Role of TGF beta s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Ganan, Y.
	Articles by Hurle, J. M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Ganan, Y.
	Articles by Hurle, J. M.

Aulthouse, A. L. and Solursh, M (1987). The detection of a precartilage, blastema-specific marker. Dev. Biol 120, 377-384.[Medline]

Coelho, C. N. D., Sumoy, L., Rodgers, B. J., Davidson, D. R., Hill, R., Upholt, W. B. and Kosher, R. A (1991). Expression of the chicken homeobox-containing gene GHox-8 during embryonic chick limb development. Mech. Dev 34, 143-154.[Medline]

Coelho, C. N. D., Sumoy, L., Kosher, R. A. and Upholt, W. B (1992). GHox-7, a chicken homeobox-containg gene expressed in a fashion consistent with a role in patterning events during embryonic chick limb development. Differentiation 49, 85-92.[Medline]

Dhordain, P., Dewitte, F., Desbiens, X., Stehelin, D. and Duterque-Coquillaud, M (1995). Mesodermal expression of the chicken erg gene associated with precartilaginous condensation and cartilage differentiation. Mech. Dev 50, 17-28.[Medline]

Fallon, J. F., Lopez, A., Ros, M. A., Savage, M. P., Olwin, B., B. and Simandl, B. K (1994). FGF-2, apical ridge growth signal for chick limb development. Science 264, 104-107.[Abstract/Free Full Text]

Francis, P. H., Richardson, M. K., Brickell, P. M. and Tickle C (1994). Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb bud. Development 120, 209-218.[Abstract]

Ga\226an, Y., Macias, D. and Hurle, J. M (1994). Pattern regulation in the chick autopodium at advanced stages of embryonic development. Dev. Dyn 199, 64-72.[Medline]

Garcia-Martinez, V., Macias, D., Ga\226an, Y., Garcia-Lobo, J. M., Francia, M. V., Fernandez-Teran, M. A. and Hurle, J. M (1993). Internucleosomal DNA fragmentation and programmed cell death (apoptosis) in the interdigital tissue of the embryonic chick leg bud. J. Cell Sci 106, 201-208.[Abstract]

Graham, A., Francis-West, P., Brickel, P. and Lumsden, A (1994). The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 372, 684-686.[Medline]

Hamburger, V. and Hamilton, H. L (1951). A series of normal stages in the development of the chick embryo. J. Morph 88, 49-92.

Hayamizu, T. F., Sessions, S. K., Wanek, N. and Bryant S. V (1991). Effects of localized application of transforming growth factor1 on developing chick limbs. Dev. Biol 145, 164-173.[Medline]

Helder, M. N., Ozkaynak, E., Sampath, K. T., Luyten, F. P., Latin, V., Oppermann, H. and Vukicevic, S (1995). Expression pattern of osteogenic protein-1 (bone morphogenetic protein-7) in human and mouse development. J. Histochem. Cytochem 43, 1035-1044.[Abstract]

Hurle, J. M. and Ga\226an, Y (1987). Formation of extra digits induced by surgical removal of the apical ectodermal ridge of the chick embryo leg bud in the stages previous to the onset of interdigital cell death. Anat. Embryol 176, 393-399.[Medline]

Hurle, J. M., Ga\226an, Y. and Macias, D (1989). Experimental analysis of the in vivo chondrogenic potential of the interdigital mesenchyme of the chick leg bud subjected to local ectodermal removal. Dev. Biol 132, 368-374.[Medline]

Knudson, C. B., Munaim, S. I. and Toole, B. P (1995). Ectodermal stimulation of the production of hyaluronan-dependent pericellular matrix by embryonic limb mesodermal cells. Dev. Dyn 204, 186-191.[Medline]

Kulyk, W. M., Rodgers, B. J., Greer, K. and Kosher, R. A (1989). Promotion of embryonic chick cartilage differentiation by tranforming growth factor-. Dev. Biol 135, 424-430.[Medline]

Lee, K. K. H., Li, F. C.H., Yung, W. T., Kung, J. L. S., Ng, J. L. and Cheah, K. S. E (1994). Influence of digits, ectoderm and retinoic acid on chondrogenesis by mouse interdigital mesoderm in culture. Dev. Dyn 201, 297-309.[Medline]

Leonard, C. M., Fuld, H. M., Frenz, D. A., Downie, S. A., Massague, J. and Newman, S. A (1991). Role of transforming growth factor-in chondrogenic pattern formation in the embryonic limb, Stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF- and evidence for endogenous TGF--like activity. Dev. Biol 145, 99-109.[Medline]

Luo, G., Hofmann, C., Bronckers, A. L. J. J., Sohocki, M., Bradley, A. and Karsenty, G (1995). BMP-7 is an inducer of nephrogenesis and is also required for eye development and skeletal patterning. Genes Dev 9, 2808-2820.[Abstract/Free Full Text]

Lyons, K. M., Pelton, R. W. and Hogan, B. L. M (1990). Organogenesis and pattern formation in the mouse, RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development 109, 833-844.[Abstract/Free Full Text]

Mahmood, R., Bresnick, J., Hornbruch, A., Mahony, C., Morton, N., Colquhoun, K., Martin, P., Lumsden, A., Dickson, C. and Mason, I (1995). A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgorowth. Curr. Biol 5, 797-806.[Medline]

Martin, P., Dickson, M., C., Millan, F., A. and Akhurst, R., J (1993). Rapid induction and clearance of TGF1 is an early response to wounding in the muse embryo. Dev. Gen 14, 225-238.[Medline]

Millan, F. A., Denhez, F., Kondaiah, P. and Akhurst, R. J (1991). Embryonic gene expression patterns of TGF1, 2 and3 suggest different developmental functions in vivo. Development 111, 131-144.[Abstract]

Niswander, L., Tickle, C., Vogel, A., Booth, I. and Martin, G (1993). FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75, 1-20.[Medline]

Roark, E. F. and Greer, K (1994). Transforming growth factor-and bone morphogenetic protein-2 act by distinct mechanisms to promote chick limb cartilage differentiation in vitro. Dev. Dyn 200, 103-116.[Medline]

Ros, M. A., Macias, D., Fallon, J. F. and Hurle, J. M (1994). Formation of extra digits in the interdigital spaces of the chick leg bud is not preceded by changes in the expression of Msx and Hoxd genes. Anat. Embryol 190, 375-382.[Medline]

Schofield, J. L. and Wolpert, L (1990). Effect of TGF-1, TGF- 2 and bFGF on chick cartilage and muscle differentiation. Exp. Cell Res 191, 144-148.[Medline]

Summerbel, D., Lewis, J., H. and Wolpert, L (1973). Positional information in chick limb morphogenesis. Nature 244, 482-496.

Suzuki, H. R., Padanilam, B. J., Vitale, E., Ramirez, F. and Solursh, M (1991). Repeating developmental expression of GHox-7, a novel homeobox-containing gene in the chick limb morphogenesis. Dev. Biol 148, 375-388.[Medline]

Tickle, C (1995). Vertebrate limb development. Curr. Opin. Genet. Dev 5, 478-484.[Medline]

This article has been cited by other articles:

A. Spagnoli, L. O'Rear, R. L. Chandler, F. Granero-Molto, D. P. Mortlock, A. E. Gorska, J. A. Weis, L. Longobardi, A. Chytil, K. Shimer, et al.
TGF-{beta} signaling is essential for joint morphogenesis
J. Cell Biol., July 30, 2007; 177(6): 1105 - 1117.
[Abstract] [Full Text] [PDF]

S. Pajni-Underwood, C. P. Wilson, C. Elder, Y. Mishina, and M. Lewandoski
BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling
Development, June 15, 2007; 134(12): 2359 - 2368.
[Abstract] [Full Text] [PDF]

J. C. Bemis, N. F. Alejandro, D. A. Nazarenko, A. I. Brooks, R. B. Baggs, and T. A. Gasiewicz
TCDD-Induced Alterations in Gene Expression Profiles of the Developing Mouse Paw Do Not Influence Morphological Differentiation of This Potential Target Tissue
Toxicol. Sci., January 1, 2007; 95(1): 240 - 248.
[Abstract] [Full Text] [PDF]

S. D. Weatherbee, R. R. Behringer, J. J. Rasweiler IV, and L. A. Niswander
Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification
PNAS, October 10, 2006; 103(41): 15103 - 15107.
[Abstract] [Full Text] [PDF]

L. M. Hoffman, K. Garcha, K. Karamboulas, M. F. Cowan, L. M. Drysdale, W. A. Horton, and T. M. Underhill
BMP action in skeletogenesis involves attenuation of retinoid signaling
J. Cell Biol., July 3, 2006; 174(1): 101 - 113.
[Abstract] [Full Text] [PDF]

Y. Yin, C. Lin, and L. Ma
Msx2 Promotes Vaginal Epithelial Differentiation and Wolffian Duct Regression and Dampens the Vaginal Response to Diethylstilbestrol
Mol. Endocrinol., July 1, 2006; 20(7): 1535 - 1546.
[Abstract] [Full Text] [PDF]

J. A. Jadlowiec, X. Zhang, J. Li, P. G. Campbell, and C. Sfeir
Extracellular Matrix-mediated Signaling by Dentin Phosphophoryn Involves Activation of the Smad Pathway Independent of Bone Morphogenetic Protein
J. Biol. Chem., March 3, 2006; 281(9): 5341 - 5347.
[Abstract] [Full Text] [PDF]

P. Lu, G. Minowada, and G. R. Martin
Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function
Development, January 1, 2006; 133(1): 33 - 42.
[Abstract] [Full Text] [PDF]

W. M. Knosp, V. Scott, H. P. Bachinger, and H. S. Stadler
HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis
Development, September 15, 2004; 131(18): 4581 - 4592.
[Abstract] [Full Text] [PDF]

Y. Liu, A. W. Helms, and J. E. Johnson
Distinct activities of Msx1 and Msx3 in dorsal neural tube development
Development, March 1, 2004; 131(5): 1017 - 1028.
[Abstract] [Full Text] [PDF]

K. Suzuki, D. Bachiller, Y. P. Chen, M. Kamikawa, H. Ogi, R. Haraguchi, Y. Ogino, Y. Minami, Y. Mishina, K. Ahn, et al.
Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia: development by concerted actions of BMP signaling
Development, December 22, 2003; 130(25): 6209 - 6220.
[Abstract] [Full Text] [PDF]

Y. Ito, J. Y. Yeo, A. Chytil, J. Han, P. Bringas Jr, A. Nakajima, C. F. Shuler, H. L. Moses, and Y. Chai
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects
Development, November 1, 2003; 130(21): 5269 - 5280.
[Abstract] [Full Text] [PDF]

M. Han, X. Yang, J. E. Farrington, and K. Muneoka
Digit regeneration is regulated by Msx1 and BMP4 in fetal mice
Development, November 1, 2003; 130(21): 5123 - 5132.
[Abstract] [Full Text] [PDF]

M. Kiyono and M. Shibuya
Bone Morphogenetic Protein 4 Mediates Apoptosis of Capillary Endothelial Cells during Rat Pupillary Membrane Regression
Mol. Cell. Biol., July 1, 2003; 23(13): 4627 - 4636.
[Abstract] [Full Text] [PDF]

Y. Liu, C. Liu, Y. Yamada, and C.-M. Fan
growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb
Development, March 13, 2003; 129(22): 5289 - 5300.
[Abstract] [Full Text] [PDF]

Y. Chai, Y. Ito, and J. Han
TGF-{beta} SIGNALINGANDITS FUNCTIONAL SIGNIFICANCEIN REGULATINGTHE FATEOF CRANIAL NEURAL CREST CELLS
Crit. Rev. Oral. Biol. Med., March 1, 2003; 14(2): 78 - 88.
[Abstract] [Full Text]

H. Akiyama, M.-C. Chaboissier, J. F. Martin, A. Schedl, and B. de Crombrugghe
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
Genes & Dev., November 1, 2002; 16(21): 2813 - 2828.
[Abstract] [Full Text] [PDF]

D. P. Tan, K. Nonaka, G. H. Nuckolls, Y. H. Liu, R. E. Maxson, H. C. Slavkin, and L. Shum
YY1 activates Msx2 gene independent of bone morphogenetic protein signaling
Nucleic Acids Res., March 1, 2002; 30(5): 1213 - 1223.
[Abstract] [Full Text] [PDF]

S. Zhao, F.-C. Hung, J. S. Colvin, A. White, W. Dai, F. J. Lovicu, D. M. Ornitz, and P. A. Overbeek
Patterning the optic neuroepithelium by FGF signaling and Ras activation
Development, December 15, 2001; 128(24): 5051 - 5060.
[Abstract] [Full Text] [PDF]

R. Haraguchi, R. Mo, C.-c. Hui, J. Motoyama, S. Makino, T. Shiroishi, W. Gaffield, and G. Yamada
Unique functions of Sonic hedgehog signaling during external genitalia development
Development, November 1, 2001; 128(21): 4241 - 4250.
[Abstract] [Full Text] [PDF]

J. Teixeira, S. Maheswaran, and P. K. Donahoe
Mullerian Inhibiting Substance: An Instructive Developmental Hormone with Diagnostic and Possible Therapeutic Applications
Endocr. Rev., October 1, 2001; 22(5): 657 - 674.
[Abstract] [Full Text] [PDF]

E. Arteaga-Solis, B. Gayraud, S. Y. Lee, L. Shum, L. Sakai, and F. Ramirez
Regulation of limb patterning by extracellular microfibrils
J. Cell Biol., July 23, 2001; 154(2): 275 - 282.
[Abstract] [Full Text] [PDF]

J. A. Montero, Y. Ganan, D. Macias, J. Rodriguez-Leon, J. J. Sanz-Ezquerro, R. Merino, J. Chimal-Monroy, M. A. Nieto, and J. M. Hurle
Role of FGFs in the control of programmed cell death during limb development
Development, June 1, 2001; 128(11): 2075 - 2084.
[Abstract] [Full Text] [PDF]

F. Trousse, P. Esteve, and P. Bovolenta
BMP4 Mediates Apoptotic Cell Death in the Developing Chick Eye
J. Neurosci., February 15, 2001; 21(4): 1292 - 1301.
[Abstract] [Full Text] [PDF]

K. Nakamura, E. Bossy-Wetzel, K. Burns, M. P. Fadel, M. Lozyk, I. S. Goping, M. Opas, R. C. Bleackley, D. R. Green, and M. Michalak
Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis
J. Cell Biol., August 21, 2000; 150(4): 731 - 740.
[Abstract] [Full Text] [PDF]

R. D. Dahn and J. F. Fallon
Interdigital Regulation of Digit Identity and Homeotic Transformation by Modulated BMP Signaling
Science, July 21, 2000; 289(5478): 438 - 441.
[Abstract] [Full Text]

M. Iwamoto, Y. Higuchi, E. Koyama, M. Enomoto-Iwamoto, K. Kurisu, H. Yeh, W. R. Abrams, J. Rosenbloom, and M. Pacifici
Transcription Factor ERG Variants and Functional Diversification of Chondrocytes during Limb Long Bone Development
J. Cell Biol., July 11, 2000; 150(1): 27 - 40.
[Abstract] [Full Text] [PDF]

D. C. Goldman, G. R. Martin, and P. P. Tam
Fate and function of the ventral ectodermal ridge during mouse tail development
Development, May 15, 2000; 127(10): 2113 - 2123.
[Abstract] [PDF]

J. Massagué and Y.-G. Chen
Controlling TGF-beta signaling
Genes & Dev., March 15, 2000; 14(6): 627 - 644.
[Full Text]

C. Sirard, S. Kim, C. Mirtsos, P. Tadich, P. A. Hoodless, A. Itie, R. Maxson, J. L. Wrana, and T. W. Mak
Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor beta -related Signaling
J. Biol. Chem., January 21, 2000; 275(3): 2063 - 2070.
[Abstract] [Full Text] [PDF]

D. Ellies, V Church, P Francis-West, and A Lumsden
The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain
Development, January 12, 2000; 127(24): 5285 - 5295.
[Abstract] [PDF]

Y Zhang, Z Zhang, X Zhao, X Yu, Y Hu, B Geronimo, S. Fromm, and Y. Chen
A new function of BMP4: dual role for BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ
Development, January 4, 2000; 127(7): 1431 - 1443.
[Abstract] [PDF]

P. C. Mabie, M. F. Mehler, and J. A. Kessler
Multiple Roles of Bone Morphogenetic Protein Signaling in the Regulation of Cortical Cell Number and Phenotype
J. Neurosci., August 15, 1999; 19(16): 7077 - 7088.
[Abstract] [Full Text] [PDF]

R Merino, J Rodriguez-Leon, D Macias, Y Ganan, A. Economides, and J. Hurle
The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb
Development, January 12, 1999; 126(23): 5515 - 5522.
[Abstract] [PDF]

R Merino, D Macias, Y Ganan, J Rodriguez-Leon, A. Economides, C Rodriguez-Esteban, J. Izpisua-Belmonte, and J. Hurle
Control of digit formation by activin signalling
Development, January 5, 1999; 126(10): 2161 - 2170.
[Abstract] [PDF]

M. Solloway and E. Robertson
Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup
Development, January 4, 1999; 126(8): 1753 - 1768.
[Abstract] [PDF]

E Coucouvanis and G. Martin
BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo
Development, January 2, 1999; 126(3): 535 - 546.
[Abstract] [PDF]

S Pizette and L Niswander
BMPs negatively regulate structure and function of the limb apical ectodermal ridge
Development, January 2, 1999; 126(5): 883 - 894.
[Abstract] [PDF]

I Munoz-Sanjuan, B. Simandl, J. Fallon, and J Nathans
Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development
Development, January 1, 1999; 126(2): 409 - 421.
[Abstract] [PDF]

D. Szüts, S. Eresh, and M. Bienz
Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm�induction
Genes & Dev., July 1, 1998; 12(13): 2022 - 2035.
[Abstract] [Full Text]

S Noramly and B. Morgan
BMPs mediate lateral inhibition at successive stages in feather tract development
Development, January 10, 1998; 125(19): 3775 - 3787.
[Abstract] [PDF]

M Watanabe, A Choudhry, M Berlan, A Singal, E Siwik, S Mohr, and S. Fisher
Developmental remodeling and shortening of the cardiac outflow tract involves myocyte programmed cell death
Development, January 10, 1998; 125(19): 3809 - 3820.
[Abstract] [PDF]

Y Yang, P Guillot, Y Boyd, M. Lyon, and A. McMahon
Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling
Development, January 8, 1998; 125(16): 3123 - 3132.
[Abstract] [PDF]

D. Miller and R. Cagan
Local induction of patterning and programmed cell death in the developing Drosophila retina
Development, January 6, 1998; 125(12): 2327 - 2335.
[Abstract] [PDF]

K Takahashi, G. Nuckolls, O Tanaka, I Semba, I Takahashi, R Dashner, L Shum, and H. Slavkin
Adenovirus-mediated ectopic expression of Msx2 in even-numbered rhombomeres induces apoptotic elimination of cranial neural crest cells in ovo
Development, January 5, 1998; 125(9): 1627 - 1635.
[Abstract] [PDF]

S. Tang, P. Hoodless, Z Lu, M. Breitman, R. McInnes, J. Wrana, and M Buchwald
The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development
Development, January 5, 1998; 125(10): 1877 - 1887.
[Abstract] [PDF]

M Maden, A Graham, E Gale, C Rollinson, and M Zile
Positional apoptosis during vertebrate CNS development in the absence of endogenous retinoids
Development, January 7, 1997; 124(14): 2799 - 2805.
[Abstract] [PDF]

Y Furuta, D. Piston, and B. Hogan
Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
Development, January 6, 1997; 124(11): 2203 - 2212.
[Abstract] [PDF]

D. Fekete, S. Homburger, M. Waring, A. Riedl, and L. Garcia
Involvement of programmed cell death in morphogenesis of the vertebrate inner ear
Development, January 6, 1997; 124(12): 2451 - 2461.
[Abstract] [PDF]

D Macias, Y Ganan, T. Sampath, M. Piedra, M. Ros, and J. Hurle
Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development
Development, January 3, 1997; 124(6): 1109 - 1117.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Ganan, Y.

Articles by Hurle, J. M.

Search for Related Content

PubMed

PubMed Citation

Articles by Ganan, Y.

Articles by Hurle, J. M.

				S. Pajni-Underwood, C. P. Wilson, C. Elder, Y. Mishina, and M. Lewandoski BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling Development, June 15, 2007; 134(12): 2359 - 2368. [Abstract] [Full Text] [PDF]

				J. C. Bemis, N. F. Alejandro, D. A. Nazarenko, A. I. Brooks, R. B. Baggs, and T. A. Gasiewicz TCDD-Induced Alterations in Gene Expression Profiles of the Developing Mouse Paw Do Not Influence Morphological Differentiation of This Potential Target Tissue Toxicol. Sci., January 1, 2007; 95(1): 240 - 248. [Abstract] [Full Text] [PDF]

				S. D. Weatherbee, R. R. Behringer, J. J. Rasweiler IV, and L. A. Niswander Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification PNAS, October 10, 2006; 103(41): 15103 - 15107. [Abstract] [Full Text] [PDF]

				L. M. Hoffman, K. Garcha, K. Karamboulas, M. F. Cowan, L. M. Drysdale, W. A. Horton, and T. M. Underhill BMP action in skeletogenesis involves attenuation of retinoid signaling J. Cell Biol., July 3, 2006; 174(1): 101 - 113. [Abstract] [Full Text] [PDF]

				Y. Yin, C. Lin, and L. Ma Msx2 Promotes Vaginal Epithelial Differentiation and Wolffian Duct Regression and Dampens the Vaginal Response to Diethylstilbestrol Mol. Endocrinol., July 1, 2006; 20(7): 1535 - 1546. [Abstract] [Full Text] [PDF]

				J. A. Jadlowiec, X. Zhang, J. Li, P. G. Campbell, and C. Sfeir Extracellular Matrix-mediated Signaling by Dentin Phosphophoryn Involves Activation of the Smad Pathway Independent of Bone Morphogenetic Protein J. Biol. Chem., March 3, 2006; 281(9): 5341 - 5347. [Abstract] [Full Text] [PDF]

				P. Lu, G. Minowada, and G. R. Martin Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function Development, January 1, 2006; 133(1): 33 - 42. [Abstract] [Full Text] [PDF]

				W. M. Knosp, V. Scott, H. P. Bachinger, and H. S. Stadler HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis Development, September 15, 2004; 131(18): 4581 - 4592. [Abstract] [Full Text] [PDF]

				Y. Liu, A. W. Helms, and J. E. Johnson Distinct activities of Msx1 and Msx3 in dorsal neural tube development Development, March 1, 2004; 131(5): 1017 - 1028. [Abstract] [Full Text] [PDF]

				K. Suzuki, D. Bachiller, Y. P. Chen, M. Kamikawa, H. Ogi, R. Haraguchi, Y. Ogino, Y. Minami, Y. Mishina, K. Ahn, et al. Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia: development by concerted actions of BMP signaling Development, December 22, 2003; 130(25): 6209 - 6220. [Abstract] [Full Text] [PDF]

				Y. Ito, J. Y. Yeo, A. Chytil, J. Han, P. Bringas Jr, A. Nakajima, C. F. Shuler, H. L. Moses, and Y. Chai Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects Development, November 1, 2003; 130(21): 5269 - 5280. [Abstract] [Full Text] [PDF]

				M. Han, X. Yang, J. E. Farrington, and K. Muneoka Digit regeneration is regulated by Msx1 and BMP4 in fetal mice Development, November 1, 2003; 130(21): 5123 - 5132. [Abstract] [Full Text] [PDF]

				M. Kiyono and M. Shibuya Bone Morphogenetic Protein 4 Mediates Apoptosis of Capillary Endothelial Cells during Rat Pupillary Membrane Regression Mol. Cell. Biol., July 1, 2003; 23(13): 4627 - 4636. [Abstract] [Full Text] [PDF]

				Y. Liu, C. Liu, Y. Yamada, and C.-M. Fan growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb Development, March 13, 2003; 129(22): 5289 - 5300. [Abstract] [Full Text] [PDF]

				Y. Chai, Y. Ito, and J. Han TGF-{beta} SIGNALINGANDITS FUNCTIONAL SIGNIFICANCEIN REGULATINGTHE FATEOF CRANIAL NEURAL CREST CELLS Crit. Rev. Oral. Biol. Med., March 1, 2003; 14(2): 78 - 88. [Abstract] [Full Text]

				H. Akiyama, M.-C. Chaboissier, J. F. Martin, A. Schedl, and B. de Crombrugghe The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 Genes & Dev., November 1, 2002; 16(21): 2813 - 2828. [Abstract] [Full Text] [PDF]

				D. P. Tan, K. Nonaka, G. H. Nuckolls, Y. H. Liu, R. E. Maxson, H. C. Slavkin, and L. Shum YY1 activates Msx2 gene independent of bone morphogenetic protein signaling Nucleic Acids Res., March 1, 2002; 30(5): 1213 - 1223. [Abstract] [Full Text] [PDF]

				S. Zhao, F.-C. Hung, J. S. Colvin, A. White, W. Dai, F. J. Lovicu, D. M. Ornitz, and P. A. Overbeek Patterning the optic neuroepithelium by FGF signaling and Ras activation Development, December 15, 2001; 128(24): 5051 - 5060. [Abstract] [Full Text] [PDF]

				R. Haraguchi, R. Mo, C.-c. Hui, J. Motoyama, S. Makino, T. Shiroishi, W. Gaffield, and G. Yamada Unique functions of Sonic hedgehog signaling during external genitalia development Development, November 1, 2001; 128(21): 4241 - 4250. [Abstract] [Full Text] [PDF]

				J. Teixeira, S. Maheswaran, and P. K. Donahoe Mullerian Inhibiting Substance: An Instructive Developmental Hormone with Diagnostic and Possible Therapeutic Applications Endocr. Rev., October 1, 2001; 22(5): 657 - 674. [Abstract] [Full Text] [PDF]

				E. Arteaga-Solis, B. Gayraud, S. Y. Lee, L. Shum, L. Sakai, and F. Ramirez Regulation of limb patterning by extracellular microfibrils J. Cell Biol., July 23, 2001; 154(2): 275 - 282. [Abstract] [Full Text] [PDF]

				J. A. Montero, Y. Ganan, D. Macias, J. Rodriguez-Leon, J. J. Sanz-Ezquerro, R. Merino, J. Chimal-Monroy, M. A. Nieto, and J. M. Hurle Role of FGFs in the control of programmed cell death during limb development Development, June 1, 2001; 128(11): 2075 - 2084. [Abstract] [Full Text] [PDF]

				F. Trousse, P. Esteve, and P. Bovolenta BMP4 Mediates Apoptotic Cell Death in the Developing Chick Eye J. Neurosci., February 15, 2001; 21(4): 1292 - 1301. [Abstract] [Full Text] [PDF]

				K. Nakamura, E. Bossy-Wetzel, K. Burns, M. P. Fadel, M. Lozyk, I. S. Goping, M. Opas, R. C. Bleackley, D. R. Green, and M. Michalak Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis J. Cell Biol., August 21, 2000; 150(4): 731 - 740. [Abstract] [Full Text] [PDF]

				R. D. Dahn and J. F. Fallon Interdigital Regulation of Digit Identity and Homeotic Transformation by Modulated BMP Signaling Science, July 21, 2000; 289(5478): 438 - 441. [Abstract] [Full Text]

				M. Iwamoto, Y. Higuchi, E. Koyama, M. Enomoto-Iwamoto, K. Kurisu, H. Yeh, W. R. Abrams, J. Rosenbloom, and M. Pacifici Transcription Factor ERG Variants and Functional Diversification of Chondrocytes during Limb Long Bone Development J. Cell Biol., July 11, 2000; 150(1): 27 - 40. [Abstract] [Full Text] [PDF]

				D. C. Goldman, G. R. Martin, and P. P. Tam Fate and function of the ventral ectodermal ridge during mouse tail development Development, May 15, 2000; 127(10): 2113 - 2123. [Abstract] [PDF]

				J. Massagué and Y.-G. Chen Controlling TGF-beta signaling Genes & Dev., March 15, 2000; 14(6): 627 - 644. [Full Text]

				C. Sirard, S. Kim, C. Mirtsos, P. Tadich, P. A. Hoodless, A. Itie, R. Maxson, J. L. Wrana, and T. W. Mak Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor beta -related Signaling J. Biol. Chem., January 21, 2000; 275(3): 2063 - 2070. [Abstract] [Full Text] [PDF]

				D. Ellies, V Church, P Francis-West, and A Lumsden The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain Development, January 12, 2000; 127(24): 5285 - 5295. [Abstract] [PDF]