A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing

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Alcedo, J., Ayzenzon, M., von Ohlen, T., Noll, M. and Hooper, J (1996). The Drosophila smoothened gene encodes a seven pass membrane protein, a putative receptor for the Hedgehog signal. Cell 86, 221-232.[Medline]

Aza-Blanc, P., Ram\222rez-Weber, F.-A., Laget, M.-P., Schwartz, C. and Kornberg, T. B (1997). Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.[Medline]

Basler, K. and Struhl, G (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.[Medline]

Blackman, R. K., Sanicola, M., Raftery, L. A., Gillevet, T. and Gelbart, W. M (1991). An extensive 3cis-regulatory region directs the imaginal disc expression of decapentaplegic , a member of the TGF-b family in Drosophila. Development 111, 657-665.[Abstract]

Blair, S (1992). engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila. Development 115, 21-33.[Abstract]

Brand, A. and Perrimon, N (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.[Abstract]

Burke, R. and Basler, K (1996). Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing. Development 122, 2261-2269.[Abstract]

Capdevila, J., Estrada, M. P., S\207nchez-Herrero, E. and Guerrero, I (1994). The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J 13, 71-82.[Medline]

Chen, Y. and Struhl, G (1996). Dual roles for Patched in sequestering and transducing Hedgehog. Cell 87, 553-563.[Medline]

de Celis, J. F., Barrio, R. and Kafatos, F. C (1996). A gene complex acting downstream of dpp in Drosophila wing morphogenesis. Nature 381, 421-424.[Medline]

Diaz-Benjumea, F. J. and Cohen, S. M (1995). Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development 121, 4215-4225.[Abstract]

Dominguez, M., Brunner, M., Hafen, E. and Basler, K (1996). Sending and receiving the Hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-1625.[Abstract]

Ericson, J., Morton, S., Kawakami, A., Roelink, H. and Jessell, T. M (1996). Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673.[Medline]

Ericson, J., Rashbass, P., Schedl, A., Brenner-Morton, S., Kawakami, A., van Heyningen, V., Jessell, T. M. and Briscoe, J (1997). Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling. Cell 90, 169-180.[Medline]

Fan, C. M., Porter, J. A., Chiang, C., Chang, D. T., Beachy, P. A. and Tessier-Lavigne, M (1995). Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81, 457-465.[Medline]

Fietz, M. J., Jacinto, A., Taylor, A. M., Alexandre, C. and Ingham, P. W (1995). Secretion of the amino-terminal fragment of Hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila. Curr. Biol 5, 643-650.[Medline]

Guillen, I., Mullor, J. L., Capdevilla, J., Sanchez-Herrero, E., Morata, G. and Guerrero, I (1995). The function of engrailed and the specification of Drosophila wing pattern. Development 121, 3447-3456.[Abstract]

Heemskerk, J. and DiNardo, S (1994). Drosophila hedgehog acts as a morphogen in cellular patterning. Cell 76, 449-460.[Medline]

Hidalgo, A (1994). Three distinct roles for the engrailed gene in Drosophila wing development. Curr. Biol 4, 1087-1098.[Medline]

Ingham, P. W (1993). Localized hedgehog activity controls spatially restricted transcription of wingless in the Drosophila embryo. Nature 366, 560-562.[Medline]

Ingham, P. W. and Fietz, M. J (1995). Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing. Curr. Biol 5, 432-440.[Medline]

Ingham, P. W., Taylor, A. M. and Nakano, Y (1991). Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187.[Medline]

Jiang, J. and Struhl, G (1995). Protein kinase A and Hedgehog signaling in Drosophila limb development. Cell 80, 563-572.[Medline]

Johnson, R. L., Grenier, J. K. and Scott, M. P (1995). patched overexpression alters wing disc size and pattern: transcription and post-transcriptional effects on hedgehog targets. Development 121, 4161-4170.[Abstract]

Lecuit, T., Brook, W. J., Ng, M., Calleja, M., Sun, H. and Cohen, S. M (1996). Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381, 387-393.[Medline]

Lecuit, T. and Cohen, S. M (1997). Proximal-distal axis formation in the Drosophila leg. Nature 388, 139-145.[Medline]

Lee, J. J., Ekker, S. C., von Kessler, D. P., Porter, J. A., Sun, B. I. and Beachy, P. A (1994). Autoproteolysis in hedgehog protein biogenesis. Science 266, 1528-1537.[Abstract/Free Full Text]

Lee, J. J., von Kessler, D. P., Parks, S. and Beachy, P. A (1992). Secretion and localized transcript suggest a role in positional signalling for products of the segmentation gene hedgehog. Cell 71, 33-50.[Medline]

Ma, C., Zhou, Y., Beachy, P. and Moses, K (1993). The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell 75, 927-938.[Medline]

Marigo, V., Davey, R. A., Zuo, Y., Cunnigham, J. M. and Tabin, C. J (1996). Biochemical evidence that Patched is the Hedgehog receptor. Nature 384, 176-179.[Medline]

Marigo, V. and Tabin, C. J (1996). Regulation of patched by sonic hedgehog in the developing neural tube. Proc. Natl. Acad. Sci. USA 93, 9346-9351.[Abstract/Free Full Text]

Marti, E., Takada, R., Bumcrot, D. A., Sasaki, H. and McMahon, A. P (1995). Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development 121, 2537-2547.[Abstract]

Motzny, C. K. and Holmgren, R. A (1995). The Drosophila cubitus interruptus protein and its role in wingless and hedgehog signal transduction pathways. Mech. Dev 52, 137-150.[Medline]

Mullor, J. L., Calleja, M., Capdevila, J. and Guerrero, I (1997). Hedgehog activity, independent of Decapentaplegic, participates in wing disc patterning. Development 124, 1227-1237.[Abstract]

Nellen, D., Burke, R., Struhl, G. and Basler, K (1996). Direct and long-range action of a Dpp morphogen gradient. Cell 85, 357-368.[Medline]

Neumann, C. J. and Cohen, S. M (1997). Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. Development 124, 871-880.[Abstract]

Pan, D. J. and Rubin, G (1995). Protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543-552.[Medline]

Patel, N. H., Martin-Blanco, E., Coleman, K. G., Poole, S. J., Ellis, M. C., Kornberg, T. B. and Goodman, C. S (1989). Expression of engrailed proteins in Arthropods, Annelids, and Chordates. Cell 58, 955-968.[Medline]

Phillips, R. G., Roberts, I. J. H., Ingham, P. W. and Whittle, J. R. S (1990). The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs. Development 110, 105-114.[Abstract]

Pignoni, F. and Zipursky, S. L (1997). Induction of Drosophila eye development by decapentaplegic. Development 124, 271-278.[Abstract]

Porter, J. A., von Kessler, D. P., Ekker, S. C., Young, K. E., Lee, J. J., Moses, K. and Beachy, P (1995). The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 374, 363-366.[Medline]

Porter, J. A., Ekker, S. C., Park, W.-J., von Kessler, D. P., Young, K. E., Chen, C.-H., Ma, Y., Woods, A. S., Cotter, R. J., Koonin, E. V. and Beachy, P (1996). Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell 86, 21-34.[Medline]

Porter, J. A., Young, K. E. and Beachy, P. A (1996). Cholesterol modification of hedgehog signaling proteins in animal development. Science 274, 255-259.[Abstract/Free Full Text]

Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C (1993). sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Roelink, H., Porter, J. A., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. and Jessell, T. M (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81, 445-455.[Medline]

Schwartz, C., Locke, J., Nishida, C. and Kornberg, T. B (1995). Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal discs. Development 121, 1625-1635.[Abstract]

Simmonds, A. J., Brook, W. J., Cohen, S. M. and Bell, J. B (1995). Distinguishable functions for engrailed and invected in anterior-posterior patterning in the Drosophila wing. Nature 376, 424-427.[Medline]

Singer, M. A., Penton, A., Twombly, V., Hoffmann, F. M. and Gelbart, W. M (1997). Signaling through both type I Dpp receptors is required for anterior-posterior patterning of the entire Drosophila wing. Development 124, 79-89.[Abstract]

Slusarski, D. C., Motzny, C. K. and Holmgren, R. A (1995). Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster. Genetics 139, 229-240.[Abstract]

Stone, D. M., Hynes, M., Armanini, M., Swanson, T. A., Gu, Q., Johnson, R. L., Scott, M. P., Pennica, D., Goddard, A., Phillips, H., Noll, M., Hooper, J. E., de Sauvage, F. and Rosenthal, A (1996). The tumor-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 129-134.[Medline]

Struhl, G., Barbash, D. A. and Lawrence, P. A (1997). Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen. Development 124, 2155-2165.[Abstract]

Struhl, G., Barbash, D. A. and Lawrence, P. A (1997). Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen. Development 124, 2143-2154.[Abstract]

Struhl, G. and Basler, K (1993). Organizing activity of wingless protein in Drosophila. Cell 72, 527-540.[Medline]

Strutt, D. and Mlodzik, M (1995). Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions. Development 121, 4247-4256.[Abstract]

Sturtevant, M. A., Biehs, B., Marin, E. and Bier, E. A (1997). The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing. Development 124, 21-32.[Abstract]

Tabata, T. and Kornberg, T (1994). Hedgehog is a signalling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102.[Medline]

Tabata, T., Schwartz, C., Gustavson, E., Ali, Z. and Kornberg, T. B (1995). Creating a Drosophila wing de novo: the role of engrailed and the compartment border hypothesis. Development 121, 3359-3369.[Abstract]

van den Heuvel, M. and Ingham, P. W (1996). smoothened encodes a receptor-like serpentine protein required for Hedgehog signaling. Nature 382, 547-551.[Medline]

Zecca, M., Basler, K. and Struhl, G (1995). Sequential organizing activities of engrailed,hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265-2278.[Abstract]

Zecca, M., Basler, K. and Struhl, G (1996). Direct and long-range action of a Wingless morphogen gradient. Cell 87, 833-844.[Medline]

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				R. M. Goodman, S. Thombre, Z. Firtina, D. Gray, D. Betts, J. Roebuck, E. P. Spana, and E. M. Selva Sprinter: a novel transmembrane protein required for Wg secretion and signaling Development, December 15, 2006; 133(24): 4901 - 4911. [Abstract] [Full Text] [PDF]

				T. D. Shippy, C. D. Rogers, R. W. Beeman, S. J. Brown, and R. E. Denell The Tribolium castaneum Ortholog of Sex combs reduced Controls Dorsal Ridge Development Genetics, September 1, 2006; 174(1): 297 - 307. [Abstract] [Full Text] [PDF]

				A. Gallet, L. Ruel, L. Staccini-Lavenant, and P. P. Therond Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia Development, February 1, 2006; 133(3): 407 - 418. [Abstract] [Full Text] [PDF]

				D. Huangfu and K. V. Anderson Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates Development, January 1, 2006; 133(1): 3 - 14. [Abstract] [Full Text] [PDF]

				S. K. Pallavi and L. S. Shashidhara Signaling interactions between squamous and columnar epithelia of the Drosophila wing disc J. Cell Sci., August 1, 2005; 118(15): 3363 - 3370. [Abstract] [Full Text] [PDF]

				R. T. Collins and S. M. Cohen A Genetic Screen in Drosophila for Identifying Novel Components of the Hedgehog Signaling Pathway Genetics, May 1, 2005; 170(1): 173 - 184. [Abstract] [Full Text] [PDF]

				K. S. Ho, K. Suyama, M. Fish, and M. P. Scott Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused Development, March 15, 2005; 132(6): 1401 - 1412. [Abstract] [Full Text] [PDF]

				D. J. Bornemann, J. E. Duncan, W. Staatz, S. Selleck, and R. Warrior Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways Development, May 1, 2004; 131(9): 1927 - 1938. [Abstract] [Full Text] [PDF]

				O. Cook, B. Biehs, and E. Bier brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila Development, May 1, 2004; 131(9): 2113 - 2124. [Abstract] [Full Text] [PDF]

				T. Tabata and Y. Takei Morphogens, their identification and regulation Development, February 15, 2004; 131(4): 703 - 712. [Abstract] [Full Text] [PDF]

				C. Han, T. Y. Belenkaya, B. Wang, and X. Lin Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process Development, February 1, 2004; 131(3): 601 - 611. [Abstract] [Full Text] [PDF]

				Y. Takei, Y. Ozawa, M. Sato, A. Watanabe, and T. Tabata Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans Development, January 1, 2004; 131(1): 73 - 82. [Abstract] [Full Text] [PDF]

				A. J. Giraldez and S. M. Cohen Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development Development, December 29, 2003; 130(26): 6533 - 6543. [Abstract] [Full Text] [PDF]

				J. I. Horabin, S. Walthall, C. Vied, and M. Moses A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch Development, December 15, 2003; 130(24): 6101 - 6109. [Abstract] [Full Text] [PDF]

				J. Jia, C. Tong, and J. Jiang Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail Genes & Dev., November 1, 2003; 17(21): 2709 - 2720. [Abstract] [Full Text] [PDF]

				W. Fu and N. E. Baker Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development Development, November 1, 2003; 130(21): 5229 - 5239. [Abstract] [Full Text] [PDF]

				J. E. Hooper Smoothened translates Hedgehog levels into distinct responses Development, September 1, 2003; 130(17): 3951 - 3963. [Abstract] [Full Text] [PDF]

				M. Fujise, S. Takeo, K. Kamimura, T. Matsuo, T. Aigaki, S. Izumi, and H. Nakato Dally regulates Dpp morphogen gradient formation in the Drosophila wing Development, April 15, 2003; 130(8): 1515 - 1522. [Abstract] [Full Text] [PDF]

				M. Crozatier, B. Glise, and A. Vincent Connecting Hh, Dpp and EGF signalling in patterning of the Drosophila wing; the pivotal role of collier/knot in the AP organiser Development, March 11, 2003; 129(18): 4261 - 4269. [Abstract] [Full Text] [PDF]

				C. A. Micchelli, I. The, E. Selva, V. Mogila, and N. Perrimon rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling Development, March 4, 2003; 129(4): 843 - 851. [Abstract] [Full Text] [PDF]

				Y. Nakamura, N. Haines, J. Chen, T. Okajima, K. Furukawa, T. Urano, P. Stanley, K. D. Irvine, and K. Furukawa Identification of a Drosophila Gene Encoding Xylosylprotein beta 4-Galactosyltransferase That Is Essential for the Synthesis of Glycosaminoglycans and for Morphogenesis J. Biol. Chem., November 22, 2002; 277(48): 46280 - 46288. [Abstract] [Full Text] [PDF]

				C. Maurange and R. Paro A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development Genes & Dev., October 15, 2002; 16(20): 2672 - 2683. [Abstract] [Full Text] [PDF]

				M. Ascano Jr., K. E. Nybakken, J. Sosinski, M. A. Stegman, and D. J. Robbins The Carboxyl-Terminal Domain of the Protein Kinase Fused Can Function as a Dominant Inhibitor of Hedgehog Signaling Mol. Cell. Biol., March 1, 2002; 22(5): 1555 - 1566. [Abstract] [Full Text] [PDF]

				K. Amanai and J. Jiang Distinct roles of Central missing and Dispatched in sending the Hedgehog signal Development, December 15, 2001; 128(24): 5119 - 5127. [Abstract] [Full Text] [PDF]

				P. W. Ingham Hedgehog Signaling: A Tale of Two Lipids Science, November 30, 2001; 294(5548): 1879 - 1881. [Abstract] [Full Text] [PDF]

				Y. Apidianakis, D. Grbavec, S. Stifani, and C. Delidakis Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch Development, November 1, 2001; 128(21): 4361 - 4370. [Abstract] [Full Text] [PDF]

				J. A. Kiger Jr. and C. O'Shea Genetic Evidence for a Protein Kinase A/Cubitus Interruptus Complex That Facilitates Processing of Cubitus Interruptus in Drosophila Genetics, July 1, 2001; 158(3): 1157 - 1166. [Abstract] [Full Text] [PDF]