Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body

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Acampora, D., Mazan, S., Lallemand, Y. Avantaggiato, V., Maury, M., Simeone, A. and Brulet, P (1995). Forebrain and midbrain regions are deleted in Otx/ mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121, 3279-3290.[Abstract]

Aggleton, J. P. and Mischkin, M (1985). Mammillary-body lesions and visual recognition in monkeys. Exp. Brain Res 58, 190-197.[Medline]

Aggleton, J. P., Hunt, P. R. and Shaw, C (1990). The effects of mammillary body and combined amygdalar-fornix lesions on tests of delayed non-matching-to-sample in the rat. Behav. Brain Res 40, 145-157.[Medline]

Aggleton, J. P., Keith, A. B. and Sahgal, A (1991). Both fornix and anterior thalamic, but not mammillary, lesions disrupt delayed non-matching-to-position memory in rats. Behav. Brain Res 44, 151-161.[Medline]

Allen, G. V. and Hopkins, D. A (1989). Mammillary body in the rat: topography and synaptology of projections from the subicular complex, prefrontal cortex, and midbrain tegmentum. J. Comp. Neurol 286, 311-336.[Medline]

Allen, N. D., Cran, D. G., Barton, S. C., Hettle, S., Reik, W. and Surani, M. A (1988). Transgenes as probes for active chromosomal domains in mouse development. Nature 333, 852-855.[Medline]

Ang, S. and Rossant, J (1994). HNF-3is essential for node and notochord formation in mouse development. Cell 78, 561-574.[Medline]

Ang, S. L., Wierda, A., Wong, D., Stevens, K., Cascio, S., Rossant, J. and Zaret, K. S (1993). The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 119, 1301-1315.[Abstract]

Asano, M. and Gruss, P (1992). Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development. Mech. Dev 33, 27-38.

Bach, M. E., Hawkins, R. D., Osman, M., Kandel, E. R. and Mayford, M (1995). Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell 81, 905-915.[Medline]

Brown, J.R., Ye, H., Bronson, R.T., Dikkes, P. and Greenberg, M.E (1996). A defect in nurturing in mice lacking the immediate early gene fosB. Cell 86, 297-309.[Medline]

Cadigan, K. M., Grossniklaus, U. and Gehring, W. J (1994). Functional redundancy: the respective roles of the two sloppy paired genes in Drosophila segmentation. Proc. Natl. Acad. Sci. USA 91, 6324-6328.[Abstract/Free Full Text]

Chalepakis, G., Stoykova, A., Wijnholds, J., Tremblay, P. and Gruss, P (1993). Pax: Gene regulators in the developing nervous system. J. Neurobiol 24, 1367-1384.[Medline]

Cheng, H.-J., Nakamoto, M., Bergemann, A. D. and Flanagan, J. G (1995). Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell 82, 371-381.[Medline]

Clark, K., Halay, E., Lai, E. and Burley, S (1993). Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 364, 412-420.[Medline]

Drescher, U., Kremoser, C., Handwerker, C., Loschinger, J., Noda, M. and Bonhoeffer, F (1995). In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell 82, 359-370.[Medline]

Field, T. D., Rosenstock, J., King, E. C. and Greene, E (1978). Behavioral role of the mammillary efferent system. Brain Res. Bull 3, 451-456.[Medline]

Fleming, A .S. and Rosenblatt, J. S (1974). Olfactory regulation of maternal behavior in rats: I. Effects of olfactory bulb removal in experienced and inexperienced lactating and cycling females. J. Comp. Physiol. Psych 86, 221-232.[Medline]

Fleming, A. S., Vaccarino, F. and Luebke, C (1980). Amygdaloid inhibition of maternal behavior in the nulliparous female rat. Physiol. Behav 25, 731-743.[Medline]

Fleming, A. S., Miceli, M. and Moretto, D (1983). Lesions of the medial preoptic area prevent the facilitation of maternal behavior produced by amygdala deletions. Physiol. Behav 31, 503-510.[Medline]

Gandelman, R., Zarrow, M. X., Denenberg, V. H. and Myers, M (1971). Olfactory bulb removal eliminates maternal behavior in the mouse. Science 171, 210-211.[Abstract/Free Full Text]

Grossniklaus, U., Kurth Pearsen, R. and Gehring, W. J (1992). The Drosophila sloppy paired locusencodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes Dev 6, 1030-1051.[Abstract/Free Full Text]

Guillery, R.W (1955). A quantitative study of the mammillary bodies and their connexions. J. Anat 89, 19-32.[Medline]

Hallonet, M. E. R., Teillet, M.-A. and Le Douarin, N. M (1990). A new approach to the development of the cerebellum provided by the quail-chick marker system. Development 108, 19-31.[Abstract]

Harper, D. N., Mc Lean, A. P. and Dalrymple-Alford, J. C (1994). Forgetting in rats following medial septum or mammillary body damage. Behav. Neurosci 108, 691-702.[Medline]

Hunt, P. R. and Aggleton, J. P (1991). Medial dorsal thalamic lesions and working memory in the rat. Behav. Neural Biol 55, 227-246.[Medline]

Itsaki, N., Ichijo, H., Hama, C., Matsuno, T. and Nakamura, H (1991). Establishment of rostrocaudal polarity in tectal primordium : engrailed expression and subsequent tectal polarity. Development 113, 1133-1144.[Abstract]

Jostes, B., Walther, C. and Gruss, P (1991). The murine paired box gene, Pax7 , is expressed specifically during the development of the nervous and muscular system. Mech. Dev 33, 27-38.

Joyner, A. L (1996). Engrailed , Wnt and Pax genes regulate midbrain-hindbrain development. Trends Genet 12, 15-20.[Medline]

Joyner, A. L., Kornberg, T., Coleman, K. G., Cox, D. R. and Martin, G. R (1985). Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell 43, 29-37.[Medline]

Joyner, A. L., Skarnes, W. C. and Rossant, J (1989). Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells. Nature 338, 153-156.[Medline]

Kaestner, K., Monaghan, A., Kern, H., Ang, S., Weitz, S., Lichter, P. and Schutz, G (1995). The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization. J. Biol. Chem 270, 30029-30035.[Abstract/Free Full Text]

Kaestner, K. H., Schutz, G. and Monaghan, A. P (1996). Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system. Mech. Dev 55, 221-230.[Medline]

Kaufmann, E. and Kn\232chel, W (1996). Five years on the wings of fork head. Mech. Dev 57, 3-20.[Medline]

Kopelman, M.D (1995). The Korsakoff syndrome. Brit. J. Psychiatry 166, 154-173.[Abstract/Free Full Text]

Labosky, P.A., Winnier, G.F., Sasaki, H., Blessing, M. and Hogan, B.L.M (1996). : The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development. Genomics 34, 241-245.[Medline]

Labosky, P.A., Winnier, G.E., Jetton, T. L., Hargett, L., Ryan, AimeeK. R., Rosenfeld, M.G., Parlow, A.F. and Hogan, B. L (1997). The winged helix gene, Mf3 , is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-injection reflex. Development 124, 1263-1274.[Abstract]

Logan, C., Wizenmann, A., Drescher, U., Monschau, B., Bonhoeffer, F. and Lumbsden, A (1996). Rostral optic tectum acquires caudal characteristics following ectopic Engrailed expression. Cur. Biol 6, 1006-1014.[Medline]

Mansour, S. L., Thomas, K. R. and Capecchi, M. R (1988). Disruption of the prot-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336, 348-352.[Medline]

Mansouri, A., Stoykova, A., Torres, M. and Gruss, P (1996). Dysgenesis of cephalic neural crest derivatives in Pax 7/ mutant mice. Development 122, 831-838.[Abstract]

Moser, E., Moser, M.-B. and Andersen, P (1993). Spatial learning impairments parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J. Neurosci 13, 3916-3925.[Abstract]

Matsuo, I., Kuratani, S., Kimura, C., Takeda, N. and Aizawa, S (1995). Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev 9, 2646-2658.[Abstract/Free Full Text]

McMahon, A. P. and Bradley, A (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085.[Medline]

Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. and Roder, J. C (1993). Derivation of completely cell culture-derived mice from early passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90, 8424-8428.[Abstract/Free Full Text]

Numan, M., Coromas, K.P., Numan, M.J., Factor, E.M., Piers, W.D (1988). Axon sparing lesions in the preoptic area and substantia innominata disrupt maternal behavior in rats. Behav. Neurosci 102, 381-396.[Medline]

Pellegrini, M., Mansouri, A., Simeone, A., Boncinelli, E. and Gruss, P (1996). Dentate gyrus formation requires Emx2. Development 122, 3993-3898.

Price, M., Lemaistre, M., Pischetola, M., Di Lauro, R. and Duboule, D (1991). A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature 351, 748-751.[Medline]

Qiu, M., Bulfone, A., Martinez, S., Meneses, J., Shimamura, K., Pedersen, R. and Rubenstein, J (1995). Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain. Genes Dev 9, 2523-2538.[Abstract/Free Full Text]

Rosenstock, J., Field, T. D. and Greene, E (1977). The role of mammillary bodies in spatial memory. Exp. Neurol 55, 340-352.[Medline]

Saravis, S., Sziklas, V. and Petrides, M (1990). Memory for places and the region of the mammillary bodies in rats. Eur. J. Neurosci 2, 556-564.[Medline]

Sasaki, H. and Hogan, B. L (1994). HNF-3 as a regulator of floor plate development. Cell 76, 103-115.[Medline]

Sasaki, H. and Hogan, B. L. M (1993). Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118, 47-59.[Abstract]

Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A. and Boncinelli, E (1992). Nested expression domains of four homeobox genes in developing rostral brain. Nature 358, 687-690.[Medline]

Simeone, A., Gulisano, M., Acampora, D., Stornaiuolo, A., Rambaldi, M. and Boncinelli, E (1992). Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J 11, 2541-2550.[Medline]

Soriano, P., Montgomery, C., Geske, R. and Bradley, A (1991). Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64, 693-702.[Medline]

Stoykova, A. and Gruss, P (1994). Roles of Pax -genes in developing and adult brain as suggested by expression patterns. J. Neurosci 14, 1395-1412.[Abstract]

Swanson, L. W. and Cowan, W. M (1975). Hippocampo-hypothalamic connections: origin in subicular cortex, not ammon's horn. Science 189, 303-304.[Abstract/Free Full Text]

Tam, P. P. L (1989). Regionalisation of the mouse embryonic ectoderm: allocation of prospective ectodermal tissues during gastrulation. Development 107, 55-67.[Abstract]

Tao, W. and Lai, E (1992). Telencephalon-restricted expression of BF-1 , a new member of the HNF-3/fork head gene family in the developing rat brain. Neuron 8, 957-966.[Medline]

Thomas, K. R. and Capecchi, M. R (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346, 847-850.[Medline]

Urbanek, P., Wang, Z. Q., Fetka, I., Wagner, E. F. and Busslinger, M (1994). Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79, 901-912.[Medline]

Voss, J. W. and Rosenfeld, M. G (1992). Anterior pituitary development: short tales from dwarf mice. Cell 70, 527-530.[Medline]

Weigel, D., Jurgens, G., Kuttner, F., Seifert, E. and J\212ckle, H (1989). The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo. Cell 57, 645-658.[Medline]

Weinstein, D. C., Ruiz i Altaba, A., Chen, W. S., Hoodless, P., Prezioso, V. R., Jessell, T. M. and Darnell, J. E (1994). The winged-helix transcription factor HNF-3 is required for notochord development in the mouse embryo. Cell 78, 575-588.[Medline]

Wurst, W., Auerbach, A. B. and Joyner, A. L (1994). Multiple developmental defects in Engrailed-1 mutant mice: and early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120, 2065-2075.[Abstract]

Xuan, S., Baptista, C. A., Balas, G., Tao, W., Soares, V. C. and Lai, E (1995). Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron 14, 1141-1152.[Medline]

Yuasa, J., Hirano, S., Yamagata, M. and Noda, M (1996). Visual projection map specified by topographic expression of transcription factors in the retina. Nature 382, 632-635.[Medline]

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				J. P. H. Burbach, S. M. Luckman, D. Murphy, and H. Gainer Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System Physiol Rev, July 1, 2001; 81(3): 1197 - 1267. [Abstract] [Full Text] [PDF]

				C. Perez-Sanchez, M. A. Gomez-Ferreria, C. A. de la Fuente, B. Granadino, G. Velasco, A. Esteban-Gamboa, and J. Rey-Campos FHX, a Novel Fork Head Factor with a Dual DNA Binding Specificity J. Biol. Chem., April 21, 2000; 275(17): 12909 - 12916. [Abstract] [Full Text] [PDF]

				T. Kume, K. Deng, and B. L. M. Hogan Minimal Phenotype of Mice Homozygous for a Null Mutation in the Forkhead/Winged Helix Gene, Mf2 Mol. Cell. Biol., February 15, 2000; 20(4): 1419 - 1425. [Abstract] [Full Text]

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