Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain

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Adams, B., Dorfler, P., Aguzzi, A., Kozmik, Z., Urbanek, P., Maurer-Fogy, I. and Busslinger, M (1992). Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev 6, 1589-1607.[Abstract/Free Full Text]

Altman, J. and Bayer, S. A (1981). Time of origin of neurons of the rat inferior colliculus and the relations between cytogenesis and tonotopic order in the auditory pathway. Exp. Brain Res 42, 411-423.[Medline]

Altman, J. and Bayer, S. A (1981). Time of origin of neurons of the rat superior colliculus in relation to other components of the visual and visuomotor pathways. Exp. Brain Res 42, 424-434.[Medline]

Alvarado-Mallart, R.-M., Martinez, S. and Lance-Jones, C. C (1990). Pluripotentiality of the 2-day-old avian germinative neuroepithelium. Dev. Biol 139, 75-88.[Medline]

Asano, M. and Gruss, P (1992). Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development. Mech. Dev 39, 29-39.[Medline]

Bally-Cuif, L., Alvarado-Mallart, R.-M., Darnell, D. K. and Wassef, M (1992). Relationship between Wnt-1 and En-2 expression domains during early development of normal and ectopic met-mesencephalon. Development 115, 999-1009.[Abstract]

Bally-Cuif, L. and Wassef, M (1994). Ectopic induction and reorganization of Wnt-1 expression in quail/chick chimeras. Development 120, 3379-3394.[Abstract]

Bally-Cuif, L. and Wassef, M (1995). Determination events in the nervous system of the vertebrate embryo. Curr. Opin. Genet. Dev 5, 450-458.[Medline]

Cheng, H. and Flanagan, J. G (1994). Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell 79, 157-168.[Medline]

Cheng, H., Nakamoto, M., Bergemann, A. D. and Flanagan, J. G (1995). Complementary gradients in expression and binding of ELF-1 and Mek-4 in development of the topographic retinotectal projection map. Cell 82, 371-381.[Medline]

Cohn, M. J., Izpisua-Belmonte, J.-C., Abud, H., Heath, J. K. and Tickle, C (1995). Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80, 739-746.[Medline]

Crossland, W. J., Cowan, W. M., Rogers, L. A. and Kelly, J. P (1974). Specification of the retino-tectal projection in the chick. J. Comp. Neurol 155, 127-164.[Medline]

Crossley, P. H. and Martin, G. R (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439-451.[Abstract]

Crossley, P. H., Martinez, S. and Martin, G. R (1996). Midbrain development induced by FGF8 in the chick embryo. Nature 380, 66-68.[Medline]

Crossley, P. H., Minowada, G., MacArthur, C. A. and Martin, G. R (1996). Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 84, 127-136.[Medline]

Danielian, P. S. and McMahon, A. P (1996). Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383, 332-334.[Medline]

Davis, C., A. and Joyner, A. L (1988). Expression patterns of the homeobox-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes Dev 2, 1736-1744.[Abstract/Free Full Text]

Davis, C. A., Noble-Topham, S. E., Rossant, J. and Joyner, A. L (1988). Expression patterns of the homeobox containing gene En-2 delineates a specific region in the developing mouse brain. Genes Dev 2, 361-371.[Abstract/Free Full Text]

DeLong, G. R. and Coulombre, A. J (1965). Development of the retinotectal projection in the chick embyro. Exp. Neurol 13, 351-363.[Medline]

Dickinson, M. E., Krumlauf, R. and McMahon, A. P (1994). Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development 120, 1453-1471.[Abstract]

Drescher, U., Kremoser, C., Handwerker, C., Loschinger, J., Noda, M. and Bonhoeferr, F (1995). In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for eph receptor tyrosine kinases. Cell 82, 359-370.[Medline]

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic hedgehog, a member of a family of putative signalling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.[Medline]

Echelard, Y., Vassileva, G. and McMahon, A. P (1994). Cis -acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development 120, 2213-2224.[Abstract]

Friedman, G. C. and O'Leary, D. D. M (1996). Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons. J. Neurosci 16, 5498-5509.[Abstract/Free Full Text]

Gardner, C. A. and Barald, K (1992). Expression patterns of Engrailed-like proteins in the chick embryo. Dev. Dyn 193, 370-388.[Medline]

Gardner, C. A. and Barald, K. F (1991). The cellular environment controls the expression of engrailed-like protein in the cranial neuroepithelium of quail-chick chimeric embryos. Development 113, 1037-1048.[Abstract]

Gardner, C. A., Darnell, D. K., Poole, S. J., Ordahl, C. P. and Barald, K. F (1988). Expression of an engrailed-like gene during development of the early embryonic chick nervous system. J. Neurosci. Res 21, 426-437.[Medline]

Gensburger, C., Labourdette, G. and Sensenbrenner, M (1987). Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro. FEBS Lett 217, 1-5.[Medline]

Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B. and Joyner, A. L (1995). Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269, 679-682.[Abstract/Free Full Text]

Heikinheimo, M., Lawshe, A., Shackleford, G. M., Wilson, D. B. and MacArthur, C. A (1994). Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs, and central nervous system. Mech. Dev 48, 129-138.[Medline]

Itasaki, N., Ichijo, H., Hama, C., Matsuno, T. and Nakamura, H (1991). Establishment of rostrocaudal polarity in tectal primordium: engrailed expression and subsequent tectal polarity. Development 113, 1133-1144.[Abstract]

Itasaki, N. and Nakamura, H (1992). Rostrocaudal polarity of the tectum in birds: correlation of en gradient and topographic order in retinotectal projection. Neuron 8, 787-798.[Medline]

Itasaki, N. and Nakamura, H (1996). A role for gradient en expression in positional specification on the optic tectum. Neuron 16, 55-62.[Medline]

Joyner, A. L (1996). Engrailed , Wnt and Pax genes regulate midbrain-hindbrain development. Trends Genet 12, 15-20.[Medline]

Kelly, O. G. and Melton, D. A (1995). Induction and patterning of the vertebrate nervous system. Trends Genet 11, 273-278.[Medline]

Knecht, A. K., Good, P. J., Dawid, I. B. and Harland, R. M (1995). Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm. Development 121, 1927-1936.[Abstract]

LaVail, J. H. and Cowan, W., M (1971). The development of the chick optic tectum. I. Normal morphology and cytoarchitectonic development. Brain Res 28, 391-419.[Medline]

Logan, C., Wizenmann, A., Drescher, U., Monschau, B., Bonhoeffer, F. and Lumsden, A (1996). Rostral optic tectum acquires caudal characteristics following ectopic Engrailed expression. Curr. Biol 6, 1006-1014.[Medline]

MacArthur, C. A., Lawshe, A., Shanker, D. B., Heikenheimo, M., Shackleford, G. M (1995). FGF-8 isoforms differ in NIH3T3 cell transforming potential. Cell Growth Diff 6, 817-825.[Abstract]

MacArthur, C. A., Lawshe, A., Xu, J., Santos-Ocampo, S., Heikinheimo, M., Chellaiah, A. T., and Ornitz, D. M (1995). FGF-8 isoforms activate receptor forms that are expressed in mesenchyme regions of mouse development. Development 121, 3603-3613.[Abstract]

Mahmood, R., Bresnick, J., Hornbruch, A., Mahony, C., Morton, N., Colquhoun, K., Martin, P., Lumsden, A., Dickson, C. and Mason, I (1995). A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr. Biol 5, 797-806.[Medline]

Marin, F. and Puelles, L (1994). Patterning of the embryonic avian midbrain after experimental inversion: a polarizing activity form the isthmus. Dev. Biol 163, 19-37.[Medline]

Martinez, S. and Alvarado-Mallart, R.-M (1990). Expression of the homeobox chick-en gene in chick/quail chimeras with inverted mes-metencephalic grafts. Dev. Biol 139, 432-436.[Medline]

Martinez, S., Marin, F., Nieto, M. A. and Puelles, L (1995). Induction of ectopic engrailed expression and fate change in avian rhombomeres: intersegmental boundaries as barriers. Mech. Dev 51, 289-303.[Medline]

Martinez, S., Wassef, M. and Alvarado-Mallart, R.-M (1991). Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon in preceded by the early expression of the homeobox gene en. Neuron 6, 971-981.[Medline]

Matsuno, T., Ichijo, H. and Nakamura, H (1991). Regulation of the rostrocaudal axis of the optic tectum: histological study after rostrocaudal rotation in quail-chick chimeras. Dev. Brain Res 58, 265-270.[Medline]

McMahon, A. P. and Bradley, A (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085.[Medline]

McMahon, A. P., Joyner, A. L., Bradley, A. and McMahon, J. A (1992). The midbrain-hindbrain phenotype of Wnt-1/Wnt-1 mice results from stepwise deletion of engrailed -expressing cells by 9.5 days postcoitum. Cell 69, 581-595.[Medline]

Millen, K. J., Wurst, W., Herrup, K. and Joyner, A. L (1994). Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants. Development 120, 695-706.[Abstract]

Millen, K. J., Hui, C.-C. and Joyner, A.L (1995). A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum. Development 121, 3935-3945.[Abstract]

Millet, S. and Alvarado-Mallart, R.-M (1995). Expression of the homeobox-containing gene En-2 during the development of the chick central nervous system. Eur. J. Neurosci 7, 777-791.[Medline]

Nakamoto, M., Cheng, H.-J., Friedman, G. C., McLaughlin, T., Hansen, M. J., Yoon, C. H., O'Leary, D. D. M. and Flanagan, J. G (1996). Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell 86, 755-766.[Medline]

Nornes, H. O., Dressler, G. R., Knapik, E. W., Deutsch, U. and Gruss, P (1990). Spatially and temporally restricted expression of Pax-2 during murine neurogenesis. Development 109, 797-809.[Abstract/Free Full Text]

Parr, B. P., Shea, M. J., Vassileva, G. and McMahon, A. P (1993). Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development 119, 247-261.[Abstract]

Patel, N. H., Martin-Blanceo, E., Coleman, K. G. P., S.J.Ellis, M.C., Kornberg, T. B. and Goodman, C. S (1989). Expression of engrailed proteins in arthropods, annelids, and chordates. Cell 58, 955-968.[Medline]

Puschel, A. W., Westerfield, M. and Dressler, G. R (1992). Comparative analysis of Pax-2 protein distributions during neurulation in mice and zebrafish. Mech. Dev 38, 197-208.[Medline]

Rowitch, D. H. and McMahon, A. P (1995). Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1. Mech. Dev 52, 3-8.[Medline]

Rubenstein, J. L. R., Martinez, S., Shimamura, K. and Puelles, L (1994). The embryonic vertebrate forebrain: the prosomeric model. Science 266, 578-580.[Free Full Text]

Song, D., Chalepakis, G., Gruss, P. and Joyner, A. L (1996). Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene. Development 122, 627-635.[Abstract]

Temple, S. and Qian, X (1995). bFGF, neurotrophins, and the control of cortical neurogenesis. Neuron 15, 249-252.[Medline]

Thomas, K. R. and Capecchi, M. R (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346, 847-850.[Medline]

Urbanek, P., Wang, Z., Fetla, I., Wagner, E. F. and Busslinger, M (1994). Complete block of early B cell differentialtion and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79, 901-912.[Medline]

Vogel, A., Rodriguez, C. and Izpisua-Belmonte, J.-C (1996). Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122, 1737-1750.[Abstract]

Walther, C. and Gruss, P (1991). Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113, 1435-1449.[Abstract]

Wilkinson, D. G., Bailes, J. A. and McMahon, A. P (1987). Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell 50, 79-88.[Medline]

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Development, January 5, 1999; 126(10): 2129 - 2140.
[Abstract] [PDF]

S Martinez, P. Crossley, I Cobos, J. Rubenstein, and G. Martin
FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression
Development, January 3, 1999; 126(6): 1189 - 1200.
[Abstract] [PDF]

Z Kozmik, N. Holland, A Kalousova, J Paces, M Schubert, and L. Holland
Characterization of an amphioxus paired box gene, AmphiPax2/5/8: developmental expression patterns in optic support cells, nephridium, thyroid-like structures and pharyngeal gill slits, but not in the midbrain-hindbrain boundary region
Development, January 3, 1999; 126(6): 1295 - 1304.

				M. A. Basson, D. Echevarria, C. Petersen Ahn, A. Sudarov, A. L. Joyner, I. J. Mason, S. Martinez, and G. R. Martin Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development Development, March 1, 2008; 135(5): 889 - 898. [Abstract] [Full Text] [PDF]

				Q. Guo and J. Y. H. Li Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation Development, June 15, 2007; 134(12): 2251 - 2260. [Abstract] [Full Text] [PDF]

				I. Olivera-Martinez and K. G. Storey Wnt signals provide a timing mechanism for the FGF-retinoid differentiation switch during vertebrate body axis extension Development, June 1, 2007; 134(11): 2125 - 2135. [Abstract] [Full Text] [PDF]

				P. Alexandre, I. Bachy, M. Marcou, and M. Wassef Positive and negative regulations by FGF8 contribute to midbrain roof plate developmental plasticity Development, August 1, 2006; 133(15): 2905 - 2913. [Abstract] [Full Text] [PDF]

				I. Foucher, M. Mione, A. Simeone, D. Acampora, L. Bally-Cuif, and C. Houart Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants Development, May 15, 2006; 133(10): 1891 - 1900. [Abstract] [Full Text] [PDF]

				G. Griesel, D. Treichel, P. Collombat, J. Krull, A. Zembrzycki, W. M. R. van den Akker, P. Gruss, A. Simeone, and A. Mansouri Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border Development, May 1, 2006; 133(9): 1779 - 1787. [Abstract] [Full Text] [PDF]

				S. K. Olsen, J. Y.H. Li, C. Bromleigh, A. V. Eliseenkova, O. A. Ibrahimi, Z. Lao, F. Zhang, R. J. Linhardt, A. L. Joyner, and M. Mohammadi Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain Genes & Dev., January 15, 2006; 20(2): 185 - 198. [Abstract] [Full Text] [PDF]

				N. Prakash, C. Brodski, T. Naserke, E. Puelles, R. Gogoi, A. Hall, M. Panhuysen, D. Echevarria, L. Sussel, D. M. V. Weisenhorn, et al. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo Development, January 1, 2006; 133(1): 89 - 98. [Abstract] [Full Text] [PDF]

				S. Kawauchi, J. Shou, R. Santos, J. M. Hebert, S. K. McConnell, I. Mason, and A. L. Calof Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse Development, December 1, 2005; 132(23): 5211 - 5223. [Abstract] [Full Text] [PDF]

				A. Picker and M. Brand Fgf signals from a novel signaling center determine axial patterning of the prospective neural retina Development, November 15, 2005; 132(22): 4951 - 4962. [Abstract] [Full Text] [PDF]

				A. O. Perantoni, O. Timofeeva, F. Naillat, C. Richman, S. Pajni-Underwood, C. Wilson, S. Vainio, L. F. Dove, and M. Lewandoski Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development Development, September 1, 2005; 132(17): 3859 - 3871. [Abstract] [Full Text] [PDF]

				F. P. O'Hara, E. Beck, L. K. Barr, L. L. Wong, D. S. Kessler, and R. D. Riddle Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer Development, July 15, 2005; 132(14): 3163 - 3173. [Abstract] [Full Text] [PDF]

				T. Langenberg and M. Brand Lineage restriction maintains a stable organizer cell population at the zebrafish midbrain-hindbrain boundary Development, July 15, 2005; 132(14): 3209 - 3216. [Abstract] [Full Text] [PDF]

				Y. Kawakami, C. R. Esteban, T. Matsui, J. Rodriguez-Leon, S. Kato, and J. C. I. Belmonte Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos Development, October 1, 2004; 131(19): 4763 - 4774. [Abstract] [Full Text] [PDF]

				T. Sato and H. Nakamura The Fgf8 signal causes cerebellar differentiation by activating the Ras-ERK signaling pathway Development, September 1, 2004; 131(17): 4275 - 4285. [Abstract] [Full Text] [PDF]

				R. C. Milewski, N. C. Chi, J. Li, C. Brown, M. M. Lu, and J. A. Epstein Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3 Development, February 15, 2004; 131(4): 829 - 837. [Abstract] [Full Text] [PDF]

				J. Jaszai, F. Reifers, A. Picker, T. Langenberg, and M. Brand Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity Development, December 29, 2003; 130(26): 6611 - 6623. [Abstract] [Full Text] [PDF]

				A. Liu, J. Y. H. Li, C. Bromleigh, Z. Lao, L. A. Niswander, and A. L. Joyner FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors Development, December 22, 2003; 130(25): 6175 - 6185. [Abstract] [Full Text] [PDF]

				M. M. Braun, A. Etheridge, A. Bernard, C. P. Robertson, and H. Roelink Wnt signaling is required at distinct stages of development for the induction of the posterior forebrain Development, December 1, 2003; 130(23): 5579 - 5587. [Abstract] [Full Text] [PDF]

				S. Scholpp, C. Lohs, and M. Brand Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon Development, October 15, 2003; 130(20): 4881 - 4893. [Abstract] [Full Text] [PDF]

				C. L. Chi, S. Martinez, W. Wurst, and G. R. Martin The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum Development, June 15, 2003; 130(12): 2633 - 2644. [Abstract] [Full Text] [PDF]

				R. Dono Fibroblast growth factors as regulators of central nervous system development and function Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R867 - R881. [Abstract] [Full Text] [PDF]

				E. Matsunaga, T. Katahira, and H. Nakamura Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development Development, March 13, 2003; 129(22): 5269 - 5277. [Abstract] [Full Text] [PDF]

				M. Ishibashi and A. P. McMahon A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo Development, March 12, 2003; 129(20): 4807 - 4819. [Abstract] [Full Text] [PDF]

				D. C. Lie, G. Dziewczapolski, A. R. Willhoite, B. K. Kaspar, C. W. Shults, and F. H. Gage The Adult Substantia Nigra Contains Progenitor Cells with Neurogenic Potential J. Neurosci., August 1, 2002; 22(15): 6639 - 6649. [Abstract] [Full Text] [PDF]

				C. Irving, A. Malhas, S. Guthrie, and I. Mason Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8 Development, January 12, 2002; 129(23): 5389 - 5398. [Abstract] [Full Text] [PDF]

				R. D. del Corral, D. N. Breitkreuz, and K. G. Storey Onset of neuronal differentiation is regulated by paraxial mesoderm and requires attenuation of FGF signalling Development, January 4, 2002; 129(7): 1681 - 1691. [Abstract] [Full Text] [PDF]

				J. Y. H. Li and A. L. Joyner Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression Development, December 15, 2001; 128(24): 4979 - 4991. [Abstract] [Full Text] [PDF]

				R. A. Schneider, D. Hu, J. L. R. Rubenstein, M. Maden, and J. A. Helms Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH Development, July 15, 2001; 128(14): 2755 - 2767. [Abstract] [Full Text] [PDF]

				T. Sato, I. Araki, and H. Nakamura Inductive signal and tissue responsiveness defining the tectum and the cerebellum Development, July 1, 2001; 128(13): 2461 - 2469. [Abstract] [Full Text] [PDF]