Retinoic acid signaling is required during early chick limb development

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Helms, J. A.
	Articles by Thaller, C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Helms, J. A.
	Articles by Thaller, C.

Chan, D. C., Wynshaw-Boris, A and Leder, P (1995). Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud. Development 121, 3152-3162.

Chaube, S (1959). On axiation and symmetry in transplanted wing of the chick. J. Exp. Zool 140, 29-77.[Medline]

Cohn, M. J., Izpis\234a-Belmonte, J. C., Abud, H., Heath, J. K. and Tickle, C (1995). Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80, 739-746.[Medline]

Crossley, P. H. and Martin, G. R (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439-451.[Abstract]

Crossley, H.P.,Minowada, C.A., MacArthur and Martin, G.R (1996). Roles for FGF8 in the induction, initiation and maintenance of chick limb development. Cell 84, 128-136.

Eichele, G., Tickle, C. and Alberts, B (1984). Micro-controlled release of biologically active compounds in chick embryos: beads of 200m diameter for the local release of retinoids. Anal. Biochem 142, 542-555.[Medline]

Francis, P. H., Richardson, M. K., Brickell, P. M. and Tickle, C (1994). Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. Development 120, 209-18.[Abstract]

Hamburger, H. and Hamilton, V (1951). A series of normal stages in the development of the chick embryo. J. Morphol 88, 49-92.

Haramis, A. G., Brown, J. M. and Zeller, R (1995). The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5 HoxD genes during limb pattern formation. Development 121, 4237-4245.[Abstract]

Helms, J., Thaller, C. and Eichele G (1994). Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud. Development 120, 3267-3274.[Abstract]

Hornbruch, A. and Wolpert, L (1991). The spatial and temporal distribution of polarizing activity in the flank of the pre-limb-bud stages in the chick embryo. Development 111, 725-731.[Abstract]

Izpis\234a-Belmonte, J.-C., Tickle, C., Dolle, P, Wolpert, L. and Duboule, D (1991). Expression of homeobox Hox-4 genes and the specification of position in chick wing development. Nature 350, 585-589.[Medline]

Izpis\234a-Belmonte, J.-C. and Duboule, D (1992). Homeobox genes and pattern formation in the vertebrate limb. Dev. Biol 152, 26-36.[Medline]

Kastner, P., Grondona J. M., Mark, M., Gansmuller, A., LeMeur, M.,Decimo, D. Vonesch, J-L., Dolle P. and Chambon, P (1994). Genetic analysis of RXRdevelopmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell 78, 987-1003.[Medline]

Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.[Medline]

Li, E., Sucov, H. M., Lee, K.-F., Evans, R. M., Jaenisch, R (1993). Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. Proc. Natl. Acad. Sci. USA 90, 1590-1594.[Abstract/Free Full Text]

Lohnes, D., Kastner, P., Dierich, A., Mark, M., LeMeur, M. and Chambon, P (1993). Function of retinoic acid receptor gamma in the mouse. Cell 73, 643-658.[Medline]

Lohnes, D., Mark, M., Mendelsohn, C., Dolle, P., Dierich, A., Gorry, P., Gansmuller A. and Chambon, P (1994). Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants. Development 120, 2723-2748.[Abstract]

Lufkin, T., Lohnes, D., Mark, M., Dierich, A., Gorry, P., Gaub, M. P., LeMeur, M., Chambon, P (1993). High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc. Natl. Acad. Sci. USA 90, 7225-7229.[Abstract/Free Full Text]

Luo, J., Pasceri, P., Conlon, R. A., Rossant, J. and Giguere, V (1995). Mice lacking all isoforms of retinoic acid receptordevelop normally and are susceptable to the teratogenic effects of retinoic acid. Mech. Dev 52, 1-11.

Mahmood, R., Bresnick, J., Hornbruch, A., Mahony, C., Morton, N., Colquhoun, K., Martin, P., Lumsden, A., Dickson, C. and Mason, I (1995). A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Current Biology 5, 797-806.[Medline]

Mendelsohn, C., Ruberte, E., LeMeur, M., Morriss-Kay, G. and Chambon, P (1991). Developmental analysis of the retinoic acid-inducible RAR-\2472 promoter in transgenic animals. Development 113, 723-734.[Abstract]

Mendelsohn, C., Lohnes, D., Decimo, D., Lufkin, T., LeMeur, M., Chambon P. and Mark, M (1994). Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 120, 2749-2771.[Abstract]

Murillo-Ferrol, N. L (1965). \203tude causale de la differenciation la plus precoce de l'ebauche morphologique des membres. Analyse experimentale chez les embryons d'oiseaux. Acta Anat 62, 80-103.[Medline]

Niswander, L. and Martin, G. R (1993). FGF-4 and BMP-2 have opposite effects on limb growth. Nature 361, 68-71.[Medline]

Niswander, L., Tickle, C., Vogel, A., Booth, I. and Martin, G. R (1993). FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75, 579-587.[Medline]

Niswander, L., Jeffrey, S. Martin, G. R. and Tickle, C (1994). A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371, 609-612.[Medline]

Nohno, T., Noji, S., Koyama, E., Ohyama, K., Myokai, F., Kuroiwa, A., Saito, T. and Taniguchi, S (1991). Involvement of Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development. Cell 64, 1197-1205.[Medline]

Noji, S., Nohno, T., Koyama, E., Muto, K., Ohyama, K., Yoshinobu, A., Tamura, K., Ohsugi, K., Ide, H., Taniguchi, S. and Saito, T (1991). Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud. Nature 350, 83-86.[Medline]

Ohuchi, H., Nakagawa, T, Yamauchi, M., Ohata, T., Yoshioka, H., Kuwana, T., Mima, T., Mikawa, T., Nohno, T. and Noji, S (1995). An additional limb can be induced from the flank of the chick embryo by FGF4. Biochem. Biophys. Res. Comm 209, 809-816.[Medline]

Parr, B. and McMahon, A (1995). Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374, 350-353.[Medline]

Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Saunders, J. W (1948). The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. J. Exp. Zool 108, 363-403.

Sucov, H. M., Dyson, E., Gumeringer, C. L., Price, J., Chien, K. R. and Evans, R. M (1994). RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev 8, 1007-1018.[Abstract/Free Full Text]

Summerbell, D (1983). The effect of local application of retinoic acid to the anterior margin of the developing chick limb. J. Embryol. exp. Morph 78, 269-289.[Medline]

Sundin, O., Busse, H., Rogers, M., Gudas, L. and Eichele, G (1990). Region specific expression in early chick and mouse embryos of Ghox-lab and Hox 1. 6, vertebrate homeo box-containing genes related to Drosophila labial. Development 108, 47-58.[Abstract]

Tabin, C (1995). The initiation of the limb bud: growth factors, Hox genes, and retinoids. Cell 80, 671-674.[Medline]

Tamura, K., Aoki, Y. and Ide, H (1993). Induction of polarizing activity by retinoic acid occurs independently of duplicate formation in developing chick limb buds. Dev. Biol 158, 341-349.[Medline]

Thaller, C. and Eichele, G (1987). Identification and spatial distribution of retinoids in the developing chick limb bud. Nature 327, 625-628.[Medline]

Tickle, C (1981). The number of polarizing region cells required to specify additional digits in the developing chick wing. Nature 289, 295-298.[Medline]

Tickle, C., Summerbell, D. and Wolpert, L (1975). Positional signalling and specification of digits in chick limb morphogenesis. Nature 254, 199-202.[Medline]

Tickle, C., Alberts, B., Wolpert, L. and Lee, J (1982). Local application of retinoic acid to the limb bud mimics the action of the polarizing region. Nature 296, 564-566.[Medline]

Tickle C., Lee J. and Eichele, G (1985). A quantitative analysis of the effect of all- trans -retinoic acid on the pattern of chick wing development. Dev. Biol 109, 82-95.[Medline]

Tickle, C. and Eichele G (1994). Vertebrate limb development. Ann. Rev. Cell Biol 10, 121-52.[Medline]

Todt, W. L. and Fallon, J. F (1987). Posterior apical ectodermal ridge removal in the chick wing bud triggers a series of events resulting in defective anterior pattern formation. Development 101, 501-515.[Abstract]

Vogel, A. and Tickle, C (1993). FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro. Development 119, 199-206.[Abstract]

Wanek N., Gardiner, D. M., Muneoka, K. and Bryant, S. V (1991). Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud. Nature 350, 81-83.[Medline]

Wedden, S. E., Thaller, C. and Eichele, G (1990). Targeted slow release of retinoids into chick embryos. Meth. Enzymol 190, 201-209.[Medline]

Yang Y. and Niswander L (1995). Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell 80, 939-947.[Medline]

This article has been cited by other articles:

L. L. Sandell, B. W. Sanderson, G. Moiseyev, T. Johnson, A. Mushegian, K. Young, J.-P. Rey, J.-x. Ma, K. Staehling-Hampton, and P. A. Trainor
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development
Genes & Dev., May 1, 2007; 21(9): 1113 - 1124.
[Abstract] [Full Text] [PDF]

D. S. Durica, D. Kupfer, F. Najar, H. Lai, Y. Tang, K. Griffin, P. M. Hopkins, and B. Roe
EST library sequencing of genes expressed during early limb regeneration in the fiddler crab and transcriptional responses to ecdysteroid exposure in limb bud explants
Integr. Comp. Biol., December 1, 2006; 46(6): 948 - 964.
[Abstract] [Full Text] [PDF]

W. Bi, T. Ohyama, H. Nakamura, J. Yan, J. Visvanathan, M. J. Justice, and J. R. Lupski
Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome
Hum. Mol. Genet., April 15, 2005; 14(8): 983 - 995.
[Abstract] [Full Text] [PDF]

F. A. Mic, I. O. Sirbu, and G. Duester
Retinoic Acid Synthesis Controlled by Raldh2 Is Required Early for Limb Bud Initiation and Then Later as a Proximodistal Signal during Apical Ectodermal Ridge Formation
J. Biol. Chem., June 18, 2004; 279(25): 26698 - 26706.
[Abstract] [Full Text] [PDF]

O. Krebs, C. M. Schreiner, W. J. Scott Jr, S. M. Bell, D. J. Robbins, J. A. Goetz, H. Alt, N. Hawes, E. Wolf, and J. Favor
Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud
Development, December 15, 2003; 130(24): 6037 - 6047.
[Abstract] [Full Text] [PDF]

H. Grandel, K. Lun, G.-J. Rauch, M. Rhinn, T. Piotrowski, C. Houart, P. Sordino, A. M. Kuchler, S. Schulte-Merker, R. Geisler, et al.
Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud
Development, March 8, 2003; 129(12): 2851 - 2865.
[Abstract] [Full Text] [PDF]

K. Niederreither, J. Vermot, B. Schuhbaur, P. Chambon, and P. Dolle
Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse
Development, August 1, 2002; 129(15): 3563 - 3574.
[Abstract] [Full Text] [PDF]

A. Molotkov and G. Duester
Retinol/Ethanol Drug Interaction during Acute Alcohol Intoxication in Mice Involves Inhibition of Retinol Metabolism to Retinoic Acid by Alcohol Dehydrogenase
J. Biol. Chem., June 14, 2002; 277(25): 22553 - 22557.
[Abstract] [Full Text] [PDF]

R. A. Schneider, D. Hu, J. L. R. Rubenstein, M. Maden, and J. A. Helms
Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH
Development, July 15, 2001; 128(14): 2755 - 2767.
[Abstract] [Full Text] [PDF]

H.-C. Lu, E. C. Swindell, W. D. Sierralta, G. Eichele, and C. Thaller
Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud
Development, July 1, 2001; 128(13): 2451 - 2460.
[Abstract] [Full Text] [PDF]

S. A. Ross, P. J. McCaffery, U. C. Drager, and L. M. De Luca
Retinoids in Embryonal Development
Physiol Rev, July 1, 2000; 80(3): 1021 - 1054.
[Abstract] [Full Text] [PDF]

A. Tavares, T Tsukui, and J. Izpisua Belmonte
Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development
Development, January 12, 2000; 127(23): 5133 - 5144.
[Abstract] [PDF]

N Mercader, E Leonardo, M. Piedra, C Martinez-A, M. Ros, and M Torres
Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes
Development, January 9, 2000; 127(18): 3961 - 3970.
[Abstract] [PDF]

L. E. Purton, I. D. Bernstein, and S. J. Collins
All-Trans Retinoic Acid Delays the Differentiation of Primitive Hematopoietic Precursors (lin-c-kit+Sca-1+) While Enhancing the Terminal Maturation of Committed Granulocyte/Monocyte Progenitors
Blood, July 15, 1999; 94(2): 483 - 495.
[Abstract] [Full Text] [PDF]

D. Warburton, J. Zhao, M. A. Berberich, and M. Bernfield
Molecular embryology of the lung: then, now, and in the future
Am J Physiol Lung Cell Mol Physiol, May 1, 1999; 276(5): L697 - L704.
[Abstract] [Full Text] [PDF]

D Hu and J. Helms
The role of sonic hedgehog in normal and abnormal craniofacial morphogenesis
Development, January 11, 1999; 126(21): 4873 - 4884.
[Abstract] [PDF]

A Zuniga and R Zeller
Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity
Development, January 1, 1999; 126(1): 13 - 21.
[Abstract] [PDF]

M Takahashi, K Tamura, D Buscher, H Masuya, S Yonei-Tamura, K Matsumoto, M Naitoh-Matsuo, J Takeuchi, K Ogura, T Shiroishi, et al.
The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development
Development, January 11, 1998; 125(22): 4417 - 4425.
[Abstract] [PDF]

T. Stratford, K Kostakopoulou, and M Maden
Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb
Development, January 11, 1997; 124(21): 4225 - 4234.
[Abstract] [PDF]

Y Yang, G Drossopoulou, P. Chuang, D Duprez, E Marti, D Bumcrot, N Vargesson, J Clarke, L Niswander, A McMahon, et al.
Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb
Development, January 11, 1997; 124(21): 4393 - 4404.
[Abstract] [PDF]

H. Lu, J. Revelli, L Goering, C Thaller, and G Eichele
Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation
Development, January 5, 1997; 124(9): 1643 - 1651.
[Abstract] [PDF]

M. Ros, M Sefton, and M. Nieto
Slug, a zinc finger gene previously implicated in the early patterning of the mesoderm and the neural crest, is also involved in chick limb development
Development, January 5, 1997; 124(9): 1821 - 1829.
[Abstract] [PDF]

H. Lu, G Eichele, and C Thaller
Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis
Development, January 1, 1997; 124(1): 195 - 203.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Helms, J. A.

Articles by Thaller, C.

Search for Related Content

PubMed

PubMed Citation

Articles by Helms, J. A.

Articles by Thaller, C.

				D. S. Durica, D. Kupfer, F. Najar, H. Lai, Y. Tang, K. Griffin, P. M. Hopkins, and B. Roe EST library sequencing of genes expressed during early limb regeneration in the fiddler crab and transcriptional responses to ecdysteroid exposure in limb bud explants Integr. Comp. Biol., December 1, 2006; 46(6): 948 - 964. [Abstract] [Full Text] [PDF]

				W. Bi, T. Ohyama, H. Nakamura, J. Yan, J. Visvanathan, M. J. Justice, and J. R. Lupski Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome Hum. Mol. Genet., April 15, 2005; 14(8): 983 - 995. [Abstract] [Full Text] [PDF]

				F. A. Mic, I. O. Sirbu, and G. Duester Retinoic Acid Synthesis Controlled by Raldh2 Is Required Early for Limb Bud Initiation and Then Later as a Proximodistal Signal during Apical Ectodermal Ridge Formation J. Biol. Chem., June 18, 2004; 279(25): 26698 - 26706. [Abstract] [Full Text] [PDF]

				O. Krebs, C. M. Schreiner, W. J. Scott Jr, S. M. Bell, D. J. Robbins, J. A. Goetz, H. Alt, N. Hawes, E. Wolf, and J. Favor Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud Development, December 15, 2003; 130(24): 6037 - 6047. [Abstract] [Full Text] [PDF]

				H. Grandel, K. Lun, G.-J. Rauch, M. Rhinn, T. Piotrowski, C. Houart, P. Sordino, A. M. Kuchler, S. Schulte-Merker, R. Geisler, et al. Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud Development, March 8, 2003; 129(12): 2851 - 2865. [Abstract] [Full Text] [PDF]

				K. Niederreither, J. Vermot, B. Schuhbaur, P. Chambon, and P. Dolle Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse Development, August 1, 2002; 129(15): 3563 - 3574. [Abstract] [Full Text] [PDF]

				A. Molotkov and G. Duester Retinol/Ethanol Drug Interaction during Acute Alcohol Intoxication in Mice Involves Inhibition of Retinol Metabolism to Retinoic Acid by Alcohol Dehydrogenase J. Biol. Chem., June 14, 2002; 277(25): 22553 - 22557. [Abstract] [Full Text] [PDF]

				R. A. Schneider, D. Hu, J. L. R. Rubenstein, M. Maden, and J. A. Helms Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH Development, July 15, 2001; 128(14): 2755 - 2767. [Abstract] [Full Text] [PDF]

				H.-C. Lu, E. C. Swindell, W. D. Sierralta, G. Eichele, and C. Thaller Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud Development, July 1, 2001; 128(13): 2451 - 2460. [Abstract] [Full Text] [PDF]

				S. A. Ross, P. J. McCaffery, U. C. Drager, and L. M. De Luca Retinoids in Embryonal Development Physiol Rev, July 1, 2000; 80(3): 1021 - 1054. [Abstract] [Full Text] [PDF]

				A. Tavares, T Tsukui, and J. Izpisua Belmonte Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development Development, January 12, 2000; 127(23): 5133 - 5144. [Abstract] [PDF]

				N Mercader, E Leonardo, M. Piedra, C Martinez-A, M. Ros, and M Torres Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes Development, January 9, 2000; 127(18): 3961 - 3970. [Abstract] [PDF]

				L. E. Purton, I. D. Bernstein, and S. J. Collins All-Trans Retinoic Acid Delays the Differentiation of Primitive Hematopoietic Precursors (lin-c-kit+Sca-1+) While Enhancing the Terminal Maturation of Committed Granulocyte/Monocyte Progenitors Blood, July 15, 1999; 94(2): 483 - 495. [Abstract] [Full Text] [PDF]

				D. Warburton, J. Zhao, M. A. Berberich, and M. Bernfield Molecular embryology of the lung: then, now, and in the future Am J Physiol Lung Cell Mol Physiol, May 1, 1999; 276(5): L697 - L704. [Abstract] [Full Text] [PDF]

				D Hu and J. Helms The role of sonic hedgehog in normal and abnormal craniofacial morphogenesis Development, January 11, 1999; 126(21): 4873 - 4884. [Abstract] [PDF]

				A Zuniga and R Zeller Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity Development, January 1, 1999; 126(1): 13 - 21. [Abstract] [PDF]

				M Takahashi, K Tamura, D Buscher, H Masuya, S Yonei-Tamura, K Matsumoto, M Naitoh-Matsuo, J Takeuchi, K Ogura, T Shiroishi, et al. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development Development, January 11, 1998; 125(22): 4417 - 4425. [Abstract] [PDF]

				T. Stratford, K Kostakopoulou, and M Maden Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb Development, January 11, 1997; 124(21): 4225 - 4234. [Abstract] [PDF]

				Y Yang, G Drossopoulou, P. Chuang, D Duprez, E Marti, D Bumcrot, N Vargesson, J Clarke, L Niswander, A McMahon, et al. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb Development, January 11, 1997; 124(21): 4393 - 4404. [Abstract] [PDF]

				H. Lu, J. Revelli, L Goering, C Thaller, and G Eichele Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation Development, January 5, 1997; 124(9): 1643 - 1651. [Abstract] [PDF]

				M. Ros, M Sefton, and M. Nieto Slug, a zinc finger gene previously implicated in the early patterning of the mesoderm and the neural crest, is also involved in chick limb development Development, January 5, 1997; 124(9): 1821 - 1829. [Abstract] [PDF]

				H. Lu, G Eichele, and C Thaller Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis Development, January 1, 1997; 124(1): 195 - 203. [Abstract] [PDF]