The NIMA-related kinase 2, Nek2, is expressed in specific stages of the meiotic cell cycle and associates with meiotic chromosomes

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Rhee, K.
	Articles by Wolgemuth, D. J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Rhee, K.
	Articles by Wolgemuth, D. J.

Allshire, R. C., Gosden, J. R., Cross, S. H., Cranston, G., Rout, D., Sugawara, N., Szostak, J. W., Fantes, P. A. and Hastie, N. D (1988). Telomeric repreat from T. thermophila cross hybridizes with human telomeres. Nature 332, 656-659.[Medline]

Bellve, A. R., Cavicchia, J. C., Millette, C. F., O'Brien, D. A., Bhatnager, Y.M. and Dym, M (1977). Spermatogenic cells of the prepubertal mouse: Isolation and morphological characterization. J. Cell Biol 74, 68-85.[Abstract/Free Full Text]

Chapman, D. L. and Wolgemuth, D. J (1994). Regulation of M-phase promoting factor activity during development of mouse male germ cells. Dev. Biol 165, 500-506.[Medline]

Chomczynski, P. and Sacchi, N (1987). Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 162, 156-159.[Medline]

de Vantery, C., Gavin, A. C., Vassalli, J. D. and Schorderet-Slatkine, S (1996). An accumulation of p34cdc2at the end of mouse oocyte growth correlates with the acquisition of meiotic competence. Dev. Biol 174, 335-344.[Medline]

Devereux, J., Haeberli, P. and Smithies, O (1984). A comprehensive set of sequence analysis programs for the VAX. Nucl. Acids Res 12, 387-395.

Fry, A. M. and Nigg, E. A (1995). The NIMA kinase joins forces with Cdc2. Curr. Biol 5, 1122-1125.[Medline]

Fry, A. M., Schultz, S. J., Bartek, J. and Nigg, E. A (1995). Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans. J. Biol. Chem 270, 12899-12905.[Abstract/Free Full Text]

Gallant, P., Fry, A. M., and Nigg, E. A (1995). Protein kinases in the control of mitosis: focus on nucleocytoplasmic trafficking. J. Cell Sci. Supp 19, 21-28.[Abstract]

Gasser, S. M (1995). Coiling up chromosomes. Curr. Biol 5, 357-360.[Medline]

Gavin, A. C., Vassalli, J. D., Cavadore, J. C. and Schorderet-Slatkine, S (1992). Okadaic acid and p13suc1modulate the reinitiation of meiosis in mouse oocytes. Mol. Reprod. Dev 33, 287-296.[Medline]

Guo, X. W., Th'ng, J. P. H., Swank, R. A., Anderson, H. J., Tudan, C., Bradbury, E. M. and Roberge, M (1995). Chromosome condensation induced by fostriecin does not require p34 cdc2 kinase activity and histone H1 phosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation. EMBO J 14, 976-985.[Medline]

Handel, M. A. and Hunt, P. A (1992). Sex-chromosome pairing and activity during mammalian meiosis. BioEssays 14, 817-822.[Medline]

Hanks, S. K. and Hunter, T (1995). The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 9, 576-596.[Abstract]

Hirano, T. and Mitchison, T. M (1994). A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro. Cell 79, 449-458.[Medline]

Kimura, K., Nozaki, N., Saijo, M., Kikuchi, A., Ui, M. and Enomoto, T (1994). Identification of the nature of modification that causes the shift of DNA topoisomerase IIto apparent higher molecular weight forms in the M phase. J. Biol. Chem 269, 24523-24526.[Abstract/Free Full Text]

Laemmli, U. K (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 335, 251-254.

Letwin K., Mizzen, L., Motro, B., Ben-David, Y., Bernstein, A. and Pawson, T (1992). A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J 11, 3521-3531.[Medline]

Levedakou, E. N., He, M., Baptist, E. W., Craven, R. J., Cance, W. G., Welcsh, P. L., Simmons, A., Naylor, S. L., Leach, R. J., Lewis, T. B., Bowcock, A. and Liu, E. T (1994). Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Oncogene 9, 1977-1988.[Medline]

Lu, K. P., Hanes, S. D. and Hunter, T (1996). A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380, 544-547.[Medline]

Lu, K. P., Kemp, B. E. and Means, A. R (1994). Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase. J. Biol. Chem 269, 6603-6607.[Abstract/Free Full Text]

Lu, K. P. and Means, A. R (1994). Expression of the catalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans. EMBO J 13, 2103-2113.[Medline]

Lu, K. P. and Hunter, T (1995). Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell 81, 413-424.[Medline]

Lu, K. P. and Means, A. R (1994). Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans. EMBO J 13, 2103-2113.

Lu, K. P., Osmani, S. A. and Means, A. R (1993). Properties and regulation ofthe cell cycle-specific NIMA protein kinase of Aspergillus nidulans. J. Biol. Chem 268, 8769-8776.[Abstract/Free Full Text]

Meredith, R (1969). A simple method for preparing meiotic chromosomes from mammalian testes. Chromosoma 26, 254-258.[Medline]

Mintz, B. and Russell, E. S (1957). Gene-induced embryological modifications of primordial germ cell in the mouse. J. Exp. Zool 134, 207-230.[Medline]

Moens, P. B (1990). Unravelling meiotic chromosomes: topoisomerase II and other proteins. J. Cell Sci 97, 1-3.[Free Full Text]

Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M., Deaven,, L. L., Jones, M. D., Meyne, J., Ratliff, R. L. and Wu, J.-R (1988). A highly conserved repetitive DNA sequence, (TTAGGG) n , present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA 85, 6622-6626.[Abstract/Free Full Text]

Oakberg, E. F (1956). A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal. Am. J. Anat 99, 391-409.[Medline]

O'Connell, M. J., Norbury, C. and Nurse, P (1994). Premature chromatic condensation upon accumulation of NIMA. EMBO J 13, 4926-4937.[Medline]

Osmani, A. H., McGuire, S. L. and Osmani, S. A (1991). Parallel activation of the NIMA and p34cdc2cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans. Cell 67, 283-291.[Medline]

Osmani, S. A., Pu, R. T. and Morris, N. R (1988). Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase. Cell 53, 237-244.[Medline]

Pu, R. T. and Osmani, S. A (1995). Mitotic destruction of the cell cycle regulated NIMA protein kinase of Aspergillus nidulans is required for mitotic exit. EMBO J 14, 995-1003.[Medline]

Ravnik, S. E. and Wolgemuth, D. J (1996). The developmentally restricted pattern of expression in the male germ line of a murine cyclin A , cyclin A2 , suggests roles in both mitotic and meiotic cell cycles. Dev. Biol 173, 69-78.[Medline]

Rechsteiner, M. and Rogers, S. W (1996). PEST sequences and regulation by proteolysis. Trends Biochem. Sci 21, 267-271.[Medline]

Rhee, K. and Wolgemuth, D. J (1995). Cdk family genes are expressed not only in dividing but also terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiation. Dev. Dynam 204, 406-420.[Medline]

Rose, D., Thomas, W. and Holm, C (1990). Segregation of recombined chromosomes in meiosis I requires DNA topoisomerase II. Cell 60, 1009-1017.[Medline]

Scherthan, H., Weich, S., Schwegler, H., Heyting, C., Harle, M. and Cremer, T (1996). Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. J. Cell Biol 134, 1109-1125.[Abstract/Free Full Text]

Schultz, S. J., Fry, A. M., Sutterlin, C., Ried, T. and Nigg, E. A (1994). Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. Cell Growth Diff 5, 625-635.[Abstract]

Schultz, S. J. and Nigg, E. A (1993). Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. Cell Growth Diff 4, 821-830.[Abstract]

Shi, S.-R., Key, M. E. and Karla, K. L (1991). Antigen retrieval in formalin-fixed paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J. Histochem. Cytochem 39, 741-748.[Abstract]

Sweeney, C., Murphy, M., Kubelka, M., Ravnik, S. E., Hawkins, C. F., Wolgemuth, D. J. and Carrington, M (1996). A different mammalian cyclin A, murine cyclin A1, is expressed exclusively in germ cells and during early embryogenesis. Development 122, 53-64.[Abstract]

Tsai, L.-H., Delalle, I., Caviness, V. S., Chae, T. and Harlow, E (1994). p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371, 419-423.[Medline]

Wiltshire, T., Park, C., Caldwell, K. A. and Handel, M. A (1995). Induced premature G2/M-phase transition in pachytene spermatocytes includes events unique to meiosis. Dev. Biol 169, 557-567.[Medline]

Wolgemuth, D. J., Gizang-Ginsberg, E., Engelmyer, E., Gavin, B. J. and Ponzetto, C (1985). Separation of mouse testis cells on a Celsep apparatus and their usefulness as a source of high molecular weight DNA or RNA. Gamete Res 12, 1-10.[Medline]

Wolgemuth, D. J., Rhee, K., Wu, S. and Ravnik, S. E (1995). Genetic control of mitosis, meiosis and cellular differentiation during mammalian spermatogenesis. Reprod. Fertil. Dev 7, 669-683.[Medline]

Ye, X. S., Xu, G., Pu, R. T., Fincher, R. R., McGuire, S. L., Osmani, A. H. and Osmani, S. A (1995). The NIMA protein kinase is hyperphosphorylated and activated downstream of p34 cdc2 /cyclin B: coordination of two mitosis promoting kinases. EMBO J 14, 986-994.[Medline]

This article has been cited by other articles:

T. Almog, S. Lazar, N. Reiss, N. Etkovitz, E. Milch, N. Rahamim, M. Dobkin-Bekman, R. Rotem, M. Kalina, J. Ramon, et al.
Identification of Extracellular Signal-regulated Kinase 1/2 and p38 MAPK as Regulators of Human Sperm Motility and Acrosome Reaction and as Predictors of Poor Spermatozoan Quality
J. Biol. Chem., May 23, 2008; 283(21): 14479 - 14489.
[Abstract] [Full Text] [PDF]

W. Wu, J. E. Baxter, S. L. Wattam, D. G. Hayward, M. Fardilha, A. Knebel, E. M. Ford, E. F. da Cruz e Silva, and A. M. Fry
Alternative Splicing Controls Nuclear Translocation of the Cell Cycle-regulated Nek2 Kinase
J. Biol. Chem., September 7, 2007; 282(36): 26431 - 26440.
[Abstract] [Full Text] [PDF]

Y. Jeong, J. Lee, K. Kim, J. C. Yoo, and K. Rhee
Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization
J. Cell Sci., June 15, 2007; 120(12): 2106 - 2116.
[Abstract] [Full Text] [PDF]

L. C. Pradel, M. Bonhivers, N. Landrein, and D. R. Robinson
NIMA-related kinase TbNRKC is involved in basal body separation in Trypanosoma brucei
J. Cell Sci., May 1, 2006; 119(9): 1852 - 1863.
[Abstract] [Full Text] [PDF]

S. Sonn, I. Khang, K. Kim, and K. Rhee
Suppression of Nek2A in mouse early embryos confirms its requirement for chromosome segregation
J. Cell Sci., November 1, 2004; 117(23): 5557 - 5566.
[Abstract] [Full Text] [PDF]

S. Di Agostino, F. Botti, A. Di Carlo, C. Sette, and R. Geremia
Meiotic progression of isolated mouse spermatocytes under simulated microgravity
Reproduction, July 1, 2004; 128(1): 25 - 32.
[Abstract] [Full Text] [PDF]

J. Lee, J. Hong, E. Kim, K. Kim, S. W. Kim, H. Krishnamurthy, S. S.W. Chung, D. J. Wolgemuth, and K. Rhee
Developmental stage-specific expression of Rbm suggests its involvement in early phases of spermatogenesis
Mol. Hum. Reprod., April 1, 2004; 10(4): 259 - 264.
[Abstract] [Full Text] [PDF]

S. Di Agostino, M. Fedele, P. Chieffi, A. Fusco, P. Rossi, R. Geremia, and C. Sette
Phosphorylation of High-Mobility Group Protein A2 by Nek2 Kinase during the First Meiotic Division in Mouse Spermatocytes
Mol. Biol. Cell, March 1, 2004; 15(3): 1224 - 1232.
[Abstract] [Full Text] [PDF]

A. H. Osmani, J. Davies, C. E. Oakley, B. R. Oakley, and S. A. Osmani
TINA Interacts with the NIMA Kinase in Aspergillus nidulans and Negatively Regulates Astral Microtubules during Metaphase Arrest
Mol. Biol. Cell, August 1, 2003; 14(8): 3169 - 3179.
[Abstract] [Full Text] [PDF]

K. I. Swenson, K. E. Winkler, and A. R. Means
A New Identity for MLK3 as an NIMA-related, Cell Cycle-regulated Kinase That Is Localized near Centrosomes and Influences Microtubule Organization
Mol. Biol. Cell, January 1, 2003; 14(1): 156 - 172.
[Abstract] [Full Text]

M. R. Mahjoub, B. Montpetit, L. Zhao, R. J. Finst, B. Goh, A. C. Kim, and L. M. Quarmby
The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation
J. Cell Sci., April 15, 2002; 115(8): 1759 - 1768.
[Abstract] [Full Text] [PDF]

E. Shang, K. Lai, A. I. Packer, J. Paik, W. S. Blaner, M. de Morais Vieira, P. Gouras, and D. J. Wolgemuth
Targeted disruption of the mouse cis-retinol dehydrogenase gene: visual and nonvisual functions
J. Lipid Res., April 1, 2002; 43(4): 590 - 597.
[Abstract] [Full Text] [PDF]

R. Graf
DdNek2, the first non-vertebrate homologue of human Nek2, is involved in the formation of microtubule-organizing centers
J. Cell Sci., January 5, 2002; 115(9): 1919 - 1929.
[Abstract] [Full Text] [PDF]

S. Di Agostino, P. Rossi, R. Geremia, and C. Sette
The MAPK pathway triggers activation of Nek2 during chromosome condensation in mouse spermatocytes
Development, January 4, 2002; 129(7): 1715 - 1727.
[Abstract] [Full Text] [PDF]

D. Escalier
Genetic approach to male meiotic division deficiency: the human macronuclear spermatozoa
Mol. Hum. Reprod., January 1, 2002; 8(1): 1 - 7.
[Abstract] [Full Text] [PDF]

D. J. Wolgemuth, E. Laurion, and K. M. Lele
Regulation of the Mitotic and Meiotic Cell Cycles in the Male Germ Line
Recent Prog. Horm. Res., January 1, 2002; 57(1): 75 - 101.
[Abstract] [Full Text] [PDF]

A. Fry, P Descombes, C Twomey, R Bacchieri, and E. Nigg
The NIMA-related kinase X-Nek2B is required for efficient assembly of the zygotic centrosome in Xenopus laevis
J. Cell Sci., January 6, 2000; 113(11): 1973 - 1984.
[Abstract] [PDF]

M. V. Gamble, E. Shang, R. P. Zott, J. R. Mertz, D. J. Wolgemuth, and W. S. Blaner
Biochemical properties, tissue expression, and gene structure of a short chain dehydrogenase/ reductase able to catalyze cis-retinol oxidation
J. Lipid Res., December 1, 1999; 40(12): 2279 - 2292.
[Abstract] [Full Text] [PDF]

C. Sette, M. Barchi, A. Bianchini, M. Conti, P. Rossi, and R. Geremia
Activation of the Mitogen-activated Protein Kinase ERK1 during Meiotic Progression of Mouse Pachytene Spermatocytes
J. Biol. Chem., November 19, 1999; 274(47): 33571 - 33579.
[Abstract] [Full Text] [PDF]

A. M. Fry, L. Arnaud, and E. A. Nigg
Activity of the Human Centrosomal Kinase, Nek2, Depends on an Unusual Leucine Zipper Dimerization Motif
J. Biol. Chem., June 4, 1999; 274(23): 16304 - 16310.
[Abstract] [Full Text] [PDF]

K. Tanaka and E. A. Nigg
Cloning and Characterization of the Murine Nek3 Protein Kinase, a Novel Member of the NIMA Family of Putative Cell Cycle Regulators
J. Biol. Chem., May 7, 1999; 274(19): 13491 - 13497.
[Abstract] [Full Text] [PDF]

L. Ever, R. Steiner, S. Shalom, and J. Don
Two Alternatively Spliced Meig1 Messenger RNA Species Are Differentially Expressed in the Somatic and in the Germ-Cell Compartments of the Testis
Cell Growth Differ., January 1, 1999; 10(1): 19 - 26.
[Abstract] [Full Text]

A. M. Fry, T. Mayor, P. Meraldi, Y.-D. Stierhof, K. Tanaka, and E. A. Nigg
C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle-regulated Protein Kinase Nek2
J. Cell Biol., June 29, 1998; 141(7): 1563 - 1574.
[Abstract] [Full Text] [PDF]

K Rhee, M Brunori, V Besset, R Trousdale, and D. Wolgemuth
Expression and potential role of Fsrg1, a murine bromodomain-containing homologue of the Drosophila gene female sterile homeotic
J. Cell Sci., January 12, 1998; 111(23): 3541 - 3550.
[Abstract] [PDF]

L. Scrittori, F. Hans, D. Angelov, M. Charra, C. Prigent, and S. Dimitrov
pEg2 Aurora-A Kinase, Histone H3 Phosphorylation, and Chromosome Assembly in Xenopus Egg Extract
J. Biol. Chem., August 3, 2001; 276(32): 30002 - 30010.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Rhee, K.

Articles by Wolgemuth, D. J.

Search for Related Content

PubMed

PubMed Citation

Articles by Rhee, K.

Articles by Wolgemuth, D. J.

				W. Wu, J. E. Baxter, S. L. Wattam, D. G. Hayward, M. Fardilha, A. Knebel, E. M. Ford, E. F. da Cruz e Silva, and A. M. Fry Alternative Splicing Controls Nuclear Translocation of the Cell Cycle-regulated Nek2 Kinase J. Biol. Chem., September 7, 2007; 282(36): 26431 - 26440. [Abstract] [Full Text] [PDF]

				Y. Jeong, J. Lee, K. Kim, J. C. Yoo, and K. Rhee Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization J. Cell Sci., June 15, 2007; 120(12): 2106 - 2116. [Abstract] [Full Text] [PDF]

				L. C. Pradel, M. Bonhivers, N. Landrein, and D. R. Robinson NIMA-related kinase TbNRKC is involved in basal body separation in Trypanosoma brucei J. Cell Sci., May 1, 2006; 119(9): 1852 - 1863. [Abstract] [Full Text] [PDF]

				S. Sonn, I. Khang, K. Kim, and K. Rhee Suppression of Nek2A in mouse early embryos confirms its requirement for chromosome segregation J. Cell Sci., November 1, 2004; 117(23): 5557 - 5566. [Abstract] [Full Text] [PDF]

				S. Di Agostino, F. Botti, A. Di Carlo, C. Sette, and R. Geremia Meiotic progression of isolated mouse spermatocytes under simulated microgravity Reproduction, July 1, 2004; 128(1): 25 - 32. [Abstract] [Full Text] [PDF]

				J. Lee, J. Hong, E. Kim, K. Kim, S. W. Kim, H. Krishnamurthy, S. S.W. Chung, D. J. Wolgemuth, and K. Rhee Developmental stage-specific expression of Rbm suggests its involvement in early phases of spermatogenesis Mol. Hum. Reprod., April 1, 2004; 10(4): 259 - 264. [Abstract] [Full Text] [PDF]

				S. Di Agostino, M. Fedele, P. Chieffi, A. Fusco, P. Rossi, R. Geremia, and C. Sette Phosphorylation of High-Mobility Group Protein A2 by Nek2 Kinase during the First Meiotic Division in Mouse Spermatocytes Mol. Biol. Cell, March 1, 2004; 15(3): 1224 - 1232. [Abstract] [Full Text] [PDF]

				A. H. Osmani, J. Davies, C. E. Oakley, B. R. Oakley, and S. A. Osmani TINA Interacts with the NIMA Kinase in Aspergillus nidulans and Negatively Regulates Astral Microtubules during Metaphase Arrest Mol. Biol. Cell, August 1, 2003; 14(8): 3169 - 3179. [Abstract] [Full Text] [PDF]

				K. I. Swenson, K. E. Winkler, and A. R. Means A New Identity for MLK3 as an NIMA-related, Cell Cycle-regulated Kinase That Is Localized near Centrosomes and Influences Microtubule Organization Mol. Biol. Cell, January 1, 2003; 14(1): 156 - 172. [Abstract] [Full Text]

				M. R. Mahjoub, B. Montpetit, L. Zhao, R. J. Finst, B. Goh, A. C. Kim, and L. M. Quarmby The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation J. Cell Sci., April 15, 2002; 115(8): 1759 - 1768. [Abstract] [Full Text] [PDF]

				E. Shang, K. Lai, A. I. Packer, J. Paik, W. S. Blaner, M. de Morais Vieira, P. Gouras, and D. J. Wolgemuth Targeted disruption of the mouse cis-retinol dehydrogenase gene: visual and nonvisual functions J. Lipid Res., April 1, 2002; 43(4): 590 - 597. [Abstract] [Full Text] [PDF]

				R. Graf DdNek2, the first non-vertebrate homologue of human Nek2, is involved in the formation of microtubule-organizing centers J. Cell Sci., January 5, 2002; 115(9): 1919 - 1929. [Abstract] [Full Text] [PDF]

				S. Di Agostino, P. Rossi, R. Geremia, and C. Sette The MAPK pathway triggers activation of Nek2 during chromosome condensation in mouse spermatocytes Development, January 4, 2002; 129(7): 1715 - 1727. [Abstract] [Full Text] [PDF]

				D. Escalier Genetic approach to male meiotic division deficiency: the human macronuclear spermatozoa Mol. Hum. Reprod., January 1, 2002; 8(1): 1 - 7. [Abstract] [Full Text] [PDF]

				D. J. Wolgemuth, E. Laurion, and K. M. Lele Regulation of the Mitotic and Meiotic Cell Cycles in the Male Germ Line Recent Prog. Horm. Res., January 1, 2002; 57(1): 75 - 101. [Abstract] [Full Text] [PDF]

				A. Fry, P Descombes, C Twomey, R Bacchieri, and E. Nigg The NIMA-related kinase X-Nek2B is required for efficient assembly of the zygotic centrosome in Xenopus laevis J. Cell Sci., January 6, 2000; 113(11): 1973 - 1984. [Abstract] [PDF]

				M. V. Gamble, E. Shang, R. P. Zott, J. R. Mertz, D. J. Wolgemuth, and W. S. Blaner Biochemical properties, tissue expression, and gene structure of a short chain dehydrogenase/ reductase able to catalyze cis-retinol oxidation J. Lipid Res., December 1, 1999; 40(12): 2279 - 2292. [Abstract] [Full Text] [PDF]

				C. Sette, M. Barchi, A. Bianchini, M. Conti, P. Rossi, and R. Geremia Activation of the Mitogen-activated Protein Kinase ERK1 during Meiotic Progression of Mouse Pachytene Spermatocytes J. Biol. Chem., November 19, 1999; 274(47): 33571 - 33579. [Abstract] [Full Text] [PDF]

				A. M. Fry, L. Arnaud, and E. A. Nigg Activity of the Human Centrosomal Kinase, Nek2, Depends on an Unusual Leucine Zipper Dimerization Motif J. Biol. Chem., June 4, 1999; 274(23): 16304 - 16310. [Abstract] [Full Text] [PDF]

				K. Tanaka and E. A. Nigg Cloning and Characterization of the Murine Nek3 Protein Kinase, a Novel Member of the NIMA Family of Putative Cell Cycle Regulators J. Biol. Chem., May 7, 1999; 274(19): 13491 - 13497. [Abstract] [Full Text] [PDF]

				L. Ever, R. Steiner, S. Shalom, and J. Don Two Alternatively Spliced Meig1 Messenger RNA Species Are Differentially Expressed in the Somatic and in the Germ-Cell Compartments of the Testis Cell Growth Differ., January 1, 1999; 10(1): 19 - 26. [Abstract] [Full Text]

				A. M. Fry, T. Mayor, P. Meraldi, Y.-D. Stierhof, K. Tanaka, and E. A. Nigg C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle-regulated Protein Kinase Nek2 J. Cell Biol., June 29, 1998; 141(7): 1563 - 1574. [Abstract] [Full Text] [PDF]

				K Rhee, M Brunori, V Besset, R Trousdale, and D. Wolgemuth Expression and potential role of Fsrg1, a murine bromodomain-containing homologue of the Drosophila gene female sterile homeotic J. Cell Sci., January 12, 1998; 111(23): 3541 - 3550. [Abstract] [PDF]

				L. Scrittori, F. Hans, D. Angelov, M. Charra, C. Prigent, and S. Dimitrov pEg2 Aurora-A Kinase, Histone H3 Phosphorylation, and Chromosome Assembly in Xenopus Egg Extract J. Biol. Chem., August 3, 2001; 276(32): 30002 - 30010. [Abstract] [Full Text] [PDF]