A male-specific role for SOX9 in vertebrate sex determination

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C. A. Smith, M. Katz, and A. H. Sinclair
DMRT1 Is Upregulated in the Gonads During Female-to-Male Sex Reversal in ZW Chicken Embryos
Biol Reprod, February 1, 2003; 68(2): 560 - 570.
[Abstract] [Full Text] [PDF]

S. P. Scherrer, D. A. Rice, and L. L. Heckert
Expression of Steroidogenic Factor 1 in the Testis Requires an Interactive Array of Elements Within Its Proximal Promoter
Biol Reprod, November 1, 2002; 67(5): 1509 - 1521.
[Abstract] [Full Text] [PDF]

K. L. BRITT, J. KERR, L. O'DONNELL, M. E. E. JONES, A. E. DRUMMOND, S. R. DAVIS, E. R. SIMPSON, and J. K. FINDLAY
Estrogen regulates development of the somatic cell phenotype in the eutherian ovary
FASEB J, September 1, 2002; 16(11): 1389 - 1397.
[Abstract] [Full Text] [PDF]

R. Zhou, N. Bonneaud, C.-X. Yuan, P. de Santa Barbara, B. Boizet, S. Tibor, G. Scherer, R. G. Roeder, F. Poulat, and P. Berta
SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex
Nucleic Acids Res., July 15, 2002; 30(14): 3245 - 3252.
[Abstract] [Full Text] [PDF]

C. Hoyle, V. Narvaez, G. Alldus, R. Lovell-Badge, and A. Swain
Dax1 Expression Is Dependent on Steroidogenic Factor 1 in the Developing Gonad
Mol. Endocrinol., April 1, 2002; 16(4): 747 - 756.
[Abstract] [Full Text] [PDF]

J. H.-C. Shen and H. A. Ingraham
Regulation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Sox Proteins
Mol. Endocrinol., March 1, 2002; 16(3): 529 - 540.
[Abstract] [Full Text] [PDF]

N. Lei and L. L. Heckert
Sp1 and Egr1 Regulate Transcription of the Dmrt1 Gene in Sertoli Cells
Biol Reprod, March 1, 2002; 66(3): 675 - 684.
[Abstract] [Full Text] [PDF]

S. G. Tevosian, K. H. Albrecht, J. D. Crispino, Y. Fujiwara, E. M. Eicher, and S. H. Orkin
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2
Development, January 10, 2002; 129(19): 4627 - 4634.
[Abstract] [Full Text] [PDF]

C. Tilmann and B. Capel
Cellular and Molecular Pathways Regulating Mammalian Sex Determination
Recent Prog. Horm. Res., January 1, 2002; 57(1): 1 - 18.
[Abstract] [Full Text] [PDF]

E. Sock, K. Schmidt, I. Hermanns-Borgmeyer, M. R. Bosl, and M. Wegner
Idiopathic Weight Reduction in Mice Deficient in the High-Mobility-Group Transcription Factor Sox8
Mol. Cell. Biol., October 15, 2001; 21(20): 6951 - 6959.
[Abstract] [Full Text] [PDF]

S. Liu, R. Guo, and L. D. Quarles
Cloning and Characterization of the Proximal Murine Phex Promoter
Endocrinology, September 1, 2001; 142(9): 3987 - 3995.
[Abstract] [Full Text] [PDF]

J. k. Chen and L. L. Heckert
Dmrt1 Expression Is Regulated by Follicle-Stimulating Hormone and Phorbol Esters in Postnatal Sertoli Cells
Endocrinology, March 1, 2001; 142(3): 1167 - 1178.
[Abstract] [Full Text] [PDF]

E. M. Perera, H. Martin, T. Seeherunvong, L. Kos, I. A. Hughes, J. R. Hawkins, and G. D. Berkovitz
Tescalcin, a Novel Gene Encoding a Putative EF-Hand Ca2+-Binding Protein, Col9a3, and Renin Are Expressed in the Mouse Testis during the Early Stages of Gonadal Diffe

				K. Piper Hanley, F. Oakley, S. Sugden, D. I. Wilson, D. A. Mann, and N. A. Hanley Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis J. Biol. Chem., May 16, 2008; 283(20): 14063 - 14071. [Abstract] [Full Text] [PDF]

				H. Chang, F. Gao, F. Guillou, M. M. Taketo, V. Huff, and R. R. Behringer Wt1 negatively regulates {beta}-catenin signaling during testis development Development, May 15, 2008; 135(10): 1875 - 1885. [Abstract] [Full Text] [PDF]

				Y. Ishimaru, T. Komatsu, M. Kasahara, Y. Katoh-Fukui, H. Ogawa, Y. Toyama, M. Maekawa, K. Toshimori, R. A. S. Chandraratna, K.-i. Morohashi, et al. Mechanism of asymmetric ovarian development in chick embryos Development, February 15, 2008; 135(4): 677 - 685. [Abstract] [Full Text] [PDF]

				S. Ijiri, H. Kaneko, T. Kobayashi, D.-S. Wang, F. Sakai, B. Paul-Prasanth, M. Nakamura, and Y. Nagahama Sexual Dimorphic Expression of Genes in Gonads During Early Differentiation of a Teleost Fish, the Nile Tilapia Oreochromis niloticus Biol Reprod, February 1, 2008; 78(2): 333 - 341. [Abstract] [Full Text] [PDF]

				Y. Kim, N. Bingham, R. Sekido, K. L. Parker, R. Lovell-Badge, and B. Capel Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination PNAS, October 16, 2007; 104(42): 16558 - 16563. [Abstract] [Full Text] [PDF]

				P. Val, J.-P. Martinez-Barbera, and A. Swain Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage Development, June 15, 2007; 134(12): 2349 - 2358. [Abstract] [Full Text] [PDF]

				E. Sumi, N. Iehara, H. Akiyama, T. Matsubara, A. Mima, H. Kanamori, A. Fukatsu, D. J. Salant, T. Kita, H. Arai, et al. SRY-Related HMG Box 9 Regulates the Expression of Col4a2 through Transactivating Its Enhancer Element in Mesangial Cells Am. J. Pathol., June 1, 2007; 170(6): 1854 - 1864. [Abstract] [Full Text] [PDF]

				T. Svingen, A. Beverdam, P. Bernard, P. McClive, V. R Harley, A. H Sinclair, and P. Koopman Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation Reproduction, May 1, 2007; 133(5): 983 - 989. [Abstract] [Full Text] [PDF]

				D. Wilhelm, R. Hiramatsu, H. Mizusaki, L. Widjaja, A. N. Combes, Y. Kanai, and P. Koopman SOX9 Regulates Prostaglandin D Synthase Gene Transcription in Vivo to Ensure Testis Development J. Biol. Chem., April 6, 2007; 282(14): 10553 - 10560. [Abstract] [Full Text] [PDF]

				F. Gao, S. Maiti, N. Alam, Z. Zhang, J. M. Deng, R. R. Behringer, C. Lecureuil, F. Guillou, and V. Huff The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis PNAS, August 8, 2006; 103(32): 11987 - 11992. [Abstract] [Full Text] [PDF]

				S. Rajender, V. Rajani, N. J. Gupta, B. Chakravarty, L. Singh, and K. Thangaraj SRY-negative 46,XX male with normal genitals, complete masculinization and infertility Mol. Hum. Reprod., May 1, 2006; 12(5): 341 - 346. [Abstract] [Full Text] [PDF]

				A. Beverdam and P. Koopman Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes Hum. Mol. Genet., February 1, 2006; 15(3): 417 - 431. [Abstract] [Full Text] [PDF]

				F. Barrionuevo, S. Bagheri-Fam, J. Klattig, R. Kist, M. M. Taketo, C. Englert, and G. Scherer Homozygous Inactivation of Sox9 Causes Complete XY Sex Reversal in Mice Biol Reprod, January 1, 2006; 74(1): 195 - 201. [Abstract] [Full Text] [PDF]

				X. Huang, Y. Guo, Y. Shui, S. Gao, H. Yu, H. Cheng, and R. Zhou Multiple Alternative Splicing and Differential Expression of dmrt1 During Gonad Transformation of the Rice Field Eel Biol Reprod, November 1, 2005; 73(5): 1017 - 1024. [Abstract] [Full Text] [PDF]

				A. Jeanes, D. Wilhelm, M. J Wilson, J. Bowles, P. J McClive, A. H Sinclair, and P. Koopman Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis Reproduction, October 1, 2005; 130(4): 509 - 516. [Abstract] [Full Text] [PDF]

				Y. Kanai, R. Hiramatsu, S. Matoba, and T. Kidokoro From SRY to SOX9: Mammalian Testis Differentiation J. Biochem., July 1, 2005; 138(1): 13 - 19. [Abstract] [Full Text] [PDF]

				C. J. Guigon, N. Coudouel, S. Mazaud-Guittot, M. G. Forest, and S. Magre Follicular Cells Acquire Sertoli Cell Characteristics after Oocyte Loss Endocrinology, July 1, 2005; 146(7): 2992 - 3004. [Abstract] [Full Text] [PDF]

				S. Matoba, Y. Kanai, T. Kidokoro, M. Kanai-Azuma, H. Kawakami, Y. Hayashi, and M. Kurohmaru A novel Sry-downstream cellular event which preserves the readily available energy source of glycogen in mouse sex differentiation J. Cell Sci., April 1, 2005; 118(7): 1449 - 1459. [Abstract] [Full Text] [PDF]

				A. K. Hett, C. Pitra, I. Jenneckens, and A. Ludwig Characterization of Sox9 in European Atlantic Sturgeon (Acipenser sturio) J. Hered., March 1, 2005; 96(2): 150 - 154. [Abstract] [Full Text] [PDF]

				M. J. Wilson, P. Jeyasuria, K. L. Parker, and P. Koopman The Transcription Factors Steroidogenic Factor-1 and SOX9 Regulate Expression of Vanin-1 during Mouse Testis Development J. Biol. Chem., February 18, 2005; 280(7): 5917 - 5923. [Abstract] [Full Text] [PDF]

				C. Poirier, Y. Qin, C. P. Adams, Y. Anaya, J. B. Singer, A. E. Hill, E. S. Lander, J. H. Nadeau, and C. E. Bishop A Complex Interaction of Imprinted and Maternal-Effect Genes Modifies Sex Determination in Odd Sex (Ods) Mice Genetics, November 1, 2004; 168(3): 1557 - 1562. [Abstract] [Full Text] [PDF]

				J. Schmahl, Y. Kim, J. S. Colvin, D. M. Ornitz, and B. Capel Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination Development, August 1, 2004; 131(15): 3627 - 3636. [Abstract] [Full Text] [PDF]

				P. Blache, M. van de Wetering, I. Duluc, C. Domon, P. Berta, J.-N. Freund, H. Clevers, and P. Jay SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes J. Cell Biol., July 5, 2004; 166(1): 37 - 47. [Abstract] [Full Text] [PDF]

				J. E. Shima, D. J. McLean, J. R. McCarrey, and M. D. Griswold The Murine Testicular Transcriptome: Characterizing Gene Expression in the Testis During the Progression of Spermatogenesis Biol Reprod, July 1, 2004; 71(1): 319 - 330. [Abstract] [Full Text] [PDF]

				Y. Qin, L.-k. Kong, C. Poirier, C. Truong, P. A. Overbeek, and C. E. Bishop Long-range activation of Sox9 in Odd Sex (Ods) mice Hum. Mol. Genet., June 15, 2004; 13(12): 1213 - 1218. [Abstract] [Full Text] [PDF]

				M.-C. Chaboissier, A. Kobayashi, V. I. P. Vidal, S. Lutzkendorf, H. J. G. van de Kant, M. Wegner, D. G. de Rooij, R. R. Behringer, and A. Schedl Functional analysis of Sox8 and Sox9 during sex determination in the mouse Development, May 1, 2004; 131(9): 1891 - 1901. [Abstract] [Full Text] [PDF]

				H. Akiyama, M.-C. Chaboissier, R. R. Behringer, D. H. Rowitch, A. Schedl, J. A. Epstein, and B. de Crombrugghe Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa PNAS, April 27, 2004; 101(17): 6502 - 6507. [Abstract] [Full Text] [PDF]

				R Pop, C Conz, K S Lindenberg, S Blesson, B Schmalenberger, S Briault, D Pfeifer, and G Scherer Screening of the 1 Mb SOX9 5' control region by array CGH identifies a large deletion in a case of campomelic dysplasia with XY sex reversal J. Med. Genet., April 1, 2004; 41(4): e47 - e47. [Full Text] [PDF]

				N. Moreno-Mendoza, L. Torres-Maldonado, J. Chimal-Monroy, V. Harley, and H. Merchant-Larios Disturbed Expression of Sox9 in Pre-Sertoli Cells Underlies Sex-Reversal in Mice B6.Ytir Biol Reprod, January 1, 2004; 70(1): 114 - 122. [Abstract] [Full Text] [PDF]

				P. G. Buxton, B. Hall, C. W. Archer, and P. Francis-West Secondary chondrocyte-derived Ihh stimulates proliferation of periosteal cells during chick development Development, October 1, 2003; 130(19): 4729 - 4739. [Abstract] [Full Text] [PDF]