The Dorsal-related immunity factor (Dif) can define the dorsal-ventral axis of polarity in the Drosophila embryo

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Alberga, A., Boulay, J.-L., Kempe, E., Dennefield, C. and Haenlin, M (1991). The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers. Development 111, 983-992.[Abstract/Free Full Text]

Beg, A. A. and Baldwin, A. S., Jr (1993). The IB proteins: multifunctional regulators of Rel/NF- B transcription factors. Genes Dev 7, 2064-2070.[Free Full Text]

Beg, A. A., Ruben, S. M., Scheinman, R. I., Haskill, S., Rosen, C. A. and Baldwin, A. S., Jr (1992). IB interacts with nuclear localization sequences of the subunits of NF- B: a mechanism for cytoplasmic retention. Genes Dev 6, 1899-1913.[Abstract/Free Full Text]

Belvin, M. P., Jin, Y. and Anderson, K. V (1995). Cactus protein degradation mediates Drosophila dorsal-ventral signaling. Genes Dev 9, 783-793.[Abstract/Free Full Text]

Bergmann, A., Stein, D., Geisler, R., Hagenmaier, S., Schmid, B., Fernandez, N., Schnell, B. and Nusslein-Volhard, C (1996). A gradientof cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila. Mech. Dev 60, 109-123.[Medline]

Berleth, T., Burri, M., Thoma, G., Richstein, S., Frigerio, G., Noll, M. and Nusslein-Volhard, C (1988). The role of the localization of bicoid in organizing the anterior pattern of the Drosophila embryo. EMBO J 7, 1749-1756.[Medline]

Bouley, J. L., Dennefeld, C. and Alberga, A (1987). The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers. Nature 330, 395-398.[Medline]

Bours, V., Villalobos, J., Burd, P. R., Kelly, K. and Siebenlist, U (1990). Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs. Nature 348, 76-80.[Medline]

Brown, N. H. and Kafatos, F. C (1988). Functional cDNA libraries from Drosophila embryos. J. Mol. Biol 203, 425-437.[Medline]

Cao, Z., Henzel, W. J. and Gao, X (1996). IRAK: a kinase associated with the interleukin-1 receptor. Science 271, 1128-31.[Abstract]

Colicelli, J., Birchmeier, C. Michaeli, T., O'Neill, K., Riggs, M. and Wigler, M (1989). Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Proc. Nat. Acad. Sci. USA 86, 3599-3603.[Abstract/Free Full Text]

Crews S. T., Thomas, J. B. and Goodman, C. S (1988). The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. Cell 52, 143-151.[Medline]

Doyle, H. J., Kraut, R. and Levine, M (1989). Spatial regulation of zerknullt : a dorsal-ventral patterning gene in Drosophila. Genes Dev 3, 1518-1533.[Abstract/Free Full Text]

Driever, W., Siegel, V. and Nusslein-Volhard, C (1990). Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen. Development 109, 811-820.[Abstract/Free Full Text]

Dubnicoff, T., Valentine, S. A., Chen, G., Shi, T., Lengyel, J. A., Paroush, Z. and Courey, A. J (1997). Conversion of Dorsal from an activator to a repressor by the global corepressor Groucho. Genes Dev 11, 2952-2957.[Abstract/Free Full Text]

Engstrom, Y., Kadalayil, L., Sun, S.-C., Samakovlis, C., Hultmark, D. and Faye, I (1993). B-like motifs regulate the induction of immune genes in Drosophila. J. Mol. Biol 232, 327-333.[Medline]

Fields, S. and Song, O.-K (1989). A novel genetic system to detect protein-protein interactions. Nature 340, 245-246.[Medline]

Ganchi, P. A., Sun, S.-C., Greene, W. C. and Ballard, D. W (1992). IB/MAD-3 masks the nuclear localization signal of NF B p65 and requires the transactivation domain to inhibit NFB p65 DNA binding. Mol. Biol. Cell 3, 1339-1352.[Abstract]

Gay, N. J. and Keith, F. J (1991). Drosophila Toll and IL-1 receptor. Nature 351, 355-356.[Medline]

Geisler, R., Bergmann, A., Hiromi, Y. and Nusslein-Volhard, C (1992). cactus , a gene involved in dorsoventral pattern formation in Drosophila , is related to the IB gene family of vertebrates. Cell 71, 613-621.[Medline]

Georgel, P., Kappler, C., Langley, E., Gross, I., Nicolas, E., Reichhart, J. M. and Hoffmann, J. A (1995). Drosophila immunity. A sequence homologous to mammalian interferon consensus response element enhances the activity of the diptericin promoter. Nucleic Acids Res 23, 1140-1145.[Abstract/Free Full Text]

Ghosh, S., Gifford, A. M., Riviere, L. R., Tempst, P., Nolan, G. P. and Baltimore, D (1990). Cloning of the p50 DNA binding subunit of NF-B: homology to rel and dorsal. Cell 62, 1019-1029.[Medline]

Gillespie, S. K. H. and Wasserman, S. A (1994). Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll. Mol. Cell. Biol 14, 3559-3568.[Abstract/Free Full Text]

Gonzalez-Crespo, S. and Levine, M (1993). Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila. Genes Dev 7, 1703-1717.[Abstract/Free Full Text]

Govind, S., Brennan, L. and Steward R (1993). Homeostatic balance between Dorsal and Cactus proteins in the Drosophila embryo. Development 117, 135-148.[Abstract]

Gross, I., Georgel, P., Kappler, C., Reichart, J.-M. and Hoffman, J. A (1996). Drosophila immunity: a comparative analysis of the Rel proteins Dorsal and Dif in the induction of the genes encoding diptericin and cecropin. Nucleic Acids Res 24, 1238-1245.[Abstract/Free Full Text]

Hashimoto, C., Hudson, K. L. and Anderson, K. V (1988). The Toll gene of Drosophila , required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52, 269-279.[Medline]

Hemavathy, K., Meng, X. and Ip, Y. T (1997). Differential regulation of gastrulation and neuroectodermal gene expression by Snail in the Drosophila embryo. Development 124, 3683-3691.[Abstract]

Henkel, T., Zabel, U., van Zee, K., Muller, J. M., Fanning, E. and Baeuerle, P. A (1992). Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NFB Subunit. Cell 68, 1121-1133.[Medline]

Huang, J.-D., Dubnicoff, T., Liaw, G.-J., Bai, Y., Valentine, S., Shirokawa J. M., Lengyel, J. and Courey, A. J (1995). Binding sites for transcription factor NTF-1/Elf-1 contribute to the ventral repression of decapentaplegic. Genes Dev 9, 3177-3189.[Abstract/Free Full Text]

Huang, J.-D., Schwyter, D. H., Shirokawa, J. M. and Courey, A. J (1993). The interplay between multiple enhancer and silencer elements defines the pattern of decapentaplegic expression. Genes Dev 7, 694-704.[Abstract/Free Full Text]

Hultmark, D (1993). Immune reactions in Drosophila and other insects: a model for innate immunity. Trends Genet 9, 178-193.[Medline]

Hultmark. D (1994). Ancient relationships. Nature 367, 116-117.[Medline]

Ip, Y. T., Park, R. E., Kosman, D., Bier, E. and Levine, M (1992). The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev 6, 1728-1739.[Abstract/Free Full Text]

Ip, Y. T., Park, R. E., Kosman, D., Yazdanbakhsh, K. and Levine, M (1992). dorsal - twist interactions establish snail expression in the pre-sumptive mesoderm of the Drosophila embryo. Genes Dev 6, 1518-1530.[Abstract/Free Full Text]

Ip, Y. T., Reach, M., Engstrom, Y., Kadalayil, L., Cai, H., Gonzalez-Crespo, S., Tatei, K. and Levine, M (1993). Dif , a dorsal -related gene that mediates an immune response in Drosophila. Cell 75, 753-763.[Medline]

Ip, Y. T (1995). Converting an activator into a repressor. Curr. Biol 5, 1-3.[Medline]

Ito, H., Fukuda, K., Murata, K., amd Kimura, A (1983). Transformation of intact yeast cells treated with alkali cations. J. Bacteriol 153, 163-168.[Abstract/Free Full Text]

Jiang, J., Cai, H., Zhou, Q. and Levine, M (1993). Conversion of a dorsal -dependent silencer into an enhancer: evidence for dorsal corepressors. EMBO J 12, 3201-3209.[Medline]

Jiang, J., Kosman, D., Ip, Y. T. and Levine, M (1991). The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes Dev 5, 1881-1891.[Abstract/Free Full Text]

Jiang, J. and Levine, M (1993). Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the Dorsal gradient morphogen. Cell 72, 741-752.[Medline]

Jiang, J., Rushlow, C. A., Zhou, Q., Small., S. and Levine, M (1992). Individual Dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo. EMBO J 11, 3147-3154.[Medline]

Kidd, S (1992). Characterization of the Drosophilacactus locus and analysis of interactions between Cactus and Dorsal proteins. Cell 71, 623-635.[Medline]

Kieran, M., Blank, V., Logeat, F., Vandekerckhove, J., Lottspeich, F., Le Bail, O., Urban, M. B., Kourilsky, P., Bauerle, P. A. and Isra\221l, A (1990). The DNA binding subunit of NF-B is identical to factor KBF1 and homologous to the rel oncogene product. Cell 62, 1007-1018.[Medline]

Kirov, N., Zhelnin, L., Shah, J. and Rushlow, C. A (1993). Conversion of a silencer into an enhancer: evidence for a co-repressor in Dorsal-mediated repression in Drosophila. EMBO J 12, 3193-3199.[Medline]

Kosman, D., Ip, Y. T., Levine, M. and Arora, K (1991). Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo. Science 254, 118-122.[Abstract/Free Full Text]

Lehming, N., McGuire, S., Brickman, J. M. and Ptashne, M (1995). Interactions of a Rel protein with its inhibitor. Proc. Nat. Acad. Sci. USA 92, 10242-10246.[Abstract/Free Full Text]

Lehming, N., Thanos, D., Brickman, J. M., Ma, J., Maniatis, T. and Ptashne, M (1994). An HMG-like protein that can switch a transcriptional activator to a repressor. Nature 371, 175-179.[Medline]

Lemaitre, B., Meister, M., Govind, S., Georgel, P., Steward, R., Reichhart, J. M. and Hoffmann, J. A (1995). Functional analysis and regulation of nuclear import of Dorsal during the immune response in Drosophila. EMBO J 14, 536-45.[Medline]

Lemaitre, B., Nicolas, E., Michaut, L, Reichhart, J.-M. and Hoffman, J.A (1996). The dorsoventral regulatory gene cassette sp\212tzle / Toll / cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983.[Medline]

Leptin, M (1991). twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev 5, 1568-1576.[Abstract/Free Full Text]

Meister, M., Braun, A., Kappler, C., Reichhart, J. M. and Hoffmann, J. A (1994). A transgenic analysis in Drosophila defines several functional domains in the diptericin promoter. EMBO J 13, 5958-5966.[Medline]

Morisato, D. and Anderson, K. V (1994). The sp\212tzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo. Cell 76, 677-688.[Medline]

Morisato, D. and Anderson, K. V (1995). Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo. Ann. Rev. Genet 29, 371-399.[Medline]

Nolan, G. P., Ghosh, S., Liou, H.-C., Tempst, P. and Baltimore, D (1991). DNA binding and IB inhibition of the cloned p65 subunit of NF B, a Rel-related polypeptide. Cell 64, 961-969.[Medline]

Norris, J. L. and Manley, J. L (1992). Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A. Genes Dev 6, 1654-1667.[Abstract/Free Full Text]

Nusslein-Volhard, C., Lohs-Schardin, M., Sander, K. and Cremer, C (1980). A dorsoventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila. Nature 283, 474-476.[Medline]

Pan, D. and Courey, A. J (1992). The same Dorsal binding site mediates both activation and repression in a context-dependent manner. EMBO J 11, 1837-1842.[Medline]

Pan, D., Huang J.-D. and Courey, A. J (1991). Functional analysis of the Drosophilatwist promoter reveals a Dorsal-binding ventral activator region. Genes Dev 5, 1892-1901.[Abstract/Free Full Text]

Petersen, U.-M., Bj\232rklund, G., Ip, Y. T. and Engstrom, Y (1995). The dorsal -related immunity factor, Dif, is a sequence-specific trans-activator of DrosophilaCecropin gene expression. EMBO J 14, 3146-3158.[Medline]

Ray, R. P., Arora, K., Nusslein-Volhard, C. and Gelbart,W. M (1991). The control of cell fate along the dorsal-ventral axis of the Drosophila embryo. Development 113, 35-54.[Abstract]

Reach, M., Galindo, R. L., Towb, P., Allen, J. L., Karin, M. and Wasserman, S. A (1996). A gradient of Cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo. Dev. Biol 180, 353-364.[Medline]

Reichhart, J. M., Meister, M., Dimarcq, J. L., Zachary, D., Hoffmann, D., Ruiz, C., Richards, G. and Hoffmann, J. A (1992). Insect immunity: developmental and inducible activity of the Drosophila diptericin promoter. EMBO J 11, 1469-1477.[Medline]

Roth, S., Hiromi, Y., Godt, D. and Nusslein-Volhard, C (1991). cactus , a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos. Development 112, 371-388.[Abstract]

Ruben, S. M., Dillon, P. J., Schreck, R., Henkel, T., Chen, C.-H., Maher, M., Baeuerle, P. A. and Rosen, C. A (1991). Isolation of a rel -related human cDNA that potentially encodes the 65-kd subunit of NF-B. Science 251, 1490-1493.[Abstract/Free Full Text]

Rusch, J. and Levine, M (1996). Threshold responses to the dorsal regulatory gradient and the subdivision of primary territories in the Drosophila embryo. Curr. Opin. Genet. Dev 6, 416-423.[Medline]

Rushlow, C. and Arora, K (1990). Dorsal ventral polarity and pattern formation in the Drosophila embryo. Sem. Cell Biol 1, 137-149.[Medline]

St Johnston, R. D. and Gelbart, W. M (1987). Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo. EMBO J 6, 2785-2791.[Medline]

Schneider, D. S., Hudson, K. L., Lin, T.-Y. and Anderson, K. V (1991). Dominant and recessive mutations define functional domains of Toll , a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes Dev 5, 797-807.[Abstract/Free Full Text]

Schneider, D. S., Jin, Y., Morisato, D. and Anderson, K. V (1994). A processed form of the Sp\212tzle protein defines dorsal-ventral polarity in the Drosophila embryo. Development 120, 1243-50.[Abstract]

Shelton, C. A. and Wasserman, S. A (1993). pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Cell 72, 515-525.[Medline]

Shirokawa, J. and Courey, A. J (1997). A Direct contact between the Dorsal rel homology domain and Twist may mediate transcriptional synergy. Mol. Cell. Biol 17, 3345-3355.[Abstract]

Stein, D., Roth, S., Vogelsang, E. and Nusslein-Volhard, C (1991). The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal. Cell 65, 725-735.[Medline]

Stephens, R. M., Rice, N. R., Hiebsch, R. R., Bose, H. R., Jr. and Gilden, R. V (1983). Nucleotide sequence of v-rel : the oncogene of reticuloendotheliosis virus. Proc. Nat. Acad. Sci. USA 80, 6229-33.[Abstract/Free Full Text]

Steward, R (1987). Dorsal , an embryonic polarity gene in Drosophila , is homologous to the vertebrate proto-oncogene, c-rel. Science 238, 692-694.[Abstract/Free Full Text]

Szymanski, P. and Levine, M (1995). Multiple modes of Dorsal-bHLH transcriptional synergy in the Drosophila embryo. EMBO J 14, 2229-2238.[Medline]

Tatei, K. and Levine, M (1995). Specificity of Rel-inhibitor interactions in Drosophila embryos. Mol. Cell. Biol 15, 3627-3634.[Abstract]

Tautz, D. and Pfeifle, C (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.[Medline]

Thisse, B., Stoetzal, C., El Messal, M. and Perrin-Schmitt, F (1987). Genes of the Drosophila maternal dorsal group control the specific expression of the zygotic gene twist in presumptive mesodermal cells. Genes Dev 1, 709-715.[Abstract/Free Full Text]

Thisse, B., Stoetzal, C., Gorostiza-Thisse, C. and Perrin-Schmitt, F (1988). Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos. EMBO J 7, 2175-2183.[Medline]

Thisse, C., Perrin-Schmitt, F., Stoetzal, C. and Thisse, B (1991). Sequence-specific transactivation of the Drosophilatwist gene by the dorsal gene product. Cell 65, 1191-1201.[Medline]

Thomas, J. B., Crews, S. T. and Goodman, C. S (1988). Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system. Cell 52, 133-141.[Medline]

van der Meer, J. M (1977). Optical clean and permanent whole mount preparations for phase-contrast microscopy of cuticular structures of insect larvae. Dros. Inf. Serv 52, 160-.

Verma, I. M., Stevenson, J. K., Schwartz, E. M., Van Antwerp, D. and Miyamoto, S (1995). Rel/NF-B/I B family: intimate tales of association and dissociation. Genes Dev 9, 2723-2735.[Free Full Text]

Wasserman, S. A (1992). A conserved signal transduction pathway regulating the activity of the rel -like proteins Dorsal and NF-B. Mol. Biol. Cell 4, 767-771.[Medline]

Whalen, A.M. and Steward, R (1993). Dissociation of the dorsal-cactus complex and phsophorylation of the dorsal protein correlate with the nuclear localization of dorsal. J. Cell Biol 123, 523-534.[Abstract/Free Full Text]

Wilhelmsen, K. C., Eggleton, K. and Temin, H. M (1984). Nucleic acid sequences of the oncogene v-rel in reticuloendotheliosis virus strain T and its cellular homolog, the proto-oncogene c-rel. J. Virol 52, 172-82.[Abstract/Free Full Text]

Wilhelmsen, K. C. and Temin, H. M (1984). Structure and dimorphism of c-rel (turkey), the cellular homolog to the oncogene of reticuloendotheliosis virus strain T. J. Virol 49, 521-9.[Abstract/Free Full Text]

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				N. Q. Fernandez, J. Grosshans, J. S. Goltz, and D. Stein Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation Development, August 1, 2001; 128(15): 2963 - 2974. [Abstract] [Full Text] [PDF]

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