Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation

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Apfel, C., Bauer, F., Crettaz, M., Forni, L., Kamber, M., Kaufmann, F., LeMotte, P., Pirson, W. and Klaus, M (1992). A retinoic acid receptorantagonist selectively counteracts retinoic acid effects. Proc. Natl. Acad. Sci. USA 89, 7129-7133.[Abstract/Free Full Text]

Balkan, W., Colbert, M., Bock, C. and Linney, E (1992). Transgenic indicator mice for studying activated retinoic acid receptors during development. Proc. Natl. Acad. Sci. USA 89, 3347-3351.[Abstract/Free Full Text]

Burke, A. C., Nelson, C. E., Morgan, B. A. and Tabin, C (1995). Hox genes and the evolution of vertebrate axial morphology. Development 121, 333-346.[Abstract]

Charite, J., Graaff, W. D., Shen, S. and Deschamps, J (1994). Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures. Cell 78, 589-601.[Medline]

Chaube, S (1959). On axiation and symmetry in the transplanted wing of the chick. J. Exp. Zool 140, 29-77.

Chen, Y.-P., Huang, L., Russo, A. F. and Solursh, M (1992). Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo. Proc. Natl. Acad. Sci. USA 89, 10056-10059.[Abstract/Free Full Text]

Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A (1996). Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature 383, 407-413.[Medline]

Cooke, J. and Summerbell, D (1980). Cell cycle and experimental pattern duplication in the chick wing during embryonic development. Nature 287, 697-701.[Medline]

Crossley, P. H., Minowanda, G., MacArthur, C. A. and Martin, G. R (1996). Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 84, 127-136.[Medline]

Davis, A. P. and Capecchi, M. R (1996). A mutational analysis of the 5 HoxD genes: dissection of genetic interactions during limb development in the mouse. Development 122, 1175-1185.[Abstract]

de The, H., Mar Vivanco-Ruiz, M. D., Tiollais, P., Stunnenberg, H. and DeJean, A (1990). Identification of a retinoic acid response element in the retinoic acid receptorgene. Nature 343, 177-180.[Medline]

Deschamps, J. and Wijgerde, M (1993). Two phases in the establishment of HOX expression domains. Dev. Biol 156, 473-480.[Medline]

Duprez, D. M., Kostakopoulou, K., Francis-West, P. H., Tickle, C. and Brickell, P. M (1996). Activation of Fgf-4 and HoxD gene expression by BMP-2 expression cells in the developing chick limb. Development 122, 1821-1828.[Abstract]

Eichele, G., Tickle, C. and Alberts, B. M (1985). Studies on the mechanism of retinoid-induced pattern duplications in the early chick limb bud: temporal and spacial aspects. J. Cell Biol 101, 1913-1920.[Abstract/Free Full Text]

Francis, P. H., Richardson, M. K., Brickell, P. M. and Tickle, C (1994). Bone morphogenetic proteins and a signaling pathway that controls patterning in the developing chick limb. Development 120, 209-218.[Abstract]

Gerard, M., Chen, J.-Y., Gronemeyer, H., Chambon, P., Duboule, D. and Z\207k\207ny, J (1996). In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries. Genes Dev 10, 2326-2334.[Abstract/Free Full Text]

Goulding, M., Lumsden, A. and Paquette, A. J (1994). Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. Development 120, 957-971.[Abstract]

Hamburger, H. and Hamilton, V (1951). A series of normal stages in the development of the chick embryo. J. Morphol 88, 49-92.

Helms, J., Thaller, C. and Eichele, G (1994). Relationship between retinoic acid and sonic hedgehog , two polarizing signals in the chick wing bud. Development 120, 3267-3274.[Abstract]

Helms, J., Kim, C. H., Thaller, C. and Eichele, G (1996). Retinoic acid signaling is required during early limb development. Development 122, 1385-1394.[Abstract]

Hogan, B. L. M., Thaller, C. and Eichele, G (1992). Evidence that Hensen's node is a site of retinoic acid synthesis. Nature 359, 237-241.[Medline]

Horan, G. S. B., Ramiro, R.-S., Featherstone, M. S., Wolgemuth, D. J., Bradley, A. and Beringer, R. R (1995). Compound mutants for the paralogous hoxa-4 , hoxb-4 , and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. Genes Dev 9, 1667-1677.[Abstract/Free Full Text]

Hornbruch, A. and Wolpert, L (1991). The spatial and temporal distribution of polarizing activity in the flank of the pre-limb-bud stages in the chick embryos. Development 111, 725-731.[Abstract]

Izpis\234a-Belmonte, J.-C., Tickle, C., Dolle, P., Wolpert, L. and Duboule, D (1991). Expression of homeobox Hox-4 genes and the specification of position in chick wing development. Nature 350, 585-589.[Medline]

Krumlauf, R (1994). Hox genes in vertebrate development. Cell 78, 191-201.[Medline]

Lala, D. S., Mukherjee, R., Schulman, I. G., Canan Koch, S. S., Dardashti, L. J., Nadzan, A. M., Croston, G. E., Evans, R. M. and Heyman, R. A (1996). Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature 383, 450-453.[Medline]

Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.[Medline]

Lu, H.-C., Eichele, G. and Thaller, C (1997). Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis. Development 124, 195-203.[Abstract]

Lund, L. R., R\277nne, E., Roldan, A. L., Behrend, N., R\277mer, J., Biasi, F. and Dan\277, K (1991). Urokinase receptor mRNA level and gene transcription are strongly and rapidly increased by phorbol myristate acetate in human monocyte-like U937 cells. J. Biol. Chem 266, 5177-5181.[Abstract/Free Full Text]

McGinnis, W. and Krumlauf, R (1992). Homeobox genes and axial patterning. Cell 68, 283-302.[Medline]

Murphy, P. and Hill, R. E (1991). Expression of the mouse labial -like homeobox-containing genes, Hox 2.9 and Hox 1.6 , during segmentation of the hindbrain. Development 111, 61-74.[Abstract]

Niswander, L., Jeffrey, S., Martin, G. R. and Tickle, C (1994). A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371, 609-612.[Medline]

Nohno, T., Noji, S., Koyama, E., Ohyama, K., Myokai, F., Kuroiwa, A., Saito, T. and Taniguchi, S (1991). Involvement of Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development. Cell 64, 1197-1205.[Medline]

Noji, S., Nohno, T., Koyama, E., Muto, K. and Ohyama, K (1991). Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud. Nature 350, 83-86.[Medline]

Oliver, G., Robertis, E. M. D., Wolpert, L.,and Tickle, C (1990). Expression of a homeobox gene in the chick wing bud following application of retinoic acid and grafts of polarizing region tissue. EMBO J 9, 3093-3099.[Medline]

P\232pper, H., M. Bienz, M. Studer, S.-K. Chan, S. Aparicio, S. Brenner, R. S. Mann and Krumlauf, R (1995). Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx. Cell 81, 1031-1042.[Medline]

Psychoyos, D. and Stern, C. D (1996). Fates and migratory routes of primitive streak cells in the chick embryo. Development 122, 1523-1534.[Abstract]

Rancourt, D. E., Tsuzuki, T. and Capecchi, M. R (1995). Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev 9, 108-122.[Abstract/Free Full Text]

Reynolds, K., Mezey, E. and Zimmer, A (1991). Activity of the-retinoic acid receptor promoter in transgenic mice. Mech. Dev 36, 15-29.[Medline]

Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. M. and Dodd,J (1994). Floor plate and motor neuron induction by vhh-1 , a vertebrate homolog of hedgehog expressed by the notochord. Cell 76, 761-775.[Medline]

Rossant, J., Zirngibl, R., Cado, D., Shago, M. and Giguere, V (1991). Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes Dev 5, 1333-1344.[Abstract/Free Full Text]

Saunders, J. W (1948). The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. J. Exp. Zool 108, 363-403.[Medline]

Scotting, P. J., Hewitt, M. and Keynes, R. J (1990). Isolation and analysis of chick homeobox cDNA clones. Nucl. Acids Res 18, 3999-.[Free Full Text]

Smith, S. M. and Eichele, G (1991). Temporal and regional differences in the expression pattern of distinct retinoic acid receptor-transcripts in the chick embryo. Development 111, 245-252.[Abstract]

Stratford, T., Horton, C. and Maden, M (1996). Retinoic acid is required for the initiation of outgrowth in the chick limb bud. Current Biology 6, 1124-1133.[Medline]

Sucov, H. M., Murakami, K. K. and Evans, R. M (1990). Characterization of an autoregulated response element in the mouse retinoic acid receptor typegene. Proc. Natl. Acad. Sci. USA 87, 5392-5396.[Abstract/Free Full Text]

Summerbell, D., Lewis, J. and Wolpert, L (1973). Positional information in chick limb morphogenesis. Nature 224, 492-496.

Summerbell, D (1974). A quantitative analysis of the effect of excision of the AER from the chick limb bud. J. Embryol. Exp. Morph 32, 651-660.[Medline]

Sundin, O. and Eichele, G (1990). Antibody to a homeo domain protein reveals the metameric nature of the developing chick hindbrain. Genes Dev 4, 1267-1276.[Abstract/Free Full Text]

Tabin, C (1995). The initiation of the limb bud: growth factors, Hox genes, and retinoids. Cell 80, 671-674.[Medline]

Tickle, C (1995). Vertebrate limb development. Current Biology 5, 478-484.

Tickle, C. and Eichele, G (1994). Vertebrate limb development. Ann. Rev. Cell Biol 10, 121-152.

Tickle, C., Summerbell, D. and Wolpert, L (1975). Positional signaling and specification of digits in chick limb morphogenesis. Nature 254, 199-202.[Medline]

Vogel, A., Rodriguez, C. and Izpis\234a-Belmonte, J.-C (1996). Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122, 1737-1750.[Abstract]

Wanek, N., Gardiner, D. M., Muneoka, K. and Bryant, S. V (1991). Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud. Nature 350, 81-83.[Medline]

Wedden, S. E., Thaller, C. and Eichele, G (1990). Targeted slow release of retinoids into chick embryos. Methods Enzymol 190, 201-209.[Medline]

Yang, Y. and Niswander, L (1995). Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell 80, 939-947.[Medline]

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				A. Tavares, T Tsukui, and J. Izpisua Belmonte Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development Development, January 12, 2000; 127(23): 5133 - 5144. [Abstract] [PDF]

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				D. Warburton, J. Zhao, M. A. Berberich, and M. Bernfield Molecular embryology of the lung: then, now, and in the future Am J Physiol Lung Cell Mol Physiol, May 1, 1999; 276(5): L697 - L704. [Abstract] [Full Text] [PDF]

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				T. Stratford, K Kostakopoulou, and M Maden Hoxb-8 has a role in establishing early anterior-posterior polarity in chick forelimb but not hindlimb Development, January 11, 1997; 124(21): 4225 - 4234. [Abstract] [PDF]