ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice

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Altiok, N., Bessereau. J. and Changeux, J (1995). ErbB3 and ErbB2/ neu mediate the effect of heregulin on acetylcholine receptor gene expression in muscle: differential expression at the endplate. EMBO J 14, 4258-4266.[Medline]

Altman, J. and Bayer, S. A (1985). Embryonic development of the rat cerebellum. I. Delineation of the cerebellar primordium and early cell movements. J. Comp. Neuro 231, 1-26.[Medline]

Bally-Cuif, L., Alvarado-Mallart, R., Darnell, D. K. and Wassef, M (1992). Relationship between Wnt-1 and En-2 expression domains during early development of normal and ectopic met-mesencephalon. Development 115, 999-1009.[Abstract]

Carraway K. L. R. and Cantley L. C (1994). A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell 78, 5-8.[Medline]

Carraway, K., Sliwkowski, M., Akita, R., Platko, J., Guy, P., Nuijens, A., Diamonti, J., Vandlen, R., Cantley, L. and Cerione, R (1994). The erbB3 gene product is a receptor for heregulin. J. Biol. Chem 269, 14303-14306.[Abstract/Free Full Text]

Choi, H. K., Won, L., Roback, J. D., Wainer, B. H. and Heller, A (1992). Specific modulation of dopamine expression in neuronal hybrid cells by primary cells from different brain regions. Proc. Natl. Acad. Sci. USA 89, 8943-8947.[Abstract/Free Full Text]

Corfas, G., Rosen, K. M., Aratake, H., Krauss, R. and Fischbach, G. D (1995). Differential expression of ARIA isoforms in the rat brain. Neuron 14, 103-115.[Medline]

Coussens, L., Yang-Feng, T. L., Liao, Y., Chen, E., Gray, A., McGrath, J., Seeburg, P. H., Libermann, T. A., Schlessinger, J., Francke, U., Levinson, A. and Ullrich, A (1985). Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 230, 1132-1139.[Abstract/Free Full Text]

Culouscou, J., Plowman, G., Carlton, G., Green, J. and Shoyab, M (1993). Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180 erbB4 receptor. J. Biol. Chem 268, 18407-18410.[Abstract/Free Full Text]

D'Amico-Martel, A. and Noden, D. M (1983). Contributions of placodal and neural crest cells to avian cranial peripheral ganglia. Am. J. Anat 166, 445-468.[Medline]

Danielian, P. S. and McMahon, A. P (1996). Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383, 332-334.[Medline]

Davis, C. A., Holmyard, D. P., Millen, K. J. and Joyner, A. L (1991). Examining pattern formation in mouse, chicken and frog embryos with an En -specific antiserum. Development 111, 287-298.[Abstract]

Desmond, M. E. and Schoenwolf, G. C (1986). Evaluation of the roles of intrinsic and extrinsic factors in occlusion of the spinal neurocoel during rapid brain enlargement in the chick embryo. J. Embryol. Exp. Morph 97, 25-46.[Medline]

Dent, J. A., Polson, A. G. and Klymkowsky, M. W (1989). A whole-mount immunocytochemical analysis of the expression of the intermediate filament protein vimentin in Xenopus. Development 105, 61-74.[Abstract]

Dong, Z., Brennan, A., Liu, N., Yarden,Y., Lefkowitz, G., Mirsky, R. and Jessen, K. R (1995). Neu differentiation factor is a neuron-glial signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. Neuron 15, 585-596.[Medline]

Earp, H. S., Dawson, T. L., Li, X. and Yu, H (1995). Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research. Breast Cancer Research and Treatment 35, 115-132.[Medline]

Eisenberg, L. M. and Markwald, R. R (1995). Molecular regulation of valvuloseptal morphogenesis. Circ. Res 77, 1-6.[Free Full Text]

Falls, D. L., Rosen, K. M., Corfas, G., Lane, W. S. and Fischbach, G. D (1993). ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family. Cell 72, 801-15.[Medline]

Francoeur, J. R., Richardson, P. M., Dunn, R. J. and Carbonetto, S (1995). Distribution of erb-B2, erb-B3 and erb-B4 in the developing avian nervous system. J. Neurosci. Res 41, 836-845.[Medline]

Gassmann, M., Casagranda, F., Orioli, D., Simon, H., Lai, C. Klein, R. and Lemke, G (1995). Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378, 390-394.[Medline]

Graus-Porta, D., Beerli, R. R. and Hynes, N. E (1995). Single-chain antibody-mediated intracellular retention of ErbB-2 impairs neu differentiation factor and epidermal growth factor signaling. Molec. Cell. Biol 15, 1182-91.[Abstract]

Gudas, L. J (1994). Retinoids and vertebrate development. J. Biol. Chem 269, 15399-402.[Abstract/Free Full Text]

Guy, P., Platko, J., Cantley, L., Cerione, R. and Carraway, K (1994). Insect cell-expressed p180 erbB3 possesses an impaired tyrosine kinase activity. Proc. Natl. Acad. Sci. USA 91, 8132-8136.[Abstract/Free Full Text]

Hellyer, N. J., Kim, H-H., Greaves, C. H., Sierke, S. L. and Koland, J. G (1995). Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein. Gene 165, 279-284.[Medline]

Ho, W.-H., Armanini, M. P., Nuijens, A., Phillips, H. S. and Osheroff, P. L (1995). SMDF: A novel heregulin isoform highly expressed in sensory and motor neurons. J. Biol. Chem 270, 14523-14532.[Abstract/Free Full Text]

Holmes, W. E., Sliwkowski, M. X., Akita, R. W., Henzel, W. J., Lee, J., Park, J. W., Yansura, D., Abadi, N., Raab, H., Lewis, G. D., Shepard, H. M., Kuang, W., Wood, W. I., Goeddel, D. V. and Vandlen, R. L (1992). Identification of heregulin, a specific activator of p185erbB2. Science 256, 1205-1210.[Abstract/Free Full Text]

Horton, C. and Maden, M (1995). Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo. Dev. Dynamics 202, 312-323.[Medline]

Hynes, N. E. and Stern, D. F (1994). The biology of erbB-2 /neu/ HER-2 and its role in cancer. Biochim. Biophys. Acta 1198, 165-84.[Medline]

Karunagaran, D., Tzahar, E., Liu, N., Wen, D. and Yarden, Y (1995). Neu differentiation factor inhibits EGF binding. A model for trans-regulation within the ErbB family of receptor tyrosine kinases. J. Biol. Chem 270, 9982-90.[Abstract/Free Full Text]

Kokai, Y.,Cohen, J. A., Drebin, J. A. and Greene, M. I. ( (1987). Stage-and tissue-specific expression of the neu oncogene in rat development. Proc. Natl. Acad. Sci. USA 84, 8498-8501.[Abstract/Free Full Text]

Kraus, M. H., Issing, W., Miki, T., Popescu, N. C. and Aaronson, S (1989). Isolation and characterization of ErbB3, a third member of the ErbB/epidermal growth factor family: Evidence of overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. USA 86, 9193-9197.[Abstract/Free Full Text]

Kraus, M. H., Fedi P., Starks R., Muraro, R. and Aaronson, S. A (1993). Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells. Proc. Natl. Acad. Sci. USA 90, 2900-2904.[Abstract/Free Full Text]

LeDouarin, N., Dulac, C., Dupin, E. and Cameron-Curry, P (1991). Glial cell lineages in the neural crest. Glia 4, 175-184.[Medline]

Lee, K., Simon, H., Chen, H., Bates, B., Hung, M. and Hauser, C., ( (1995). Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 387, 394-398.

Lee, M., Tuttle, J., Rebhun, L., Cleveland, D. and Frankfurter, A (1990). The expression and post-translational modification of a neuron-specific b-tubulin isotype during chick embryogenesis. Cell Mot. and Cytoskeleton 17, 118-132.[Medline]

Lemoine, N. R., Lobresco, M., Leung, H., Barton, C., Hughes, C. M., Prigent, S. A., Gullick, W. J. and Kloppel, G (1992). The erbB -3 gene in human pancreatic cancer. J. Pathol 168, 269-273.[Medline]

Mansour, S. L., Thomas, K. R. and Capecchi, M. R (1988). Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to nonselectable genes. Nature 336, 348-352.[Medline]

Marchionni, M. A., Goodearl, A. D., Chen, M. S., Bermingham-McDonogh, O., Kirk, C., Hendricks, M., Danehy, F., Misumi, D., Sudhalter, J., Kobayashi, K., Wroblewski, D., Lynch, C., Baldassare, M., Hiles, I., Davis, J. B., Hsuan, J. J., Totty, N. F., Otsu, M., McBurney, R. N., Waterfield, M. D., Stroobant, P. and Gwynne, D (1993). Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362, 312-8.[Medline]

Marikovsky, M., Lavi, S., Pinkas-Kramarski, R., Karunagaran, D., Liu, N., Wen, D. and Yarden, Y (1995). ErbB3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes. Oncogene 10, 1403-1411.[Medline]

McMahon, A. P. and Bradley, A (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085.[Medline]

Meyer, D. and Birchmeier, C (1994). Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development. Proc. Natl. Acad. Sci. USA 91, 1064-1068.[Abstract/Free Full Text]

Meyer, D. and Birchmeier, C (1995). Multiple essential functions of neuregulin in development. Nature 378, 386-390.[Medline]

Morrissey, T., Kleitman, N. and Bunge, R (1991). Isolation and functional characterization of Schwann cells derived from adult peripheral nerve. J. Neuroscience 11, 2433-2442.[Abstract]

Moscoso, L. H., Chu, G. C., Gautam, M., Noakes, P. G., Merlie, J. P. and Sanes, J. R (1995). Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, erbB2 and erbB3, in developing mammalian muscle. Dev. Biol 172, 158-169.[Medline]

Orr-Urtreger, A., Trakhtenbrot, L., Ben-Levy, R., Wen, D., Rechavi, G., Lonai, P. and Yarden, Y (1993). Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21. Proc. Natl. Acad. Sci. USA 90, 1867-1871.[Abstract/Free Full Text]

Peles, E., Bacus, S. S., Koski, R. A., Lu, H. S., Wen, D., Ogden, S. G., Levy, R. B. and Yarden, Y (1992). Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells. Cell 69, 205-216.[Medline]

Pinkas-Kramarski, R., Soussan, L. Waterman, H., Levkowitz, G., Alroy, I., Klapper, L., Lavi, S., Seger. R., Ratzkin, B., Sela, M. and Yarden, Y (1996). Diversification of neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J 15, 2452-24367.[Medline]

Plowman, G. D., Whitney, G. S., Neubauer, M. G., Green, J. M., McDonald, V. L., Todaro, G. J. and Shoyab, M (1990). Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Proc. Natl. Acad. Sci. USA 87, 4905-4909.[Abstract/Free Full Text]

Plowman, G. D., Culouscou, J. M., Whitney, G. S., Green, J. M., Carlton, G. W., Foy, L., Neubauer, M. G. and Shoyab, M (1993). Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc. Natl. Acad. Sci. USA 90, 1746-50.[Abstract/Free Full Text]

Plowman, G. D., Green, J. M., Culouscou, J. M., Carlton, G. W., Rothwell, V. M. and Buckley, S (1993). Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. Nature 366, 473-5.[Medline]

Schechter, A. L., Stern, D. F., Vaidyanathan, L., Decker, S. J., Drebib, J. A., Greene, M. I. and Weinberg, R. A (1984). The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature 312, 513-516.[Medline]

Shah, N. M., Marchionni, M. A., Isaacs, I., Stroobant, P. and Anderson, D. J (1994). Glial growth factor restricts mammalian neural crest stem cells to a glial fate. Cell 77, 349-360.[Medline]

Shih, C., Padhy, L. C., Murray, M. and Weinberg, R. A (1981). Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts. Nature 290, 261-264.[Medline]

Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A. and McGuire, W. L (1987). Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235, 177-82.[Abstract/Free Full Text]

Slamon, D. J., Godolphin, W., Jones, L. A., Holt, J. A., Wong, S. G., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J., Ullrich, A. and et al (1989). Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707-12.[Abstract/Free Full Text]

Sliwkowski, M. X., Schaefer, G., Akita, R., Lofgren, J., Fitzpatrick, V. D., Nuijens, A., Fendley, B., Cerione, R., Vandlen, R. and Carraway, K (1994). Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J. Biol. Chem 269, 14661-14665.[Abstract/Free Full Text]

Syroid, D. E., Maycox, P. R., Burrola, P. G., Liu, N., Wen, D., Lee, K., Lemke, G. and Kilpatrick, T. J (1996). Cell death in the Schwann cell lineage and its regulation by neuregulin. Proc. Natl. Acad. Sci. USA 93, 9229-9234.[Abstract/Free Full Text]

Tahara, E (1995). Molecular biology of gastric cancer. World J. Surg 19, 484-490.[Medline]

Thomas, K. R. and Capecchi, M. R (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503-512.[Medline]

Tzahar, E., Levkowitz, G., Karunagaran, D., Yi, L., Peles, E., Lavi, S., Chang, D., Liu, N., Yayon, A. and et al (1994). ErbB3 and erbB4 function as the respective low and high affinity receptors of all neu differentiation factor/heregulin isoforms. J. Biol. Chem 269, 25226-25233.[Abstract/Free Full Text]

Wen, D., Peles, E., Cupples, R., Suggs, S. V., Bacus, S. S., Luo, Y., Trail, G., Hu, S., Silbiger, S. M., Levy, R. B. and et al (1992). Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit. Cell 69, 559-72.[Medline]

Wilkinson, D. G., Bailes, J. A. and McMahon, A. P (1987). Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell 50, 79-88.[Medline]

Wurst, W., Auerbach, A. B. and Joyner, A. L (1994). Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120, 2065-2075.[Abstract]

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[Abstract] [Full Text] [PDF]

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Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function
PNAS, March 18, 2003; 100(6): 3221 - 3226.
[Abstract] [Full Text] [PDF]

J. M. Enciso, D. Gratzinger, T. D. Camenisch, S. Canosa, E. Pinter, and J. A. Madri
Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2
J. Cell Biol., February 18, 2003; 160(4): 605 - 615.
[Abstract] [Full Text] [PDF]

V. Prevot, C. Rio, G. J. Cho, A. Lomniczi, S. Heger, C. M. Neville, N. A. Rosenthal, S. R. Ojeda, and G. Corfas
Normal Female Sexual Development Requires Neuregulin-erbB Receptor Signaling in Hypothalamic Astrocytes
J. Neurosci., January 1, 2003; 23(1): 230 - 239.
[Abstract] [Full Text] [PDF]

D. L. Brutsaert
Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity
Physiol Rev, January 1, 2003; 83(1): 59 - 115.
[Abstract] [Full Text] [PDF]

M.-A. Huotari, P. J. Miettinen, J. Palgi, T. Koivisto, J. Ustinov, D. Harari, Y. Yarden, and T. Otonkoski
ErbB Signaling Regulates Lineage Determination of Developing Pancreatic Islet Cells in Embryonic Organ Culture
Endocrinology, November 1, 2002; 143(11): 4437 - 4446.
[Abstract] [Full Text] [PDF]

E. R. Andrechek, W. R. Hardy, A. A. Girgis-Gabardo, R. L. S. Perry, R. Butler, F. L. Graham, R. C. Kahn, M. A. Rudnicki, and W. J. Muller
ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival
Mol. Cell. Biol., July 1, 2002; 22(13): 4714 - 4722.
[Abstract] [Full Text] [PDF]

S.-K. Park, R. Miller, I. Krane, and T. Vartanian
The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes
J. Cell Biol., September 17, 2001; 154(6): 1245 - 1258.
[Abstract] [Full Text] [PDF]

S. O'Shea, K. Johnson, R. Clark, M. X. Sliwkowski, and S. L. Erickson
Effects of in Vivo Heregulin {beta}1 Treatment in Wild-Type and ErbB Gene-Targeted Mice Depend on Receptor Levels and Pregnancy
Am. J. Pathol., May 1, 2001; 158(5): 1871 - 1880.
[Abstract] [Full Text] [PDF]

S. Britsch, D. E. Goerich, D. Riethmacher, R. I. Peirano, M. Rossner, K.-A. Nave, C. Birchmeier, and M. Wegner
The transcription factor Sox10 is a key regulator of peripheral glial development
Genes & Dev., January 1, 2001; 15(1): 66 - 78.
[Abstract] [Full Text]

L. Fiorentino, C. Pertica, M. Fiorini, C. Talora, M. Crescenzi, L. Castellani, S. Alemà, P. Benedetti, and O. Segatto
Inhibition of ErbB-2 Mitogenic and Transforming Activity by RALT, a Mitogen-Induced Signal Transducer Which Binds to the ErbB-2 Kinase Domain
Mol. Cell. Biol., October 15, 2000; 20(20): 7735 - 7750.
[Abstract] [Full Text]

A. I. Flores, B. S. Mallon, T. Matsui, W. Ogawa, A. Rosenzweig, T. Okamoto, and W. B. Macklin
Akt-Mediated Survival of Oligodendrocytes Induced by Neuregulins
J. Neurosci., October 15, 2000; 20(20): 7622 - 7630.
[Abstract] [Full Text] [PDF]

N. V. Patel, M. J. Acarregui, J. M. Snyder, J. M. Klein, M. X. Sliwkowski, and J. A. Kern
Neuregulin-1 and Human Epidermal Growth Factor Receptors 2 and 3 Play a Role in Human Lung Development In Vitro
Am. J. Respir. Cell Mol. Biol., April 1, 2000; 22(4): 432 - 440.
[Abstract] [Full Text]

C. Rio, J. D. Buxbaum, J. J. Peschon, and G. Corfas
Tumor Necrosis Factor-alpha -converting Enzyme Is Required for Cleavage of erbB4/HER4
J. Biol. Chem., March 31, 2000; 275(14): 10379 - 10387.
[Abstract] [Full Text] [PDF]

A. N. Garratt, O. Voiculescu, P. Topilko, P. Charnay, and C. Birchmeier
A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool
J. Cell Biol., March 6, 2000; 148(5): 1035 - 1046.
[Abstract] [Full Text] [PDF]

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				V. Rajagopalan, I. H. Zucker, J. A. Jones, M. Carlson, and Y. J. Ma Cardiac ErbB-1/ErbB-2 mutant expression in young adult mice leads to cardiac dysfunction Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H543 - H554. [Abstract] [Full Text] [PDF]

				K. Niessen and A. Karsan Notch Signaling in Cardiac Development Circ. Res., May 23, 2008; 102(10): 1169 - 1181. [Abstract] [Full Text] [PDF]

				K. Lemmens, K. Doggen, and G. W. De Keulenaer Role of Neuregulin-1/ErbB Signaling in Cardiovascular Physiology and Disease: Implications for Therapy of Heart Failure Circulation, August 21, 2007; 116(8): 954 - 960. [Abstract] [Full Text] [PDF]

				M. L. Telli, S. A. Hunt, R. W. Carlson, and A. E. Guardino Trastuzumab-Related Cardiotoxicity: Calling Into Question the Concept of Reversibility J. Clin. Oncol., August 10, 2007; 25(23): 3525 - 3533. [Abstract] [Full Text] [PDF]

				M. Bjarnadottir, D. L. Misner, S. Haverfield-Gross, S. Bruun, V. G. Helgason, H. Stefansson, A. Sigmundsson, D. R. Firth, B. Nielsen, R. Stefansdottir, et al. Neuregulin1 (NRG1) Signaling through Fyn Modulates NMDA Receptor Phosphorylation: Differential Synaptic Function in NRG1+/- Knock-Outs Compared with Wild-Type Mice J. Neurosci., April 25, 2007; 27(17): 4519 - 4529. [Abstract] [Full Text] [PDF]

				H. Hoshino, T. Uchida, T. Otsuki, S. Kawamoto, K. Okubo, M. Takeichi, and O. Chisaka Cornichon-like Protein Facilitates Secretion of HB-EGF and Regulates Proper Development of Cranial Nerves Mol. Biol. Cell, April 1, 2007; 18(4): 1143 - 1152. [Abstract] [Full Text] [PDF]

				K. Lemmens, V. F. M. Segers, M. Demolder, and G. W. De Keulenaer Role of Neuregulin-1/ErbB2 Signaling in Endothelium-Cardiomyocyte Cross-talk J. Biol. Chem., July 14, 2006; 281(28): 19469 - 19477. [Abstract] [Full Text] [PDF]

				C. R. Hayworth, S. E. Moody, L. A. Chodosh, P. Krieg, M. Rimer, and W. J. Thompson Induction of neuregulin signaling in mouse schwann cells in vivo mimics responses to denervation. J. Neurosci., June 21, 2006; 26(25): 6873 - 6884. [Abstract] [Full Text] [PDF]

				E. B.D. Clabough and S. O. Zeitlin Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro Hum. Mol. Genet., February 15, 2006; 15(4): 607 - 623. [Abstract] [Full Text] [PDF]

				H. Sakurai, K. T. Bush, and S. K. Nigam Heregulin Induces Glial Cell Line-derived Neurotrophic Growth Factor-independent, Non-branching Growth and Differentiation of Ureteric Bud Epithelia J. Biol. Chem., December 23, 2005; 280(51): 42181 - 42187. [Abstract] [Full Text] [PDF]

				K. E. Yutzey, M. Colbert, and J. Robbins Ras-Related Signaling Pathways in Valve Development: Ebb and Flow Physiology, December 1, 2005; 20(6): 390 - 397. [Abstract] [Full Text] [PDF]

				T. P. Maddatu, S. M. Garvey, D. G. Schroeder, W. Zhang, S.-Y. Kim, A. I. Nicholson, C. J. Davis, and G. A. Cox Dilated cardiomyopathy in the nmd mouse: transgenic rescue and QTLs that improve cardiac function and survival Hum. Mol. Genet., November 1, 2005; 14(21): 3179 - 3189. [Abstract] [Full Text] [PDF]

				D. E. Nethery, B. B. Moore, G. Minowada, J. Carroll, J. A. Faress, and J. A. Kern Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice J Appl Physiol, July 1, 2005; 99(1): 298 - 307. [Abstract] [Full Text] [PDF]

				Y. Shirakata, R. Kimura, D. Nanba, R. Iwamoto, S. Tokumaru, C. Morimoto, K. Yokota, M. Nakamura, K. Sayama, E. Mekada, et al. Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing J. Cell Sci., June 1, 2005; 118(11): 2363 - 2370. [Abstract] [Full Text] [PDF]

				R. Rangwala, F. Banine, J.-P. Borg, and L. S. Sherman Erbin Regulates Mitogen-activated Protein (MAP) Kinase Activation and MAP Kinase-dependent Interactions between Merlin and Adherens Junction Protein Complexes in Schwann Cells J. Biol. Chem., March 25, 2005; 280(12): 11790 - 11797. [Abstract] [Full Text] [PDF]

				H. Ueda, A. Oikawa, A. Nakamura, F. Terasawa, K. Kawagishi, and T. Moriizumi Neuregulin Receptor ErbB2 Localization at T-tubule in Cardiac and Skeletal Muscle J. Histochem. Cytochem., January 1, 2005; 53(1): 87 - 91. [Abstract] [Full Text] [PDF]

				G. Corfas, M. O. Velardez, C.-P. Ko, N. Ratner, and E. Peles Mechanisms and Roles of Axon-Schwann Cell Interactions J. Neurosci., October 20, 2004; 24(42): 9250 - 9260. [Full Text] [PDF]

				D. Lee, R. S. Pearsall, S. Das, S. K. Dey, V. L. Godfrey, and D. W. Threadgill Epiregulin Is Not Essential for Development of Intestinal Tumors but Is Required for Protection from Intestinal Damage Mol. Cell. Biol., October 15, 2004; 24(20): 8907 - 8916. [Abstract] [Full Text] [PDF]

				K. Stankovic, C. Rio, A. Xia, M. Sugawara, J. C. Adams, M. C. Liberman, and G. Corfas Survival of Adult Spiral Ganglion Neurons Requires erbB Receptor Signaling in the Inner Ear J. Neurosci., October 6, 2004; 24(40): 8651 - 8661. [Abstract] [Full Text] [PDF]

				J. M. Britto, S. Lukehurst, R. Weller, C. Fraser, Y. Qiu, P. Hertzog, and S. J. Busfield Generation and Characterization of Neuregulin-2-Deficient Mice Mol. Cell. Biol., September 15, 2004; 24(18): 8221 - 8226. [Abstract] [Full Text] [PDF]

				E. J. Armstrong and J. Bischoff Heart Valve Development: Endothelial Cell Signaling and Differentiation Circ. Res., September 3, 2004; 95(5): 459 - 470. [Abstract] [Full Text] [PDF]

				T. Pietri, O. Eder, M. A. Breau, P. Topilko, M. Blanche, C. Brakebusch, R. Fassler, J.-P. Thiery, and S. Dufour Conditional {beta}1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system Development, August 15, 2004; 131(16): 3871 - 3883. [Abstract] [Full Text] [PDF]

				H. Akiyama, M.-C. Chaboissier, R. R. Behringer, D. H. Rowitch, A. Schedl, J. A. Epstein, and B. de Crombrugghe Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa PNAS, April 27, 2004; 101(17): 6502 - 6507. [Abstract] [Full Text] [PDF]

				P. J. Gruber and J. A. Epstein Development Gone Awry: Congenital Heart Disease Circ. Res., February 20, 2004; 94(3): 273 - 283. [Abstract] [Full Text] [PDF]

				K. Lemmens, P. Fransen, S. U. Sys, D. L. Brutsaert, and G. W. De Keulenaer Neuregulin-1 Induces a Negative Inotropic Effect in Cardiac Muscle: Role of Nitric Oxide Synthase Circulation, January 27, 2004; 109(3): 324 - 326. [Abstract] [Full Text] [PDF]

				E. A. Perez and R. Rodeheffer Clinical Cardiac Tolerability of Trastuzumab J. Clin. Oncol., January 15, 2004; 22(2): 322 - 329. [Abstract] [Full Text] [PDF]

				A. Negro, B. K. Brar, and K.-F. Lee Essential Roles of Her2/erbB2 in Cardiac Development and Function Recent Prog. Horm. Res., January 1, 2004; 59(1): 1 - 12. [Abstract] [Full Text]

				M. P. Piechocki, Y.-S. Ho, S. Pilon, and W.-Z. Wei Human ErbB-2 (Her-2) Transgenic Mice: A Model System for Testing Her-2 Based Vaccines J. Immunol., December 1, 2003; 171(11): 5787 - 5794. [Abstract] [Full Text] [PDF]

				A. F. M. MOORMAN and V. M. CHRISTOFFELS Cardiac Chamber Formation: Development, Genes, and Evolution Physiol Rev, October 1, 2003; 83(4): 1223 - 1267. [Abstract] [Full Text] [PDF]

				M. Sibilia, B. Wagner, A. Hoebertz, C. Elliott, S. Marino, W. Jochum, and E. F. Wagner Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart Development, October 1, 2003; 130(19): 4515 - 4525. [Abstract] [Full Text] [PDF]