A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Sasaki, H.
	Articles by Kondoh, H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Sasaki, H.
	Articles by Kondoh, H.

Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M. and Hooper, J. E (1996). The drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86, 221-232.[Medline]

Alexandre, C., Jacinto, A. and Ingham, P. W (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 10, 2003-2013.[Abstract/Free Full Text]

Ang, S.-L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J. and Zaret, K. S (1993). The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/ fork head proteins. Development 119, 1301-1315.[Abstract]

Chen, Y. and Struhl, G (1996). Dual roles for patched in sequestering and transducing hedgehog. Cell 87, 553-563.[Medline]

Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413.[Medline]

Colamarino, S. A. and Tessier-Lavigne, M (1995). The axonal chemoattractant Netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81, 621-629.[Medline]

Currie, P. D. and Ingham, P. W (1996). Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish. Nature 382, 452-455.[Medline]

Dom\222nguez, M., Brunner, M., Hafen, E. and Basler, K (1996). Sending and recieveing the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-1625.[Abstract]

Echelard, Y., D.J., E., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic hedgenog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.[Medline]

Ekker, S. C., McGrew, L. L., Lai, C. J., Lee, J. J., von Kessler, D. P., Moon, R. T. and Beachy, P. A (1995). Distinct expression and shared activities of the hedgehog gene family of Xenopus laevis. Development 121, 2337-2347.[Abstract]

Ekker, S. C., Ungar, A. R., Greenstein, P., von Kessler, D. P., Porter, J. A., Moon, R. T. and Beachy, P. A (1995). Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr. Biol 5, 944-955.[Medline]

Ericson, J., Morton, S., Kawakami, A., Roelink, H. and Jessell, T. M (1996). Two critical periods of Sonic hedgehog signalling required for the specification of motor neuron identity. Cell 87, 661-673.[Medline]

Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessell, T. M. and Edlund, T (1995). Sonic hedgehog induces the differentiation of ventral forbrain neurons: a common signal for ventral patterning within the neural tube. Cell 81, 747-756.[Medline]

Guan, K. and Dixon, J. E (1991). Eukaryotic proteins expressed in Escherichia coli : an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem 192, 262-267.[Medline]

Hammerschmidt, M., Bitgood, M. J. and McMahon, A. P (1996). Protein kinase A is a common negative regulator of Hedgehog signalling in the vertebrate embryo. Genes Dev 10, 647-658.[Abstract/Free Full Text]

Hui, C.-C., Slusarski, D., Platt, K. A., Holmgreen, R. and Joyner, A. L (1994). Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2 and Gli-3, in ectoderm-and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol 162, 402-413.[Medline]

Hynes, M., Porter, J. A., Chiang, C., Chang, D., Tessier-Lavigne, M., Beachy, P. A. and Rosenthal, A (1995). Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron 15, 35-44.[Medline]

Jessell, T. M. and Dodd, J (1992). Floor plate-derived signals and the control of neural cell pattern in vertebrates. Harvey Lect 86, 87-128.

Johnson, R. L., Laufer, E., Riddle, R. D. and Tabin, C (1994). Ectopic expression of sonic hedgehog alters dorsal-ventral patterning of somites. Cell 79, 1165-1173.[Medline]

Kamachi, Y. and Kondoh, H (1993). Overlapping positive and negative regulatory elements determine lens-specific activity of the1-crystallin enhancer. Mol. Cell. Biol 13, 5206-5215.[Abstract/Free Full Text]

Kennedy, T. E., Serafini, T., Torre, J. R. d. l. and Tessier-Lavigne, M (1994). Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 74, 425-435.

Kinzler, K. W., Bigner, S. H., Bigner, D. D., Trent, J. M., Law, M. L., O'Brien, S. J., Wong, A. J. and Vogelstein, B (1987). Identification of an amplified, highly expressed gene in a human glioma. Science 236, 70-73.[Abstract/Free Full Text]

Kinzler, K. W., Ruppert, J. M., Bigner, S. H. and Vogelstein, B (1988). The GLI gene is a member of Kruppel family of zinc finger proteins. Nature 332, 371-374.[Medline]

Kinzler, K. W. and Vogelstein, B (1990). The GLI gene encoles a nuclear protein which binds specific sequences in the human genome. Mol. Cell. Biol 10, 634-642.[Abstract/Free Full Text]

Marigo, V., Davey, R. A., Zuo, Y., Cunninghan, J. M. and Tabin, C. J (1996). Biochemical evidence that Patched is the Hedgehog receptor. Nature 384, 176-179.[Medline]

Marigo, V., Johnson, R. L., Vortkamp, A. and Tabin, C. J (1996). Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol 180, 273-283.[Medline]

Marti, E., Bumcrot, D. A., Takada, R. and McMahon, A. P (1995). Requirement of 19K form of Sonic hedgehog for inductionn of distinct ventral cell types in CNS explants. Nature 375, 322-325.[Medline]

Nakagawa, Y., Kanako, T., Ogura, T., Suzuki, T., Torii, M., Kaibuchi, K., Arai, K.-I., Nakamura, S. and Nakafuku, M (1996). Roles of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells. Development 122, 2449-2464.[Abstract]

Orenic, T. V., Slusarski, D. C., Kroll, K. L. and Holmgren, R. A (1990). Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev 4, 1053-1067.[Abstract/Free Full Text]

Orentas, D. M. and Miller, R. H (1996). The origin of spinal cord oligodendrycytes is dependent on local influences from notochord. Dev. Biol 177, 43-53.[Medline]

Perrimon, N (1995). Hedgehog and beyond. Cell 80, 517-520.[Medline]

Pringle, N. P., Yu, W.-P., Guthrie, S., Roelink, H., Lumsden, A., Peterson, A. C. and Richardson, W. D (1996). Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and Sonic hedgehog. Dev. Biol 177, 30-42.[Medline]

Roelink, H., Porter, J., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. and Jessell, T. M (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81, 445-455.[Medline]

Ruiz i Altaba, A., Jessell, T. M. and Roelink, H (1995). Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos. Mol. Cell. Neurosci 6, 106-121.[Medline]

Ruiz i Altaba, A., Placzek, M., Baldassare, M., Dodd, J. and Jessell, T (1995). Early stages of notochord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3. Dev. Biol 170, 299-313.[Medline]

Ruiz i Altaba, A., Prezioso, V. R., Darvell, J. E. and Jessell, T. M (1993). Sequential expression of HNF-3and HNF-3 by embryonic organizing centers: the dorsal lip/node, notochord and floor plate. Mech. Dev 44, 91-108.[Medline]

Ruppert, J. M., Kinzler, K. W., Wong, A. J., Bigner, S. H., Kao, F., Law, M. L., Seuanez, H. N., O'Brien, J. O. and Vogelstein, B (1988). The GLI-Kruppel family of human genes. Mol. Cell. Biol 8, 3104-3113.[Abstract/Free Full Text]

Ruppert, J. M., Vogelstein, B., Arheden, K. and Kinzler, K. W (1990). GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol. Cell. Biol 10, 5408-5415.[Abstract/Free Full Text]

Sasaki, H. and Hogan, B. L. M (1993). Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118, 47-59.[Abstract]

Sasaki, H. and Hogan, B. L. M (1994). HNF-3 as a regulator of floor plate development. Cell 76, 103-115.[Medline]

Stone, D. M., Hynes, M., Armanini, M., Swanson, T. A., Gu, Q., Johnson, R. L., Scott, M. P., Pennica, D., Goddard, A., Phillips, H., Noll, M., Hooper, J. E., de Sauvage, F. and Rosenthal, A (1996). The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 126-134.

Takebe, Y., Seki, M., Fujisawa, J., Hoy, P., Yokota, K., Arai, K., Yoshida, M. and Arai, N (1988). SRpromoter: an efficient and versatile mammalian cDNA expression system composed of teh simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol 8, 466-472.[Abstract/Free Full Text]

van den Heuvel, M. and Ingham, P. W (1996). smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382, 547-551.[Medline]

Vortkamp, A., Gessler, M. and Grzeschik, K.-H (1995). Identification of optimized target sequences for the GLI3 zinc finger protein. DNA Cell Biol 14, 629-634.[Medline]

Walterhouse, D., Ahmed, M., Slusarski, D., Kalamaras, J., Boucher, D., Holmgren, R. and Iannaccone, P (1993). gli , a zinc finger transcription factor and oncogene, is expressed during normal mouse development. Dev. Dyn 196, 91-102.[Medline]

Yang, Y. and Niswander, L (1995). Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell 80, 939-947.[Medline]

This article has been cited by other articles:

M. A. Willaredt, K. Hasenpusch-Theil, H. A. R. Gardner, I. Kitanovic, V. C. Hirschfeld-Warneken, C. P. Gojak, K. Gorgas, C. L. Bradford, J. Spatz, S. Wolfl, et al.
A Crucial Role for Primary Cilia in Cortical Morphogenesis
J. Neurosci., November 26, 2008; 28(48): 12887 - 12900.
[Abstract] [Full Text] [PDF]

K. Tanese, M. Fukuma, T. Yamada, T. Mori, T. Yoshikawa, W. Watanabe, A. Ishiko, M. Amagai, T. Nishikawa, and M. Sakamoto
G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation
Am. J. Pathol., September 1, 2008; 173(3): 835 - 843.
[Abstract] [Full Text] [PDF]

E. Dessaud, A. P. McMahon, and J. Briscoe
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
Development, August 1, 2008; 135(15): 2489 - 2503.
[Abstract] [Full Text] [PDF]

M. Tada, F. Kanai, Y. Tanaka, K. Tateishi, M. Ohta, Y. Asaoka, M. Seto, R. Muroyama, K. Fukai, F. Imazeki, et al.
Down-Regulation of Hedgehog-Interacting Protein through Genetic and Epigenetic Alterations in Human Hepatocellular Carcinoma
Clin. Cancer Res., June 15, 2008; 14(12): 3768 - 3776.
[Abstract] [Full Text] [PDF]

R. Alvarez-Medina, J. Cayuso, T. Okubo, S. Takada, and E. Marti
Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression
Development, January 15, 2008; 135(2): 237 - 247.
[Abstract] [Full Text] [PDF]

Y. Zavros, M. Waghray, A. Tessier, L. Bai, A. Todisco, D. L. Gumucio, L. C. Samuelson, A. Dlugosz, and J. L. Merchant
Reduced Pepsin A Processing of Sonic Hedgehog in Parietal Cells Precedes Gastric Atrophy and Transformation
J. Biol. Chem., November 16, 2007; 282(46): 33265 - 33274.
[Abstract] [Full Text] [PDF]

S. Thiyagarajan, N. Bhatia, S. Reagan-Shaw, D. Cozma, A. Thomas-Tikhonenko, N. Ahmad, and V. S. Spiegelman
Role of GLI2 Transcription Factor in Growth and Tumorigenicity of Prostate Cells
Cancer Res., November 15, 2007; 67(22): 10642 - 10646.
[Abstract] [Full Text] [PDF]

Y. Zhang, J. P. Bressler, J. Neal, B. Lal, H.-E. C. Bhang, J. Laterra, and M. G. Pomper
ABCG2/BCRP Expression Modulates D-Luciferin Based Bioluminescence Imaging
Cancer Res., October 1, 2007; 67(19): 9389 - 9397.
[Abstract] [Full Text] [PDF]

G. A. Bien-Willner, P. Stankiewicz, and J. R. Lupski
SOX9cre1, a cis-acting regulatory element located 1.1 Mb upstream of SOX9, mediates its enhancement through the SHH pathway
Hum. Mol. Genet., May 15, 2007; 16(10): 1143 - 1156.
[Abstract] [Full Text] [PDF]

S. A. Vokes, H. Ji, S. McCuine, T. Tenzen, S. Giles, S. Zhong, W. J. R. Longabaugh, E. H. Davidson, W. H. Wong, and A. P. McMahon
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
Development, May 15, 2007; 134(10): 1977 - 1989.
[Abstract] [Full Text] [PDF]

Z. Ji, F. C. Mei, J. Xie, and X. Cheng
Oncogenic KRAS Activates Hedgehog Signaling Pathway in Pancreatic Cancer Cells
J. Biol. Chem., May 11, 2007; 282(19): 14048 - 14055.
[Abstract] [Full Text] [PDF]

R. Haraguchi, J. Motoyama, H. Sasaki, Y. Satoh, S. Miyagawa, N. Nakagata, A. Moon, and G. Yamada
Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling
Development, February 1, 2007; 134(3): 525 - 533.
[Abstract] [Full Text] [PDF]

K. Tateishi, M. Ohta, F. Kanai, B. Guleng, Y. Tanaka, Y. Asaoka, M. Tada, M. Seto, A. Jazag, L. Lianjie, et al.
Dysregulated Expression of Stem Cell Factor Bmi1 in Precancerous Lesions of the Gastrointestinal Tract
Clin. Cancer Res., December 1, 2006; 12(23): 6960 - 6966.
[Abstract] [Full Text] [PDF]

J. He, T. Sheng, A. A. Stelter, C. Li, X. Zhang, M. Sinha, B. A. Luxon, and J. Xie
Suppressing Wnt Signaling by the Hedgehog Pathway through sFRP-1
J. Biol. Chem., November 24, 2006; 281(47): 35598 - 35602.
[Abstract] [Full Text] [PDF]

A. R. Meloni, G. B. Fralish, P. Kelly, A. Salahpour, J. K. Chen, R. J. Wechsler-Reya, R. J. Lefkowitz, and M. G. Caron
Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2
Mol. Cell. Biol., October 15, 2006; 26(20): 7550 - 7560.
[Abstract] [Full Text] [PDF]

J. Xu, B. P. Srinivas, S. Y. Tay, A. Mak, X. Yu, S. G. P. Lee, H. Yang, K. R. Govindarajan, B. Leong, G. Bourque, et al.
Genomewide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development
Genetics, October 1, 2006; 174(2): 735 - 752.
[Abstract] [Full Text] [PDF]

E. Nieuwenhuis, J. Motoyama, P. C. Barnfield, Y. Yoshikawa, X. Zhang, R. Mo, M. A. Crackower, and C.-c. Hui
Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia.
Mol. Cell. Biol., September 1, 2006; 26(17): 6609 - 6622.
[Abstract] [Full Text] [PDF]

M. Zhao, M. Qiao, S. E. Harris, D. Chen, B. O. Oyajobi, and G. R. Mundy
The zinc finger transcription factor gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.
Mol. Cell. Biol., August 1, 2006; 26(16): 6197 - 6208.
[Abstract] [Full Text] [PDF]

M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al.
Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes.
Mol. Cell. Biol., August 1, 2006; 26(16): 6283 - 6298.
[Abstract] [Full Text] [PDF]

N. Bhatia, S. Thiyagarajan, I. Elcheva, M. Saleem, A. Dlugosz, H. Mukhtar, and V. S. Spiegelman
Gli2 Is Targeted for Ubiquitination and Degradation by beta-TrCP Ubiquitin Ligase
J. Biol. Chem., July 14, 2006; 281(28): 19320 - 19326.
[Abstract] [Full Text] [PDF]

T Akiyoshi, M Nakamura, K Koga, H Nakashima, T Yao, M Tsuneyoshi, M Tanaka, and M Katano
Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation
Gut, July 1, 2006; 55(7): 991 - 999.
[Abstract] [Full Text] [PDF]

T. Koide, T. Hayata, and K. W. Y. Cho
Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase
Development, June 15, 2006; 133(12): 2395 - 2405.
[Abstract] [Full Text] [PDF]

J. Feng, C. Bi, B. S. Clark, R. Mady, P. Shah, and J. D. Kohtz
The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator
Genes & Dev., June 1, 2006; 20(11): 1470 - 1484.
[Abstract] [Full Text] [PDF]

M. C. Hu, R. Mo, S. Bhella, C. W. Wilson, P.-T. Chuang, C.-c. Hui, and N. D. Rosenblum
GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
Development, February 1, 2006; 133(3): 569 - 578.
[Abstract] [Full Text] [PDF]

T. Sheng, S. Chi, X. Zhang, and J. Xie
Regulation of Gli1 Localization by the cAMP/Protein Kinase A Signaling Axis through a Site Near the Nuclear Localization Signal
J. Biol. Chem., January 6, 2006; 281(1): 9 - 12.
[Abstract] [Full Text] [PDF]

M. Ohta, K. Tateishi, F. Kanai, H. Watabe, S. Kondo, B. Guleng, Y. Tanaka, Y. Asaoka, A. Jazag, J. Imamura, et al.
p53-Independent Negative Regulation of p21/Cyclin-Dependent Kinase-Interacting Protein 1 by the Sonic Hedgehog-Glioma-Associated Oncogene 1 Pathway in Gastric Carcinoma Cells
Cancer Res., December 1, 2005; 65(23): 10822 - 10829.
[Abstract] [Full Text] [PDF]

A. Sawada, Y. Nishizaki, H. Sato, Y. Yada, R. Nakayama, S. Yamamoto, N. Nishioka, H. Kondoh, and H. Sasaki
Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor
Development, November 1, 2005; 132(21): 4719 - 4729.
[Abstract] [Full Text] [PDF]

M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang
Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development
Mol. Cell. Biol., August 15, 2005; 25(16): 7042 - 7053.
[Abstract] [Full Text] [PDF]

N. Gao, K. Ishii, J. Mirosevich, S. Kuwajima, S. R. Oppenheimer, R. L. Roberts, M. Jiang, X. Yu, S. B. Shappell, R. M. Caprioli, et al.
Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation
Development, August 1, 2005; 132(15): 3431 - 3443.
[Abstract] [Full Text] [PDF]

P. J. Gianakopoulos and I. S. Skerjanc
Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells
J. Biol. Chem., June 3, 2005; 280(22): 21022 - 21028.
[Abstract] [Full Text] [PDF]

T. Yamamoto and N. Suzuki
Expression and Function of cGMP-dependent Protein Kinase Type I during Medaka Fish Embryogenesis
J. Biol. Chem., April 29, 2005; 280(17): 16979 - 16986.
[Abstract] [Full Text] [PDF]

V. Stepan, S. Ramamoorthy, H. Nitsche, Y. Zavros, J. L. Merchant, and A. Todisco
Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells
J. Biol. Chem., April 22, 2005; 280(16): 15700 - 15708.
[Abstract] [Full Text] [PDF]

C. Rallis, J. Del Buono, and M. P. O. Logan
Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo
Development, April 15, 2005; 132(8): 1961 - 1970.
[Abstract] [Full Text] [PDF]

D. Stamataki, F. Ulloa, S. V. Tsoni, A. Mynett, and J. Briscoe
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
Genes & Dev., March 1, 2005; 19(5): 626 - 641.
[Abstract] [Full Text] [PDF]

S. L. Lopez, M. V. Rosato-Siri, P. G. Franco, A. R. Paganelli, and A. E. Carrasco
The Notch-target gene hairy2a impedes the involution of notochordal cells by promoting floor plate fates in Xenopus embryos
Development, March 1, 2005; 132(5): 1035 - 1046.
[Abstract] [Full Text] [PDF]

C. A. Callahan, T. Ofstad, L. Horng, J. K. Wang, H. H. Zhen, P. A. Coulombe, and A. E. Oro
MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription
Genes & Dev., November 15, 2004; 18(22): 2724 - 2729.
[Abstract] [Full Text] [PDF]

A. Brancaccio, A. Minichiello, M. Grachtchouk, D. Antonini, H. Sheng, R. Parlato, N. Dathan, A. A. Dlugosz, and C. Missero
Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis
Hum. Mol. Genet., November 1, 2004; 13(21): 2595 - 2606.
[Abstract] [Full Text] [PDF]

C. Cui, T. Elsam, Q. Tian, J. T. Seykora, M. Grachtchouk, A. Dlugosz, and H. Tseng
Gli Proteins Up-Regulate the Expression of Basonuclin in Basal Cell Carcinoma
Cancer Res., August 15, 2004; 64(16): 5651 - 5658.
[Abstract] [Full Text] [PDF]

Q. Lei, A. K. Zelman, E. Kuang, S. Li, and M. P. Matise
Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
Development, August 1, 2004; 131(15): 3593 - 3604.
[Abstract] [Full Text] [PDF]

Y. Chen, V. Knezevic, V. Ervin, R. Hutson, Y. Ward, and S. Mackem
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh
Development, May 15, 2004; 131(10): 2339 - 2347.
[Abstract] [Full Text] [PDF]

O. V. Bulgakov, J. T. Eggenschwiler, D.-H. Hong, K. V. Anderson, and T. Li
FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
Development, May 1, 2004; 131(9): 2149 - 2159.
[Abstract] [Full Text] [PDF]

R. L. H. Bigelow, N. S. Chari, A. B. Unden, K. B. Spurgers, S. Lee, D. R. Roop, R. Toftgard, and T. J. McDonnell
Transcriptional Regulation of bcl-2 Mediated by the Sonic Hedgehog Signaling Pathway through gli-1
J. Biol. Chem., January 9, 2004; 279(2): 1197 - 1205.
[Abstract] [Full Text] [PDF]

L. Buttitta, R. Mo, C.-C. Hui, and C.-M. Fan
Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction
Development, December 22, 2003; 130(25): 6233 - 6243.
[Abstract] [Full Text] [PDF]

E. Roessler, Y.-Z. Du, J. L. Mullor, E. Casas, W. P. Allen, G. Gillessen-Kaesbach, E. R. Roeder, J. E. Ming, A. R. i Altaba, and M. Muenke
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features
PNAS, November 11, 2003; 100(23): 13424 - 13429.
[Abstract] [Full Text] [PDF]

F. Santagati, K. Abe, V. Schmidt, T. Schmitt-John, M. Suzuki, K.-i. Yamamura, and K. Imai
Identification of Cis-regulatory Elements in the Mouse Pax9/Nkx2-9 Genomic Region: Implication for Evolutionary Conserved Synteny
Genetics, September 1, 2003; 165(1): 235 - 242.
[Abstract] [Full Text] [PDF]

Y. Jeong and D. J. Epstein
Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node
Development, August 15, 2003; 130(16): 3891 - 3902.
[Abstract] [Full Text] [PDF]

S. L. Lopez, A. R. Paganelli, M. V. R. Siri, O. H. Ocana, P. G. Franco, and A. E. Carrasco
Notch activates sonic hedgehog and both are involved in the specification of dorsal midline cell-fates in Xenopus
Development, May 15, 2003; 130(10): 2225 - 2238.
[Abstract] [Full Text] [PDF]

R. O. Karlstrom, O. V. Tyurina, A. Kawakami, N. Nishioka, W. S. Talbot, H. Sasaki, and A. F. Schier
Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
Development, April 15, 2003; 130(8): 1549 - 1564.
[Abstract] [Full Text] [PDF]

C. B. Bai, W. Auerbach, J. S. Lee, D. Stephen, and A. L. Joyner
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
Development, March 12, 2003; 129(20): 4753 - 4761.
[Abstract] [Full Text] [PDF]

H. Yamagishi, J. Maeda, T. Hu, J. McAnally, S. J. Conway, T. Kume, E. N. Meyers, C. Yamagishi, and D. Srivastava
Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer
Genes & Dev., January 15, 2003; 17(2): 269 - 281.
[Abstract] [Full Text] [PDF]

P. Dai, T. Shinagawa, T. Nomura, J. Harada, S. C. Kaul, R. Wadhwa, M. M. Khan, H. Akimaru, H. Sasaki, C. Colmenares, et al.
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
Genes & Dev., November 15, 2002; 16(22): 2843 - 2848.
[Abstract] [Full Text] [PDF]

M. Persson, D. Stamataki, P. te Welscher, E. Andersson, J. Bose, U. Ruther, J. Ericson, and J. Briscoe
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
Genes & Dev., November 15, 2002; 16(22): 2865 - 2878.
[Abstract] [Full Text] [PDF]

I. D. Louro, E. C. Bailey, X. Li, L. S. South, P. R. McKie-Bell, B. K. Yoder, C. C. Huang, M. R. Johnson, A. E. Hill, R. L. Johnson, et al.
Comparative Gene Expression Profi

				K. Tanese, M. Fukuma, T. Yamada, T. Mori, T. Yoshikawa, W. Watanabe, A. Ishiko, M. Amagai, T. Nishikawa, and M. Sakamoto G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation Am. J. Pathol., September 1, 2008; 173(3): 835 - 843. [Abstract] [Full Text] [PDF]

				E. Dessaud, A. P. McMahon, and J. Briscoe Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network Development, August 1, 2008; 135(15): 2489 - 2503. [Abstract] [Full Text] [PDF]

				M. Tada, F. Kanai, Y. Tanaka, K. Tateishi, M. Ohta, Y. Asaoka, M. Seto, R. Muroyama, K. Fukai, F. Imazeki, et al. Down-Regulation of Hedgehog-Interacting Protein through Genetic and Epigenetic Alterations in Human Hepatocellular Carcinoma Clin. Cancer Res., June 15, 2008; 14(12): 3768 - 3776. [Abstract] [Full Text] [PDF]

				R. Alvarez-Medina, J. Cayuso, T. Okubo, S. Takada, and E. Marti Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression Development, January 15, 2008; 135(2): 237 - 247. [Abstract] [Full Text] [PDF]

				Y. Zavros, M. Waghray, A. Tessier, L. Bai, A. Todisco, D. L. Gumucio, L. C. Samuelson, A. Dlugosz, and J. L. Merchant Reduced Pepsin A Processing of Sonic Hedgehog in Parietal Cells Precedes Gastric Atrophy and Transformation J. Biol. Chem., November 16, 2007; 282(46): 33265 - 33274. [Abstract] [Full Text] [PDF]

				S. Thiyagarajan, N. Bhatia, S. Reagan-Shaw, D. Cozma, A. Thomas-Tikhonenko, N. Ahmad, and V. S. Spiegelman Role of GLI2 Transcription Factor in Growth and Tumorigenicity of Prostate Cells Cancer Res., November 15, 2007; 67(22): 10642 - 10646. [Abstract] [Full Text] [PDF]

				Y. Zhang, J. P. Bressler, J. Neal, B. Lal, H.-E. C. Bhang, J. Laterra, and M. G. Pomper ABCG2/BCRP Expression Modulates D-Luciferin Based Bioluminescence Imaging Cancer Res., October 1, 2007; 67(19): 9389 - 9397. [Abstract] [Full Text] [PDF]

				G. A. Bien-Willner, P. Stankiewicz, and J. R. Lupski SOX9cre1, a cis-acting regulatory element located 1.1 Mb upstream of SOX9, mediates its enhancement through the SHH pathway Hum. Mol. Genet., May 15, 2007; 16(10): 1143 - 1156. [Abstract] [Full Text] [PDF]

				S. A. Vokes, H. Ji, S. McCuine, T. Tenzen, S. Giles, S. Zhong, W. J. R. Longabaugh, E. H. Davidson, W. H. Wong, and A. P. McMahon Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning Development, May 15, 2007; 134(10): 1977 - 1989. [Abstract] [Full Text] [PDF]

				Z. Ji, F. C. Mei, J. Xie, and X. Cheng Oncogenic KRAS Activates Hedgehog Signaling Pathway in Pancreatic Cancer Cells J. Biol. Chem., May 11, 2007; 282(19): 14048 - 14055. [Abstract] [Full Text] [PDF]

				R. Haraguchi, J. Motoyama, H. Sasaki, Y. Satoh, S. Miyagawa, N. Nakagata, A. Moon, and G. Yamada Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling Development, February 1, 2007; 134(3): 525 - 533. [Abstract] [Full Text] [PDF]

				K. Tateishi, M. Ohta, F. Kanai, B. Guleng, Y. Tanaka, Y. Asaoka, M. Tada, M. Seto, A. Jazag, L. Lianjie, et al. Dysregulated Expression of Stem Cell Factor Bmi1 in Precancerous Lesions of the Gastrointestinal Tract Clin. Cancer Res., December 1, 2006; 12(23): 6960 - 6966. [Abstract] [Full Text] [PDF]

				J. He, T. Sheng, A. A. Stelter, C. Li, X. Zhang, M. Sinha, B. A. Luxon, and J. Xie Suppressing Wnt Signaling by the Hedgehog Pathway through sFRP-1 J. Biol. Chem., November 24, 2006; 281(47): 35598 - 35602. [Abstract] [Full Text] [PDF]

				A. R. Meloni, G. B. Fralish, P. Kelly, A. Salahpour, J. K. Chen, R. J. Wechsler-Reya, R. J. Lefkowitz, and M. G. Caron Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2 Mol. Cell. Biol., October 15, 2006; 26(20): 7550 - 7560. [Abstract] [Full Text] [PDF]

				J. Xu, B. P. Srinivas, S. Y. Tay, A. Mak, X. Yu, S. G. P. Lee, H. Yang, K. R. Govindarajan, B. Leong, G. Bourque, et al. Genomewide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development Genetics, October 1, 2006; 174(2): 735 - 752. [Abstract] [Full Text] [PDF]

				E. Nieuwenhuis, J. Motoyama, P. C. Barnfield, Y. Yoshikawa, X. Zhang, R. Mo, M. A. Crackower, and C.-c. Hui Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia. Mol. Cell. Biol., September 1, 2006; 26(17): 6609 - 6622. [Abstract] [Full Text] [PDF]

				M. Zhao, M. Qiao, S. E. Harris, D. Chen, B. O. Oyajobi, and G. R. Mundy The zinc finger transcription factor gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol. Cell. Biol., August 1, 2006; 26(16): 6197 - 6208. [Abstract] [Full Text] [PDF]

				M. Kasper, H. Schnidar, G. W. Neill, M. Hanneder, S. Klingler, L. Blaas, C. Schmid, C. Hauser-Kronberger, G. Regl, M. P. Philpott, et al. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes. Mol. Cell. Biol., August 1, 2006; 26(16): 6283 - 6298. [Abstract] [Full Text] [PDF]

				N. Bhatia, S. Thiyagarajan, I. Elcheva, M. Saleem, A. Dlugosz, H. Mukhtar, and V. S. Spiegelman Gli2 Is Targeted for Ubiquitination and Degradation by beta-TrCP Ubiquitin Ligase J. Biol. Chem., July 14, 2006; 281(28): 19320 - 19326. [Abstract] [Full Text] [PDF]

				T Akiyoshi, M Nakamura, K Koga, H Nakashima, T Yao, M Tsuneyoshi, M Tanaka, and M Katano Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation Gut, July 1, 2006; 55(7): 991 - 999. [Abstract] [Full Text] [PDF]

				T. Koide, T. Hayata, and K. W. Y. Cho Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase Development, June 15, 2006; 133(12): 2395 - 2405. [Abstract] [Full Text] [PDF]

				J. Feng, C. Bi, B. S. Clark, R. Mady, P. Shah, and J. D. Kohtz The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator Genes & Dev., June 1, 2006; 20(11): 1470 - 1484. [Abstract] [Full Text] [PDF]

				M. C. Hu, R. Mo, S. Bhella, C. W. Wilson, P.-T. Chuang, C.-c. Hui, and N. D. Rosenblum GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis Development, February 1, 2006; 133(3): 569 - 578. [Abstract] [Full Text] [PDF]

				T. Sheng, S. Chi, X. Zhang, and J. Xie Regulation of Gli1 Localization by the cAMP/Protein Kinase A Signaling Axis through a Site Near the Nuclear Localization Signal J. Biol. Chem., January 6, 2006; 281(1): 9 - 12. [Abstract] [Full Text] [PDF]

				M. Ohta, K. Tateishi, F. Kanai, H. Watabe, S. Kondo, B. Guleng, Y. Tanaka, Y. Asaoka, A. Jazag, J. Imamura, et al. p53-Independent Negative Regulation of p21/Cyclin-Dependent Kinase-Interacting Protein 1 by the Sonic Hedgehog-Glioma-Associated Oncogene 1 Pathway in Gastric Carcinoma Cells Cancer Res., December 1, 2005; 65(23): 10822 - 10829. [Abstract] [Full Text] [PDF]

				A. Sawada, Y. Nishizaki, H. Sato, Y. Yada, R. Nakayama, S. Yamamoto, N. Nishioka, H. Kondoh, and H. Sasaki Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor Development, November 1, 2005; 132(21): 4719 - 4729. [Abstract] [Full Text] [PDF]

				M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development Mol. Cell. Biol., August 15, 2005; 25(16): 7042 - 7053. [Abstract] [Full Text] [PDF]

				N. Gao, K. Ishii, J. Mirosevich, S. Kuwajima, S. R. Oppenheimer, R. L. Roberts, M. Jiang, X. Yu, S. B. Shappell, R. M. Caprioli, et al. Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation Development, August 1, 2005; 132(15): 3431 - 3443. [Abstract] [Full Text] [PDF]

				P. J. Gianakopoulos and I. S. Skerjanc Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells J. Biol. Chem., June 3, 2005; 280(22): 21022 - 21028. [Abstract] [Full Text] [PDF]

				T. Yamamoto and N. Suzuki Expression and Function of cGMP-dependent Protein Kinase Type I during Medaka Fish Embryogenesis J. Biol. Chem., April 29, 2005; 280(17): 16979 - 16986. [Abstract] [Full Text] [PDF]