The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Lai, E. C.
	Articles by Posakony, J. W.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Lai, E. C.
	Articles by Posakony, J. W.

Ashburner, M (1982). The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of Hairless. Genetics 101, 447-459.[Abstract/Free Full Text]

Bailey, A. M. and Posakony, J. W (1995). Suppressor of Hairless directly activates transcription of Enhancer of split Complex genes in response to Notch receptor activity. Genes Dev 9, 2609-2622.[Abstract/Free Full Text]

Bang, A. G., Hartenstein, V. and Posakony, J. W (1991). Hairless is required for the development of adult sensory organ precursor cells in Drosophila. Development 111, 89-104.[Abstract]

Beverley, S. M. and Wilson, A. C (1984). Molecular evolution in Drosophila and the higher Diptera II. A time scale for fly evolution. J. Mol. Evol 21, 1-13.[Medline]

Brown, S. J., Patel, N. H. and Denell, R. E (1994). Embryonic expression of the single Tribolium engrailed homolog. Dev. Genet 15, 7-18.[Medline]

Cabrera, C. V. and Alonso, M. C (1991). Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila. EMBO J 10, 2965-2973.[Medline]

Caccone, A. and Powell, J. R (1990). Extreme rates and heterogeneity in insect DNA evolution. J. Mol. Evol 30, 273-280.[Medline]

Chen, C. Y. and Shyu, A.-B (1995). AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci 20, 465-470.[Medline]

Coleman, K. G., Poole, S. J., Weir, M. P., Soeller, W. C. and Kornberg, T (1987). The invected gene of Drosophila : Sequence analysis and expression studies reveal a close kinship to the engrailed gene. Genes Dev 1, 19-28.[Abstract/Free Full Text]

Cubas, P., de Celis, J.-F., Campuzano, S. and Modolell, J (1991). Proneuralclusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev 5, 996-1008.[Abstract/Free Full Text]

Curtis, D., Lehmann, R. and Zamore, P. D (1995). Translational regulation in development. Cell 81, 171-178.[Medline]

de Celis, J. F., Bray, S. and Garcia-Bellido, A (1997). Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development 124, 1919-1928.[Abstract]

de Celis, J. F., de Celis, J., Ligoxygakis, P., Preiss, A., Delidakis, C. and Bray, S (1996). Functional relationships between Notch , Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development 122, 2719-2728.[Abstract]

Dietrich, U. and Campos-Ortega, J. A (1984). The expression of neurogenic loci in the imaginal epidermal cells of Drosophila melanogaster. J. Neurogenetics 1, 315-332.[Medline]

Ellis, H. M., Spann, D. R. and Posakony, J. W (1990). extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins. Cell 61, 27-38.[Medline]

Fisher, A. L. and Caudy, M (1998). Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates. Genes Dev 12, 1931-1940.[Free Full Text]

Fleming, R. J., Scottgale, N. T., Diederich, R. J. and Artavanis-Tsakonas, S (1990). The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev 4, 2188-2201.[Abstract/Free Full Text]

Furukawa, T., Kobayakawa, Y., Tamura, K., Kimura, K., Kawaichi, M., Tanimura, T. and Honjo, T (1995). Suppressor of Hairless, the Drosophila homologue of RBP-J, transactivates the neurogenic gene E(spl)m8. Jpn. J. Genet 70, 505-524.[Medline]

Garrell, J. and Modolell, J (1990). The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein. Cell 61, 39-48.[Medline]

Giebel, B. and Campos-Ortega, J. A (1997). Functional dissection of the Drosophila Enhancer of split protein, a suppressor of neurogenesis. Proc. Natl. Acad. Sci. USA 94, 6250-6254.[Abstract/Free Full Text]

Gomez-Skarmeta, J. L., del Corral, R. D., de la Calle-Mustienes, E., Ferres-Marco, D. and Modolell, J (1996). araucan and caupolican , two members of the novel Iroquois Complex, encode homeoproteins that control proneural and vein-forming genes. Cell 85, 95-105.[Medline]

Hartenstein, V. and Posakony, J. W (1989). Development of adult sensilla on the wing and notum of Drosophila melanogaster. Development 107, 389-405.[Abstract]

Hartenstein, V. and Posakony, J. W (1990). A dual function of the Notch gene in Drosophila sensillum development. Dev. Biol 142, 13-30.[Medline]

Heitzler, P. and Simpson, P (1991). The choice of cell fate in the epidermis of Drosophila. Cell 64, 1083-1092.[Medline]

Hertz, G. Z., Hartzell, G. W. and Stormo, G. D (1990). Identification of consensus patterns in unaligned DNA sequences known to be functionally related. Comput. Appl. Biosci 6, 81-92.[Abstract/Free Full Text]

Huang, F., Dambly-Chaudiere, C. and Ghysen, A (1991). The emergence of sense organs in the wing disc of Drosophila. Development 111, 1087-1095.[Abstract/Free Full Text]

Kassis, J. A., Poole, S. J., Wright, D. K. and O'Farrell, P. H (1986). Sequence conservation in the protein coding and intron regions of the engrailed transcription unit. EMBO J 5, 3583-3589.[Medline]

Kehl, B. T., Cho, K.-O. and Choi, K.-W (1998). mirror , a Drosophila homeobox gene in the iroquois complex, is required for sensory organ and alula formation. Development 125, 1217-1227.[Abstract]

Kl\212mbt, C., Knust, E., Tietze, K. and Campos-Ortega, J (1989). Closely related transcripts encoded by the neurogenic gene complex Enhancer of split of Drosophila melanogaster. EMBO J 8, 203-210.[Medline]

Knust, E., Tietze, K. and Campos-Ortega, J. A (1987). Molecular analysis of the neurogenic locus Enhancer of split of Drosophila melanogaster. EMBO J 6, 4113-4123.[Medline]

Kramatschek, B. and Campos-Ortega, J. A (1994). Neuroectodermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes. Development 120, 815-826.[Abstract]

Lai, E. C. and Posakony, J. W (1997). The Bearded box, a novel 3UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression. Development 124, 4847-4856.[Abstract]

Lai, E. C. and Posakony, J. W (1998). Regulation of Drosophila neurogenesis by RNA:RNA duplexes?. Cell 93, 1103-1104.[Medline]

Lecourtois, M. and Schweisguth, F (1995). The neurogenic Suppressor ofHairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split Complex genes triggered by Notch signaling. Genes Dev 9, 2598-2608.[Abstract/Free Full Text]

Leviten, M. W., Lai, E. C. and Posakony, J. W (1997). The Drosophila gene Bearded encodes a novel small protein and shares 3UTR sequence motifs with multiple Enhancer of split Complex genes. Development 124, 4039-4051.[Abstract]

Leviten, M. W. and Posakony, J. W (1996). Gain-of-function alleles of Bearded interfere with alternative cell fate decisions in Drosophila adult sensory organ development. Dev. Biol 176, 264-283.[Medline]

Maier, D., Marte, B. M., Schafer, W., Yu, Y. and Preiss, A (1993). Drosophila evolution challenges postulated redundancy in the E(spl) gene complex. Proc. Natl. Acad. Sci. USA 90, 5464-5468.[Abstract/Free Full Text]

Margolis, J. S., Borowsky, M. L., Steingrimsson, E., Shim, C. W., Lengyel, J. A. and Posakony, J. W (1995). Posterior stripe expression of hunchback is driven from two promoters by a common enhancer element. Development 121, 3067-3077.[Abstract]

McNeill, H., Yang, C. H., Brodsky, M., Ungos, J. and Simon, M. A (1997). mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. Genes Dev 11, 1073-1082.[Abstract/Free Full Text]

Miklos, G. L. and Rubin, G. M (1996). The role of the genome project in determining gene function: Insights from model organisms. Cell 86, 521-529.[Medline]

Nakao, K. and Campos-Ortega, J. A (1996). Persistent expression of genes of the Enhancer of split complex suppresses neural development in Drosophila. Neuron 16, 275-286.[Medline]

Parks, A. L. and Muskavitch, M. A (1993). Delta function is required for bristle organ determination and morphogenesis in Drosophila. Dev. Biol 157, 484-496.[Medline]

Paroush, Z., Finley, R. L., Jr., Kidd, T., Wainwright, S. M., Ingham, P. W., Brent, R. and Ish-Horowicz, D (1994). Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 79, 805-815.[Medline]

Poole, S. J., Kauvar, L. M., Drees, B. and Kornberg, T (1985). The engrailed locus of Drosophila : Structural analysis of an embryonic transcript. Cell 40, 37-43.[Medline]

Posakony, J. W (1994). Nature versus nurture: asymmetric cell divisions in Drosophila bristle development. Cell 76, 415-418.[Medline]

Rebay, I., Fleming, R. J., Fehon, R. G., Cherbas, L., Cherbas, P. and Artavanis-Tsakonas, S (1991). Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor. Cell 67, 687-699.[Medline]

Romani, S., Campuzano, S., Macagno, E. R. and Modolell, J (1989). Expression of achaete and scute genes in Drosophila imaginal discs and their function in sensory organ development. Genes Dev 3, 997-1007.[Abstract/Free Full Text]

Rosenthal, A., Rhee, L., Yadegari, R., Paro, R., Ullrich, A. and Goeddel, D. V (1987). Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene. EMBO J 6, 433-441.[Medline]

Rubin, G. M. and Spradling, A. C (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353.[Abstract/Free Full Text]

Schaeffer, E., Smith, D., Mardon, G., Quinn, W. and Zuker, C (1989). Isolation and characterization of two new drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells. Cell 57, 403-12.[Medline]

Schrons, H., Knust, E. and Campos-Ortega, J. A (1992). The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaste r are required for segregation of neural and epidermal progenitor cells. Genetics 132, 481-503.[Abstract]

Schweisguth, F. and Posakony, J. W (1992). Suppressor of Hairless , the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Cell 69, 1199-1212.[Medline]

Schweisguth, F. and Posakony, J. W (1994). Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis. Development 120, 1433-1441.[Abstract]

Singson, A., Leviten, M. W., Bang, A. G., Hua, X. H. and Posakony, J. W (1994). Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes Dev 8, 2058-2071.[Abstract/Free Full Text]

Skeath, J. B. and Carroll, S. B (1991). Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes Dev 5, 984-995.[Abstract/Free Full Text]

St. Johnston, D (1995). The intracellular localization of messenger RNAs. Cell 81, 161-170.[Medline]

Tata, F. and Hartley, D. A (1995). Inhibition of cell fate in Drosophila by Enhancer of split genes. Mech. Dev 51, 305-315.[Medline]

Thomas, U., Jonsson, F., Speicher, S. A. and Knust, E (1995). Phenotypic and molecular characterization of SerD , a dominant allele of the Drosophila gene Serrate. Genetics 139, 203-213.[Abstract]

Tietze, K., Oellers, N. and Knust, E (1992). Enhancer of splitD , a dominant mutation of Drosophila , and its use in the study of functional domains of a helix-loop-helix protein. Proc. Natl. Acad. Sci. USA 89, 6152-6156.[Abstract/Free Full Text]

Van Doren, M., Ellis, H. M. and Posakony, J. W (1991). The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes. Development 113, 245-255.[Abstract]

Van Doren, M., Powell, P. A., Pasternak, D., Singson, A. and Posakony, J. W (1992). Spatial regulation of proneural gene activity: auto-and cross-activation of achaete is antagonized by extramacrochaetae. Genes Dev 6, 2592-2605.[Abstract/Free Full Text]

Vincent, J. P., Girdham, C. H. and O'Farrell, P. H (1994). A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. Dev. Biol 164, 328-331.[Medline]

This article has been cited by other articles:

A. Tsirigos and I. Rigoutsos
Human and mouse introns are linked to the same processes and functions through each genome's most frequent non-conserved motifs
Nucleic Acids Res., June 1, 2008; 36(10): 3484 - 3493.
[Abstract] [Full Text] [PDF]

A. Stark, P. Kheradpour, L. Parts, J. Brennecke, E. Hodges, G. J. Hannon, and M. Kellis
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
Genome Res., December 1, 2007; 17(12): 1865 - 1879.
[Abstract] [Full Text] [PDF]

P. Kheradpour, A. Stark, S. Roy, and M. Kellis
Reliable prediction of regulator targets using 12 Drosophila genomes
Genome Res., December 1, 2007; 17(12): 1919 - 1931.
[Abstract] [Full Text] [PDF]

S. J. Silver, J. W. Hagen, K. Okamura, N. Perrimon, and E. C. Lai
Functional screening identifies miR-315 as a potent activator of Wingless signaling
PNAS, November 13, 2007; 104(46): 18151 - 18156.
[Abstract] [Full Text] [PDF]

S. J. Macdonald, T. Pastinen, and A. D. Long
The Effect of Polymorphisms in the Enhancer of split Gene Complex on Bristle Number Variation in a Large Wild-Caught Cohort of Drosophila melanogaster
Genetics, December 1, 2005; 171(4): 1741 - 1756.
[Abstract] [Full Text] [PDF]

T. Du and P. D. Zamore
microPrimer: the biogenesis and function of microRNA
Development, November 1, 2005; 132(21): 4645 - 4652.
[Abstract] [Full Text] [PDF]

I. Alvarez-Garcia and E. A. Miska
MicroRNA functions in animal development and human disease
Development, November 1, 2005; 132(21): 4653 - 4662.
[Abstract] [Full Text] [PDF]

B. Castro, S. Barolo, A. M. Bailey, and J. W. Posakony
Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless
Development, August 1, 2005; 132(15): 3333 - 3344.
[Abstract] [Full Text] [PDF]

E. C. Lai, B. Tam, and G. M. Rubin
Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs
Genes & Dev., May 1, 2005; 19(9): 1067 - 1080.
[Abstract] [Full Text] [PDF]

S. J. Macdonald and A. D. Long
Identifying Signatures of Selection at the Enhancer of split Neurogenic Gene Complex in Drosophila
Mol. Biol. Evol., March 1, 2005; 22(3): 607 - 619.
[Abstract] [Full Text] [PDF]

L. E. Jensen and A. S. Whitehead
The 3' Untranslated Region of the Membrane-Bound IL-1R Accessory Protein mRNA Confers Tissue-Specific Destabilization
J. Immunol., November 15, 2004; 173(10): 6248 - 6258.
[Abstract] [Full Text] [PDF]

A. Boutla, C. Delidakis, and M. Tabler
Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes
Nucleic Acids Res., September 1, 2003; 31(17): 4973 - 4980.
[Abstract] [Full Text] [PDF]

D. A. Dansereau, M. D. Lunke, A. Finkielsztein, M. A. Russell, and W. J. Brook
hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster
Development, March 14, 2003; 129(24): 5553 - 5566.
[Abstract] [Full Text] [PDF]

J. DOSTIE, Z. MOURELATOS, M. YANG, A. SHARMA, and G. DREYFUSS
Numerous microRNPs in neuronal cells containing novel microRNAs
RNA, February 1, 2003; 9(2): 180 - 186.
[Abstract] [Full Text] [PDF]

M. Rebeiz, N. L. Reeves, and J. W. Posakony
SCORE: A computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data
PNAS, July 23, 2002; 99(15): 9888 - 9893.
[Abstract] [Full Text] [PDF]

R. Mancebo, X. Zhou, W. Shillinglaw, W. Henzel, and P. M. Macdonald
BSF Binds Specifically to the bicoid mRNA 3' Untranslated Region and Contributes to Stabilization of bicoid mRNA
Mol. Cell. Biol., May 15, 2001; 21(10): 3462 - 3471.
[Abstract] [Full Text]

J. Parsch, J. A. Russell, I. Beerman, D. L. Hartl, and W. Stephan
Deletion of a Conserved Regulatory Element in the Drosophila Adh Gene Leads to Increased Alcohol Dehydrogenase Activity but Also Delays Development
Genetics, September 1, 2000; 156(1): 219 - 227.
[Abstract] [Full Text]

E. Lai, R Bodner, and J. Posakony
The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family
Development, January 8, 2000; 127(16): 3441 - 3455.
[Abstract] [PDF]

S Zaffran and M Frasch
Barbu: an E(spl) m4/m(alpha)-related gene that antagonizes Notch signaling and is required for the establishment of ommatidial polarity
Development, January 3, 2000; 127(5): 1115 - 1130.
[Abstract] [PDF]

E. Lai, R Bodner, J Kavaler, G Freschi, and J. Posakony
Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes
Development, January 1, 2000; 127(2): 291 - 306.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Lai, E. C.

Articles by Posakony, J. W.

Search for Related Content

PubMed

PubMed Citation

Articles by Lai, E. C.

Articles by Posakony, J. W.

				A. Stark, P. Kheradpour, L. Parts, J. Brennecke, E. Hodges, G. J. Hannon, and M. Kellis Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes Genome Res., December 1, 2007; 17(12): 1865 - 1879. [Abstract] [Full Text] [PDF]

				P. Kheradpour, A. Stark, S. Roy, and M. Kellis Reliable prediction of regulator targets using 12 Drosophila genomes Genome Res., December 1, 2007; 17(12): 1919 - 1931. [Abstract] [Full Text] [PDF]

				S. J. Silver, J. W. Hagen, K. Okamura, N. Perrimon, and E. C. Lai Functional screening identifies miR-315 as a potent activator of Wingless signaling PNAS, November 13, 2007; 104(46): 18151 - 18156. [Abstract] [Full Text] [PDF]

				S. J. Macdonald, T. Pastinen, and A. D. Long The Effect of Polymorphisms in the Enhancer of split Gene Complex on Bristle Number Variation in a Large Wild-Caught Cohort of Drosophila melanogaster Genetics, December 1, 2005; 171(4): 1741 - 1756. [Abstract] [Full Text] [PDF]

				T. Du and P. D. Zamore microPrimer: the biogenesis and function of microRNA Development, November 1, 2005; 132(21): 4645 - 4652. [Abstract] [Full Text] [PDF]

				I. Alvarez-Garcia and E. A. Miska MicroRNA functions in animal development and human disease Development, November 1, 2005; 132(21): 4653 - 4662. [Abstract] [Full Text] [PDF]

				B. Castro, S. Barolo, A. M. Bailey, and J. W. Posakony Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless Development, August 1, 2005; 132(15): 3333 - 3344. [Abstract] [Full Text] [PDF]

				E. C. Lai, B. Tam, and G. M. Rubin Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs Genes & Dev., May 1, 2005; 19(9): 1067 - 1080. [Abstract] [Full Text] [PDF]

				S. J. Macdonald and A. D. Long Identifying Signatures of Selection at the Enhancer of split Neurogenic Gene Complex in Drosophila Mol. Biol. Evol., March 1, 2005; 22(3): 607 - 619. [Abstract] [Full Text] [PDF]

				L. E. Jensen and A. S. Whitehead The 3' Untranslated Region of the Membrane-Bound IL-1R Accessory Protein mRNA Confers Tissue-Specific Destabilization J. Immunol., November 15, 2004; 173(10): 6248 - 6258. [Abstract] [Full Text] [PDF]

				A. Boutla, C. Delidakis, and M. Tabler Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes Nucleic Acids Res., September 1, 2003; 31(17): 4973 - 4980. [Abstract] [Full Text] [PDF]

				D. A. Dansereau, M. D. Lunke, A. Finkielsztein, M. A. Russell, and W. J. Brook hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster Development, March 14, 2003; 129(24): 5553 - 5566. [Abstract] [Full Text] [PDF]

				J. DOSTIE, Z. MOURELATOS, M. YANG, A. SHARMA, and G. DREYFUSS Numerous microRNPs in neuronal cells containing novel microRNAs RNA, February 1, 2003; 9(2): 180 - 186. [Abstract] [Full Text] [PDF]

				M. Rebeiz, N. L. Reeves, and J. W. Posakony SCORE: A computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data PNAS, July 23, 2002; 99(15): 9888 - 9893. [Abstract] [Full Text] [PDF]

				R. Mancebo, X. Zhou, W. Shillinglaw, W. Henzel, and P. M. Macdonald BSF Binds Specifically to the bicoid mRNA 3' Untranslated Region and Contributes to Stabilization of bicoid mRNA Mol. Cell. Biol., May 15, 2001; 21(10): 3462 - 3471. [Abstract] [Full Text]

				J. Parsch, J. A. Russell, I. Beerman, D. L. Hartl, and W. Stephan Deletion of a Conserved Regulatory Element in the Drosophila Adh Gene Leads to Increased Alcohol Dehydrogenase Activity but Also Delays Development Genetics, September 1, 2000; 156(1): 219 - 227. [Abstract] [Full Text]

				E. Lai, R Bodner, and J. Posakony The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family Development, January 8, 2000; 127(16): 3441 - 3455. [Abstract] [PDF]

				S Zaffran and M Frasch Barbu: an E(spl) m4/m(alpha)-related gene that antagonizes Notch signaling and is required for the establishment of ommatidial polarity Development, January 3, 2000; 127(5): 1115 - 1130. [Abstract] [PDF]

				E. Lai, R Bodner, J Kavaler, G Freschi, and J. Posakony Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes Development, January 1, 2000; 127(2): 291 - 306. [Abstract] [PDF]