Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Yang, Y.
	Articles by McMahon, A. P.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Yang, Y.
	Articles by McMahon, A. P.

Bedell, M. A., Brannan, C. I., Evans, E. P., Copela, N. G., Jenkins, N. A. and Donovan, P.J (1995). DNA rearrangements located over 100 kb 5of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development. Genes Dev 9, 455-470.[Abstract/Free Full Text]

Bitgood, M. J. and McMahon, A. P (1995). Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol 172, 126-138.[Medline]

Buscher, D., Bosse, B., Heymer, J. and Ruther, U (1997). Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech. Dev 62, 175-182.[Medline]

Buscher, D. and Ruther, U (1998). Expression profile of Gli family members and Shh in normal and mutant mouse limb development. Dev. Dyn 211, 88-96.[Medline]

Chan, D. C., Laufer, E., Tabin, C. and Leder, P (1995). Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity. Development 121, 1971-1978.[Abstract]

Charite, J., de Graaff, W., Shen, S. and Deschamps, J (1994). Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures. Cell 78, 589-601.[Medline]

Cooke, J. and Summerbell, D (1981). Control of growth related to pattern specification in chick wing-bud mesenchyme. J. Embryol. Exp. Morphol 65, 169-185.

Crossley, P. and Martin, G (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439-451.[Abstract]

Cygan, J., Johnson, R. and McMahon, A (1997). Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development 124, 5021-5032.[Abstract]

Dolle, P., Izpisua-Belmonte, J. C., Boncinelli, E. and Duboule, D (1991). The Hox-4.8 gene is localized at the 5extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development. Mech, Dev 36, 3-13.[Medline]

Dominguez, M., Brunner, M., Hafen, E. and Basler, K (1996). Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-1625.[Abstract]

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic hedgehog, a memberof a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.[Medline]

Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessell, T. M. and Edlund, T (1995). Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube. Cell 81, 747-756.[Medline]

Fallon, J. F, Lopez, A., Ros, M. A., Savage, M. P., Olwin, B. B. and Simandl, B. K (1994). FGF-2: apical ectodermal ridge growth signal for chick limb development. Science 264, 104-107.[Abstract/Free Full Text]

Fan, C. M., Porter, J. A., Chiang, C., Chang, D. T., Beachy, P. A. and Tessier-Lavigne, M (1995). Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81, 457-465.[Medline]

Ganan, Y., Macias, D., Duterque-Coquillaud, M., Ros, M. A. and Hurle, J. M (1996). Role of TGF beta s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod. Development 122, 2349-2357.[Abstract]

Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A. and Scott, M. P (1996). Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev 10, 301-312.[Abstract/Free Full Text]

Goulding, M. D., Chalepakis, G., Deutsch, U., Erselius, J. R. and Gruss, P (1991). Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J 10, 1135-1147.[Medline]

Hayes, C., Brown, J. M., Lyon, M. F. and Morriss-Kay, G. M (1998). Sonic hedgehog is not required for polarizing activity in the Doublefoot mutant mouse limb bud. Development 125, 351-357.[Abstract]

Hui, C. C. and Joyner, A. L (1993). A mouse model of greig cephalopolysyndactyly syndrome: the extra-toes mutation contains an intragenic deletion of the Gli3 gene. Nat. Genet 3, 241-246.[Medline]

Johnson, R. L. and Tabin, C. J (1997). Molecular models for vertebrate limb development. Cell 90, 979-990.[Medline]

Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.[Medline]

Loomis, C., Kimmel, R., Tong. C. X., Michaud, J. and Joyner, A (1998). Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs. Development 125, 1137-1148.[Abstract]

Lopez-Martinez, A., Chang, D. T., Chiang, C., Porter, J. A., Ros, M. A., Simandl, B. K., Beachy, P. A. and Fallon, J. F (1995). Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage. Curr. Biol 5, 791-796.[Medline]

Lyon, M. F., Quinney, R., Glenister, P. H., Kerscher, S., Guillot, P. and Boyd, Y (1996). Doublefoot: a new mouse mutant affecting development of limbs and head. Genet. Res 68, 221-231.[Medline]

Lyons, K. M., Pelton, R. W. and Hogan, B. L (1989). Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. Genes Dev 3, 1657-1668.[Abstract/Free Full Text]

Marigo, V., Roberts, D. J., Lee, S. M., Tsukurov, O., Levi, T., Gastier, J. M., Epstein, D. J., Gilbert, D. J., Copeland, N. G. and Seidman, C. E (1995). Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog. Genomics 28, 44-51.[Medline]

Marigo, V., Scott, M. P., Johnson, R. L., Goodrich, L. V. and Tabin, C. J (1996). Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development 122, 1225-1233.[Abstract]

Marigo, V. and Tabin, C. J (1996). Regulation of patched by sonic hedgehog in the developing neural tube. Proc. Natl. Acad. Sci. USA 93, 9346-9351.[Abstract/Free Full Text]

Marti, E., Bumcrot, D. A., Takada, R. and McMahon, A. P (1995). Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 375, 322-325.[Medline]

Masuya, H., Sagai, T., Moriwaki, K. and Shiroishi, T (1997). Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Dev. Biol 182, 42-51.[Medline]

Masuya, H., Sagai, T., Wakana, S., Moriwaki, K. and Shiroishi, T (1995). A duplicated zone of polarizing activity in polydactylous mouse mutants. Genes Dev 9, 1645-1653.[Abstract/Free Full Text]

Milaire, J. and Goffard, J. C (1995). Histological analysis of limb defectsinduced in developing limb buds of NMRI mouse embryos after oral administration of 3-3-dimethyl-1-phenyltriazene (DMPT) to their mother on day 10 of gestation. Eur. J. Morphol 33, 491-508.[Medline]

Mo, R., Freer, A. M., Zinyk, D. L., Crackower, M. A., Michaud, J., Heng, H. H., Chik, K. W., Shi, X. M., Tsui, L. C., Cheng, S. H., Joyner, A. L. and Hui, C (1997). Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124, 113-123.[Abstract]

Motoyama, J., Takabatake, T., Takeshima, K. and Hui, C (1998). Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nat. Genet 18, 104-106.[Medline]

Niswander, L. and Martin, G. R (1992). Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114, 755-768.[Abstract]

Niswander, L., Jeffrey, S., Martin, G. R. and Tickle, C (1994). A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature 371, 609-612.[Medline]

Niswander, L., Tickle, C., Vogel, A., Booth, I. and Martin, G. R (1993). FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75, 579-587.[Medline]

Parr, B. A. and McMahon, A. P (1995). Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374, 350-353.[Medline]

Qu, S., Niswender, K. D., Ji, Q., van der Meer, R., Keeney, D., Magnuson, M. A. and Wisdom, R (1997). Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development 124, 3999-4008.[Abstract]

Riddle, R. D., Ensini, M., Nelson, C., Tsuchida, T., Jessell, T. M. and Tabin, C (1995). Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell 83, 631-640.[Medline]

Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.[Medline]

Roelink, H., Porter, J. A., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. and Jessell, T. M (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81, 445-455.[Medline]

Stone, D. M., Hynes, M., Armanini, M., Swanson, T. A., Gu, Q., Johnson, R. L., Scott, M. P., Pennica, D., Goddard, A., Phillips, H., Noll, M., Hooper, J. E., de Sauvage, F. and Rosenthal, A (1996). The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 129-134.[Medline]

Vortkamp, A., Franz, T., Gessler, M. and Grzeschik, K. H (1992). Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt). Mamm. Genome 3, 461-463.[Medline]

Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M. and Tabin, C. J (1996). Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613-622.[Abstract]

Wilkinson, D. G. and Nieto, M. A (1993). Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol 225, 361-373.[Medline]

Yang, Y., Drossopoulou, G., Chuang, P. T., Duprez, D., Marti, E., Bumcrot, D., Vargesson, N., Clarke, J., Niswander, L., McMahon, A. and Tickle, C (1997). Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development 124, 4393-4404.[Abstract]

Yokouchi, Y., Sakiyama, J., Kameda, T., Iba, H., Suzuki,A., Ueno, N. and Kuroiwa, A (1996). BMP-2/-4 mediate programmed cell death in chicken limb buds. Development 122, 3725-3734.[Abstract]

Zou, H. and Niswander, L (1996). Requirement for BMP signaling in interdigital apoptosis and scale formation. Science_Fb_272 , 738-741. Science 272, 738-741.[Abstract]

This article has been cited by other articles:

J. Vierkotten, R. Dildrop, T. Peters, B. Wang, and U. Ruther
Ftm is a novel basal body protein of cilia involved in Shh signalling
Development, July 15, 2007; 134(14): 2569 - 2577.
[Abstract] [Full Text] [PDF]

P. Lu, G. Minowada, and G. R. Martin
Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function
Development, January 1, 2006; 133(1): 33 - 42.
[Abstract] [Full Text] [PDF]

A. Liu, B. Wang, and L. A. Niswander
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
Development, July 1, 2005; 132(13): 3103 - 3111.
[Abstract] [Full Text] [PDF]

T. L. Wise and D. D. Pravtcheva
Oligosyndactylism Mice Have an Inversion of Chromosome 8
Genetics, December 1, 2004; 168(4): 2099 - 2112.
[Abstract] [Full Text] [PDF]

H Thiele, C McCann, S van't Padje, G C Schwabe, H C Hennies, G Camera, J Opitz, R Laxova, S Mundlos, and P Nurnberg
Acropectorovertebral dysgenesis (F syndrome) maps to chromosome 2q36
J. Med. Genet., March 1, 2004; 41(3): 213 - 218.
[Full Text] [PDF]

O. Krebs, C. M. Schreiner, W. J. Scott Jr, S. M. Bell, D. J. Robbins, J. A. Goetz, H. Alt, N. Hawes, E. Wolf, and J. Favor
Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud
Development, December 15, 2003; 130(24): 6037 - 6047.
[Abstract] [Full Text] [PDF]

L. Topol, X. Jiang, H. Choi, L. Garrett-Beal, P. J. Carolan, and Y. Yang
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent {beta}-catenin degradation
J. Cell Biol., September 1, 2003; 162(5): 899 - 908.
[Abstract] [Full Text] [PDF]

D. G. McFadden, J. McAnally, J. A. Richardson, J. Charite, and E. N. Olson
Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding
Development, January 7, 2002; 129(13): 3077 - 3088.
[Abstract] [Full Text] [PDF]

J Charite, D. McFadden, and E. Olson
The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development
Development, January 6, 2000; 127(11): 2461 - 2470.
[Abstract] [PDF]

C Tribioli and T Lufkin
The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen
Development, January 12, 1999; 126(24): 5699 - 5711.
[Abstract] [PDF]

K. Lewis, G Drossopoulou, I. Paton, D. Morrice, K. Robertson, D. Burt, P. Ingham, and C Tickle
Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway
Development, January 6, 1999; 126(11): 2397 - 2407.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Yang, Y.

Articles by McMahon, A. P.

Search for Related Content

PubMed

PubMed Citation

Articles by Yang, Y.

Articles by McMahon, A. P.

				P. Lu, G. Minowada, and G. R. Martin Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function Development, January 1, 2006; 133(1): 33 - 42. [Abstract] [Full Text] [PDF]

				A. Liu, B. Wang, and L. A. Niswander Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors Development, July 1, 2005; 132(13): 3103 - 3111. [Abstract] [Full Text] [PDF]

				T. L. Wise and D. D. Pravtcheva Oligosyndactylism Mice Have an Inversion of Chromosome 8 Genetics, December 1, 2004; 168(4): 2099 - 2112. [Abstract] [Full Text] [PDF]

				H Thiele, C McCann, S van't Padje, G C Schwabe, H C Hennies, G Camera, J Opitz, R Laxova, S Mundlos, and P Nurnberg Acropectorovertebral dysgenesis (F syndrome) maps to chromosome 2q36 J. Med. Genet., March 1, 2004; 41(3): 213 - 218. [Full Text] [PDF]

				O. Krebs, C. M. Schreiner, W. J. Scott Jr, S. M. Bell, D. J. Robbins, J. A. Goetz, H. Alt, N. Hawes, E. Wolf, and J. Favor Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud Development, December 15, 2003; 130(24): 6037 - 6047. [Abstract] [Full Text] [PDF]

				L. Topol, X. Jiang, H. Choi, L. Garrett-Beal, P. J. Carolan, and Y. Yang Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent {beta}-catenin degradation J. Cell Biol., September 1, 2003; 162(5): 899 - 908. [Abstract] [Full Text] [PDF]

				D. G. McFadden, J. McAnally, J. A. Richardson, J. Charite, and E. N. Olson Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding Development, January 7, 2002; 129(13): 3077 - 3088. [Abstract] [Full Text] [PDF]

				J Charite, D. McFadden, and E. Olson The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development Development, January 6, 2000; 127(11): 2461 - 2470. [Abstract] [PDF]

				C Tribioli and T Lufkin The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen Development, January 12, 1999; 126(24): 5699 - 5711. [Abstract] [PDF]

				K. Lewis, G Drossopoulou, I. Paton, D. Morrice, K. Robertson, D. Burt, P. Ingham, and C Tickle Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway Development, January 6, 1999; 126(11): 2397 - 2407. [Abstract] [PDF]