text]

O'Neill, E. M., Rebay, I., Tjian, R. and Rubin, G. M (1994). The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78, 137-147.[Medline]

Olivier, J. P., Raabe, T., Henkemeyer, M., Dickson, B., Mbamalu, G., Margolis, B., Schlessinger, J., Hafen, E. and Pawson, T (1993). A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73, 179-191.[Medline]

Perkins, L. A., Larsen, I. and Perrimon, N (1992). corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell 70, 225-236.[Medline]

Raabe, T., Olivier, J. P., Dickson, B., Liu, X., Gish, G. D., Pawson, T. and Hafen, E (1995). Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila. EMBO J 14, 2509-2518.[Medline]

Rebay, I. and Rubin, G. M (1995). Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 81, 857-866.[Medline]

Rivard, N., McKenzie, F. R., Brondello, J. M. and Pouyssegur, J (1995). The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors. J. Biol. Chem 270, 11017-11024.[Abstract/Free Full Text]

Robinow, S. and White, K (1988). The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages. Dev. Biol 126, 294-303.[Medline]

Rogge, R. D., Karlovich, C. A. and Banerjee, U (1991). Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases. Cell 64, 39-48.[Medline]

Schlessinger, J (1994). SH2/SH3 signaling proteins. Curr. Opin. Genet. Dev 4, 25-30.[Medline]

Simon, M. A., Drees, B., Kornberg, T. and Bishop, J. M (1985). The nucleotide sequence and the tissue-specific expression of Drosophila c-src. Cell 42, 831-840.[Medline]

Simon, M. A., Bowtell, D. D. and Rubin, G. M (1989). Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila. Proc. Natl. Acad. Sci. USA 86, 8333-8337.[Abstract/Free Full Text]

Simon, M. A., Bowtell, D. D., Dodson, G. S., Laverty, T. R. and Rubin, G. M (1991). Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67, 701-716.[Medline]

Simon, M. A., Dodson, G. S. and Rubin, G. M (1993). An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro. Cell 73, 169-177.[Medline]

Tang, T. L., Freeman, R. M., Jr., O'Reilly, A. M., Neel, B. G. and Sokol, S.Y (1995). The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 80, 473-483.[Medline]

Tomlinson, A. and Ready, D. F (1987). Neuronal differentiation in the Drosophila ommatidium. Dev. Biol 120, 366-376.[Medline]

van der Geer, P., Hunter, T. and Lindberg, R. A (1994). Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell. Biol 10, 251-337.

Vogel, W., Lammers, R., Huang, J. and Ullrich, A (1993). Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259, 1611-1614.[Abstract/Free Full Text]

Xiao, S., Rose, D. W., Sasaoka, T., Maegawa, H., Burke, T. R.,Jr., Roller, P. P., Shoelson, S. E. and Olefsky, J. M (1994). Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J. Biol. Chem 269, 21244-21248.[Abstract/Free Full Text]

Yamauchi, K., Milarski, K. L., Saltiel, A. R. and Pessin, J. E (1995). Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc. Natl. Acad. Sci. USA 92, 664-668.[Abstract/Free Full Text]

Zhao, Z., Tan, Z., Wright, J. H., Diltz, C. D., Shen, S. H., Krebs, E. G. and Fischer, E. H (1995). Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen-activated protein kinase activation. J. Biol. Chem 270, 11765-11769.[Abstract/Free Full Text]

Zipursky, S. L. and Rubin, G. M (1994). Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu. Rev. Neurosci 17, 373-397.[Medline]

This article has been cited by other articles:

B. P. James, T. A. Bunch, S. Krishnamoorthy, L. A. Perkins, and D. L. Brower
Nuclear Localization of the ERK MAP Kinase Mediated by Drosophila {alpha}PS2betaPS Integrin and Importin-7
Mol. Biol. Cell, October 1, 2007; 18(10): 4190 - 4199.
[Abstract] [Full Text] [PDF]

L. A. Jarvis, S. J. Toering, M. A. Simon, M. A. Krasnow, and R. K. Smith-Bolton
Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases
Development, March 15, 2006; 133(6): 1133 - 1142.
[Abstract] [Full Text] [PDF]

C. Kon, K. M. Cadigan, S. L. da Silva, and R. Nusse
Developmental Roles of the Mi-2/NURD-Associated Protein p66 in Drosophila
Genetics, April 1, 2005; 169(4): 2087 - 2100.
[Abstract] [Full Text] [PDF]

R. Wilson, A. Battersby, A. Csiszar, E. Vogelsang, and M. Leptin
A Functional Domain of Dof That Is Required for Fibroblast Growth Factor Signaling
Mol. Cell. Biol., March 15, 2004; 24(6): 2263 - 2276.
[Abstract] [Full Text] [PDF]

Y. M. Agazie and M. J. Hayman
Development of an Efficient "Substrate-trapping" Mutant of Src Homology Phosphotyrosine Phosphatase 2 and Identification of the Epidermal Growth Factor Receptor, Gab1, and Three Other Proteins as Target Substrates
J. Biol. Chem., April 11, 2003; 278(16): 13952 - 13958.
[Abstract] [Full Text] [PDF]

S. E. Baker, J. A. Lorenzen, S. W. Miller, T. A. Bunch, A. L. Jannuzi, M. H. Ginsberg, L. A. Perkins, and D. L. Brower
Genetic Interaction Between Integrins and moleskin, a Gene Encoding a Drosophila Homolog of Importin-7
Genetics, September 1, 2002; 162(1): 285 - 296.
[Abstract] [Full Text] [PDF]

R. J. Harrington, M. J. Gutch, M. O. Hengartner, N. K. Tonks, and A. D. Chisholm
The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis
Development, January 5, 2002; 129(9): 2141 - 2153.
[Abstract] [Full Text] [PDF]

I. Wolf, B. J. Jenkins, Y. Liu, M. Seiffert, J. M. Custodio, P. Young, and L. R. Rohrschneider
Gab3, a New DOS/Gab Family Member, Facilitates Macrophage Differentiation
Mol. Cell. Biol., January 1, 2002; 22(1): 231 - 244.
[Abstract] [Full Text] [PDF]

R. K. Smith, P. M. Carroll, J. D. Allard, and M. A. Simon
MASK, a large ankyrin repeat and KH domain-containing protein involved in Drosophila receptor tyrosine kinase signaling
Development, January 1, 2002; 129(1): 71 - 82.
[Abstract] [Full Text] [PDF]

J. L. Schutzman, C. Z. Borland, J. C. Newman, M. K. Robinson, M. Kokel, and M. J. Stern
The Caenorhabditis elegans EGL-15 Signaling Pathway Implicates a DOS-Like Multisubstrate Adaptor Protein in Fibroblast Growth Factor Signal Transduction
Mol. Cell. Biol., December 1, 2001; 21(23): 8104 - 8116.
[Abstract] [Full Text] [PDF]

M. R. J. Hamlet and L. A. Perkins
Analysis of Corkscrew Signaling in the Drosophila Epidermal Growth Factor Receptor Pathway During Myogenesis
Genetics, November 1, 2001; 159(3): 1073 - 1087.
[Abstract] [Full Text] [PDF]

J. Lorenzen, S. Baker, F Denhez, M. Melnick, D. Brower, and L. Perkins
Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin
Development, January 4, 2001; 128(8): 1403 - 1414.
[Abstract] [PDF]

C. R. Maroun, M. A. Naujokas, M. Holgado-Madruga, A. J. Wong, and M. Park
The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase
Mol. Cell. Biol., November 15, 2000; 20(22): 8513 - 8525.
[Abstract] [Full Text]

L. Firth, J. Manchester, J. A. Lorenzen, M. Baron, and L. A. Perkins
Identification of Genomic Regions That Interact With a Viable Allele of the Drosophila Protein Tyrosine Phosphatase Corkscrew
Genetics, October 1, 2000; 156(2): 733 - 748.
[Abstract] [Full Text]

Z.-Q. Shi, D.-H. Yu, M. Park, M. Marshall, and G.-S. Feng
Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity
Mol. Cell. Biol., March 1, 2000; 20(5): 1526 - 1536.
[Abstract] [Full Text]

K. Fukunaga, T. Noguchi, H. Takeda, T. Matozaki, Y. Hayashi, H. Itoh, and M. Kasuga
Requirement for Protein-tyrosine Phosphatase SHP-2 in Insulin-induced Activation of c-Jun NH2-terminal Kinase
J. Biol. Chem., February 18, 2000; 275(7): 5208 - 5213.
[Abstract] [Full Text] [PDF]

A. M. O'Reilly, S. Pluskey, S. E. Shoelson, and B. G. Neel
Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps
Mol. Cell. Biol., January 1, 2000; 20(1): 299 - 311.
[Abstract] [Full Text]

K. P. White, S. A. Rifkin, P. Hurban, and D. S. Hogness
Microarray Analysis of Drosophila Development During Metamorphosis
Science, December 10, 1999; 286(5447): 2179 - 2184.
[Abstract] [Full Text]

C.-K. Qu, W.-M. Yu, B. Azzarelli, and G.-S. Feng
Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals
PNAS, July 20, 1999; 96(15): 8528 - 8533.
[Abstract] [Full Text] [PDF]

E.-S. Oh, H. Gu, T. M. Saxton, J. F. Timms, S. Hausdorff, E. U. Frevert, B. B. Kahn, T. Pawson, B. G. Neel, and S. M. Thomas
Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2
Mol. Cell. Biol., April 1, 1999; 19(4): 3205 - 3215.
[Abstract] [Full Text] [PDF]

S Kramer, M Okabe, N Hacohen, M. Krasnow, and Y Hiromi
Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila
Development, January 6, 1999; 126(11): 2515 - 2525.
[Abstract] [PDF]

D.-H. Yu, C.-K. Qu, O. Henegariu, X. Lu, and G.-S. Feng
Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion
J. Biol. Chem., August 14, 1998; 273(33): 21125 - 21131.
[Abstract] [Full Text] [PDF]

N. Le and M. A. Simon
Disabled Is a Putative Adaptor Protein That Functions during Signaling by the Sevenless Receptor Tyrosine Kinase
Mol. Cell. Biol., August 1, 1998; 18(8): 4844 - 4854.
[Abstract] [Full Text]

K. Nakamura and J. C. Cambier
B Cell Antigen Receptor (BCR)-Mediated Formation of a SHP-2-pp120 Complex and Its Inhibition by Fe{gamma}RIIB1-BCR Coligation
J. Immunol., July 15, 1998; 161(2): 684 - 691.
[Abstract] [Full Text] [PDF]

T. B. Deb, L. Wong, D. S. Salomon, G. Zhou, J. E. Dixon, J. S. Gutkind, S. A. Thompson, and G. R. Johnson
A Common Requirement for the Catalytic Activity and Both SH2 Domains of SHP-2 in Mitogen-activated Protein (MAP) Kinase Activation by the ErbB Family of Receptors. A SPECIFIC ROLE FOR SHP-2 IN MAP, BUT NOT c-Jun AMINO-TERMINAL KINASE ACTIVATION
J. Biol. Chem., July 3, 1998; 273(27): 16643 - 16646.
[Abstract] [Full Text] [PDF]

J. D. Allard, R. Herbst, P. M. Carroll, and M. A. Simon
Mutational Analysis of the SRC Homology 2�Domain Protein-tyrosine Phosphatase Corkscrew
J. Biol. Chem., May 22, 1998; 273(21): 13129 - 13135.
[Abstract] [Full Text] [PDF]

M. Tsuda, T. Matozaki, K. Fukunaga, Y. Fujioka, A. Imamoto, T. Noguchi, T. Takada, T. Yamao, H. Takeda, F. Ochi, et al.
Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2. ROLES OF Fak AND Src FAMILY KINASES
J. Biol. Chem., May 22, 1998; 273(21): 13223 - 13229.
[Abstract] [Full Text] [PDF]

T. Takada, T. Matozaki, H. Takeda, K. Fukunaga, T. Noguchi, Y. Fujioka, I. Okazaki, M. Tsuda, T. Yamao, F. Ochi, et al.
Roles of the Complex Formation of SHPS-1 with SHP-2 in Insulin-stimulated Mitogen-activated Protein Kinase Activation
J. Biol. Chem., April 10, 1998; 273(15): 9234 - 9242.
[Abstract] [Full Text] [PDF]

M. J. Gutch, A. J. Flint, J. Keller, N. K. Tonks, and M. O. Hengartner
The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval�development
Genes & Dev., February 15, 1998; 12(4): 571 - 585.
[Abstract] [Full Text]

Z. Yu, L. Su, O. Hoglinger, M. L. Jaramillo, D. Banville, and S.-H. Shen
SHP-1 Associates with Both Platelet-derived Growth Factor Receptor and the p85 Subunit of Phosphatidylinositol 3-Kinase
J. Biol. Chem., February 6, 1998; 273(6): 3687 - 3694.
[Abstract] [Full Text] [PDF]

P Towb, R. Galindo, and S. Wasserman
Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo
Development, January 7, 1998; 125(13): 2443 - 2450.
[Abstract] [PDF]

H. Gu, J. D. Griffin, and B. G. Neel
Characterization of Two SHP-2-associated Binding Proteins and Potential Substrates in Hematopoietic Cells
J. Biol. Chem., June 27, 1997; 272(26): 16421 - 16430.
[Abstract] [Full Text] [PDF]

K. Carlberg and L. R. Rohrschneider
Characterization of a Novel Tyrosine Phosphorylated 100-kDa Protein That Binds to SHP-2 and Phosphatidylinositol 3'-Kinase in Myeloid Cells
J. Biol. Chem., June 20, 1997; 272(25): 15943 - 15950.
[Abstract] [Full Text] [PDF]

R C Kauffmann, S Li, P A Gallagher, J Zhang, and R W Carthew
Ras1 signaling and transcriptional competence in the R7 cell of Drosophila.
Genes & Dev., September 1, 1996; 10(17): 2167 - 2178.
[Abstract] [PDF]

L. Wong and G. R. Johnson
Epidermal Growth Factor Induces Coupling of Protein-tyrosine Phosphatase 1D to GRB2 via the COOH-terminal SH3 Domain of GRB2
J. Biol. Chem., August 30, 1996; 271(35): 20981 - 20984.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Allard, J. D.

Articles by Simon, M. A.

Search for Related Content

PubMed

PubMed Citation

Articles by Allard, J. D.

Articles by Simon, M. A.

				L. A. Jarvis, S. J. Toering, M. A. Simon, M. A. Krasnow, and R. K. Smith-Bolton Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases Development, March 15, 2006; 133(6): 1133 - 1142. [Abstract] [Full Text] [PDF]

				C. Kon, K. M. Cadigan, S. L. da Silva, and R. Nusse Developmental Roles of the Mi-2/NURD-Associated Protein p66 in Drosophila Genetics, April 1, 2005; 169(4): 2087 - 2100. [Abstract] [Full Text] [PDF]

				R. Wilson, A. Battersby, A. Csiszar, E. Vogelsang, and M. Leptin A Functional Domain of Dof That Is Required for Fibroblast Growth Factor Signaling Mol. Cell. Biol., March 15, 2004; 24(6): 2263 - 2276. [Abstract] [Full Text] [PDF]

				Y. M. Agazie and M. J. Hayman Development of an Efficient "Substrate-trapping" Mutant of Src Homology Phosphotyrosine Phosphatase 2 and Identification of the Epidermal Growth Factor Receptor, Gab1, and Three Other Proteins as Target Substrates J. Biol. Chem., April 11, 2003; 278(16): 13952 - 13958. [Abstract] [Full Text] [PDF]

				S. E. Baker, J. A. Lorenzen, S. W. Miller, T. A. Bunch, A. L. Jannuzi, M. H. Ginsberg, L. A. Perkins, and D. L. Brower Genetic Interaction Between Integrins and moleskin, a Gene Encoding a Drosophila Homolog of Importin-7 Genetics, September 1, 2002; 162(1): 285 - 296. [Abstract] [Full Text] [PDF]

				R. J. Harrington, M. J. Gutch, M. O. Hengartner, N. K. Tonks, and A. D. Chisholm The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis Development, January 5, 2002; 129(9): 2141 - 2153. [Abstract] [Full Text] [PDF]

				I. Wolf, B. J. Jenkins, Y. Liu, M. Seiffert, J. M. Custodio, P. Young, and L. R. Rohrschneider Gab3, a New DOS/Gab Family Member, Facilitates Macrophage Differentiation Mol. Cell. Biol., January 1, 2002; 22(1): 231 - 244. [Abstract] [Full Text] [PDF]

				R. K. Smith, P. M. Carroll, J. D. Allard, and M. A. Simon MASK, a large ankyrin repeat and KH domain-containing protein involved in Drosophila receptor tyrosine kinase signaling Development, January 1, 2002; 129(1): 71 - 82. [Abstract] [Full Text] [PDF]

				J. L. Schutzman, C. Z. Borland, J. C. Newman, M. K. Robinson, M. Kokel, and M. J. Stern The Caenorhabditis elegans EGL-15 Signaling Pathway Implicates a DOS-Like Multisubstrate Adaptor Protein in Fibroblast Growth Factor Signal Transduction Mol. Cell. Biol., December 1, 2001; 21(23): 8104 - 8116. [Abstract] [Full Text] [PDF]

				M. R. J. Hamlet and L. A. Perkins Analysis of Corkscrew Signaling in the Drosophila Epidermal Growth Factor Receptor Pathway During Myogenesis Genetics, November 1, 2001; 159(3): 1073 - 1087. [Abstract] [Full Text] [PDF]

				J. Lorenzen, S. Baker, F Denhez, M. Melnick, D. Brower, and L. Perkins Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin Development, January 4, 2001; 128(8): 1403 - 1414. [Abstract] [PDF]

				C. R. Maroun, M. A. Naujokas, M. Holgado-Madruga, A. J. Wong, and M. Park The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase Mol. Cell. Biol., November 15, 2000; 20(22): 8513 - 8525. [Abstract] [Full Text]

				L. Firth, J. Manchester, J. A. Lorenzen, M. Baron, and L. A. Perkins Identification of Genomic Regions That Interact With a Viable Allele of the Drosophila Protein Tyrosine Phosphatase Corkscrew Genetics, October 1, 2000; 156(2): 733 - 748. [Abstract] [Full Text]

				Z.-Q. Shi, D.-H. Yu, M. Park, M. Marshall, and G.-S. Feng Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity Mol. Cell. Biol., March 1, 2000; 20(5): 1526 - 1536. [Abstract] [Full Text]

				K. Fukunaga, T. Noguchi, H. Takeda, T. Matozaki, Y. Hayashi, H. Itoh, and M. Kasuga Requirement for Protein-tyrosine Phosphatase SHP-2 in Insulin-induced Activation of c-Jun NH2-terminal Kinase J. Biol. Chem., February 18, 2000; 275(7): 5208 - 5213. [Abstract] [Full Text] [PDF]

				A. M. O'Reilly, S. Pluskey, S. E. Shoelson, and B. G. Neel Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps Mol. Cell. Biol., January 1, 2000; 20(1): 299 - 311. [Abstract] [Full Text]

				K. P. White, S. A. Rifkin, P. Hurban, and D. S. Hogness Microarray Analysis of Drosophila Development During Metamorphosis Science, December 10, 1999; 286(5447): 2179 - 2184. [Abstract] [Full Text]

				C.-K. Qu, W.-M. Yu, B. Azzarelli, and G.-S. Feng Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals PNAS, July 20, 1999; 96(15): 8528 - 8533. [Abstract] [Full Text] [PDF]

				E.-S. Oh, H. Gu, T. M. Saxton, J. F. Timms, S. Hausdorff, E. U. Frevert, B. B. Kahn, T. Pawson, B. G. Neel, and S. M. Thomas Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2 Mol. Cell. Biol., April 1, 1999; 19(4): 3205 - 3215. [Abstract] [Full Text] [PDF]

				S Kramer, M Okabe, N Hacohen, M. Krasnow, and Y Hiromi Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila Development, January 6, 1999; 126(11): 2515 - 2525. [Abstract] [PDF]

				D.-H. Yu, C.-K. Qu, O. Henegariu, X. Lu, and G.-S. Feng Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion J. Biol. Chem., August 14, 1998; 273(33): 21125 - 21131. [Abstract] [Full Text] [PDF]

				N. Le and M. A. Simon Disabled Is a Putative Adaptor Protein That Functions during Signaling by the Sevenless Receptor Tyrosine Kinase Mol. Cell. Biol., August 1, 1998; 18(8): 4844 - 4854. [Abstract] [Full Text]

				K. Nakamura and J. C. Cambier B Cell Antigen Receptor (BCR)-Mediated Formation of a SHP-2-pp120 Complex and Its Inhibition by Fe{gamma}RIIB1-BCR Coligation J. Immunol., July 15, 1998; 161(2): 684 - 691. [Abstract] [Full Text] [PDF]

				T. B. Deb, L. Wong, D. S. Salomon, G. Zhou, J. E. Dixon, J. S. Gutkind, S. A. Thompson, and G. R. Johnson A Common Requirement for the Catalytic Activity and Both SH2 Domains of SHP-2 in Mitogen-activated Protein (MAP) Kinase Activation by the ErbB Family of Receptors. A SPECIFIC ROLE FOR SHP-2 IN MAP, BUT NOT c-Jun AMINO-TERMINAL KINASE ACTIVATION J. Biol. Chem., July 3, 1998; 273(27): 16643 - 16646. [Abstract] [Full Text] [PDF]

				J. D. Allard, R. Herbst, P. M. Carroll, and M. A. Simon Mutational Analysis of the SRC Homology 2�Domain Protein-tyrosine Phosphatase Corkscrew J. Biol. Chem., May 22, 1998; 273(21): 13129 - 13135. [Abstract] [Full Text] [PDF]

				M. Tsuda, T. Matozaki, K. Fukunaga, Y. Fujioka, A. Imamoto, T. Noguchi, T. Takada, T. Yamao, H. Takeda, F. Ochi, et al. Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2. ROLES OF Fak AND Src FAMILY KINASES J. Biol. Chem., May 22, 1998; 273(21): 13223 - 13229. [Abstract] [Full Text] [PDF]

				T. Takada, T. Matozaki, H. Takeda, K. Fukunaga, T. Noguchi, Y. Fujioka, I. Okazaki, M. Tsuda, T. Yamao, F. Ochi, et al. Roles of the Complex Formation of SHPS-1 with SHP-2 in Insulin-stimulated Mitogen-activated Protein Kinase Activation J. Biol. Chem., April 10, 1998; 273(15): 9234 - 9242. [Abstract] [Full Text] [PDF]

				M. J. Gutch, A. J. Flint, J. Keller, N. K. Tonks, and M. O. Hengartner The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval�development Genes & Dev., February 15, 1998; 12(4): 571 - 585. [Abstract] [Full Text]

				Z. Yu, L. Su, O. Hoglinger, M. L. Jaramillo, D. Banville, and S.-H. Shen SHP-1 Associates with Both Platelet-derived Growth Factor Receptor and the p85 Subunit of Phosphatidylinositol 3-Kinase J. Biol. Chem., February 6, 1998; 273(6): 3687 - 3694. [Abstract] [Full Text] [PDF]

				P Towb, R. Galindo, and S. Wasserman Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo Development, January 7, 1998; 125(13): 2443 - 2450. [Abstract] [PDF]