Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart

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				H. Chen, Y. Qiu, L. Chen, L. Li, J. Chen, C. Zhang, B. Wang, Y. Yu, Z. Zhu, F. Zhu, et al. The Expression of Neurofibromin in Human Osteoblasts and Chondrocytes Ann. Clin. Lab. Sci., January 1, 2008; 38(1): 25 - 30. [Abstract] [Full Text] [PDF]

				J. Xu, F. A. Ismat, T. Wang, J. Yang, and J. A. Epstein NF1 Regulates a Ras-Dependent Vascular Smooth Muscle Proliferative Injury Response Circulation, November 6, 2007; 116(19): 2148 - 2156. [Abstract] [Full Text] [PDF]

				M. Wagner and M. A. Q. Siddiqui Signal Transduction in Early Heart Development (II): Ventricular Chamber Specification, Trabeculation, and Heart Valve Formation Experimental Biology and Medicine, July 1, 2007; 232(7): 866 - 880. [Abstract] [Full Text] [PDF]

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				J. Rivera-Feliciano, K.-H. Lee, S. W. Kong, S. Rajagopal, Q. Ma, Z. Springer, S. Izumo, C. J. Tabin, and W. T. Pu Development of heart valves requires Gata4 expression in endothelial-derived cells Development, September 15, 2006; 133(18): 3607 - 3618. [Abstract] [Full Text] [PDF]

				M. I. Kontaridis, K. D. Swanson, F. S. David, D. Barford, and B. G. Neel PTPN11 (Shp2) Mutations in LEOPARD Syndrome Have Dominant Negative, Not Activating, Effects J. Biol. Chem., March 10, 2006; 281(10): 6785 - 6792. [Abstract] [Full Text] [PDF]

				K. E. Yutzey, M. Colbert, and J. Robbins Ras-Related Signaling Pathways in Valve Development: Ebb and Flow Physiology, December 1, 2005; 20(6): 390 - 397. [Abstract] [Full Text] [PDF]

				M. Krenz, K. E. Yutzey, and J. Robbins Noonan Syndrome Mutation Q79R in Shp2 Increases Proliferation of Valve Primordia Mesenchymal Cells via Extracellular Signal-Regulated Kinase 1/2 Signaling Circ. Res., October 14, 2005; 97(8): 813 - 820. [Abstract] [Full Text] [PDF]

				M. Tadano, H. Edamatsu, S. Minamisawa, U. Yokoyama, Y. Ishikawa, N. Suzuki, H. Saito, D. Wu, M. Masago-Toda, Y. Yamawaki-Kataoka, et al. Congenital Semilunar Valvulogenesis Defect in Mice Deficient in Phospholipase C{varepsilon} Mol. Cell. Biol., March 15, 2005; 25(6): 2191 - 2199. [Abstract] [Full Text] [PDF]

				H. Hallaq, E. Pinter, J. Enciso, J. McGrath, C. Zeiss, M. Brueckner, J. Madri, H. C. Jacobs, C. M. Wilson, H. Vasavada, et al. A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels Development, October 15, 2004; 131(20): 5197 - 5209. [Abstract] [Full Text] [PDF]

				B. Wang, J. Weidenfeld, M. M. Lu, S. Maika, W. A. Kuziel, E. E. Morrisey, and P. W. Tucker Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation Development, September 15, 2004; 131(18): 4477 - 4487. [Abstract] [Full Text] [PDF]

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				A. O. Stemmer-Rachamimov, D. N. Louis, G. P. Nielsen, C. R. Antonescu, A. D. Borowsky, R. T. Bronson, D. K. Burns, P. Cervera, M. E. McLaughlin, G. Reifenberger, et al. Comparative Pathology of Nerve Sheath Tumors in Mouse Models and Humans Cancer Res., May 15, 2004; 64(10): 3718 - 3724. [Abstract] [Full Text] [PDF]

				H. Akiyama, M.-C. Chaboissier, R. R. Behringer, D. H. Rowitch, A. Schedl, J. A. Epstein, and B. de Crombrugghe Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa PNAS, April 27, 2004; 101(17): 6502 - 6507. [Abstract] [Full Text] [PDF]

				L. A. Timmerman, J. Grego-Bessa, A. Raya, E. Bertran, J. M. Perez-Pomares, J. Diez, S. Aranda, S. Palomo, F. McCormick, J. C. Izpisua-Belmonte, et al. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation Genes & Dev., January 1, 2004; 18(1): 99 - 115. [Abstract] [Full Text] [PDF]

				K. Jiao, H. Kulessa, K. Tompkins, Y. Zhou, L. Batts, H. S. Baldwin, and B. L.M. Hogan An essential role of Bmp4 in the atrioventricular septation of the mouse heart Genes & Dev., October 1, 2003; 17(19): 2362 - 2367. [Abstract] [Full Text] [PDF]

				D. L. Brutsaert Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity Physiol Rev, January 1, 2003; 83(1): 59 - 115. [Abstract] [Full Text] [PDF]

				E. C. Delot, M. E. Bahamonde, M. Zhao, and K. M. Lyons BMP signaling is required for septation of the outflow tract of the mammalian heart Development, January 1, 2003; 130(1): 209 - 220. [Abstract] [Full Text] [PDF]

				M. Costell, R. Carmona, E. Gustafsson, M. Gonzalez-Iriarte, R. Fassler, and R. Munoz-Chapuli Hyperplastic Conotruncal Endocardial Cushions and Transposition of Great Arteries in Perlecan-Null Mice Circ. Res., July 26, 2002; 91(2): 158 - 164. [Abstract] [Full Text] [PDF]

				A.D. GITLER, C.B. BROWN, L. KOCHILAS, J. LI, and J.A. EPSTEIN Neural Crest Migration and Mouse Models of Congenital Heart Disease Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 57 - 62. [Abstract] [PDF]

				G. Paranya, S. Vineberg, E. Dvorin, S. Kaushal, S. J. Roth, E. Rabkin, F. J. Schoen, and J. Bischoff Aortic Valve Endothelial Cells Undergo Transforming Growth Factor-{beta}-Mediated and Non-Transforming Growth Factor-{beta}-Mediated Transdifferentiation in Vitro Am. J. Pathol., October 1, 2001; 159(4): 1335 - 1343. [Abstract] [Full Text]

				Y Dor, T. Camenisch, A Itin, G. Fishman, J. McDonald, P Carmeliet, and E Keshet A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects Development, January 5, 2001; 128(9): 1531 - 1538. [Abstract] [PDF]

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