Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Wassarman, K. M.
	Articles by Martin, G. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Wassarman, K. M.
	Articles by Martin, G. R.

Abbott, L. and Jacobowitz, D (1995). Development of calretinin-immunoreactive unipolar brush-like cells and an afferent pathway to the embryonic and early postnatal mouse cerebellum. Anat. Embryol 191, 541-559.[Medline]

Acampora, D., Mazan, S., Lallemand, Y., Avantaggiato, V., Maury, M., Simeone, A. and Brulet, P (1995). Forebrain and midbrain regions are deleted in Otx2/ mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121, 3279-3290.[Abstract]

Ang, S., Conlon, R., Jin, O. and Rossant, J (1994). Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development 120, 2979-2989.[Abstract]

Bally-Cuif, L., Cholley, B. and Wassef, M (1995). Involvement of Wnt-1 in the formation of the mes/metencephalic boundary. Mech. Dev 53, 23-34.[Medline]

Bouillet, P., Chazaud, C., Oulad-Abdelghani, M., Dolle, P. and Chambon, P (1995). Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells. Dev. Dynam 204, 372-382.[Medline]

Brand, M., Heisenberg, C., Jiang, Y., Beuchle, D., Lun, K., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D., Kelsh, R., Mullins, M., Odenthal, J., van Eeden, F. and Nusslein-Volhard, C (1996). Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development 123, 179-190.[Abstract]

Bulfone, A., Puelles, L., Porteus, M. H., Frohman, M. A., Martin, G. R. and Rubenstein, J. L. R (1993). Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J. Neurosci 13, 3155-3172.[Abstract]

Chapman, G. and Rathjen, P (1995). Sequence and evolutionary conservation of the murine Gbx-2 homeobox gene. FEBS Lett 364, 289-292.[Medline]

Chiang, C., Young, K. and Beachy, P (1995). Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax complex. Development 121, 3901-3912.[Abstract]

Couly, G., Grapin-Botton, A., Coltey, P. and Le Douarin, N (1996). The regeneration of the cephalic neural crest, a problem revisited: the regenerating cells originate from the contralateral or from the anterior and posterior neural fold. Development 122, 3393-3407.[Abstract]

Crossley, P., Martinez, S. and Martin, G (1996). Midbrain development induced by FGF8 in the chick embryo. Nature 380, 66-68.[Medline]

Crossley, P. H. and Martin, G. R (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439-451.[Abstract]

Danielian, P. and McMahon, A (1996). Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383, 332-334.[Medline]

Davis, C. A. and Joyner, A. L (1988). Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes Dev 2, 1736-1744.[Abstract/Free Full Text]

Favor, J., Sandulache, R., Neuhauser-Klaus, A., Pretsch, W., Chatterjee, B., Senft, E., Wurst, W., Blanquet, V., Grimes, P., Sporle, R. and Schughart, K (1996). The mouse Pax2 (1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney. Proc. Natl. Acad. Sci. USA 93, 13870-13875.[Abstract/Free Full Text]

Flenniken, A. M., Gale, N. W., Yancopoulos, G. D. and Wilkinson, D. G (1996). Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis. Dev. Biol 179, 382-401.[Medline]

Frohman, M. A., Boyle, M. and Martin, G. R (1990). Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior posterior axis is specified by mesoderm. Development 110, 589-607.[Abstract/Free Full Text]

Gilland, E. and Baker, R (1993). Conservation of neuroepithelial and mesodermal segments in the embryonic vertebrate head. Acta Anat 148, 110-123.[Medline]

Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B. and Joyner, A. L (1995). Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269, 679-682.[Abstract/Free Full Text]

Heikinheimo, M., Lawshe, A., Shackleford, G. M., Wilson, D. B. and MacArthur, C. A (1994). Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs, and central nervous system. Mech. Dev 48, 129-138.[Medline]

Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J. and Ish-Horowicz, D (1995). Expression of a Delta homologue in prospective neurons in the chick. Nature 375, 787-790.[Medline]

Hui, C. and Joyner, A (1993). A mouse model of Greig cephalopolysyndactyly syndrome: the extra-toes mutation contains an intragenic deletion of the Gli3 gene. Nature Genet 3, 241-246.[Medline]

Joyner, A. L (1996). Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development. Trends Genet 12, 15-20.[Medline]

Karnovsky, M. and Roots, L (1964). A direct coloring thiocholine method for cholinestereases. J. Histochem. Cytochem 12, 219-221.[Medline]

Kilby, N. J., Snaith, M. R. and Murray, J. A (1993). Site-specific recombinases: tools for genome engineering. Trends Genet 9, 413-421.[Medline]

K\232ntges, G. and Lumsden, A (1996). Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny. Development 122, 3229-3242.[Abstract]

Lee, S. M. K., Danielian, P. S., Fritzsch, B. and McMahon, A. P (1997). Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development 124, 959-969.[Abstract]

Lewandoski, M., Wassarman, K. M. and Martin, G. R (1997). Zp3-cre , a transgenic mouse line for the activation or inactivation of loxP -flanked target genes specifically in the female germ line. Curr. Biol 7, 148-151.[Medline]

Lumsden, A. and Krumlauf, R (1996). Patterning the vertebrate neuraxis. Science 274, 1109-1115.[Abstract/Free Full Text]

Mahmood, R., Bresnick, J., Hornbruch, A., Mahony, C., Morton, N., Colquhoun, K., Martin, P., Lumsden, A., Dickson, C. and Mason, I (1995). A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr. Biol 5, 797-806.[Medline]

Marin, F. and Puelles, L (1995). Morphological fate of rhombomeres in quail/chick chimeras: a segmental analysis of hindbrain nuclei. Eur. J. Neurosci 7, 1714-1738.[Medline]

Martinez, S., Wassef, M. and Alvarado-Mallart, R.-M (1991). Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en. Neuron 6, 971-981.[Medline]

Matsui, T., Hirai, M., Hirano, M. and Kurosawa, Y (1993). The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans. FEBS Lett 336, 107-110.[Medline]

McLeod, M. J (1980). Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red. Teratology 22, 299-301.[Medline]

McMahon, A., Joyner, A., Bradley, A. and McMahon, J (1992). The midbrain-hindbrain phenotype of Wnt-1/Wnt-1 mice results from stepwise deletion of engrailed -expressing cells by 9.5 days postcoitum. Cell 69, 581-595.[Medline]

McMahon, A. P. and Bradley, A (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085.[Medline]

Meinhardt, H (1983). Cell determination boundaries as organizing regions for secondary embryonic fields. Dev. Biol 96, 375-385.[Medline]

Millet, S., Bloch-Gallego, E., Simeone, A. and Alvarado-Mallart, R.-M (1996). The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts. Development 122, 3785-3797.[Abstract]

Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. and Roder, J. C (1993). Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90, 8424-8428.[Abstract/Free Full Text]

Ohuchi, H., Yoshioka, H., Tanaka, A., Kawakami, Y., Nohno, T. and Noji,S (1994). Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis. Biochem. Biophys. Res. Comm 204, 882-888.[Medline]

Osumi-Yamashita, N., Ninomiya, Y., Doi, H. and Eto, K (1996). Rhombomere formation and hindbrain crest cell migration from prorhombomeric origins in mouse embryos. Dev. Growth Differ 38, 107-118.

Retaux, S. and Harris, W (1996). Engrailed and retinotectal topography. Trends Neurosci 19, 542-546.[Medline]

Siegfried, E. and Perrimon, N (1994). Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling. BioEssays 16, 395-404.[Medline]

Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A. and Boncinelli, E (1992). Nested expression domains of four homeobox genes in developing rostral brain. Nature 358, 687-690.[Medline]

Simeone, A., Acampora, D., Mallamaci, A., Stornaiuolo, A., D'Apice, M., Nigro, V. and Boncinelli, E (1993). A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J 12, 2735-2747.[Medline]

Song, D., Chalepakis, G., Gruss, P. and AL, J (1996). Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene. Development 122, 627-635.[Abstract]

Sutherland, D., Samakovlis, C. and Krasnow, M (1996). branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Cell 87, 1091-1101.[Medline]

Thomas, K. R. and Capecchi, M. R (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346, 847-850.[Medline]

Tybulewicz, V. L., Crawford, C. E., Jackson, P. K., Bronson, R. T. and Mulligan, R. C (1991). Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c- abl proto-oncogene. Cell 65, 1153-1163.[Medline]

Urbanek, P., Wang, Z., Fetka, I., Wagner, E. and Busslinger, M (1994). Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79, 901-912.[Medline]

von Bubnoff, A., Schmidt, J. and Kimelman, D (1995). The Xenopuslaevis homeobox gene Xgbx-2 is an early marker of anteroposterior patterning in the ectoderm. Mech. Dev 54, 149-160.

Wassef, M., Zanetta, J., Brehier, A. and Sotelo, C (1985). Transient biochemical compartmentalization of Purkinje cells during early cerebellar development. Dev. Biol 111, 129-137.[Medline]

Wilkinson, D. G., Bhatt, S., Chavrier, P., Bravo, R. and Charnay, P (1989). Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse. Nature 337, 461-464.[Medline]

Wilkinson, D. G., Bhatt, S., Cook, M., Boncinelli, E. and Krumlauf, R (1989). Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature 341, 405-409.[Medline]

Wurst, W., Auerbach, A. and Joyner, A (1994). Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120, 2065-2075.[Abstract]

This article has been cited by other articles:

S. Prabhakar, A. Visel, J. A. Akiyama, M. Shoukry, K. D. Lewis, A. Holt, I. Plajzer-Frick, H. Morrison, D. R. FitzPatrick, V. Afzal, et al.
Human-Specific Gain of Function in a Developmental Enhancer
Science, September 5, 2008; 321(5894): 1346 - 1350.
[Abstract] [Full Text] [PDF]

E. P. Hatch, C. A. Noyes, X. Wang, T. J. Wright, and S. L. Mansour
Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium
Development, October 15, 2007; 134(20): 3615 - 3625.
[Abstract] [Full Text] [PDF]

C. Guo, H.-Y. Qiu, Y. Huang, H. Chen, R.-Q. Yang, S.-D. Chen, R. L. Johnson, Z.-F. Chen, and Y.-Q. Ding
Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice
Development, January 15, 2007; 134(2): 317 - 325.
[Abstract] [Full Text] [PDF]

T. Heimbucher, C. Murko, B. Bajoghli, N. Aghaallaei, A. Huber, R. Stebegg, D. Eberhard, M. Fink, A. Simeone, and T. Czerny
Gbx2 and Otx2 Interact with the WD40 Domain of Groucho/Tle Corepressors
Mol. Cell. Biol., January 1, 2007; 27(1): 340 - 351.
[Abstract] [Full Text] [PDF]

I. Foucher, M. Mione, A. Simeone, D. Acampora, L. Bally-Cuif, and C. Houart
Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants
Development, May 15, 2006; 133(10): 1891 - 1900.
[Abstract] [Full Text] [PDF]

S. T. Waters and M. Lewandoski
A threshold requirement for Gbx2 levels in hindbrain development.
Development, May 1, 2006; 133(10): 1991 - 2000.
[Abstract] [Full Text] [PDF]

G. Griesel, D. Treichel, P. Collombat, J. Krull, A. Zembrzycki, W. M. R. van den Akker, P. Gruss, A. Simeone, and A. Mansouri
Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border
Development, May 1, 2006; 133(9): 1779 - 1787.
[Abstract] [Full Text] [PDF]

M. Carapuco, A. Novoa, N. Bobola, and M. Mallo
Hox genes specify vertebral types in the presomitic mesoderm
Genes & Dev., September 15, 2005; 19(18): 2116 - 2121.
[Abstract] [Full Text] [PDF]

C. Colarossi, Y. Chen, H. Obata, V. Jurukovski, L. Fontana, B. Dabovic, and D. B. Rifkin
Lung Alveolar Septation Defects in Ltbp-3-Null Mice
Am. J. Pathol., August 1, 2005; 167(2): 419 - 428.
[Abstract] [Full Text] [PDF]

F. P. O'Hara, E. Beck, L. K. Barr, L. L. Wong, D. S. Kessler, and R. D. Riddle
Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer
Development, July 15, 2005; 132(14): 3163 - 3173.
[Abstract] [Full Text] [PDF]

H. Lickert, B. Cox, C. Wehrle, M. M. Taketo, R. Kemler, and J. Rossant
Dissecting Wnt/{beta}-catenin signaling during gastrulation using RNA interference in mouse embryos
Development, June 1, 2005; 132(11): 2599 - 2609.
[Abstract] [Full Text] [PDF]

Z. Lin, R. Cantos, M. Patente, and D. K. Wu
Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
Development, May 15, 2005; 132(10): 2309 - 2318.
[Abstract] [Full Text] [PDF]

B. Vernay, M. Koch, F. Vaccarino, J. Briscoe, A. Simeone, R. Kageyama, and S.-L. Ang
Otx2 Regulates Subtype Specification and Neurogenesis in the Midbrain
J. Neurosci., May 11, 2005; 25(19): 4856 - 4867.
[Abstract] [Full Text] [PDF]

J. Y. H. Li, Z. Lao, and A. L. Joyner
New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression
Development, April 15, 2005; 132(8): 1971 - 1981.
[Abstract] [Full Text] [PDF]

M. Rhinn, K. Lun, M. Luz, M. Werner, and M. Brand
Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling
Development, March 15, 2005; 132(6): 1261 - 1272.
[Abstract] [Full Text] [PDF]

K. J. Huffman, S. Garel, and J. L. R. Rubenstein
Fgf8 Regulates the Development of Intra-Neocortical Projections
J. Neurosci., October 13, 2004; 24(41): 8917 - 8923.
[Abstract] [Full Text] [PDF]

A. Ohtoshi and R. R. Behringer
Neonatal Lethality, Dwarfism, and Abnormal Brain Development in Dmbx1 Mutant Mice
Mol. Cell. Biol., September 1, 2004; 24(17): 7548 - 7558.
[Abstract] [Full Text] [PDF]

A. M. Masino, T. D. Gallardo, C. A. Wilcox, E. N. Olson, R. S. Williams, and D. J. Garry
Transcriptional Regulation of Cardiac Progenitor Cell Populations
Circ. Res., August 20, 2004; 95(4): 389 - 397.
[Abstract] [Full Text] [PDF]

D. Kurokawa, H. Kiyonari, R. Nakayama, C. Kimura-Yoshida, I. Matsuo, and S. Aizawa
Regulation of Otx2 expression and its functions in mouse forebrain and midbrain
Development, July 15, 2004; 131(14): 3319 - 3331.
[Abstract] [Full Text] [PDF]

A. Louvi, S. S. Sisodia, and E. A. Grove
Presenilin 1 in migration and morphogenesis in the central nervous system
Development, July 1, 2004; 131(13): 3093 - 3105.
[Abstract] [Full Text] [PDF]

O. G. Kelly, K. I. Pinson, and W. C. Skarnes
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
Development, June 15, 2004; 131(12): 2803 - 2815.
[Abstract] [Full Text] [PDF]

A. Tallafuss and L. Bally-Cuif
Tracing of her5 progeny in zebrafish transgenics reveals the dynamics of midbrain-hindbrain neurogenesis and maintenance
Development, September 15, 2003; 130(18): 4307 - 4323.
[Abstract] [Full Text] [PDF]

T. J. Wright and S. L. Mansour
Fgf3 and Fgf10 are required for mouse otic placode induction
Development, August 1, 2003; 130(15): 3379 - 3390.
[Abstract] [Full Text] [PDF]

C. L. Chi, S. Martinez, W. Wurst, and G. R. Martin
The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
Development, June 15, 2003; 130(12): 2633 - 2644.
[Abstract] [Full Text] [PDF]

F. Hirth, L. Kammermeier, E. Frei, U. Walldorf, M. Noll, and H. Reichert
An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila
Development, June 1, 2003; 130(11): 2365 - 2373.
[Abstract] [Full Text] [PDF]

G. Reim and M. Brand
spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development
Development, March 4, 2003; 129(4): 917 - 933.
[Abstract] [Full Text] [PDF]

J. Rathjen, B. P. Haines, K. M. Hudson, A. Nesci, S. Dunn, and P. D. Rathjen
Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population
Development, January 6, 2002; 129(11): 2649 - 2661.
[Abstract] [Full Text] [PDF]

A. Glavic, J. L. Gomez-Skarmeta, and R. Mayor
The homeoprotein Xiro1 is required for midbrain-hindbrain boundary formation
Development, January 4, 2002; 129(7): 1609 - 1621.
[Abstract] [Full Text] [PDF]

J. Y. H. Li and A. L. Joyner
Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
Development, December 15, 2001; 128(24): 4979 - 4991.
[Abstract] [Full Text] [PDF]

J. P. Martinez-Barbera, M. Signore, P. P. Boyl, E. Puelles, D. Acampora, R. Gogoi, F. Schubert, A. Lumsden, and A. Simeone
Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2
Development, December 1, 2001; 128(23): 4789 - 4800.
[Abstract] [Full Text] [PDF]

H.-G. Belting, G. Hauptmann, D. Meyer, S. Abdelilah-Seyfried, A. Chitnis, C. Eschbach, I. Soll, C. Thisse, B. Thisse, K. B. Artinger, et al.
spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer
Development, November 1, 2001; 128(21): 4165 - 4176.
[Abstract] [Full Text] [PDF]

A. Beverdam, A. Brouwer, M. Reijnen, J. Korving, and F. Meijlink
Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice
Development, October 15, 2001; 128(20): 3975 - 3986.
[Abstract] [Full Text] [PDF]

A. Tallafu{beta}, T. P. Wilm, M. Crozatier, P. Pfeffer, M. Wassef, and L. Bally-Cuif
The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2.1 expression during mid-hindbrain development
Development, October 15, 2001; 128(20): 4021 - 4034.
[Abstract] [Full Text] [PDF]

A Liu and A. Joyner
EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region
Development, January 1, 2001; 128(2): 181 - 191.
[Abstract] [PDF]

H. B. Samat and J. H. Menkes
How to Construct a Neural Tube
J Child Neurol, February 1, 2000; 15(2): 110 - 124.
[PDF]

S Kitajima, A Takagi, T Inoue, and Y Saga
MesP1 and MesP2 are essential for the development of cardiac mesoderm
Development, January 8, 2000; 127(15): 3215 - 3226.
[Abstract] [PDF]

K. Adams, J. Maida, J. Golden, and R. Riddle
The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer
Development, January 5, 2000; 127(9): 1857 - 1867.
[Abstract] [PDF]

P. Pfeffer, M Bouchard, and M Busslinger
Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary
Development, January 3, 2000; 127(5): 1017 - 1028.
[Abstract] [PDF]

C Irving and I Mason
Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression
Development, January 1, 2000; 127(1): 177 - 186.
[Abstract] [PDF]

J. L.R. Rubenstein, S. Anderson, L. Shi, E. Miyashita-Lin, A. Bulfone, and R. Hevner
Genetic Control of Cortical Regionalization and Connectivity
Cereb Cortex, September 1, 1999; 9(6): 524 - 532.
[Abstract] [Full Text] [PDF]

K. J. Millen, J. H. Millonig, R. J. T. Wingate, J. Alder, and M. E. Hatten
Neurogenetics of the Cerebellar System
J Child Neurol, September 1, 1999; 14(9): 574 - 581.
[Abstract] [PDF]

E. M. Miyashita-Lin, R. Hevner, K. M. Wassarman, S. Martinez, and J. L. Rubenstein
Early Neocortical Regionalization in the Absence of Thalamic Innervation
Science, August 6, 1999; 285(5429): 906 - 909.
[Abstract] [Full Text]

X. Sun, E. N. Meyers, M. Lewandoski, and G. R. Martin
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
Genes & Dev., July 15, 1999; 13(14): 1834 - 1846.
[Abstract] [Full Text]

S. Pradervand, P. M. Barker, Q. Wang, S. A. Ernst, F. Beermann, B. R. Grubb, M. Burnier, A. Schmidt, R. J.�M. Bindels, J. T. Gatzy, et al.
Salt restriction induces pseudohypoaldosteronism type 1�in mice expressing low levels of the beta -subunit of the amiloride-sensitive epithelial sodium channel
PNAS, February 16, 1999; 96(4): 1732 - 1737.
[Abstract] [Full Text] [PDF]

A Liu, K Losos, and A. Joyner
FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate
Development, January 11, 1999; 126(21): 4827 - 4838.
[Abstract] [PDF]

F Ristoratore, M Carl, K Deschet, L Richard-Parpaillon, D Boujard, J Wittbrodt, D Chourrout, F Bourrat, and J. Joly
The midbrain-hindbrain boundary genetic cascade is activated ectopically in the diencephalon in response to the widespread expression of one of its components, the medaka gene Ol-eng2
Development, January 9, 1999; 126(17): 3769 - 3779.
[Abstract] [PDF]

C Irving and I Mason
Regeneration of isthmic tissue is the result of a specific and direct interaction between rhombomere 1 and midbrain
Development, January 9, 1999; 126(18): 3981 - 3989.
[Abstract] [PDF]

A Picker, C Brennan, F Reifers, J. Clarke, N Holder, and M Brand
Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection
Development, January 7, 1999; 126(13): 2967 - 2978.
[Abstract] [PDF]

M Hidalgo-Sanchez, A Simeone, and R. Alvarado-Mallart
Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon
Development, January 6, 1999; 126(14): 3191 - 3203.
[Abstract] [PDF]

S Martinez, P. Crossley, I Cobos, J. Rubenstein, and G. Martin
FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression
Development, January 3, 1999; 126(6): 1189 - 1200.
[Abstract] [PDF]

T. Yamaguchi, A Bradley, A. McMahon, and S Jones
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo
Development, January 3, 1999; 126(6): 1211 - 1223.
[Abstract] [PDF]

Y Suda, J Nakabayashi, I Matsuo, and S Aizawa
Functional equivalency between Otx2 and Otx1 in development of the rostral head
Development, January 2, 1999; 126(4): 743 - 757.
[Abstract] [PDF]

				E. P. Hatch, C. A. Noyes, X. Wang, T. J. Wright, and S. L. Mansour Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium Development, October 15, 2007; 134(20): 3615 - 3625. [Abstract] [Full Text] [PDF]

				C. Guo, H.-Y. Qiu, Y. Huang, H. Chen, R.-Q. Yang, S.-D. Chen, R. L. Johnson, Z.-F. Chen, and Y.-Q. Ding Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice Development, January 15, 2007; 134(2): 317 - 325. [Abstract] [Full Text] [PDF]

				T. Heimbucher, C. Murko, B. Bajoghli, N. Aghaallaei, A. Huber, R. Stebegg, D. Eberhard, M. Fink, A. Simeone, and T. Czerny Gbx2 and Otx2 Interact with the WD40 Domain of Groucho/Tle Corepressors Mol. Cell. Biol., January 1, 2007; 27(1): 340 - 351. [Abstract] [Full Text] [PDF]

				I. Foucher, M. Mione, A. Simeone, D. Acampora, L. Bally-Cuif, and C. Houart Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants Development, May 15, 2006; 133(10): 1891 - 1900. [Abstract] [Full Text] [PDF]

				S. T. Waters and M. Lewandoski A threshold requirement for Gbx2 levels in hindbrain development. Development, May 1, 2006; 133(10): 1991 - 2000. [Abstract] [Full Text] [PDF]

				G. Griesel, D. Treichel, P. Collombat, J. Krull, A. Zembrzycki, W. M. R. van den Akker, P. Gruss, A. Simeone, and A. Mansouri Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border Development, May 1, 2006; 133(9): 1779 - 1787. [Abstract] [Full Text] [PDF]

				M. Carapuco, A. Novoa, N. Bobola, and M. Mallo Hox genes specify vertebral types in the presomitic mesoderm Genes & Dev., September 15, 2005; 19(18): 2116 - 2121. [Abstract] [Full Text] [PDF]

				C. Colarossi, Y. Chen, H. Obata, V. Jurukovski, L. Fontana, B. Dabovic, and D. B. Rifkin Lung Alveolar Septation Defects in Ltbp-3-Null Mice Am. J. Pathol., August 1, 2005; 167(2): 419 - 428. [Abstract] [Full Text] [PDF]

				F. P. O'Hara, E. Beck, L. K. Barr, L. L. Wong, D. S. Kessler, and R. D. Riddle Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer Development, July 15, 2005; 132(14): 3163 - 3173. [Abstract] [Full Text] [PDF]

				H. Lickert, B. Cox, C. Wehrle, M. M. Taketo, R. Kemler, and J. Rossant Dissecting Wnt/{beta}-catenin signaling during gastrulation using RNA interference in mouse embryos Development, June 1, 2005; 132(11): 2599 - 2609. [Abstract] [Full Text] [PDF]

				Z. Lin, R. Cantos, M. Patente, and D. K. Wu Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling Development, May 15, 2005; 132(10): 2309 - 2318. [Abstract] [Full Text] [PDF]

				B. Vernay, M. Koch, F. Vaccarino, J. Briscoe, A. Simeone, R. Kageyama, and S.-L. Ang Otx2 Regulates Subtype Specification and Neurogenesis in the Midbrain J. Neurosci., May 11, 2005; 25(19): 4856 - 4867. [Abstract] [Full Text] [PDF]

				J. Y. H. Li, Z. Lao, and A. L. Joyner New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression Development, April 15, 2005; 132(8): 1971 - 1981. [Abstract] [Full Text] [PDF]

				M. Rhinn, K. Lun, M. Luz, M. Werner, and M. Brand Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling Development, March 15, 2005; 132(6): 1261 - 1272. [Abstract] [Full Text] [PDF]

				K. J. Huffman, S. Garel, and J. L. R. Rubenstein Fgf8 Regulates the Development of Intra-Neocortical Projections J. Neurosci., October 13, 2004; 24(41): 8917 - 8923. [Abstract] [Full Text] [PDF]

				A. Ohtoshi and R. R. Behringer Neonatal Lethality, Dwarfism, and Abnormal Brain Development in Dmbx1 Mutant Mice Mol. Cell. Biol., September 1, 2004; 24(17): 7548 - 7558. [Abstract] [Full Text] [PDF]

				A. M. Masino, T. D. Gallardo, C. A. Wilcox, E. N. Olson, R. S. Williams, and D. J. Garry Transcriptional Regulation of Cardiac Progenitor Cell Populations Circ. Res., August 20, 2004; 95(4): 389 - 397. [Abstract] [Full Text] [PDF]

				D. Kurokawa, H. Kiyonari, R. Nakayama, C. Kimura-Yoshida, I. Matsuo, and S. Aizawa Regulation of Otx2 expression and its functions in mouse forebrain and midbrain Development, July 15, 2004; 131(14): 3319 - 3331. [Abstract] [Full Text] [PDF]

				A. Louvi, S. S. Sisodia, and E. A. Grove Presenilin 1 in migration and morphogenesis in the central nervous system Development, July 1, 2004; 131(13): 3093 - 3105. [Abstract] [Full Text] [PDF]

				O. G. Kelly, K. I. Pinson, and W. C. Skarnes The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice Development, June 15, 2004; 131(12): 2803 - 2815. [Abstract] [Full Text] [PDF]

				A. Tallafuss and L. Bally-Cuif Tracing of her5 progeny in zebrafish transgenics reveals the dynamics of midbrain-hindbrain neurogenesis and maintenance Development, September 15, 2003; 130(18): 4307 - 4323. [Abstract] [Full Text] [PDF]

				T. J. Wright and S. L. Mansour Fgf3 and Fgf10 are required for mouse otic placode induction Development, August 1, 2003; 130(15): 3379 - 3390. [Abstract] [Full Text] [PDF]

				C. L. Chi, S. Martinez, W. Wurst, and G. R. Martin The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum Development, June 15, 2003; 130(12): 2633 - 2644. [Abstract] [Full Text] [PDF]

				F. Hirth, L. Kammermeier, E. Frei, U. Walldorf, M. Noll, and H. Reichert An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila Development, June 1, 2003; 130(11): 2365 - 2373. [Abstract] [Full Text] [PDF]

				G. Reim and M. Brand spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development Development, March 4, 2003; 129(4): 917 - 933. [Abstract] [Full Text] [PDF]

				J. Rathjen, B. P. Haines, K. M. Hudson, A. Nesci, S. Dunn, and P. D. Rathjen Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population Development, January 6, 2002; 129(11): 2649 - 2661. [Abstract] [Full Text] [PDF]

				A. Glavic, J. L. Gomez-Skarmeta, and R. Mayor The homeoprotein Xiro1 is required for midbrain-hindbrain boundary formation Development, January 4, 2002; 129(7): 1609 - 1621. [Abstract] [Full Text] [PDF]

				J. Y. H. Li and A. L. Joyner Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression Development, December 15, 2001; 128(24): 4979 - 4991. [Abstract] [Full Text] [PDF]

				J. P. Martinez-Barbera, M. Signore, P. P. Boyl, E. Puelles, D. Acampora, R. Gogoi, F. Schubert, A. Lumsden, and A. Simeone Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2 Development, December 1, 2001; 128(23): 4789 - 4800. [Abstract] [Full Text] [PDF]

				H.-G. Belting, G. Hauptmann, D. Meyer, S. Abdelilah-Seyfried, A. Chitnis, C. Eschbach, I. Soll, C. Thisse, B. Thisse, K. B. Artinger, et al. spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer Development, November 1, 2001; 128(21): 4165 - 4176. [Abstract] [Full Text] [PDF]