The role of p53 and cell death by apoptosis and necrosis in 4-hydroperoxycyclophosphamide-induced limb malformations

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Moallem, S. A.
	Articles by Hales, B. F.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Moallem, S. A.
	Articles by Hales, B. F.

Alles, A. J. and Sulik, K. K (1989). Retinoic-acid-induced limb-reduction malformation defects: Perturbation of zones of programmed cell death as a pathogenic mechanism. Teratology 40, 163-171.[Medline]

Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A. and Nicotera, P (1995). Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15, 961-973.[Medline]

Armstrong, J. F., Kaufman, M. H., Harrison, D. J. and Clarke A. R (1995). High-frequency developmental abnormalities in p53-deficient mice. Curr. Biol 5, 931-936.[Medline]

Bhaumick, B (1993). Insulin-like growth factor (IGF) binding proteins and insulin-like growth factor secretion by cultured chondrocyte cells: identification, characterization and ontogeny during cell differentiation. Regul. Pept 48, 113-122.[Medline]

Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P. and Lipton, S. A (1995). Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA 92, 7162-7166.[Abstract/Free Full Text]

Boyle, C. C. and Hickman, J. A (1997). Toxin-induced increase in survival factor receptors: modulation of the threshold for apoptosis. Cancer Res 57, 2404-2409.[Abstract/Free Full Text]

Buckbinder, L., Talbott, R., Velasco-Miguel, S., Takenaka, I., Faha, B., Seizinger, B. R. and Kley, N (1995). Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377, 646-649.[Medline]

Bursch, W., Oberhammer, F. and Schulte-Hermann, R (1992). Cell death by apoptosis and its protective role against disease. Trends Pharmacol. Sci 13, 245-251.[Medline]

Cano, A., Gamallo, C., Kemp, C. J., Benito, N., Palacios, J., Quintanilla,M. and Balmain, A (1996). Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 integrin is altered in pre-malignant skin tumors of p53-deficient mice. Int. J. Cancer 65, 254-262.[Medline]

Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L. and Wyllie, A.H (1993). Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852.[Medline]

Cross, S. M., Sanchez, C. A., Morgan, C. A., Schimke, M. A., Ramel, S., Idzera, R. L., Raskind, W. H. and Reid, B. J (1995). A p53-dependent mouse spindle checkpoint. Science 267, 1353-1356.[Abstract/Free Full Text]

Dealy, C. N. and Kosher, R. A (1995). Studies on insulin-like growth factor-I and insulin in chick limb morphogenesis. Dev. Dyn 202, 67-79.[Medline]

Dypbukt, J. M., Ankarcrona, M., Burkitt, M., Sj\232holm, \201., Str\232m, K., Orrenius, S. and Nicotera, P (1994). Different prooxidant levels stimulate cell growth, activate apoptosis, or produce necrosis in insulin-secreting RINm5F cells. J. Biol. Chem 269, 30553-30560.[Abstract/Free Full Text]

English, H. F., Kyprianou, N. and Isaacs, J. T (1989). Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration. Prostate 15, 233-250.[Medline]

Fukuda, K., Kojiro, M. and Chiu, J. F (1993). Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma 7777 tissue: apoptosis or necrosis?. Am. J. Pathol 142, 935-946.[Abstract]

Geduspan, J. S., Padanilam, B. J. and Solursh, M (1992). Coordinate expression of IGF-1 and its receptor during limb outgrowth. Dev. Dyn 195, 67-73.[Medline]

Gerschenson, L. E. and Rotello R. J (1992). Apoptosis: a different type of cell death. FASEB J 6, 2450-2455.[Abstract]

Gibson, J.E. and Becker, B.A (1968). The teratogenicity of cyclophosphamide in mice. Cancer Res 28, 475-480.[Abstract/Free Full Text]

Hales, B. F. and Jain, R (1986). Differential effects of 4-hydroperoxycyclophosphamide on limb development in vitro. Teratology 34, 303-311.[Medline]

Hall, P.A. and Lane, D.P (1997). Tumor suppressors: a developing role for p53?. Curr. Biol 7, 144-.[Medline]

Harvey, M., Sands, A.T., Weiss, R.S., Hegi, M.E., Wiseman, R.W., Pantazis, P., Giovanella, B.C., Tainsky, M.A., Bradley, A. and Donehower, L.A (1993). In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8, 2457-2467.[Medline]

Hickman, J. A (1992). Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11, 121-139.[Medline]

Hurle, J. M., Ros, M. A., Climent, V. and Garcia-Martinez, V (1996). Morphology and significance of programmed cell death in the developing limb bud of the vertebrate embryo. Micros. Res. Tech 34, 236-246.[Medline]

Ishibashi, M., Akazawa, S., Sakamaki, H., Matsumoto, K., Yamasaki, H., Yamagushi, Y., Goto, S., Urata, Y., Kondo, T. and Nagataki, S (1997). Oxygen-induced embryopathy and the significance of glutathione-dependent antioxidant system in the rat embryo during early embryogenesis. Free Radic. Biol. Med 22, 447-454.[Medline]

Kaneko, H., Sugita, K., Kiyokawa, N., Iizuka, K., Takada, K., Saito, M., Yoshimoto, K., Itakura, M., Kokai, Y. and Fujimoto, J (1996). Lack of CD54 expression and mutation of p53 gene relate to the prognosis of childhood Burkitt's lymphoma. Leuk. Lymphoma 21, 449-455.[Medline]

Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B. and Fornace, A. J (1992). A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597.[Medline]

Kerr, J. F. R., Wyllie, A. H. and Currie, A. R (1972). Apoptosis; A basic biological phenomenon with wide ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.[Medline]

Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V. and Kastan, M. B (1992). Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA 89, 7491-7495.[Abstract/Free Full Text]

Kurishita, A (1989). Histological study of cell death in digital malformations induced by 5-azacytidine: Suppressive effect of caffeine. Teratology 39, 163-172.[Medline]

Kwasigroch, T. E., Skalko, R. G. and Church, J. K (1984). Mouse limb bud development in submerged culture: quantitative assessment of theeffects of in vivo exposure to retinoic acid. Teratog. Carcinog. Mutagen 4, 311-326.[Medline]

Lane, D. P (1992). Cancer. p53, guardian of the genome. Nature 358, 15-16.[Medline]

Leist, M. and Nicotera, P (1997). The shape of cell death. Biochem. Biophys. Res. Comm 236, 1-9.[Medline]

Leist, M., Single, B., Castoldi, A. F., Kuhnle, S. and Nicotera, P (1997). Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J. Exp. Med 185, 1481-1486.[Abstract/Free Full Text]

Lennon, S. V., Martin, S. J. and Cotter, T. G (1991). Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif 24, 203-214.[Medline]

Levakau, B., Herren B., Koyama, H., Ross, R. and Raines, E.W (1998). Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis. J. Exp. Med 187, 579-586.[Abstract/Free Full Text]

Li, G., Mitchell, D. L., Ho, V. C., Reed, J. C. and Tron, V. A (1996). Decreased DNA repair but normal apoptosis in UV-irradiated skin of p53 transgenic mice. Am. J. Pathol 148, 1113-1124.[Abstract]

Lotem, J. and Sachs, L (1993). Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and-defective myeloid leukemic cells. Cell. Growth Diff 4, 41-47.[Abstract]

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. and Jacks, T (1993). p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.[Medline]

Lowe, S. W., Ruley, H. E., Jacks, T. and Housman, D. E (1993). p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74, 957-967.[Medline]

Mirkes, P. E (1985). Cyclophosphamide teratogenesis \320 A review. Teratog. Carcinog. Mutagen 5, 75-88.[Medline]

Moallem, S. A. and Hales, B. F (1995). Induction of apoptosis and cathepsin D in limbs exposed in vitro to an activated analog of cyclophosphamide. Teratology 52, 3-14.[Medline]

Moallem, S.A. and Hales, B.F (1996). Transglutaminase and clusterin induction during normal and abnormal limb development in the mouse. Biol. Reprod 55, 281-290.[Abstract]

Nicol, C. J., Harrison, M. L., Laposa, R. R., Gimelshtein, I. L. and Wells, P. G (1995). A teratological suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice. Nat. Genet 10, 181-187.[Medline]

Norimura, T., Nomoto, S., Katsuki, M., Gondo, Y. and Kondo, S (1996). p53-dependent apoptosis suppresses radiation-induced teratogenesis. Nat. Med 2, 577-580.[Medline]

Oren, M (1992). p53: the ultimate tumor suppressor gene?. FASEB J 6, 3169-3176.[Abstract]

Ozolins, T. R. and Hales, B. F (1997). Oxidative stress regulates the expression and activity of transcription factor activator protein-1 in rat conceptus. J. Pharmacol. Exp. Ther 280, 1085-1093.[Abstract/Free Full Text]

Paules, R.S., Levedakou, E.N., Wilson, S.J., Innes, C.L., Rhodes, N., Tlsty, T.D., Galloway, D.A., Donehower, L.A., Tainsky, M.A. ans Kaufmann, W.K (1995). Defective G2checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res 55, 1763-1773.[Abstract/Free Full Text]

Peluso, J.J (1997). Putative mechanism throug which N-cadherin-mediated cell contact maintains calcium homeostasis and thereby prevents ovarian cells from undergoing apoptosis. Biochem. Pharmacol 54, 847-853.[Medline]

Rowan, S., Ludwig, R. L., Haupt, Y., Bates, S., Lu, X., Oren, M. and Vousden, K. H (1996). Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J 15, 827-838.[Medline]

Sah, V. P., Attardi, L. D., Mulligan, G. J., Williams, B. O., Bronson, R. T. and Jacks, T (1995). A subset of p53-deficient embryos exhibit exencephaly. Nat. Genet 10, 175-180.[Medline]

Sanders, E. J. and Wride, M. A (1995). Programmed cell death in development. Int. Rev. Cytol 163, 105-173.[Medline]

Sato, N., Iwata, S., Nakamura, K., Hori, T., Mori, K. and Yodoi, J (1995). Thiol-mediated redox regulation of apoptosis. J. Immunol 154, 3194-3203.[Abstract]

Schmid, P., Lorenz, A., Hameister, H. and Montenarh, M (1991). Expression of p53 during mouse embryogenesis. Development 113, 857-865.[Abstract]

Schrek, R., Chandra, S., Molnar, Z. and Stefani, S. S (1980). Two types of interphase death of lymphocytes exposed to temperatures of 37-45 degrees C. Radiation Res 82, 162-170.[Medline]

Schwartzman, R. A., and Cidlowski, J. A (1993). Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocr. Rev 14, 133-151.[Medline]

Sen, S (1992). Programmed cell death: concept, mechanism and control. Biol. Rev. Camb. Philos. Soc 67, 287-319.[Medline]

Serrano, N. and O'Farrell, P. H (1997). Limb morphogenesis: connections between patterning and growth. Curr. Biol 7, 186-.

Shah, G. M., Shah, R. G. and Poirier G. G (1996). Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells. Biochem. Biophys. Res. Comm 229, 838-844.[Medline]

Shimizu, S., Eguchi, Y., Kamiike, W., Waguri, S., Uchiyama, Y., Matsuda, H. and Tsujimoto, Y (1996). Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene 12, 2045-2050.[Medline]

Shimizu, S., Eguchi, Y., Kamiike, W., Itoh, Y., Hasegawa, J., Yamabe, K., Otsuki, Y., Matsuda, H. and Tsujimoto Y (1996). Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL. Cancer Res 56, 2161-2166.[Abstract/Free Full Text]

Slater, A.F., Stefan, C., Nobel, I., van den Dobbelsteen, D.J. and Orrenius, S (1995). Signalling mechanisms and oxidative stress in apoptosis. Toxicol. Lett 82, 149-153.

Smith, M. L., Chen, I. T., Zhan, Q., O'Connor, P. M. and Fornace, A. J. Jr (1995). Involvement of the p53 tumor suppressor in repair of UV-type DNA damage. Oncogene 10, 1053-1059.[Medline]

Smith, M. L. and Fornace, A. J. Jr (1996). The two faces of tumor suppressor p53. Am. J. Pathol 148, 1019-1022.[Medline]

Studier, F. W (1973). Analysis of bacteriophage T7 early RNAs and proteins on slab gels. J. Mol. Biol 79, 237-248.[Medline]

Subramanian, T., Tarodi, B. and Chinnadurai G (1995). p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: suppression by E1B 19K and Bcl-2 proteins. Cell Growth Differ 6, 131-137.[Abstract]

Tilly, J. L. and Hsueh, A. J (1993). Microscale autoradigraphic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation. J. Cell. Physiol 154, 519-526.[Medline]

Towbin, H., Staehelin, T. and Gordon, J (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.[Abstract/Free Full Text]

Vermes, I., Haanen, C., Richel, D.J., Schaafsma, M.R., Kalsbeek-Batenburg, E. and Reutelingsperger, C.P (1997). Apoptosis and secondary necrosis of lympgocytes in culture. Acta Haematol 98, 8-13.[Medline]

Wells, P.G., Kim, P.M., Laposa, R.R., Nicol, C.J., Parman, T. and Winn, L.M (1997). Oxidative damage in chemical teratogenesis. Mutat. Res 396, 65-78.[Medline]

Wubah, J. A., Ibrahim, M. M., Gao, X., Nguyen, D., Pisano, M. M. and Knudsen, T. B (1996). Teratogen-induced eye defects mediated by p53-dependent apoptosis. Curr. Biol 6, 60-69.[Medline]

Wyllie A. H (1993). Apoptosis (The 1992 Frank Rose memorial lecture). Br. J. Cancer 67, 205-208.[Medline]

Wyllie, A. H., Kerr, J. F. R. and Currie, A. R (1980). Cell death: the significance of apoptosis. Int. Rev. Cytol 68, 251-306.[Medline]

Zakeri, Z. F. and Ahuja, H. S (1994). Apoptotic cell death in the limb and its relationship to pattern formation. Biochem. Cell Biol 72, 603-613.[Medline]

This article has been cited by other articles:

A. W. Wong, G. P. McCallum, W. Jeng, and P. G. Wells
Oxoguanine Glycosylase 1 Protects Against Methamphetamine-Enhanced Fetal Brain Oxidative DNA Damage and Neurodevelopmental Deficits
J. Neurosci., September 3, 2008; 28(36): 9047 - 9054.
[Abstract] [Full Text] [PDF]

O. Pekar, N. Molotski, S. Savion, A. Fein, V. Toder, and A. Torchinsky
p53 regulates cyclophosphamide teratogenesis by controlling caspases 3, 8, 9 activation and NF-{kappa}B DNA binding
Reproduction, August 1, 2007; 134(2): 379 - 388.
[Abstract] [Full Text] [PDF]

Y. Bhuller, W. Jeng, and P. G. Wells
Variable In Vivo Embryoprotective Role for Ataxia-Telangiectasia-Mutated against Constitutive and Phenytoin-Enhanced Oxidative Stress in Atm Knockout Mice
Toxicol. Sci., September 1, 2006; 93(1): 146 - 155.
[Abstract] [Full Text] [PDF]

Y. Bhuller and P. G. Wells
A Developmental Role for Ataxia-Telangiectasia Mutated in Protecting the Embryo from Spontaneous and Phenytoin-Enhanced Embryopathies in Culture
Toxicol. Sci., September 1, 2006; 93(1): 156 - 163.
[Abstract] [Full Text] [PDF]

A. Seluanov, V. Gorbunova, A. Falcovitz, A. Sigal, M. Milyavsky, I. Zurer, G. Shohat, N. Goldfinger, and V. Rotter
Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53
Mol. Cell. Biol., March 1, 2001; 21(5): 1552 - 1564.
[Abstract] [Full Text]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Moallem, S. A.

Articles by Hales, B. F.

Search for Related Content

PubMed

PubMed Citation

Articles by Moallem, S. A.

Articles by Hales, B. F.

				O. Pekar, N. Molotski, S. Savion, A. Fein, V. Toder, and A. Torchinsky p53 regulates cyclophosphamide teratogenesis by controlling caspases 3, 8, 9 activation and NF-{kappa}B DNA binding Reproduction, August 1, 2007; 134(2): 379 - 388. [Abstract] [Full Text] [PDF]

				Y. Bhuller, W. Jeng, and P. G. Wells Variable In Vivo Embryoprotective Role for Ataxia-Telangiectasia-Mutated against Constitutive and Phenytoin-Enhanced Oxidative Stress in Atm Knockout Mice Toxicol. Sci., September 1, 2006; 93(1): 146 - 155. [Abstract] [Full Text] [PDF]

				Y. Bhuller and P. G. Wells A Developmental Role for Ataxia-Telangiectasia Mutated in Protecting the Embryo from Spontaneous and Phenytoin-Enhanced Embryopathies in Culture Toxicol. Sci., September 1, 2006; 93(1): 156 - 163. [Abstract] [Full Text] [PDF]

				A. Seluanov, V. Gorbunova, A. Falcovitz, A. Sigal, M. Milyavsky, I. Zurer, G. Shohat, N. Goldfinger, and V. Rotter Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53 Mol. Cell. Biol., March 1, 2001; 21(5): 1552 - 1564. [Abstract] [Full Text]