Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Ciruna, B. G.
	Articles by Rossant, J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Ciruna, B. G.
	Articles by Rossant, J.

Amaya, E., Musci, T. J. and Kirschner, M. W (1991). Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell 66, 257-70.[Medline]

Amaya, E., Stein, P. A., Musci, T. J. and Kirschner, M. W (1993). FGF signalling in the early specification of mesoderm in Xenopus. Development 118, 477-87.[Abstract]

Beddington, R. S., Puschel, A. W. and Rashbass, P (1992). Use of chimeras to study gene function in mesodermal tissues during gastrulation and early organogenesis. Ciba Found. Symp 165, 61-74.[Medline]

Beddington, R. S (1994). Induction of a second neural axis by the mouse node. Development 120, 613-20.[Abstract]

Beiman, M., Shilo, B. Z. and Volk, T (1996). Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. Genes Dev 10, 2993-3002.[Abstract/Free Full Text]

Boyer, B., Dufour, S. and Thiery, J. P (1992). E-cadherin expression during the acidic FGF-induced dispersion of a rat bladder carcinoma cell line. Exp. Cell Res 201, 347-57.[Medline]

Burdsal, C. A., Damsky, C. H. and Pedersen, R. A (1993). The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak. Development 118, 829-44.[Abstract]

Candia, A. F., Hu, J., Crosby, J., Lalley, P. A., Noden, D., Nadeau, J. H. and Wright, C. V (1992). Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development 116, 1123-36.[Abstract]

Cogliatti, S. B (1986). Diplomyelia: caudal duplication of the neural tube in mice. Teratology 34, 343-52.[Medline]

Collignon, J., Sockanathan, S., Hacker, A., Cohen-Tannoudji, M., Norris, D., Rastan, S., Stevanovic, M., Goodfellow, P. N. and Lovell-Badge, R (1996). A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122, 509-520.[Abstract]

Conlon, R. A. and Rossant, J (1992). Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. Development 116, 357-68.[Medline]

Cox, W. G. and Hemmati-Brivanlou, A (1995). Caudalization of neural fate by tissue recombination and bFGF. Development 121, 4349-4358.[Abstract]

Damjanov, I., Damjanov, A. and Damsky, C. H (1986). Developmentally regulated expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in peri-implantation mouse embryos and extraembryonic membranes. Dev. Biol 116, 194-202.[Medline]

Deng, C. X., Wynshaw-Boris, A., Shen, M. M., Daugherty, C., Ornitz, D. M. and Leder, P (1994). Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev 8, 3045-3057.[Abstract/Free Full Text]

DeVore, D. L., Horvitz, H. R. and Stern, M. J (1995). An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. Cell 83, 611-620.[Medline]

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-30.[Medline]

Feldman, B., Poueymirou, W., Papaioannou, V. E., DeChiara, T. M. and Goldfarb, M (1995). Requirement of FGF-4 for postimplantation mouse development. Science 267, 246-249.[Abstract/Free Full Text]

Friedrich, G. and Soriano, P (1991). Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5, 1513-23.[Abstract/Free Full Text]

Furuta, Y., Ilic, D., Kanazawa, S., Takeda, N., Yamamoto, T. and Aizawa, S (1995). Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene 11, 1989-1995.[Medline]

George, E. L., Georges-Labouesse, E. N., Patel-King, R. S., Rayburn, H. and Hynes, R. O (1993). Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119, 1079-91.[Abstract]

Gisselbrecht, S., Skeath, J. B., Doe, C. Q. and Michelson, A. M (1996). heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. Genes Dev 10, 3003-3017.[Abstract/Free Full Text]

Givol, D. and Yayon, A (1992). Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. Faseb J 6, 3362-9.[Abstract]

Goulding, M. D., Chalepakis, G., Deutsch, U., Erselius, J. R. and Gruss, P (1991). Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J 10, 1135-47.[Medline]

Greco, T. L., Takada, S., Newhouse, M. M., McMahon, J. A., McMahon, A. P. and Camper, S. A (1996). Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev 10, 313-324.[Abstract/Free Full Text]

Green, P. J., Walsh, F. S. and Doherty, P (1996). Promiscuity of fibroblast growth factor receptors. BioEssays 18, 639-646.[Medline]

Gruneberg, H. and Wickramaratne, G. A (1974). A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch). J. Embryol. Exp. Morphol 31, 207-22.[Medline]

Haub, O. and Goldfarb, M (1991). Expression of the fibroblast growth factor-5 gene in the mouse embryo. Development 112, 397-406.[Abstract]

Hebert, J. M., Boyle, M. and Martin, G. R (1991). mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation. Development 112, 407-15.[Abstract]

Hebert, J. M., Rosenquist, T., Gotz, J. and Martin, G. R (1994). FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 78, 1017-1025.[Medline]

Hemmati-Brivanlou, A. and Melton, D. A (1997). Vertebrate embryonic cells will become nerve cells unless told otherwise. Cell 88, 13-17.[Medline]

Herrmann, B. G (1991). Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryos. Development 113, 913-917.[Abstract]

Isaacs, H. V., Pownall, M. E. and Slack, J. M. W (1994). eFGF regulates Xbra expression during Xenopus gastrulation. EMBOJ 13, 4469-4481.[Medline]

Kimelman, D. and Kirschner, M (1987). Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo. Cell 51, 869-77.[Medline]

Kroll, K. L. and Amaya, E (1996). Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation. Development 122, 3173-3183.[Abstract]

Lamb, T. M. and Harland, R. M (1995). Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern. Development 121, 3627-3636.[Abstract]

Lawson, K. A., Meneses, J. J. and Pedersen, R. A (1991). Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113, 891-911.[Abstract]

Mansour, S. L., Goddard, J. M. and Capecchi, M. R (1993). Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development 117, 13-28.[Abstract]

McWhir, J., Schnieke, A. E., Ansell, R., Wallace, H., Colman, A., Scott, A. R. and Kind, A. J (1996). Selective ablation of differentiated cells permits isolation of embryonic stem cell lines from murine embryos with a non-permissive genetic background. Nat. Genet 14, 223-226.[Medline]

Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. and Roder, J. C (1993). Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90, 8424-2428.[Abstract/Free Full Text]

Nicolas, J. F., Mathis, L., Bonnerot, C. and Saurin, W (1996). Evidence in the mouse for self-renewing stem cells in the formation of a segmented longitudinal structure, the myotome. Development 122, 2933-2946.[Abstract]

Niswander, L. and Martin, G. R (1992). Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114, 755-768.[Abstract]

Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G. and Goldfarb, M (1996). Receptor specificity of the fibroblast growth factor family. J. Biol. Chem 271, 15292-15297.[Abstract/Free Full Text]

Orr-Urtreger, A., Givol, D., Yayon, A., Yarden, Y. and Lonai, P (1991). Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development 113, 1419-1434.[Abstract]

Parameswaran, M. and Tam, P. P (1995). Regionalisation of cell fate and morphogenetic movement of the mesoderm during mouse gastrulation. Dev. Genet 17, 16-28.[Medline]

Paterno, G. D., Gillespie, L. L., Dixon, M. S., Slack, J. M. and Heath, J. K (1989). Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF. Development 106, 79-83.[Abstract]

Pownall, M. E., Tucker, A. S., Slack, J. M. and Isaacs, H. V (1996). eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus. Development 122, 3881-3892.[Abstract]

Reichman-Fried, M., Dickson, B., Hafen, E. and Shilo, B. Z (1994). Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration. Genes Dev 8, 428-439.[Abstract/Free Full Text]

Slack, J. M., Darlington, B. G., Gillespie, L. L., Godsave, S. F., Isaacs, H. V. and Paterno, G. D (1989). The role of fibroblast growth factor in early Xenopus development. Development 107, 141-148.

Smith, D. E., Franco del Amo, F. and Gridley, T (1992). Isolation of Sna , a mouse gene homologous to the Drosophila genes snail and escargot : its expression pattern suggests multiple roles during postimplantation development. Development 116, 1033-1039.[Abstract]

Takada, S., Stark, K. L., Shea, M. J., Vassileva, G., McMahon, J. A. and McMahon, A. P (1994). Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev 8, 174-189.[Abstract/Free Full Text]

Tam, P. P. and Beddington, R. S (1987). The formation of mesodermal tissues in the mouse embryo during gastrulation and early organogenesis. Development 99, 109-126.[Abstract]

Tam, P. P (1989). Regionalisation of the mouse embryonic ectoderm: allocation of prospective ectodermal tissues during gastrulation. Development 107, 55-67.[Abstract]

Theiler, K. and Varnum, D. S (1985). Development of rib-vertebrae: a new mutation in the house mouse with accessory caudal duplications. Anat. Embryol 173, 111-6.[Medline]

Walther, C. and Gruss, P (1991). Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113, 1435-49.[Abstract]

Wilkinson, D. G., Peters, G., Dickson, C. and McMahon, A. P (1988). Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. EMBO J 7, 691-5.[Medline]

Wilson, V., Rashbass, P. and Beddington, R. S (1993). Chimeric analysis of T (Brachyury) gene function. Development 117, 1321-31.[Abstract]

Wilson, V., Manson, L., Skarnes, W. C. and Beddington, R. S (1995). The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation. Development 121, 877-886.[Abstract]

Wolf, C., Thisse, C., Stoetzel, C., Thisse, B., Gerlinger, P. and Perrin-Schmitt, F (1991). The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes. Dev. Biol 143, 363-73.[Medline]

Yamaguchi, T. P., Conlon, R. A. and Rossant, J (1992). Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo. Dev. Biol 152, 75-88.[Medline]

Yamaguchi, T. P., Harpal, K., Henkemeyer, M. and Rossant, J (1994). fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev 8, 3032-3044.[Abstract/Free Full Text]

Yoshikawa, Y., Fujimori, T., McMahon, A. P. and Takada, S (1997). Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev. Biol 183, 234-242.[Medline]

This article has been cited by other articles:

J. Gaulden and J. F. Reiter
Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells
Hum. Mol. Genet., April 15, 2008; 17(R1): R60 - R66.
[Abstract] [Full Text] [PDF]

N. Shiraki, T. Yoshida, K. Araki, A. Umezawa, Y. Higuchi, H. Goto, K. Kume, and S. Kume
Guided Differentiation of Embryonic Stem Cells into Pdx1-Expressing Regional-Specific Definitive Endoderm
Stem Cells, April 1, 2008; 26(4): 874 - 885.
[Abstract] [Full Text] [PDF]

S. J. Arnold, U. K. Hofmann, E. K. Bikoff, and E. J. Robertson
Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
Development, February 1, 2008; 135(3): 501 - 511.
[Abstract] [Full Text] [PDF]

A. Shimada, M. Yabusaki, H. Niwa, H. Yokoi, K. Hatta, D. Kobayashi, and H. Takeda
Maternal-zygotic medaka mutants for fgfr1 reveal its essential role in the migration of the axial mesoderm but not the lateral mesoderm
Development, January 15, 2008; 135(2): 281 - 290.
[Abstract] [Full Text] [PDF]

A. Di-Gregorio, M. Sancho, D. W. Stuckey, L. A. Crompton, J. Godwin, Y. Mishina, and T. A. Rodriguez
BMP signalling inhibits premature neural differentiation in the mouse embryo
Development, September 15, 2007; 134(18): 3359 - 3369.
[Abstract] [Full Text] [PDF]

M. Pick, L. Azzola, A. Mossman, E. G. Stanley, and A. G. Elefanty
Differentiation of Human Embryonic Stem Cells in Serum-Free Medium Reveals Distinct Roles for Bone Morphogenetic Protein 4, Vascular Endothelial Growth Factor, Stem Cell Factor, and Fibroblast Growth Factor 2 in Hematopoiesis
Stem Cells, September 1, 2007; 25(9): 2206 - 2214.
[Abstract] [Full Text] [PDF]

Q. Guo and J. Y. H. Li
Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation
Development, June 15, 2007; 134(12): 2251 - 2260.
[Abstract] [Full Text] [PDF]

L. A. Taneyhill, E. G. Coles, and M. Bronner-Fraser
Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest
Development, April 15, 2007; 134(8): 1481 - 1490.
[Abstract] [Full Text] [PDF]

L. A. Naiche and V. E. Papaioannou
Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth
Development, January 1, 2007; 134(1): 93 - 103.
[Abstract] [Full Text] [PDF]

R. V. Hoch and P. Soriano
Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development
Development, February 15, 2006; 133(4): 663 - 673.
[Abstract] [Full Text] [PDF]

T. Takemoto, M. Uchikawa, Y. Kamachi, and H. Kondoh
Convergence of Wnt and FGF signals in the genesis of posterior neural plate through activation of the Sox2 enhancer N-1
Development, January 15, 2006; 133(2): 297 - 306.
[Abstract] [Full Text] [PDF]

S. R. Smukler, S. B. Runciman, S. Xu, and D. van der Kooy
Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences
J. Cell Biol., January 3, 2006; 172(1): 79 - 90.
[Abstract] [Full Text] [PDF]

Y. Takeuchi, K. Molyneaux, C. Runyan, K. Schaible, and C. Wylie
The roles of FGF signaling in germ cell migration in the mouse
Development, December 15, 2005; 132(24): 5399 - 5409.
[Abstract] [Full Text] [PDF]

W. Xian, K. L. Schwertfeger, T. Vargo-Gogola, and J. M. Rosen
Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model
J. Cell Biol., November 21, 2005; 171(4): 663 - 673.
[Abstract] [Full Text] [PDF]

J. M. Verheyden, M. Lewandoski, C. Deng, B. D. Harfe, and X. Sun
Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning
Development, October 1, 2005; 132(19): 4235 - 4245.
[Abstract] [Full Text] [PDF]

M. Delfino-Machin, J. S. Lunn, D. N. Breitkreuz, J. Akai, and K. G. Storey
Specification and maintenance of the spinal cord stem zone
Development, October 1, 2005; 132(19): 4273 - 4283.
[Abstract] [Full Text] [PDF]

J. P. Frederick, D. Mattiske, J. A. Wofford, L. C. Megosh, L. Y. Drake, S.-T. Chiou, B. L. M. Hogan, and J. D. York
An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production
PNAS, June 14, 2005; 102(24): 8454 - 8459.
[Abstract] [Full Text] [PDF]

N. Gotoh, K. Manova, S. Tanaka, M. Murohashi, Y. Hadari, A. Lee, Y. Hamada, T. Hiroe, M. Ito, T. Kurihara, et al.
The Docking Protein FRS2{alpha} Is an Essential Component of Multiple Fibroblast Growth Factor Responses during Early Mouse Development
Mol. Cell. Biol., May 15, 2005; 25(10): 4105 - 4116.
[Abstract] [Full Text] [PDF]

E. S. Ng, L. Azzola, K. Sourris, L. Robb, E. G. Stanley, and A. G. Elefanty
The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells
Development, March 1, 2005; 132(5): 873 - 884.
[Abstract] [Full Text] [PDF]

Y. Takahashi, S. Kitajima, T. Inoue, J. Kanno, and Y. Saga
Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites
Development, February 15, 2005; 132(4): 787 - 796.
[Abstract] [Full Text] [PDF]

R. T. Bottcher and C. Niehrs
Fibroblast Growth Factor Signaling during Early Vertebrate Development
Endocr. Rev., February 1, 2005; 26(1): 63 - 77.
[Abstract] [Full Text] [PDF]

R. Wilson, E. Vogelsang, and M. Leptin
FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos
Development, February 1, 2005; 132(3): 491 - 501.
[Abstract] [Full Text] [PDF]

E. Delaune, P. Lemaire, and L. Kodjabachian
Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition
Development, January 15, 2005; 132(2): 299 - 310.
[Abstract] [Full Text] [PDF]

I. Bossis and C. A. Stratakis
Minireview: PRKAR1A: Normal and Abnormal Functions
Endocrinology, December 1, 2004; 145(12): 5452 - 5458.
[Abstract] [Full Text] [PDF]

K. S. O'Shea
Self-renewal vs. Differentiation of Mouse Embryonic Stem Cells
Biol Reprod, December 1, 2004; 71(6): 1755 - 1765.
[Abstract] [Full Text] [PDF]

M. Hofmann, K. Schuster-Gossler, M. Watabe-Rudolph, A. Aulehla, B. G. Herrmann, and A. Gossler
WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos
Genes & Dev., November 15, 2004; 18(22): 2712 - 2717.
[Abstract] [Full Text] [PDF]

M. Hirashima, A. Bernstein, W. L. Stanford, and J. Rossant
Gene-trap expression screening to identify endothelial-specific genes
Blood, August 1, 2004; 104(3): 711 - 718.
[Abstract] [Full Text] [PDF]

K. Chawengsaksophak, W. de Graaff, J. Rossant, J. Deschamps, and F. Beck
Cdx2 is essential for axial elongation in mouse development
PNAS, May 18, 2004; 101(20): 7641 - 7645.
[Abstract] [Full Text] [PDF]

M. Hirashima, Y. Lu, L. Byers, and J. Rossant
Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta
PNAS, December 23, 2003; 100(26): 15637 - 15642.
[Abstract] [Full Text] [PDF]

P. P. L. Tam and J. Rossant
Mouse embryonic chimeras: tools for studying mammalian development
Development, December 22, 2003; 130(25): 6155 - 6163.
[Abstract] [Full Text] [PDF]

X. Jiang and J. R. Couchman
Perlecan and Tumor Angiogenesis
J. Histochem. Cytochem., November 1, 2003; 51(11): 1393 - 1410.
[Abstract] [Full Text] [PDF]

L. B. Corson, Y. Yamanaka, K.-M. V. Lai, and J. Rossant
Spatial and temporal patterns of ERK signaling during mouse embryogenesis
Development, October 1, 2003; 130(19): 4527 - 4537.
[Abstract] [Full Text] [PDF]

B. W. Draper, D. W. Stock, and C. B. Kimmel
Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development
Development, October 1, 2003; 130(19): 4639 - 4654.
[Abstract] [Full Text] [PDF]

P. Dell'Era, R. Ronca, L. Coco, S. Nicoli, M. Metra, and M. Presta
Fibroblast Growth Factor Receptor-1 Is Essential for In Vitro Cardiomyocyte Development
Circ. Res., September 5, 2003; 93(5): 414 - 420.
[Abstract] [Full Text] [PDF]

K. BOELAERT, L. A. TANNAHILL, J. N. BULMER, S. KACHILELE, S. Y. CHAN, D. KIM, N. J. L. GITTOES, J. A. FRANKLYN, M. D. KILBY, and C. J. MCCABE
A potential role for PTTG/securin in the developing human fetal brain
FASEB J, September 1, 2003; 17(12): 1631 - 1639.
[Abstract] [Full Text] [PDF]

P. H. White, D. R. Farkas, E. E. McFadden, and D. L. Chapman
Defective somite patterning in mouse embryos with reduced levels of Tbx6
Development, April 15, 2003; 130(8): 1681 - 1690.
[Abstract] [Full Text] [PDF]

R. Dono
Fibroblast growth factors as regulators of central nervous system development and function
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R867 - R881.
[Abstract] [Full Text] [PDF]

B. Nait-Oumesmar, B. Stecca, G. Fatterpekar, T. Naidich, J. Corbin, and R. A. Lazzarini
Ectopic expression of Gcm1 induces congenital spinal cord abnormalities
Development, March 10, 2003; 129(16): 3957 - 3964.
[Abstract] [Full Text] [PDF]

M. D. Tallquist and P. Soriano
Cell autonomous requirement for PDGFR{alpha} in populations of cranial and cardiac neural crest cells
Development, February 1, 2003; 130(3): 507 - 518.
[Abstract] [Full Text] [PDF]

N. Trokovic, R. Trokovic, P. Mai, and J. Partanen
Fgfr1 regulates patterning of the pharyngeal region
Genes & Dev., January 1, 2003; 17(1): 141 - 153.
[Abstract] [Full Text] [PDF]

C. Roberts, H. F. Sutherland, H. Farmer, W. Kimber, S. Halford, A. Carey, J. M. Brickman, A. Wynshaw-Boris, and P. J. Scambler
Targeted Mutagenesis of the Hira Gene Results in Gastrulation Defects and Patterning Abnormalities of Mesoendodermal Derivatives Prior to Early Embryonic Lethality
Mol. Cell. Biol., April 1, 2002; 22(7): 2318 - 2328.
[Abstract] [Full Text] [PDF]

G. Davidson, R. Dono, and R. Zeller
FGF signalling is required for differentiation-induced cytoskeletal reorganisation and formation of actin-based processes by podocytes
J. Cell Sci., March 11, 2002; 114(18): 3359 - 3366.
[Abstract] [Full Text] [PDF]

J. Rathjen, B. P. Haines, K. M. Hudson, A. Nesci, S. Dunn, and P. D. Rathjen
Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population
Development, January 6, 2002; 129(11): 2649 - 2661.
[Abstract] [Full Text] [PDF]

R. D. del Corral, D. N. Breitkreuz, and K. G. Storey
Onset of neuronal differentiation is regulated by paraxial mesoderm and requires attenuation of FGF signalling
Development, January 4, 2002; 129(7): 1681 - 1691.
[Abstract] [Full Text] [PDF]

Y. R. Hadari, N. Gotoh, H. Kouhara, I. Lax, and J. Schlessinger
Critical role for the docking-protein FRS2alpha in FGF receptor-mediated signal transduction pathways
PNAS, July 5, 2001; (2001) 161259898.
[Abstract] [Full Text] [PDF]

X. Li, Y. Chen, S. Scheele, E. Arman, R. Haffner-Krausz, P. Ekblom, and P. Lonai
Fibroblast Growth Factor Signaling and Basement Membrane Assembly Are Connected during Epithelial Morphogenesis of the Embryoid Body
J. Cell Biol., May 14, 2001; 153(4): 811 - 822.
[Abstract] [Full Text] [PDF]

S. L. Nutt, K. S. Dingwell, C. E. Holt, and E. Amaya
Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning
Genes & Dev., May 1, 2001; 15(9): 1152 - 1166.
[Abstract] [Full Text]

Y Luo, M Ferreira-Cornwell, H Baldwin, I Kostetskii, J Lenox, M Lieberman, and G Radice
Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin
Development, January 2, 2001; 128(4): 459 - 469.
[Abstract] [PDF]

T Yoshimizu, M Obinata, and Y Matsui
Stage-specific tissue and cell interactions play key roles in mouse germ cell specification
Development, January 2, 2001; 128(4): 481 - 490.
[Abstract] [PDF]

J. K. Yoon and B. Wold
The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm
Genes & Dev., December 15, 2000; 14(24): 3204 - 3214.
[Abstract] [Full Text]

N Bertrand, F Medevielle, and F Pituello
FGF signalling controls the timing of Pax6 activation in the neural tube
Development, January 11, 2000; 127(22): 4837 - 4843.
[Abstract] [PDF]

				N. Shiraki, T. Yoshida, K. Araki, A. Umezawa, Y. Higuchi, H. Goto, K. Kume, and S. Kume Guided Differentiation of Embryonic Stem Cells into Pdx1-Expressing Regional-Specific Definitive Endoderm Stem Cells, April 1, 2008; 26(4): 874 - 885. [Abstract] [Full Text] [PDF]

				S. J. Arnold, U. K. Hofmann, E. K. Bikoff, and E. J. Robertson Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse Development, February 1, 2008; 135(3): 501 - 511. [Abstract] [Full Text] [PDF]

				A. Shimada, M. Yabusaki, H. Niwa, H. Yokoi, K. Hatta, D. Kobayashi, and H. Takeda Maternal-zygotic medaka mutants for fgfr1 reveal its essential role in the migration of the axial mesoderm but not the lateral mesoderm Development, January 15, 2008; 135(2): 281 - 290. [Abstract] [Full Text] [PDF]

				A. Di-Gregorio, M. Sancho, D. W. Stuckey, L. A. Crompton, J. Godwin, Y. Mishina, and T. A. Rodriguez BMP signalling inhibits premature neural differentiation in the mouse embryo Development, September 15, 2007; 134(18): 3359 - 3369. [Abstract] [Full Text] [PDF]

				M. Pick, L. Azzola, A. Mossman, E. G. Stanley, and A. G. Elefanty Differentiation of Human Embryonic Stem Cells in Serum-Free Medium Reveals Distinct Roles for Bone Morphogenetic Protein 4, Vascular Endothelial Growth Factor, Stem Cell Factor, and Fibroblast Growth Factor 2 in Hematopoiesis Stem Cells, September 1, 2007; 25(9): 2206 - 2214. [Abstract] [Full Text] [PDF]

				Q. Guo and J. Y. H. Li Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation Development, June 15, 2007; 134(12): 2251 - 2260. [Abstract] [Full Text] [PDF]

				L. A. Taneyhill, E. G. Coles, and M. Bronner-Fraser Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest Development, April 15, 2007; 134(8): 1481 - 1490. [Abstract] [Full Text] [PDF]

				L. A. Naiche and V. E. Papaioannou Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth Development, January 1, 2007; 134(1): 93 - 103. [Abstract] [Full Text] [PDF]

				R. V. Hoch and P. Soriano Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development Development, February 15, 2006; 133(4): 663 - 673. [Abstract] [Full Text] [PDF]

				T. Takemoto, M. Uchikawa, Y. Kamachi, and H. Kondoh Convergence of Wnt and FGF signals in the genesis of posterior neural plate through activation of the Sox2 enhancer N-1 Development, January 15, 2006; 133(2): 297 - 306. [Abstract] [Full Text] [PDF]

				S. R. Smukler, S. B. Runciman, S. Xu, and D. van der Kooy Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences J. Cell Biol., January 3, 2006; 172(1): 79 - 90. [Abstract] [Full Text] [PDF]

				Y. Takeuchi, K. Molyneaux, C. Runyan, K. Schaible, and C. Wylie The roles of FGF signaling in germ cell migration in the mouse Development, December 15, 2005; 132(24): 5399 - 5409. [Abstract] [Full Text] [PDF]

				W. Xian, K. L. Schwertfeger, T. Vargo-Gogola, and J. M. Rosen Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model J. Cell Biol., November 21, 2005; 171(4): 663 - 673. [Abstract] [Full Text] [PDF]

				J. M. Verheyden, M. Lewandoski, C. Deng, B. D. Harfe, and X. Sun Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning Development, October 1, 2005; 132(19): 4235 - 4245. [Abstract] [Full Text] [PDF]

				M. Delfino-Machin, J. S. Lunn, D. N. Breitkreuz, J. Akai, and K. G. Storey Specification and maintenance of the spinal cord stem zone Development, October 1, 2005; 132(19): 4273 - 4283. [Abstract] [Full Text] [PDF]

				J. P. Frederick, D. Mattiske, J. A. Wofford, L. C. Megosh, L. Y. Drake, S.-T. Chiou, B. L. M. Hogan, and J. D. York An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production PNAS, June 14, 2005; 102(24): 8454 - 8459. [Abstract] [Full Text] [PDF]

				N. Gotoh, K. Manova, S. Tanaka, M. Murohashi, Y. Hadari, A. Lee, Y. Hamada, T. Hiroe, M. Ito, T. Kurihara, et al. The Docking Protein FRS2{alpha} Is an Essential Component of Multiple Fibroblast Growth Factor Responses during Early Mouse Development Mol. Cell. Biol., May 15, 2005; 25(10): 4105 - 4116. [Abstract] [Full Text] [PDF]

				E. S. Ng, L. Azzola, K. Sourris, L. Robb, E. G. Stanley, and A. G. Elefanty The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells Development, March 1, 2005; 132(5): 873 - 884. [Abstract] [Full Text] [PDF]

				Y. Takahashi, S. Kitajima, T. Inoue, J. Kanno, and Y. Saga Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites Development, February 15, 2005; 132(4): 787 - 796. [Abstract] [Full Text] [PDF]

				R. T. Bottcher and C. Niehrs Fibroblast Growth Factor Signaling during Early Vertebrate Development Endocr. Rev., February 1, 2005; 26(1): 63 - 77. [Abstract] [Full Text] [PDF]

				R. Wilson, E. Vogelsang, and M. Leptin FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos Development, February 1, 2005; 132(3): 491 - 501. [Abstract] [Full Text] [PDF]

				E. Delaune, P. Lemaire, and L. Kodjabachian Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition Development, January 15, 2005; 132(2): 299 - 310. [Abstract] [Full Text] [PDF]

				I. Bossis and C. A. Stratakis Minireview: PRKAR1A: Normal and Abnormal Functions Endocrinology, December 1, 2004; 145(12): 5452 - 5458. [Abstract] [Full Text] [PDF]

				K. S. O'Shea Self-renewal vs. Differentiation of Mouse Embryonic Stem Cells Biol Reprod, December 1, 2004; 71(6): 1755 - 1765. [Abstract] [Full Text] [PDF]

				M. Hofmann, K. Schuster-Gossler, M. Watabe-Rudolph, A. Aulehla, B. G. Herrmann, and A. Gossler WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos Genes & Dev., November 15, 2004; 18(22): 2712 - 2717. [Abstract] [Full Text] [PDF]

				M. Hirashima, A. Bernstein, W. L. Stanford, and J. Rossant Gene-trap expression screening to identify endothelial-specific genes Blood, August 1, 2004; 104(3): 711 - 718. [Abstract] [Full Text] [PDF]

				K. Chawengsaksophak, W. de Graaff, J. Rossant, J. Deschamps, and F. Beck Cdx2 is essential for axial elongation in mouse development PNAS, May 18, 2004; 101(20): 7641 - 7645. [Abstract] [Full Text] [PDF]

				M. Hirashima, Y. Lu, L. Byers, and J. Rossant Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta PNAS, December 23, 2003; 100(26): 15637 - 15642. [Abstract] [Full Text] [PDF]

				P. P. L. Tam and J. Rossant Mouse embryonic chimeras: tools for studying mammalian development Development, December 22, 2003; 130(25): 6155 - 6163. [Abstract] [Full Text] [PDF]

				X. Jiang and J. R. Couchman Perlecan and Tumor Angiogenesis J. Histochem. Cytochem., November 1, 2003; 51(11): 1393 - 1410. [Abstract] [Full Text] [PDF]