Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor

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Arber, S., Halder, G. and Caroni, P (1994). Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Cell 79, 221-231.[Medline]

Bell, J. R., Noveen, A., Liu, Y. H., Ma, L., Dobias, S., Kundu, R., Luo, W., Xia, Y., Lusis, A. J., Snead, M. L. et al (1993). Genomic structure, chromosomal location, and evolution of the mouse Hox 8 gene. Genomics 17, 800-.[Medline]

Bielinska, M. and Wilson, D. B (1995). Induction of yolk sac endoderm on the surface of GATA-4 deficient embryoid bodies by retinoic acid and dbcAMP. Mol. Biol. Cell 6, 325-.

Blobel, G. A. and Orkin, S. H (1996). Estrogen-induced apopotosis by inhibition of the erythroid transcription factor GATA-1. Mol. Cell. Biol 16, 1687-1694.[Abstract]

Blum, M., Gaunt, S. J., Cho, K. W., Steinbeisser, H., Blumberg, B., Bittner, D. and De Robertis, E. M (1992). Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69, 1097-1106.[Medline]

Chan-Thomas, P. S., Thompson, R. P., Robert, B., Yacoub, M. H. and Barton, P. J (1993). Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in the chick. Dev. Dynamics 197, 203-216.[Medline]

Chen, C. Y. and Schwartz, R. J (1995). Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2. 5. J. Biol. Chem 270, 15628-15633.[Abstract/Free Full Text]

Chen, Z., Friedrich, G. A. and Soriano, P (1994). Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev 8, 2293-2301.[Abstract/Free Full Text]

Chomczynski, P. and Sacchi, N (1987). Single-step method of RNA isolation by acid guanidium thyocyanate-phenol-chloroform-extraction. Anal. Biochem 162, 156-159.[Medline]

Cserjesi, P., Lilly, B., Bryson, L., Wang, Y., Sassoon, D. A. and Olson, E. N (1992). MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer. Development 115, 1087-1101.[Abstract]

Cserjesi, P., Brown, D., Lyons, G. E. and Olson, E. N (1995). Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev. Biol 170, 664-678.[Medline]

Dawid, I. B (1994). Intercellular signaling and gene regulation during early embryogenesis of Xenopus laevis. J. Biol. Chem 269, 6259-6262.[Free Full Text]

Durocher, D., Chen, C. Y., Ardati, A., Schwartz, R. J. and Nemer, M (1996). The ANF promoter is a downstream target for Nkx-2. 5 in the myocardium. Mol. Biol. Cell 16, 4648-4655.

Edmondson, D. G., Lyons, G. E., Martin, J. F. and Olson, E. N (1994). Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120, 1251-1263.[Abstract]

Edwards, M. K., Harris, J. F. and McBurney, M. W (1983). Induced muscle differentiation in an embryonal carcinoma cell line. Mol. Cell. Biol 3, 2280-2286.[Abstract/Free Full Text]

Frasch, M (1995). Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo. Nature 374, 464-467.[Medline]

Grepin, C., Dagnino, L., Robitaille, L., Haberstroh, L., Antakly, T. and Nemer, M (1994). A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription. Mol. Cell. Biol 14, 3115-3129.[Abstract/Free Full Text]

Grepin, C., Robitaille, L., Antakly, T. and Nemer, M (1995). Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation. Mol. Cell. Biol 15, 4095-4102.[Abstract]

Gudas, L. J (1994). Retinoids and vertebrate development. [Review]. J. Biol. Chem 269, 15399-15402.[Abstract/Free Full Text]

Heikinheimo, M., Scandrett, J. M. and Wilson, D. B (1994). Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev. Biol 164, 361-373.[Medline]

Hicks, D. C., Lee, J. A., Kilgore, B. S., Burnett, C. R., Schedewie, H. K., Hughes, E. R. and Elders, M. J (1982). Glucocorticoid effects on the embryonic chick heart. I. Glucocorticoid enlargement of the heart. Ann. Clin. Lab. Sci 12, 477-483.[Abstract]

Hill, R. E., Jones, P. F., Rees, A. R., Sime, C. M., Justice, M. J., Copeland, N. G., Jenkins, N. A., Graham, E. and Davidson, D. R (1989). A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7. 1. Genes Dev 3, 26-37.[Abstract/Free Full Text]

Hodgkinson, C. A., Moore, K. J., Nakayama, A., Steingrimsson, E., Copeland, N. G., Jenkins, N. A. and Arnheiter, H (1993). Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74, 395-404.[Medline]

Ip, H. S., Wilson, D. B., Heikinheimo, M., Tang, Z., Ting, C. N., Simon, M. C., Leiden, J. M. and Parmacek, M. S (1994). The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells. Mol. Cell. Biol 14, 7517-7526.[Abstract/Free Full Text]

James, T. N (1994). Normal and abnormal consequences of apoptosis in the human heart. From postnatal morphogenesis to paroxysmal arrhythmias. Circulation 90, 556-573.[Abstract/Free Full Text]

Jiang, Y. M. and Evans, T (1996). The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev. Biol 174, 258-270.[Medline]

Jones-Villeneuve, E. M., McBurney, M. W., Rogers, K. A. and Kalnins, V. I (1982). Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells. J. Cell Biol 94, 253-262.[Abstract/Free Full Text]

Kelley, C., Blumberg, H., Zon, L. I. and Evans, T (1993). GATA-4 is a novel transcription factor expressed in endocardium of the developing heart. Development 118, 817-827.[Abstract]

Kispert, A., Koschorz, B. and Herrmann, B. G (1995). The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO J 14, 4763-4772.[Medline]

Klein, P. S. and Melton, D. A (1994). Hormonal regulation of embryogenesis: the formation of mesoderm in Xenopus laevis. Endocr. Rev 15, 326-341.[Medline]

Komuro, I. and Izumo, S (1993). Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc. Natl. Acad. Sci. USA 90, 8145-8149.[Abstract/Free Full Text]

Kuzuoka, M., Takahashi, T., Guron, C. and Raghow, R (1994). Murine homeobox-containing gene, Msx-1: analysis of genomic organization, promoter structure, and potential autoregulatory cis-acting elements. Genomics 21, 85-91.[Medline]

Leroy-Viard, K., Vinit, M. A., Lecointe, N., Jouault, H., Hibner, U., Romeo, P. H. and Mathieu-Mahul, D (1995). Loss of TAL-1 protein activity induces premature apoptosis of Jurkat leukemic T cells upon medium depletion. EMBO J 14, 2341-2349.[Medline]

Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I. and Harvey, R. P (1993). Nkx-2. 5 : a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419-431.[Abstract]

Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L. and Harvey, R. P (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 9, 1654-1666.[Abstract/Free Full Text]

Martin, J. F., Schwarz, J. J. and Olson, E. N (1993). Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc. Natl. Acad. Sci. USA 90, 5282-5286.[Abstract/Free Full Text]

Martin, J. F., Bradley, A. and Olson, E. N (1995). The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev 9, 1237-1249.[Abstract/Free Full Text]

McBurney, M. W., Jones-Villeneuve, E. M., Edwards, M. K. and Anderson,P. J (1982). Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line. Nature 299, 165-167.[Medline]

Molkentin, J. D., Kalvakolanu, D. V. and Markham, B. E (1994). Transcription factor GATA-4 regulates cardiac muscle-specific expression of the a-myosin heavy-chain gene. Mol. Cell. Biol 14, 4947-4957.[Abstract/Free Full Text]

Muthusamy, N., Barton, K. and Leiden, J. M (1995). Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature 377, 639-642.[Medline]

Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S. F., D'Agati, V., Orkin, S. H. and Costantini, F (1991). Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349, 257-260.[Medline]

Pollock, R. and Treisman, R (1991). Human SRF-related proteins: DNA-binding properties and potential regulatory targets. Genes Dev 5, 2327-2341.[Abstract/Free Full Text]

Ranganayakulu, G., Zhao, B., Dokidis, A., Molkentin, J. D., Olson, E. N. and Schulz, R. A (1995). A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila. Dev. Biol 171, 169-181.[Medline]

Robert, B., Sassoon, D., Jacq, B., Gehring, W. and Buckingham, M (1989). Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J 8, 91-100.[Medline]

Skerjanc, I. S., Slack, R. S. and McBurney, M. W (1994). Cellular aggregation enhances MyoD-directed skeletal myogenesis in embryonal carcinoma cells. Mol. Cell. Biol 14, 8451-8459.[Abstract/Free Full Text]

Soudais, C., Wilson, D. B., Simon, M. C., Ip, H. S., Parmacek, M. S. and Leiden, J. M (1994). Targeted disruption of the GATA-4 gene in embryonic stem cells abolishes cardiac myocyte development in differentiating embryoid bodies. Circulation 90, 78-.[Abstract/Free Full Text]

Soudais, C., Bielinska, M., Heikinheimo, M., MacArthur, C. A., Narita, N., Saffitz, J. E., Simon, M. C., Leiden, J. M. and Wilson, D. B (1995). Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development 121, 3877-3888.[Abstract]

Srivastava, D., Cserjesi, P. and Olson, E. N (1995). A subclass of bHLH proteins required for cardiac morphogenesis. Science 270, 1995-1999.[Abstract/Free Full Text]

Sugi, Y. and Lough, J (1995). Activin-A and FGF-2 mimic the inductive effects of anterior endoderm on terminal cardiac myogenesis in vitro. Dev. Biol 168, 567-574.[Medline]

Tonissen, K. F., Drysdale, T. A., Lints, T. J., Harvey, R. P. and Krieg, P. A (1994). XNkx-2. 5, a Xenopus gene related to Nkx-2. 5 and tinman: evidence for a conserved role in cardiac development. Dev. Biol 162, 325-328.[Medline]

Vasseur, M., Duprey, P., Brulet, P. and Jacob, F (1985). One gene and one pseudogene for the cytokeratin endo A. Proc. Natl. Acad. Sci. USA 82, 1155-1159.[Abstract/Free Full Text]

Weiss, M. J. and Orkin, S. H (1995). Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc. Natl. Acad. Sci. USA 92, 9623-9627.[Abstract/Free Full Text]

White, E (1996). Life, death, and the pursuit of apoptossis. Genes Dev 10, 1-15.[Free Full Text]

Wu, X., Golden, K. and Bodmer, R (1995). Heart development in Drosophila requires the segment polarity gene wingless. Dev. Biol 169, 619-628.[Medline]

Wu, Z., Xie, Y., Bucher, N. L. and Farmer, S. R (1995). Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev 9, 2350-2363.[Abstract/Free Full Text]

Yu, Y. T., Breitbart, R. E., Smoot, L. B., Lee, Y., Mahdavi, V. and Nadal-Ginard, B (1992). Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev 6, 1783-1798.[Abstract/Free Full Text]

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Mol. Cell. Biol., October 1, 1999; 19(10): 7096 - 7105.
[Abstract] [Full Text] [PDF]

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Cooperative Interaction between GATA-4 and GATA-6 Regulates Myocardial Gene Expression
Mol. Cell. Biol., June 1, 1999; 19(6): 4355 - 4365.
[Abstract] [Full Text] [PDF]

T. Mano, Z. Luo, S. L. Malendowicz, T. Evans, and K. Walsh
Reversal of GATA-6 Downregulation Promotes Smooth Muscle Differentiation and Inhibits Intimal Hyperplasia in Balloon-Injured Rat Carotid Artery
Circ. Res., April 2, 1999; 84(6): 647 - 654.
[Abstract] [Full Text] [PDF]

M Koutsourakis, A Langeveld, R Patient, R Beddington, and F Grosveld
The transcription factor GATA6 is essential for early extraembryonic development
Development, January 2, 1999; 126(4): 723 - 732.
[Abstract] [PDF]

C. Lien, C Wu, B Mercer, R Webb, J. Richardson, and E. Olson
Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer
Development, January 1, 1999; 126(1): 75 - 84.
[Abstract] [PDF]

I. S. Skerjanc, H. Petropoulos, A. G. Ridgeway, and S. Wilton
Myocyte Enhancer Factor 2C and Nkx2-5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells
J. Biol. Chem., December 25, 1998; 273(52): 34904 - 34910.
[Abstract] [Full Text] [PDF]

R. Di Lisi, C. Millino, E. Calabria, F. Altruda, S. Schiaffino, and S. Ausoni
Combinatorial cis-Acting Elements Control Tissue-specific Activation of the Cardiac Troponin I Gene in Vitro and in Vivo
J. Biol. Chem., September 25, 1998; 273(39): 25371 - 25380.
[Abstract] [Full Text] [PDF]

				A. S. Philips, J. C. Kwok, and B. H. Chong Analysis of the Signals and Mechanisms Mediating Nuclear Trafficking of GATA-4: LOSS OF DNA BINDING IS ASSOCIATED WITH LOCALIZATION IN INTRANUCLEAR SPECKLES J. Biol. Chem., August 24, 2007; 282(34): 24915 - 24927. [Abstract] [Full Text] [PDF]

				J. Bian, Z. B. Popovic, C. Benejam, M. Kiedrowski, L. L. Rodriguez, and M. S. Penn Effect of Cell-Based Intercellular Delivery of Transcription Factor GATA4 on Ischemic Cardiomyopathy Circ. Res., June 8, 2007; 100(11): 1626 - 1633. [Abstract] [Full Text] [PDF]

				A. Sharma, J. Masri, O. D. Jo, A. Bernath, J. Martin, A. Funk, and J. Gera Protein Kinase C Regulates Internal Initiation of Translation of the GATA-4 mRNA following Vasopressin-induced Hypertrophy of Cardiac Myocytes J. Biol. Chem., March 30, 2007; 282(13): 9505 - 9516. [Abstract] [Full Text] [PDF]

				H. Niwa How is pluripotency determined and maintained? Development, February 15, 2007; 134(4): 635 - 646. [Abstract] [Full Text] [PDF]

				C. Karamboulas, A. Swedani, C. Ward, A. S. Al-Madhoun, S. Wilton, S. Boisvenue, A. G. Ridgeway, and I. S. Skerjanc HDAC activity regulates entry of mesoderm cells into the cardiac muscle lineage J. Cell Sci., October 15, 2006; 119(20): 4305 - 4314. [Abstract] [Full Text] [PDF]

				C. Karamboulas, G. D. Dakubo, J. Liu, Y. De Repentigny, K. Yutzey, V. A. Wallace, R. Kothary, and I. S. Skerjanc Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis J. Cell Sci., October 15, 2006; 119(20): 4315 - 4321. [Abstract] [Full Text] [PDF]

				E. Bisping, S. Ikeda, S. W. Kong, O. Tarnavski, N. Bodyak, J. R. McMullen, S. Rajagopal, J. K. Son, Q. Ma, Z. Springer, et al. Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure PNAS, September 26, 2006; 103(39): 14471 - 14476. [Abstract] [Full Text] [PDF]

				M. Schmelter, B. Ateghang, S. Helmig, M. Wartenberg, and H. Sauer Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation FASEB J, June 1, 2006; 20(8): 1182 - 1184. [Abstract] [Full Text] [PDF]

				B. Ding, C.-j. Liu, Y. Huang, R. P. Hickey, J. Yu, W. Kong, and P. Lengyel p204 Is Required for the Differentiation of P19 Murine Embryonal Carcinoma Cells to Beating Cardiac Myocytes: ITS EXPRESSION IS ACTIVATED BY THE CARDIAC GATA4, NKX2.5, AND TBX5 PROTEINS J. Biol. Chem., May 26, 2006; 281(21): 14882 - 14892. [Abstract] [Full Text] [PDF]

				J. Wang, P. Paradis, A. Aries, H. Komati, C. Lefebvre, H. Wang, and M. Nemer Convergence of Protein Kinase C and JAK-STAT Signaling on Transcription Factor GATA-4 Mol. Cell. Biol., November 15, 2005; 25(22): 9829 - 9844. [Abstract] [Full Text] [PDF]

				A. C. Houweling, M. M. van Borren, A. F.M. Moorman, and V. M. Christoffels Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease Cardiovasc Res, September 1, 2005; 67(4): 583 - 593. [Abstract] [Full Text] [PDF]

				A. Rojas, S. De Val, A. B. Heidt, S.-M. Xu, J. Bristow, and B. L. Black Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element Development, August 1, 2005; 132(15): 3405 - 3417. [Abstract] [Full Text] [PDF]

				P. J. Gianakopoulos and I. S. Skerjanc Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells J. Biol. Chem., June 3, 2005; 280(22): 21022 - 21028. [Abstract] [Full Text] [PDF]

				T. Kawamura, K. Ono, T. Morimoto, H. Wada, M. Hirai, K. Hidaka, T. Morisaki, T. Heike, T. Nakahata, T. Kita, et al. Acetylation of GATA-4 Is Involved in the Differentiation of Embryonic Stem Cells into Cardiac Myocytes J. Biol. Chem., May 20, 2005; 280(20): 19682 - 19688. [Abstract] [Full Text] [PDF]

				B. Chandrasekar, S. Mummidi, W. C. Claycomb, R. Mestril, and M. Nemer Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt-GATA4 Signaling Pathway in Cardiomyocytes J. Biol. Chem., February 11, 2005; 280(6): 4553 - 4567. [Abstract] [Full Text] [PDF]

				A. J. Watt, M. A. Battle, J. Li, and S. A. Duncan GATA4 is essential for formation of the proepicardium and regulates cardiogenesis PNAS, August 24, 2004; 101(34): 12573 - 12578. [Abstract] [Full Text] [PDF]

				E. Dodou, M. P. Verzi, J. P. Anderson, S.-M. Xu, and B. L. Black Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development Development, August 15, 2004; 131(16): 3931 - 3942. [Abstract] [Full Text] [PDF]

				S. Pikkarainen, H. Tokola, R. Kerkela, and H. Ruskoaho GATA transcription factors in the developing and adult heart Cardiovasc Res, August 1, 2004; 63(2): 196 - 207. [Abstract] [Full Text] [PDF]

				U. Lakshmipathy, B. Pelacho, K. Sudo, J. L. Linehan, E. Coucouvanis, D. S. Kaufman, and C. M. Verfaillie Efficient Transfection of Embryonic and Adult Stem Cells Stem Cells, July 1, 2004; 22(4): 531 - 543. [Abstract] [Full Text] [PDF]

				A. Aries, P. Paradis, C. Lefebvre, R. J. Schwartz, and M. Nemer Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity PNAS, May 4, 2004; 101(18): 6975 - 6980. [Abstract] [Full Text] [PDF]

				H. A. LaVoie The Role of GATA in Mammalian Reproduction Experimental Biology and Medicine, December 1, 2003; 228(11): 1282 - 1290. [Abstract] [Full Text] [PDF]

				B. V. Latinkic, S. Kotecha, and T. J. Mohun Induction of cardiomyocytes by GATA4 in Xenopus ectodermal explants Development, August 15, 2003; 130(16): 3865 - 3876. [Abstract] [Full Text] [PDF]

				M. A.G. van der Heyden and L. H.K. Defize Twenty one years of P19 cells: what an embryonal carcinoma cell line taught us about cardiomyocyte differentiation Cardiovasc Res, May 1, 2003; 58(2): 292 - 302. [Abstract] [Full Text] [PDF]

				S. G. Nir, R. David, M. Zaruba, W.-M. Franz, and J. Itskovitz-Eldor Human embryonic stem cells for cardiovascular repair Cardiovasc Res, May 1, 2003; 58(2): 313 - 323. [Abstract] [Full Text] [PDF]

				M. J. Goldenthal and J. Marin-Garcia Stem cells and cardiac disorders: an appraisal Cardiovasc Res, May 1, 2003; 58(2): 369 - 377. [Abstract] [Full Text] [PDF]

				H. Oh, S. C. Wang, A. Prahash, M. Sano, C. S. Moravec, G. E. Taffet, L. H. Michael, K. A. Youker, M. L. Entman, and M. D. Schneider Telomere attrition and Chk2 activation in human heart failure PNAS, April 29, 2003; 100(9): 5378 - 5383. [Abstract] [Full Text] [PDF]

				C. Gillio-Meina, Y. Y. Hui, and H. A. LaVoie GATA-4 and GATA-6 Transcription Factors: Expression, Immunohistochemical Localization, and Possible Function in the Porcine Ovary Biol Reprod, February 1, 2003; 68(2): 412 - 422. [Abstract] [Full Text] [PDF]

				G. Nemer and M. Nemer Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells Development, September 1, 2002; 129(17): 4045 - 4055. [Abstract] [Full Text] [PDF]

				K. R. Boheler, J. Czyz, D. Tweedie, H.-T. Yang, S. V. Anisimov, and A. M. Wobus Differentiation of Pluripotent Embryonic Stem Cells Into Cardiomyocytes Circ. Res., August 9, 2002; 91(3): 189 - 201. [Abstract] [Full Text] [PDF]

				J. Paquin, B. A. Danalache, M. Jankowski, S. M. McCann, and J. Gutkowska Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes PNAS, July 9, 2002; 99(14): 9550 - 9555. [Abstract] [Full Text] [PDF]