Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Wilson, P. A.
	Articles by Hemmati-Brivanlou, A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Wilson, P. A.
	Articles by Hemmati-Brivanlou, A.

Bolce, M. E., Hemmati-Brivanlou, A., Kushner, P. D. and Harland, R. M (1992). Ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin. Development 115, 681-688.[Abstract]

Bradley, L., Wainstock, D. and Sive, H (1996). Positive and negative signals modulate formation of the Xenopus cement gland. Development 122, 2739-2750.[Abstract]

Chen, X., Rubock, M. J. and Whitman, M (1996). A transcriptional partner for MAD proteins in TGF-beta signalling. Nature 383, 691-696.[Medline]

Dickinson, M. E., Selleck, M. A. J., McMahon, A. P. and Bronner-Fraser, M (1995). Dorsalization of the neural tube by the non-neural ectoderm. Development 121, 2099-2106.[Abstract]

Doniach, T (1995). Basic FGF as an inducer of anteroposterior neural pattern. Cell 83, 1067-70.[Medline]

Drysdale, T. and Elinson, R. P (1993). Inductive events in the patterning of the Xenopus laevis hatching and cement glands, two cell types which delimit head boundaries. Dev. Biol 158, 245-253.[Medline]

Essex, L. J., Mayor, R. M. and Sargent, M. G (1993). Expression of Xenopus snail in mesoderm and prospective neural fold ectoderm. Devel. Dynamics 198, 108-122.[Medline]

Ferguson, E. and Anderson, K (1992). Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell 71, 451-461.[Medline]

Graff, J., Thies, R. S., Song, J. J., Celeste, A. J. and Melton, D. A (1994). Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 79, 169-179.[Medline]

Graff, J. M., Bansal, A. and Melton, D. A (1996). Xenopus Mad proteins transduce distinct subsets of signals for the TGF\247 superfamily. Cell 85, 479-487.[Medline]

Grant, P. and Wacaster, J. F (1972). The amphibian grey crescent \320 a site of developmental information?. Dev. Biol 28, 454-471.[Medline]

Green, J. B. A., New, H. V. and Smith, J. C (1992). Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71, 731-739.[Medline]

Green, J. B. A., Howes, G., Symes, K., Cooke, J. and Smith, J. C (1990). The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF. Development 108, 173-183.[Abstract]

Green, J. B. A. and Smith, J. C (1990). Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. Nature 347, 391-394.[Medline]

Gurdon, J. B., Harger, P., Mitchell, A. and Lemaire, P (1994). Activin signalling and response to a morphogen gradient. Nature 371, 487-492.[Medline]

Gurdon, J. B., Mitchell, A. and Mahony, D (1995). Direct and continuous assessment by cells of their position in a morphogen gradient. Nature 376, 520-1.[Medline]

Hawley, S. H. B., Wunnenberg-Stapleton, K., Hashimoto, C., Laurent, M. N., Watabe, T., Blumberg, B. W. and Cho, K. W. Y (1995). Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes Dev 9, 2923-2935.[Abstract/Free Full Text]

Hoodless, P. A., Haerry, T., Abdollah, S., Stapleton, M., O'Connor, M. B., Attisano, L. and Wrana, J. L (1996). MADR1, a MAD-related protein that functions in BMP2 signalling pathways. Cell 85, 489-500.[Medline]

Jonas, E., Sargent, T. D. and Dawid, I. B (1985). Epidermal keratin gene expressed in embryos of Xenopus laevis. Proc. Natl. Acad. Sci. USA 82, 5413-5417.[Abstract/Free Full Text]

Kao, K. and Elinson, R (1988). The entire mesodermal mantle behaves as a Spemann organizer in dorsoanterior enhanced Xenopus embryos. Dev. Biol 127, 64-77.[Medline]

Kintner, C. R. and Melton, D. A (1987). Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. Development 99, 311-325.[Abstract]

Krieg, P., Varnum, S., Wormington, M. and Melton, D. A (1989). The mRNA encoding elongation factor 1(EF1 ) is a major transcript at the mid blastula transition in Xenopus. Dev. Biol 133, 93-100.[Medline]

Lawrence, P. A (1966). Gradients in the insect segment: the orientation of hairs in the milkweed bug Oncopeltus fasciatus. J. Exp. Biol 44, 607-620.[Abstract/Free Full Text]

Lecuit, T., Brook, W. J., Ng, M., Calleja, M., Sun, H. and Cohen, S. M (1996). Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381, 387-393.[Medline]

Liem, K. F., Tremml, G., Roelink, H. and Jessell, T. M (1995). Dorsal differentiation of neural plate cells induced by BMP-mediated signals form epidermal ectoderm. Cell 82, 969-79.[Medline]

Liu, F., Hata, A., Baker, J., Doody, J., C\207rcamo, J., Harland, R. and Massague, J (1996). A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381, 62-623.

London, C., Akers, T. and Phillips, C. R (1988). Expression of Epi1, an epidermal specific marker, in Xenopus laevis embryos is specified prior to gastrulation. Dev. Biol 129, 380-389.[Medline]

Mancilla, A. and Mayor, R (1996). Neural crest formation in Xenopus laevis : mechanisms of Xslug induction. Dev. Biol 177, 580-589.[Medline]

Mayor, R., Morgan, R. and Sargent, M. G (1995). Induction of the prospective neural crest of Xenopus. Development 121, 767-777.[Abstract]

Moury, J. M. and Jacobson, A. G (1990). The origins of neural crest cells in the Axolotl. Dev. Biol 141, 243-253.[Medline]

Nellen, D., Burke, R., Struhl, G. and Basler, K (1996). Direct and long-range action of a DPP morphogen gradient. Cell 85, 357-368.[Medline]

Piccolo, S., Sasai, Y., Lu, B. and De Robertis, E. M (1996). Dorsoventral patterning in Xenopus : inhibition of ventral signals by direct binding of chordin to BMP4. Cell 86, 589-598.[Medline]

Reilly, K. M. and Melton, D. A (1996). Short-range signaling by candidate morphogens of the TGF-beta family and evidence for a relay mechanism of induction. Cell 86, 743-754.[Medline]

Sargent, T. D., Jamrich, M. and Dawid, I. B (1986). Cell interactions and the control of gene activity during early development of Xenopus laevis. Dev. Biol 114, 238-246.[Medline]

Sasai, Y., Lu, B., Steinbeisser, H. and De Robertis, E. M (1995). Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature 376, 333-336.[Medline]

Sharpe, C. R., Fritz, A., De Robertis, E. M. and Gurdon, J. B (1987). A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction. Cell 50, 749-758.[Medline]

Sive, H. and Bradley, L (1996). A sticky problem \320 the Xenopus cement gland as a paradigm for anteroposterior patterning. Devel. Dynamics 205, 265-280.[Medline]

Smith, J. C., Price, B. M., Green, J. B., Weigel, D. and Herrmann, B. G (1991). Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell 67, 79-87.[Medline]

Smith, W. B. and Harland, R. M (1992). Expression Cloning of noggin, a New Dorsalizing Factor Localized to the Spemann Organizer in Xenopus Embryos. Cell 70, 829-840.[Medline]

Sokol, S. and Melton, D. A (1991). Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin. Nature 351, 409-411.[Medline]

Suzuki, A., Chang, C., Yingling, M., Wang, X.-F. and Hemmati-Brivanlou, A (1997). Smad5 induces ventral fates in Xenopus embryo. Dev. Biol 184, 402-405.[Medline]

Suzuki, A., Shioda, N. and Ueno, N (1995). Bone morphogenetic protein acts as a ventral mesoderm modifier in early Xenopus embryos. Develop. Growth Differ 37, 581-588.

Suzuki, A., Theis, R. S., Yamaji, N., Song, J. J., Wozney, J., Murakami, K. and Ueno, N (1994). A truncated BMP receptor affects dorsal-ventral patterning in the early Xenopus embryo. Proc. Natl. Acad. Sci. USA 91, 10255-1259.[Abstract/Free Full Text]

Thomsen, G (1996). Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. Development 122, 2359-2366.[Abstract]

Turing, A (1952). The chemical basis of morphogenesis. Philos. Trans. R. Soc. Lond 237, 37-72.

Weinstein, D. C. and Hemmati-Brivanlou, A (1997). Neural induction in Xenopus laevis ; evidence for the default model. Current Opinion in Neurobiology 7, 7-12.[Medline]

Wharton, K. A., Ray, R. P. and Gelbart, W. M (1993). An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo. Development 117, 807-822.[Abstract]

Wilson, P. A. and Hemmati-Brivanlou, A (1995). Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 376, 331-333.[Medline]

Wilson, P. A. and Melton, D. A (1994). Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Current Biology 4, 676-686.[Medline]

Wolpert, L (1969). Positional information and the spatial pattern of cellular differentiation. J. Theor. Biol 25, 1-47.[Medline]

Xu, R. H., Kim, J., Taira, M., Zhan, S., Sredni, D. and Kung, H. F (1995). A dominant-negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm. Biochem. Biophys. Res. Commun 212, 212-219.[Medline]

Yamashita, H., ten Dijke, P., Huylebroeck, D., Sampath, T. K., Andries, M., Smith, J. C., Heldin, C.-H. and Miyazono, K (1995). Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J. Cell Biol 130, 217-226.[Abstract/Free Full Text]

Zimmerman, L. B., De Jesus-Escobar, J. M. and Harland, R. M (1996). The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86, 599-606.[Medline]

This article has been cited by other articles:

B. A. Boswell, P. J. Lein, and L. S. Musil
Cross-Talk between Fibroblast Growth Factor and Bone Morphogenetic Proteins Regulates Gap Junction-mediated Intercellular Communication in Lens Cells
Mol. Biol. Cell, June 1, 2008; 19(6): 2631 - 2641.
[Abstract] [Full Text] [PDF]

J. S. Hu, L. T. Doan, D. S. Currle, M. Paff, J. Y. Rheem, R. Schreyer, B. Robert, and E. S. Monuki
Border formation in a Bmp gradient reduced to single dissociated cells
PNAS, March 4, 2008; 105(9): 3398 - 3403.
[Abstract] [Full Text] [PDF]

F. Muller, H. Rohrer, and A. Vogel-Hopker
Bone morphogenetic proteins specify the retinal pigment epithelium in the chick embryo
Development, October 1, 2007; 134(19): 3483 - 3493.
[Abstract] [Full Text] [PDF]

C.-S. Oh and S. V. Beer
AtHIPM, an Ortholog of the Apple HrpN-Interacting Protein, Is a Negative Regulator of Plant Growth and Mediates the Growth-Enhancing Effect of HrpN in Arabidopsis
Plant Physiology, October 1, 2007; 145(2): 426 - 436.
[Abstract] [Full Text] [PDF]

A. Brenner-Anantharam, C. Cebrian, R. Guillaume, R. Hurtado, T.-T. Sun, and D. Herzlinger
Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling
Development, May 15, 2007; 134(10): 1967 - 1975.
[Abstract] [Full Text] [PDF]

M.-c. Lin, J. Park, N. Kirov, and C. Rushlow
Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues
Development, December 15, 2006; 133(24): 4805 - 4813.
[Abstract] [Full Text] [PDF]

M. Knockaert, G. Sapkota, C. Alarcon, J. Massague, and A. H. Brivanlou
Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling
PNAS, August 8, 2006; 103(32): 11940 - 11945.
[Abstract] [Full Text] [PDF]

G. Reim and M. Brand
Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4
Development, July 15, 2006; 133(14): 2757 - 2770.
[Abstract] [Full Text] [PDF]

M. Ku, S. Howard, W. Ni, G. Lagna, and A. Hata
OAZ Regulates Bone Morphogenetic Protein Signaling through Smad6 Activation
J. Biol. Chem., February 24, 2006; 281(8): 5277 - 5287.
[Abstract] [Full Text] [PDF]

H. L. Ashe and J. Briscoe
The interpretation of morphogen gradients
Development, February 1, 2006; 133(3): 385 - 394.
[Abstract] [Full Text] [PDF]

M. B. Tereshina, A. G. Zaraisky, and V. V. Novoselov
Ras-dva, a member of novel family of small GTPases, is required for the anterior ectoderm patterning in the Xenopus laevis embryo
Development, February 1, 2006; 133(3): 485 - 494.
[Abstract] [Full Text] [PDF]

A. J. Levine and A. H. Brivanlou
GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos
Development, January 15, 2006; 133(2): 209 - 216.
[Abstract] [Full Text] [PDF]

S. Kuriyama, G. Lupo, K. Ohta, S.-i. Ohnuma, W. A. Harris, and H. Tanaka
Tsukushi controls ectodermal patterning and neural crest specification in Xenopus by direct regulation of BMP4 and X-delta-1 activity
Development, January 1, 2006; 133(1): 75 - 88.
[Abstract] [Full Text] [PDF]

J. Massague, J. Seoane, and D. Wotton
Smad transcription factors
Genes & Dev., December 1, 2005; 19(23): 2783 - 2810.
[Abstract] [Full Text] [PDF]

A. Litsiou, S. Hanson, and A. Streit
A balance of FGF, BMP and WNT signalling positions the future placode territory in the head
Development, September 15, 2005; 132(18): 4051 - 4062.
[Abstract] [Full Text] [PDF]

M. Matsuo-Takasaki, M. Matsumura, and Y. Sasai
An essential role of Xenopus Foxi1a for ventral specification of the cephalic ectoderm during gastrulation
Development, September 1, 2005; 132(17): 3885 - 3894.
[Abstract] [Full Text] [PDF]

T. Oren, I. Torregroza, and T. Evans
An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling
Nucleic Acids Res., August 1, 2005; 33(13): 4357 - 4367.
[Abstract] [Full Text] [PDF]

G. Keller
Embryonic stem cell differentiation: emergence of a new era in biology and medicine
Genes & Dev., May 15, 2005; 19(10): 1129 - 1155.
[Abstract] [Full Text] [PDF]

C. D. Stern
Neural induction: old problem, new findings, yet more questions
Development, May 1, 2005; 132(9): 2007 - 2021.
[Abstract] [Full Text] [PDF]

J. Tao, E. Kuliyev, X. Wang, X. Li, T. Wilanowski, S. M. Jane, P. E. Mead, and J. M. Cunningham
BMP4-dependent expression of Xenopus Grainyhead-like 1 is essential for epidermal differentiation
Development, March 1, 2005; 132(5): 1021 - 1034.
[Abstract] [Full Text] [PDF]

R. K. Ng and J. B. Gurdon
Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer
PNAS, February 8, 2005; 102(6): 1957 - 1962.
[Abstract] [Full Text] [PDF]

M. J. Morgan, J. M. Woltering, P. M. J. In der Rieden, A. J. Durston, and J. P. Thiery
YY1 Regulates the Neural Crest-associated slug Gene in Xenopus laevis
J. Biol. Chem., November 5, 2004; 279(45): 46826 - 46834.
[Abstract] [Full Text] [PDF]

A. Glavic, F. Silva, M. J. Aybar, F. Bastidas, and R. Mayor
Interplay between Notch signaling and the homeoprotein Xiro1 is required for neural crest induction in Xenopus embryos
Development, January 15, 2004; 131(2): 347 - 359.
[Abstract] [Full Text] [PDF]

C. Tribulo, M. J. Aybar, V. H. Nguyen, M. C. Mullins, and R. Mayor
Regulation of Msx genes by a Bmp gradient is essential for neural crest specification
Development, December 29, 2003; 130(26): 6441 - 6452.
[Abstract] [Full Text] [PDF]

S. M. Hussein, E. K. Duff, and C. Sirard
Smad4 and {beta}-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2
J. Biol. Chem., December 5, 2003; 278(49): 48805 - 48814.
[Abstract] [Full Text] [PDF]

E. Canalis, A. N. Economides, and E. Gazzerro
Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton
Endocr. Rev., April 1, 2003; 24(2): 218 - 235.
[Abstract] [Full Text] [PDF]

C. A. Adelman, S. Chattopadhyay, and J. J. Bieker
The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media
Development, March 3, 2003; 129(2): 539 - 549.
[Abstract] [Full Text] [PDF]

J. M. Woda, J. Pastagia, M. Mercola, and K. B. Artinger
Dlx proteins position the neural plate border and determine adjacent cell fates
Development, March 2, 2003; 130(2): 331 - 342.
[Abstract] [Full Text] [PDF]

T. Luo, Y.-H. Lee, J.-P. Saint-Jeannet, and T. D. Sargent
Induction of neural crest in Xenopus by transcription factor AP2alpha
PNAS, January 21, 2003; 100(2): 532 - 537.
[Abstract] [Full Text] [PDF]

Y. Miyanaga, I. Torregroza, and T. Evans
A Maternal Smad Protein Regulates Early Embryonic Apoptosis in Xenopus laevis
Mol. Cell. Biol., March 1, 2002; 22(5): 1317 - 1328.
[Abstract] [Full Text] [PDF]

I. Munoz-Sanjuan, E. Bell, C. R. Altmann, A. Vonica, and A. H. Brivanlou
Gene profiling during neural induction in Xenopus laevis: regulation of BMP signaling by post-transcriptional mechanisms and TAB3, a novel TAK1-binding protein
Development, January 12, 2002; 129(23): 5529 - 5540.
[Abstract] [Full Text] [PDF]

J. Larrain, M. Oelgeschlager, N. I. Ketpura, B. Reversade, L. Zakin, and E. M. De Robertis
Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling
Development, November 15, 2001; 128(22): 4439 - 4447.
[Abstract] [Full Text] [PDF]

S. A. Duncan and A. J. Watt
BMPs on the road to hepatogenesis
Genes & Dev., August 1, 2001; 15(15): 1879 - 1884.
[Full Text] [PDF]

K. Shimizu, P.-Y. Bourillot, S. J. Nielsen, A. M. Zorn, and J. B. Gurdon
Swift Is a Novel BRCT Domain Coactivator of Smad2 in Transforming Growth Factor {beta} Signaling
Mol. Cell. Biol., June 15, 2001; 21(12): 3901 - 3912.
[Abstract] [Full Text]

J. D. Potter
Morphostats: A Missing Concept in Cancer Biology
Cancer Epidemiol. Biomarkers Prev., March 1, 2001; 10(3): 161 - 170.
[Abstract] [Full Text]

C. Rushlow, P. F. Colosimo, M.-c. Lin, M. Xu, and N. Kirov
Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs
Genes & Dev., February 1, 2001; 15(3): 340 - 351.
[Abstract] [Full Text]

K. Mintzer, M. Lee, G Runke, J Trout, M Whitman, and M. Mullins
Lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation
Development, January 3, 2001; 128(6): 859 - 869.
[Abstract] [PDF]

E. M. Gonzalez, K. Fekany-Lee, A. Carmany-Rampey, C. Erter, J. Topczewski, C. V.E. Wright, and L. Solnica-Krezel
Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino
Genes & Dev., December 15, 2000; 14(24): 3087 - 3092.
[Abstract] [Full Text]

E. Pardali, X.-Q. Xie, P. Tsapogas, S. Itoh, K. Arvanitidis, C.-H. Heldin, P. ten Dijke, T. Grundstrom, and P. Sideras
Smad and AML Proteins Synergistically Confer Transforming Growth Factor beta 1 Responsiveness to Human Germ-line IgA Genes
J. Biol. Chem., February 4, 2000; 275(5): 3552 - 3560.
[Abstract] [Full Text] [PDF]

J Shou, R. Murray, P. Rim, and A. Calof
Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage
Development, January 12, 2000; 127(24): 5403 - 5413.
[Abstract] [PDF]

O Kazanskaya, A Glinka, and C Niehrs
The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning
Development, January 11, 2000; 127(22): 4981 - 4992.
[Abstract] [PDF]

K Fekany-Lee, E Gonzalez, V Miller-Bertoglio, and L Solnica-Krezel
The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways
Development, January 6, 2000; 127(11): 2333 - 2345.
[Abstract] [PDF]

V. Nguyen, J Trout, S. Connors, P Andermann, E Weinberg, and M. Mullins
Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway
Development, January 3, 2000; 127(6): 1209 - 1220.
[Abstract] [PDF]

M. Roudbaraki, A. Lorsignol, L. Langouche, G. Callewaert, H. Vankelecom, and C. Denef
Target Cells of {gamma}3-Melanocyte-Stimulating Hormone Detected through Intracellular Ca2+ Responses in Immature Rat Pituitary Constitute a Fraction of All Main Pituitary Cell Types, but Mostly Express Multiple Hormone Phenotypes at the Messenger Ribonucleic Acid Level. Refractoriness to Melanocortin-3 Receptor Blockade in the Lacto-Somatotroph Lineage
Endocrinology, October 1, 1999; 140(10): 4874 - 4885.
[Abstract] [Full Text]

D Sela-Donenfeld and C Kalcheim
Regulation of the onset of neural crest migration by coordinated activity of BMP4 and Noggin in the dorsal neural tube
Development, January 11, 1999; 126(21): 4749 - 4762.
[Abstract] [PDF]

K. Barth, Y Kishimoto, K. Rohr, C Seydler, S Schulte-Merker, and S. Wilson
Bmp activity establishes a gradient of positional information throughout the entire neural plate
Development, January 11, 1999; 126(22): 4977 - 4987.
[Abstract] [PDF]

A Jazwinska, C Rushlow, and S Roth
The role of brinker in mediating the graded response to Dpp in early Drosophila embryos
Development, January 8, 1999; 126(15): 3323 - 3334.
[Abstract] [PDF]

C Chang and A Hemmati-Brivanlou
Xenopus GDF6, a new antagonist of noggin and a partner of BMPs
Development, January 8, 1999; 126(15): 3347 - 3357.
[Abstract] [PDF]

S. Connors, J Trout, M Ekker, and M. Mullins
The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo
Development, January 6, 1999; 126(14): 3119 - 3130.
[Abstract] [PDF]

D. J. Crease, S. Dyson, and J. B. Gurdon
Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression
PNAS, April 14, 1998; 95(8): 4398 - 4403.
[Abstract] [Full Text] [PDF]

A. Hata, G. Lagna, J. Massagué, and A. Hemmati-Brivanlou
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor�suppressor
Genes & Dev., January 15, 1998; 12(2): 186 - 197.
[Abstract] [Full Text]

Y Grinblat, J Gamse, M Patel, and H Sive
Determination of the zebrafish forebrain: induction and patterning
Development, January 11, 1998; 125(22): 4403 - 4416.
[Abstract] [PDF]

C LaBonne and M Bronner-Fraser
Neural crest induction in Xenopus: evidence for a two-signal model
Development, January 7, 1998; 125(13): 2403 - 2414.
[Abstract] [PDF]

P. Mead, C. Kelley, P. Hahn, O Piedad, and L. Zon
SCL specifies hematopoietic mesoderm in Xenopus embryos
Development, January 7, 1998; 125(14): 2611 - 2620.
[Abstract] [PDF]

				J. S. Hu, L. T. Doan, D. S. Currle, M. Paff, J. Y. Rheem, R. Schreyer, B. Robert, and E. S. Monuki Border formation in a Bmp gradient reduced to single dissociated cells PNAS, March 4, 2008; 105(9): 3398 - 3403. [Abstract] [Full Text] [PDF]

				F. Muller, H. Rohrer, and A. Vogel-Hopker Bone morphogenetic proteins specify the retinal pigment epithelium in the chick embryo Development, October 1, 2007; 134(19): 3483 - 3493. [Abstract] [Full Text] [PDF]

				C.-S. Oh and S. V. Beer AtHIPM, an Ortholog of the Apple HrpN-Interacting Protein, Is a Negative Regulator of Plant Growth and Mediates the Growth-Enhancing Effect of HrpN in Arabidopsis Plant Physiology, October 1, 2007; 145(2): 426 - 436. [Abstract] [Full Text] [PDF]

				A. Brenner-Anantharam, C. Cebrian, R. Guillaume, R. Hurtado, T.-T. Sun, and D. Herzlinger Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling Development, May 15, 2007; 134(10): 1967 - 1975. [Abstract] [Full Text] [PDF]

				M.-c. Lin, J. Park, N. Kirov, and C. Rushlow Threshold response of C15 to the Dpp gradient in Drosophila is established by the cumulative effect of Smad and Zen activators and negative cues Development, December 15, 2006; 133(24): 4805 - 4813. [Abstract] [Full Text] [PDF]

				M. Knockaert, G. Sapkota, C. Alarcon, J. Massague, and A. H. Brivanlou Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling PNAS, August 8, 2006; 103(32): 11940 - 11945. [Abstract] [Full Text] [PDF]

				G. Reim and M. Brand Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4 Development, July 15, 2006; 133(14): 2757 - 2770. [Abstract] [Full Text] [PDF]

				M. Ku, S. Howard, W. Ni, G. Lagna, and A. Hata OAZ Regulates Bone Morphogenetic Protein Signaling through Smad6 Activation J. Biol. Chem., February 24, 2006; 281(8): 5277 - 5287. [Abstract] [Full Text] [PDF]

				H. L. Ashe and J. Briscoe The interpretation of morphogen gradients Development, February 1, 2006; 133(3): 385 - 394. [Abstract] [Full Text] [PDF]

				M. B. Tereshina, A. G. Zaraisky, and V. V. Novoselov Ras-dva, a member of novel family of small GTPases, is required for the anterior ectoderm patterning in the Xenopus laevis embryo Development, February 1, 2006; 133(3): 485 - 494. [Abstract] [Full Text] [PDF]

				A. J. Levine and A. H. Brivanlou GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos Development, January 15, 2006; 133(2): 209 - 216. [Abstract] [Full Text] [PDF]

				S. Kuriyama, G. Lupo, K. Ohta, S.-i. Ohnuma, W. A. Harris, and H. Tanaka Tsukushi controls ectodermal patterning and neural crest specification in Xenopus by direct regulation of BMP4 and X-delta-1 activity Development, January 1, 2006; 133(1): 75 - 88. [Abstract] [Full Text] [PDF]

				J. Massague, J. Seoane, and D. Wotton Smad transcription factors Genes & Dev., December 1, 2005; 19(23): 2783 - 2810. [Abstract] [Full Text] [PDF]

				A. Litsiou, S. Hanson, and A. Streit A balance of FGF, BMP and WNT signalling positions the future placode territory in the head Development, September 15, 2005; 132(18): 4051 - 4062. [Abstract] [Full Text] [PDF]

				M. Matsuo-Takasaki, M. Matsumura, and Y. Sasai An essential role of Xenopus Foxi1a for ventral specification of the cephalic ectoderm during gastrulation Development, September 1, 2005; 132(17): 3885 - 3894. [Abstract] [Full Text] [PDF]

				T. Oren, I. Torregroza, and T. Evans An Oct-1 binding site mediates activation of the gata2 promoter by BMP signaling Nucleic Acids Res., August 1, 2005; 33(13): 4357 - 4367. [Abstract] [Full Text] [PDF]

				G. Keller Embryonic stem cell differentiation: emergence of a new era in biology and medicine Genes & Dev., May 15, 2005; 19(10): 1129 - 1155. [Abstract] [Full Text] [PDF]

				C. D. Stern Neural induction: old problem, new findings, yet more questions Development, May 1, 2005; 132(9): 2007 - 2021. [Abstract] [Full Text] [PDF]

				J. Tao, E. Kuliyev, X. Wang, X. Li, T. Wilanowski, S. M. Jane, P. E. Mead, and J. M. Cunningham BMP4-dependent expression of Xenopus Grainyhead-like 1 is essential for epidermal differentiation Development, March 1, 2005; 132(5): 1021 - 1034. [Abstract] [Full Text] [PDF]

				R. K. Ng and J. B. Gurdon Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer PNAS, February 8, 2005; 102(6): 1957 - 1962. [Abstract] [Full Text] [PDF]

				M. J. Morgan, J. M. Woltering, P. M. J. In der Rieden, A. J. Durston, and J. P. Thiery YY1 Regulates the Neural Crest-associated slug Gene in Xenopus laevis J. Biol. Chem., November 5, 2004; 279(45): 46826 - 46834. [Abstract] [Full Text] [PDF]

				A. Glavic, F. Silva, M. J. Aybar, F. Bastidas, and R. Mayor Interplay between Notch signaling and the homeoprotein Xiro1 is required for neural crest induction in Xenopus embryos Development, January 15, 2004; 131(2): 347 - 359. [Abstract] [Full Text] [PDF]

				C. Tribulo, M. J. Aybar, V. H. Nguyen, M. C. Mullins, and R. Mayor Regulation of Msx genes by a Bmp gradient is essential for neural crest specification Development, December 29, 2003; 130(26): 6441 - 6452. [Abstract] [Full Text] [PDF]

				S. M. Hussein, E. K. Duff, and C. Sirard Smad4 and {beta}-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2 J. Biol. Chem., December 5, 2003; 278(49): 48805 - 48814. [Abstract] [Full Text] [PDF]

				E. Canalis, A. N. Economides, and E. Gazzerro Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton Endocr. Rev., April 1, 2003; 24(2): 218 - 235. [Abstract] [Full Text] [PDF]

				C. A. Adelman, S. Chattopadhyay, and J. J. Bieker The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media Development, March 3, 2003; 129(2): 539 - 549. [Abstract] [Full Text] [PDF]

				J. M. Woda, J. Pastagia, M. Mercola, and K. B. Artinger Dlx proteins position the neural plate border and determine adjacent cell fates Development, March 2, 2003; 130(2): 331 - 342. [Abstract] [Full Text] [PDF]

				T. Luo, Y.-H. Lee, J.-P. Saint-Jeannet, and T. D. Sargent Induction of neural crest in Xenopus by transcription factor AP2alpha PNAS, January 21, 2003; 100(2): 532 - 537. [Abstract] [Full Text] [PDF]

				Y. Miyanaga, I. Torregroza, and T. Evans A Maternal Smad Protein Regulates Early Embryonic Apoptosis in Xenopus laevis Mol. Cell. Biol., March 1, 2002; 22(5): 1317 - 1328. [Abstract] [Full Text] [PDF]

				I. Munoz-Sanjuan, E. Bell, C. R. Altmann, A. Vonica, and A. H. Brivanlou Gene profiling during neural induction in Xenopus laevis: regulation of BMP signaling by post-transcriptional mechanisms and TAB3, a novel TAK1-binding protein Development, January 12, 2002; 129(23): 5529 - 5540. [Abstract] [Full Text] [PDF]