Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

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Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features
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[Abstract] [Full Text] [PDF]

I. Patten, P. Kulesa, M. M. Shen, S. Fraser, and M. Placzek
Distinct modes of floor plate induction in the chick embryo
Development, October 15, 2003; 130(20): 4809 - 4821.
[Abstract] [Full Text] [PDF]

Y. Jeong and D. J. Epstein
Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node
Development, August 15, 2003; 130(16): 3891 - 3902.
[Abstract] [Full Text] [PDF]

R. O. Karlstrom, O. V. Tyurina, A. Kawakami, N. Nishioka, W. S. Talbot, H. Sasaki, and A. F. Schier
Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
Development, April 15, 2003; 130(8): 1549 - 1564.
[Abstract] [Full Text] [PDF]

E. Roessler and M. Muenke
How a Hedgehog might see holoprosencephaly
Hum. Mol. Genet., April 2, 2003; 12(90001): R15 - 25.
[Abstract] [Full Text] [PDF]

C. B. Bai, W. Auerbach, J. S. Lee, D. Stephen, and A. L. Joyner
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
Development, March 12, 2003; 129(20): 4753 - 4761.
[Abstract] [Full Text] [PDF]

P. Ybot-Gonzalez, P. Cogram, D. Gerrelli, and A. J. Copp
Sonic hedgehog and the molecular regulation of mouse neural tube closure
Development, March 7, 2003; 129(10): 2507 - 2517.
[Abstract] [Full Text] [PDF]

P. Mill, R. Mo, H. Fu, M. Grachtchouk, P. C.W. Kim, A. A. Dlugosz, and C.-c. Hui
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
Genes & Dev., January 15, 2003; 17(2): 282 - 294.
[Abstract] [Full Text] [PDF]

M. Wijgerde, J. A. McMahon, M. Rule, and A. P. McMahon
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
Genes & Dev., November 15, 2002; 16(22): 2849 - 2864.
[Abstract] [Full Text] [PDF]

				E. Dessaud, A. P. McMahon, and J. Briscoe Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network Development, August 1, 2008; 135(15): 2489 - 2503. [Abstract] [Full Text] [PDF]

				T. Eichberger, A. Kaser, C. Pixner, C. Schmid, S. Klingler, M. Winklmayr, C. Hauser-Kronberger, F. Aberger, and A.-M. Frischauf GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells J. Biol. Chem., May 2, 2008; 283(18): 12426 - 12437. [Abstract] [Full Text] [PDF]

				S. Thiyagarajan, N. Bhatia, S. Reagan-Shaw, D. Cozma, A. Thomas-Tikhonenko, N. Ahmad, and V. S. Spiegelman Role of GLI2 Transcription Factor in Growth and Tumorigenicity of Prostate Cells Cancer Res., November 15, 2007; 67(22): 10642 - 10646. [Abstract] [Full Text] [PDF]

				J. Vierkotten, R. Dildrop, T. Peters, B. Wang, and U. Ruther Ftm is a novel basal body protein of cilia involved in Shh signalling Development, July 15, 2007; 134(14): 2569 - 2577. [Abstract] [Full Text] [PDF]

				B. L. Allen, T. Tenzen, and A. P. McMahon The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development Genes & Dev., May 15, 2007; 21(10): 1244 - 1257. [Abstract] [Full Text] [PDF]

				J. Bok, D. K. Dolson, P. Hill, U. Ruther, D. J. Epstein, and D. K. Wu Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear Development, May 1, 2007; 134(9): 1713 - 1722. [Abstract] [Full Text] [PDF]

				R. Haraguchi, J. Motoyama, H. Sasaki, Y. Satoh, S. Miyagawa, N. Nakagata, A. Moon, and G. Yamada Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling Development, February 1, 2007; 134(3): 525 - 533. [Abstract] [Full Text] [PDF]

				H. Zhou, S. Kim, S. Ishii, and T. G. Boyer Mediator Modulates Gli3-Dependent Sonic Hedgehog Signaling Mol. Cell. Biol., December 1, 2006; 26(23): 8667 - 8682. [Abstract] [Full Text] [PDF]

				E. Nieuwenhuis, J. Motoyama, P. C. Barnfield, Y. Yoshikawa, X. Zhang, R. Mo, M. A. Crackower, and C.-c. Hui Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia. Mol. Cell. Biol., September 1, 2006; 26(17): 6609 - 6622. [Abstract] [Full Text] [PDF]

				M. Grachtchouk, J. Liu, A. Wang, L. Wei, C. K. Bichakjian, J. Garlick, A. F. Paulino, T. Giordano, and A. A. Dlugosz Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans Am. J. Pathol., September 1, 2006; 169(3): 806 - 814. [Abstract] [Full Text] [PDF]

				N. Bhatia, S. Thiyagarajan, I. Elcheva, M. Saleem, A. Dlugosz, H. Mukhtar, and V. S. Spiegelman Gli2 Is Targeted for Ubiquitination and Degradation by beta-TrCP Ubiquitin Ligase J. Biol. Chem., July 14, 2006; 281(28): 19320 - 19326. [Abstract] [Full Text] [PDF]

				Y. Pan, C. B. Bai, A. L. Joyner, and B. Wang Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation. Mol. Cell. Biol., May 1, 2006; 26(9): 3365 - 3377. [Abstract] [Full Text] [PDF]

				S. Blaess, J. D. Corrales, and A. L. Joyner Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region Development, May 1, 2006; 133(9): 1799 - 1809. [Abstract] [Full Text] [PDF]

				K. Saha and D. V. Schaffer Signal dynamics in Sonic hedgehog tissue patterning Development, March 1, 2006; 133(5): 889 - 900. [Abstract] [Full Text] [PDF]

				Y. Jeong, K. El-Jaick, E. Roessler, M. Muenke, and D. J. Epstein A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers Development, February 15, 2006; 133(4): 761 - 772. [Abstract] [Full Text] [PDF]

				D. Huangfu and K. V. Anderson Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates Development, January 1, 2006; 133(1): 3 - 14. [Abstract] [Full Text] [PDF]

				J. F. Reiter and W. C. Skarnes Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition Genes & Dev., January 1, 2006; 20(1): 22 - 27. [Abstract] [Full Text] [PDF]

				A. K. Dillon, S. C. Fujita, M. P. Matise, A. A. Jarjour, T. E. Kennedy, H. Kollmus, H.-H. Arnold, J. A. Weiner, J. R. Sanes, and Z. Kaprielian Molecular Control of Spinal Accessory Motor Neuron/Axon Development in the Mouse Spinal Cord J. Neurosci., November 2, 2005; 25(44): 10119 - 10130. [Abstract] [Full Text] [PDF]

				M. J. Hilton, X. Tu, J. Cook, H. Hu, and F. Long Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development Development, October 1, 2005; 132(19): 4339 - 4351. [Abstract] [Full Text] [PDF]

				M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development Mol. Cell. Biol., August 15, 2005; 25(16): 7042 - 7053. [Abstract] [Full Text] [PDF]

				M. Merchant, M. Evangelista, S.-M. Luoh, G. D. Frantz, S. Chalasani, R. A. D. Carano, M. van Hoy, J. Ramirez, A. K. Ogasawara, L. M. McFarland, et al. Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus Mol. Cell. Biol., August 15, 2005; 25(16): 7054 - 7068. [Abstract] [Full Text] [PDF]

				A. L. Hager-Theodorides, J. T. Dessens, S. V. Outram, and T. Crompton The transcription factor Gli3 regulates differentiation of fetal CD4-CD8- double-negative thymocytes Blood, August 15, 2005; 106(4): 1296 - 1304. [Abstract] [Full Text] [PDF]

				E. Roessler, A. N. Ermilov, D. K. Grange, A. Wang, M. Grachtchouk, A. A. Dlugosz, and M. Muenke A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2 Hum. Mol. Genet., August 1, 2005; 14(15): 2181 - 2188. [Abstract] [Full Text] [PDF]

				V. Nguyen, A. L. Chokas, B. Stecca, and A. R. i Altaba Cooperative requirement of the Gli proteins in neurogenesis Development, July 15, 2005; 132(14): 3267 - 3279. [Abstract] [Full Text] [PDF]

				A. Liu, B. Wang, and L. A. Niswander Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors Development, July 1, 2005; 132(13): 3103 - 3111. [Abstract] [Full Text] [PDF]

				P. J. Gianakopoulos and I. S. Skerjanc Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells J. Biol. Chem., June 3, 2005; 280(22): 21022 - 21028. [Abstract] [Full Text] [PDF]

				J. Bok, M. Bronner-Fraser, and D. K. Wu Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear Development, May 1, 2005; 132(9): 2115 - 2124. [Abstract] [Full Text] [PDF]

				L. M. Zeltser Shh-dependent formation of the ZLI is opposed by signals from the dorsal diencephalon Development, May 1, 2005; 132(9): 2023 - 2033. [Abstract] [Full Text] [PDF]

				V. Stepan, S. Ramamoorthy, H. Nitsche, Y. Zavros, J. L. Merchant, and A. Todisco Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells J. Biol. Chem., April 22, 2005; 280(16): 15700 - 15708. [Abstract] [Full Text] [PDF]

				D. Stamataki, F. Ulloa, S. V. Tsoni, A. Mynett, and J. Briscoe A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube Genes & Dev., March 1, 2005; 19(5): 626 - 641. [Abstract] [Full Text] [PDF]