Requirement of the MADS-box transcription factor MEF2C for vascular development

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Lin, Q.
	Articles by Olson, E. N.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Lin, Q.
	Articles by Olson, E. N.

Baldwin, H. S., Shen, H. M. and Yan, H. C (1994). Platelet endothelial cell adhesion molecule-1 (PECAM-1CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Development 120, 2539-2553.[Abstract/Free Full Text]

Baldwin, H. S (1995). Early embryonic vascular development. Cardiovascular Research 31, 34-.

Bergwerff, M., Verberne, M. E., DeRuiter, M. C., Poelmann, R. E. and Gittenberger-de Groot, A. C (1998). Neural crest cell contribution to the developing circulatory system. Implications for vascular morphology?. Circ. Res 82, 221-231.[Abstract/Free Full Text]

Black, B. L. and Olson, E. N (1998). Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Ann. Rev. Cell Dev. Biol 14, 167-196.[Medline]

Bour, B. A., O'Brien, M. A., Lockwood, W. L., Goldstein, E. S., Bodmer, R., Taghert, P. H., Abmayr, S. M. and Nguyen, H. T (1995). Drosophila MEF2, a transcription factor that is essential for myogenesis. Genes Dev 9, 730-741.[Abstract/Free Full Text]

Breir, G. and Risau, W (1996). The role of vascular endothelial growth factor in blood vessel formation. Cell Biol 6, 454-456.

Carmeliet, P., Ferreria, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W. and Nagy, A (1996). Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439.[Medline]

Carmeliet, P., Mackman, N., Moons, L., Luther, T., Gressens, P., Can Vlaenderen, I., Demunck, H., Kasper, M. Breier, G., Evrard, P., Muller, M., Risau, W., Edgington, T. and Collen, D (1996). Role of tissue factor in embryonic blood vessel development. Nature 383, 73-75.[Medline]

Cheng, T. C., Wallace, M. C., Merlie, J. P. and Olson, E. N (1993). Separable regulatory elements governing myogenin transcription during mouse embryogenesis. Science 261, 215-218.[Abstract/Free Full Text]

Coso, O. A., Montaner, S., Framm, C., Lacal, J. C., Prywes, R., Teramoto,H. and Gutkind, J. S (1997). Signaling from G-protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway. J. Biol. Chem 272, 20691-20691.[Abstract/Free Full Text]

Cserjesi, P., Brown, D., Lyons, G. E. and Olson, E. N (1995). Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse embryogenesis. Dev. Biol 170, 664-678.[Medline]

D'Angelo, G., Struman, I., Martial, J. and Weiner, R. I (1995). Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin. Proc. Natl. Acad. Sci. USA 92, 6374-6378.[Abstract/Free Full Text]

Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maison-Pierre, P. C. and Yancopoulos, G. D (1996). Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87, 1161-1169.[Medline]

Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S. and Akhurst, R. J (1995). Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knockout mice. Development 121, 1845-1854.[Abstract]

Dumont, D. J., Yamaguchi, T. P., Conlon, R. A., Rossant, J. and Breitman, M. L (1992). Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene 7, 1471-1480.[Medline]

Dumont, D. J., Gradwohl, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A. and Breitman, M. L (1994). Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev 8, 1897-1909.[Abstract/Free Full Text]

Edmondson, D. G., Lyons, G. E., Martin, J. F. and Olson, E. N (1994). MEF2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120, 1251-1263.[Abstract]

Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K. S., Powell-Braxton, L., Hillan, K. J. and Moore, M. W (1996). Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442.[Medline]

Firulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D. and Olson, E. N (1998). Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nature Gen 18, 266-270.[Medline]

Firulli, A. B., Miano, J. M., Bi, W., Johnson, D., Olson, E. N., Casscells, W. and Schwarz, J (1996). Myocyte enhancer binding factor-2 expression and activity in vascular smooth muscle cells: association with the activated phenotype. Circ. Res 78, 196-204.[Abstract/Free Full Text]

Fishman, M. C. and Chien, K. R (1997). Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099-2117.[Abstract]

Folkman, J. and D'Amore, P. A (1996). Blood vessel formation: what is its molecular basis?. Cell 87, 1153-1155.[Medline]

Fong, G. H., Rossant, J., Gertsenstein, M. and Breitman, M. L (1995). Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376, 66-69.[Medline]

Frohman, M. A., Boyle, M. and Martin, G. R (1990). Isolation of the mouse Hox-2. 9 gene: analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development 110, 589-607.[Abstract/Free Full Text]

Gassmann, M., Casagranda, F., Orioli, D., Simon, H., Lai, C., Klein, R. and Lemke, G (1995). Aberrant neural and cardiac development in mice lacking ErbB4 neuregulin receptor. Nature 378, 390-394.[Medline]

Han, T. H. and Prywes, R (1995). Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol. Cell. Biol 15, 2907-2915.[Abstract]

Han, J., Jiang, Y., Li, Z., Kravchenko, V. V. and Ulevitch, R. J (1997). Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 38, 296-299.

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y. and Simenza, G. L (1998). Cellular and developmental control of O2homeostasis by hypoxia-inducible factor 1. Genes Dev 12, 149-162.[Abstract/Free Full Text]

Kato, Y., Kravchenko, V. V., Tapping, R. I., Han, J., Ulevitch, R. J. and Lee, J. D (1997). BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J 16, 7054-7066.[Medline]

Kaushal, S., Schneider, J. W., Nadal-Ginard, B. and Mahdavi, V. I (1994). Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD. Science 266, 1236-1240.[Abstract/Free Full Text]

Kim, S., Ip, H. S., Lu, M. M., Clendenin, C. and Parmacek, M. S (1997). A serum response factor-dependent transcriptional regulatory program identifies distinct smooth muscle cell sublineages. Mol. Cell Biol 17, 2266-2278.[Abstract]

Kirby, M. L. and Waldo, K. L (1995). Neural crest and cardiovascular patterning. Circ. Res 77, 211-215.[Free Full Text]

Kozak, K. R., Abbott, B. and Hankinson, O (1997). ARNT-deficient mice and placental differentiation. Dev. Biol 191, 1-9.[Medline]

Kuo, C. T., Veselits, M. L., Barton, K. P., Lu, M. M., Clendenin, C. and Leiden, J. M (1997). The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev 11, 2996-3006.[Abstract/Free Full Text]

Lee, K., Simon, H., Chen, H., Bates, B., Hung, M. and Hauser, C (1995). Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378, 394-398.[Medline]

Leveen, P., Pekny, S., Gebre-Medhin, B., Swolin, B., Larsson, E. and Betsholtz, C (1994). Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalitites. Genes Dev 8, 1875-1887.[Abstract/Free Full Text]

Li, L., Miano, J. M., Cserjesi, P. and Olson, E. N (1996). SM22, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis. Cir. Res 78, 188-195.[Abstract/Free Full Text]

Li, L., Miano, J. M., Mercer, B. and Olson, E. N (1996). Expression of the SM22 promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells. J. Cell Biol, 132, 849-859.[Abstract/Free Full Text]

Li, L., Liu, Z-C., Mercer, B., Overbeek, P. and Olson, E. N (1997). Distinct serum response factor-mediated regulatory networks governing SM22 transcription in smooth, skeletal and cardiac muscle cells. Dev. Biol 187, 311-321.[Medline]

Lilly, B., Zhao, B., Ranganayakulu, G., Paterson, B. M., Schulz, R. A. and Olson, E. N (1995). Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science 267, 688-693.[Abstract/Free Full Text]

Lin, Q., Schwarz, J., Buchana, C. and Olson, E. N (1997). Control of cardiac morphogenesis and myogenesis by the myogenic transcription factor MEF2C. Science 276, 1404-1407.[Abstract/Free Full Text]

Lyons, G. E., Micales, B. K., Schwarz, J., Martin, J. F. and Olson, E. N (1995). Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. J. Neurosci 15, 5727-5738.[Abstract]

Maison-Pierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopouos, N., Daly, T. J., Davis, S., Sato, T. N. and Yancopoulos, G. D (1997). Angiopoietin-2, a natural antagonist for tie2 that disrupts in vivo angiogenesis. Science 277, 55-60.[Abstract/Free Full Text]

Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A. and Simon, M. C (1997). Abnormal angiogenesis and response to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386, 403-407.[Medline]

Meyer, D. and Birchmeier, C (1995). Multiple essential functions of neuregulin in development. Nature 378, 386-390.[Medline]

Molkentin, J. D., Black, B. L., Martin, J. F. and Olson, E. N (1995). Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83, 1125-1136.[Medline]

Molkentin, J., Firulli, A., Black, B., Lyons, G., Edmondson, D., Hustad, C. M., Copeland, N., Jenkins, N. and Olson, E. N (1996). MEF2B is a potent transactivator expressed in early myogenic lineages. Mol. Cell. Biol 16, 3814-3824.[Abstract]

Molkentin, J. and Olson, E. N (1996). Combinatorial control of muscle development by basic-helix-loop-helix and MADS-box transcription factors. Proc. Natl. Acad. Sci. USA 93, 9366-9373.[Abstract/Free Full Text]

Oshima, M., Oshima, H. and Taketo, M. M (1996). TGF-receptor type IIdeficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev. Biol 179, 297-302.[Medline]

Owens, G. K (1995). Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 75, 487-517.[Abstract/Free Full Text]

Partanen, J., Armstrong, E., Makela, T. P., Korhonen, J., Sandberg, M., Renkonen, R., Knuutila, S., Huebner, K. and Alitalo, K (1992). A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol. Cell. Biol 12, 1698-1707.[Abstract/Free Full Text]

Ranganayakulu, G., Zhao, B., Dokidis, A., Molkentin, J. D., Olson, E. N. and Schulz, R. A (1995). A series of mutations in the D-MEF2 transcription factor reveals multiple functions in larval and adult myogenesis in Drosophila. Dev. Biol 171, 169-181.[Medline]

Risau, W (1995). Differentiation of endothelium. FASEB J 9, 926-933.[Abstract]

Sato, T. N., Qin, Y., Kozak, C. A. and Audus, K. L (1993). Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc. Natl. Acad. Sci. USA 90, 9355-9358.[Abstract/Free Full Text]

Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg-Buchholz, K., Fujiwara, Y., Gendron-Maguire, M., Gridley, T., Wolburg, H., Risau, W. and Qin, Y (1995). Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376, 70-74.[Medline]

Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X. F., Breitman, M. L. and Smith, A. C (1995). Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376, 62-66.[Medline]

Shalaby, F., Ho, J., Stanford, W. L., Fisher, K. D., Schuh, A. C., Schwartz, L., Bernstein, A. and Rossant, J (1997). A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell 89, 981-990.[Medline]

Srivastava, D., Cserjesi, P. and Olson, E. N (1995). A subclass of bHLH proteins required for cardiac morphogenesis. Science 270, 1995-1999.[Abstract/Free Full Text]

Srivastava, D., Thomas, T., Lin, Q., Kirby, M., Brown, D. and Olson, E. N (1997). Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nature Gen 16, 154-160.[Medline]

Subramanian, S. V. and Nadal-Ginard, B (1996). Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell linages during mouse embryogenesis. Mech. Dev 57, 103-112.[Medline]

Suzuki, E., Guo, K., Kolman, M., Yu, Y. T. and Walsh, K (1995). Serum induction of MEF2/RSRF expression in vascular myocytes is mediated at the level of translation. Mol. Cell. Biol 15, 3415-3423.[Abstract]

Ticho, B. S., Stainier, D. Y., Fishman, M. C. and Breitbart,R. E (1996). Three zebrafish MEF2 genes delineate somitic and cardiac muscle development in wild-type and mutant embryos. Mech. Dev 59, 205-18.[Medline]

Toomey, J. R., Kratzer, K. E., Lasey, N. M. and Broze, G. J (1997). Effect of tissue factor deficiency on mouse and tumor development. Proc. Natl. Acad. Sci. USA 94, 6922-6926.[Abstract/Free Full Text]

Wilkinson, D. G., Bailes, J. A., Champion, J. E. and McMahon, A. P (1987). A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development 99, 493-500.[Abstract/Free Full Text]

Yee, S. P. and Rigby, P. W. J (1993). The regulation of myogenin gene expression during embryonic development of the mouse. Genes Dev 7, 1277-1289.[Abstract/Free Full Text]

This article has been cited by other articles:

D. Khiem, J. G. Cyster, J. J. Schwarz, and B. L. Black
A p38 MAPK-MEF2C pathway regulates B-cell proliferation
PNAS, November 4, 2008; 105(44): 17067 - 17072.
[Abstract] [Full Text] [PDF]

K. K. Schnoes, I. Z. Jaffe, L. Iyer, A. Dabreo, M. Aronovitz, B. Newfell, U. Hansen, G. Rosano, and M. E. Mendelsohn
Research Resource: Rapid Recruitment of Temporally Distinct Vascular Gene Sets by Estrogen
Mol. Endocrinol., November 1, 2008; 22(11): 2544 - 2556.
[Abstract] [Full Text] [PDF]

D. Maiti, Z. Xu, and E. J. Duh
Vascular Endothelial Growth Factor Induces MEF2C and MEF2-Dependent Activity in Endothelial Cells
Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3640 - 3648.
[Abstract] [Full Text] [PDF]

C. H. Ha, W. Wang, B. S. Jhun, C. Wong, A. Hausser, K. Pfizenmaier, T. A. McKinsey, E. N. Olson, and Z.-G. Jin
Protein Kinase D-dependent Phosphorylation and Nuclear Export of Histone Deacetylase 5 Mediates Vascular Endothelial Growth Factor-induced Gene Expression and Angiogenesis
J. Biol. Chem., May 23, 2008; 283(21): 14590 - 14599.
[Abstract] [Full Text] [PDF]

M. Du, R. L. S. Perry, N. B. Nowacki, J. W. Gordon, J. Salma, J. Zhao, A. Aziz, J. Chan, K. W. M. Siu, and J. C. McDermott
Protein Kinase A Represses Skeletal Myogenesis by Targeting Myocyte Enhancer Factor 2D
Mol. Cell. Biol., May 1, 2008; 28(9): 2952 - 2970.
[Abstract] [Full Text] [PDF]

B. Ramachandran, G. Yu, S. Li, B. Zhu, and T. Gulick
Myocyte Enhancer Factor 2A Is Transcriptionally Autoregulated
J. Biol. Chem., April 18, 2008; 283(16): 10318 - 10329.
[Abstract] [Full Text] [PDF]

K. K. K. Tanaka, A. L. Bryantsev, and R. M. Cripps
Myocyte Enhancer Factor 2 and Chorion Factor 2 Collaborate in Activation of the Myogenic Program in Drosophila
Mol. Cell. Biol., March 1, 2008; 28(5): 1616 - 1629.
[Abstract] [Full Text] [PDF]

J. Wu, C. S. Bohanan, J. C. Neumann, and J. B. Lingrel
KLF2 Transcription Factor Modulates Blood Vessel Maturation through Smooth Muscle Cell Migration
J. Biol. Chem., February 15, 2008; 283(7): 3942 - 3950.
[Abstract] [Full Text] [PDF]

M. J. Potthoff, M. A. Arnold, J. McAnally, J. A. Richardson, R. Bassel-Duby, and E. N. Olson
Regulation of Skeletal Muscle Sarcomere Integrity and Postnatal Muscle Function by Mef2c
Mol. Cell. Biol., December 1, 2007; 27(23): 8143 - 8151.
[Abstract] [Full Text] [PDF]

M. J. Potthoff and E. N. Olson
MEF2: a central regulator of diverse developmental programs
Development, December 1, 2007; 134(23): 4131 - 4140.
[Abstract] [Full Text] [PDF]

Y. Deng, J. Yang, M. McCarty, and B. Su
MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis
Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1404 - C1411.
[Abstract] [Full Text] [PDF]

N. Imai, K. Hishikawa, T. Marumo, J. Hirahashi, T. Inowa, Y. Matsuzaki, H. Okano, T. Kitamura, D. Salant, and T. Fujita
Inhibition of Histone Deacetylase Activates Side Population Cells in Kidney and Partially Reverses Chronic Renal Injury
Stem Cells, October 1, 2007; 25(10): 2469 - 2475.
[Abstract] [Full Text] [PDF]

M. Haberland, M. A. Arnold, J. McAnally, D. Phan, Y. Kim, and E. N. Olson
Regulation of HDAC9 Gene Expression by MEF2 Establishes a Negative-Feedback Loop in the Transcriptional Circuitry of Muscle Differentiation
Mol. Cell. Biol., January 15, 2007; 27(2): 518 - 525.
[Abstract] [Full Text] [PDF]

E. E. Creemers, L. B. Sutherland, J. McAnally, J. A. Richardson, and E. N. Olson
Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development
Development, November 1, 2006; 133(21): 4245 - 4256.
[Abstract] [Full Text] [PDF]

C. Karamboulas, G. D. Dakubo, J. Liu, Y. De Repentigny, K. Yutzey, V. A. Wallace, R. Kothary, and I. S. Skerjanc
Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis
J. Cell Sci., October 15, 2006; 119(20): 4315 - 4321.
[Abstract] [Full Text] [PDF]

A. Hamik, B. Wang, and M. K. Jain
Transcriptional Regulators of Angiogenesis
Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 1936 - 1947.
[Abstract] [Full Text] [PDF]

J. Li, M. Stouffs, L. Serrander, B. Banfi, E. Bettiol, Y. Charnay, K. Steger, K.-H. Krause, and M. E. Jaconi
The NADPH Oxidase NOX4 Drives Cardiac Differentiation: Role in Regulating Cardiac Transcription Factors and MAP Kinase Activation
Mol. Biol. Cell, September 1, 2006; 17(9): 3978 - 3988.
[Abstract] [Full Text] [PDF]

J. T. Durham, O. M. Brand, M. Arnold, J. G. Reynolds, L. Muthukumar, H. Weiler, J. A. Richardson, and F. J. Naya
Myospryn Is a Direct Transcriptional Target for MEF2A That Encodes a Striated Muscle, {alpha}-Actinin-interacting, Costamere-localized Protein
J. Biol. Chem., March 10, 2006; 281(10): 6841 - 6849.
[Abstract] [Full Text] [PDF]

J.E. Ferguson III, R. W. Kelley, and C. Patterson
Mechanisms of Endothelial Differentiation in Embryonic Vasculogenesis
Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2246 - 2254.
[Abstract] [Full Text] [PDF]

S. J. Sohn, D. Li, L. K. Lee, and A. Winoto
Transcriptional Regulation of Tissue-Specific Genes by the ERK5 Mitogen-Activated Protein Kinase
Mol. Cell. Biol., October 1, 2005; 25(19): 8553 - 8566.
[Abstract] [Full Text] [PDF]

A. Armulik, A. Abramsson, and C. Betsholtz
Endothelial/Pericyte Interactions
Circ. Res., September 16, 2005; 97(6): 512 - 523.
[Abstract] [Full Text] [PDF]

S. Morin, G. Pozzulo, L. Robitaille, J. Cross, and M. Nemer
MEF2-dependent Recruitment of the HAND1 Transcription Factor Results in Synergistic Activation of Target Promoters
J. Biol. Chem., September 16, 2005; 280(37): 32272 - 32278.
[Abstract] [Full Text] [PDF]

R. A. Deaton, C. Su, T. G. Valencia, and S. R. Grant
Transforming Growth Factor-{beta}1-induced Expression of Smooth Muscle Marker Genes Involves Activation of PKN and p38 MAPK
J. Biol. Chem., September 2, 2005; 280(35): 31172 - 31181.
[Abstract] [Full Text] [PDF]

B. Zhu, B. Ramachandran, and T. Gulick
Alternative Pre-mRNA Splicing Governs Expression of a Conserved Acidic Transactivation Domain in Myocyte Enhancer Factor 2 Factors of Striated Muscle and Brain
J. Biol. Chem., August 5, 2005; 280(31): 28749 - 28760.
[Abstract] [Full Text] [PDF]

S. Sen-Banerjee, S. Mir, Z. Lin, A. Hamik, G. B. Atkins, H. Das, P. Banerjee, A. Kumar, and M. K. Jain
Kruppel-Like Factor 2 as a Novel Mediator of Statin Effects in Endothelial Cells
Circulation, August 2, 2005; 112(5): 720 - 726.
[Abstract] [Full Text] [PDF]

B. Illi, A. Scopece, S. Nanni, A. Farsetti, L. Morgante, P. Biglioli, M. C. Capogrossi, and C. Gaetano
Epigenetic Histone Modification and Cardiovascular Lineage Programming in Mouse Embryonic Stem Cells Exposed to Laminar Shear Stress
Circ. Res., March 18, 2005; 96(5): 501 - 508.
[Abstract] [Full Text] [PDF]

R. L. C. Carvalho, L. Jonker, M.-J. Goumans, J. Larsson, P. Bouwman, S. Karlsson, P. t. Dijke, H. M. Arthur, and C. L. Mummery
Defective paracrine signalling by TGF{beta} in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia
Development, December 15, 2004; 131(24): 6237 - 6247.
[Abstract] [Full Text] [PDF]

B. Zhu and T. Gulick
Phosphorylation and Alternative Pre-mRNA Splicing Converge To Regulate Myocyte Enhancer Factor 2C Activity
Mol. Cell. Biol., September 15, 2004; 24(18): 8264 - 8275.
[Abstract] [Full Text] [PDF]

E. Dodou, M. P. Verzi, J. P. Anderson, S.-M. Xu, and B. L. Black
Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development
Development, August 15, 2004; 131(16): 3931 - 3942.
[Abstract] [Full Text] [PDF]

E. Suzuki, H. Satonaka, H. Nishimatsu, S. Oba, R. Takeda, M. Omata, T. Fujita, R. Nagai, and Y. Hirata
Myocyte Enhancer Factor 2 Mediates Vascular Inflammation via the p38-Dependent Pathway
Circ. Res., July 9, 2004; 95(1): 42 - 49.
[Abstract] [Full Text] [PDF]

K. Kuida and D. M. Boucher
Functions of MAP Kinases: Insights from Gene-Targeting Studies
J. Biochem., June 1, 2004; 135(6): 653 - 656.
[Abstract] [Full Text] [PDF]

K. M. Mann, J. L. Ray, E. S. Moon, K. M. Sass, and M. R. Benson
Calcineurin initiates smooth muscle differentiation in neural crest stem cells
J. Cell Biol., May 24, 2004; 165(4): 483 - 491.
[Abstract] [Full Text] [PDF]

J. P. Anderson, E. Dodou, A. B. Heidt, S. J. De Val, E. J. Jaehnig, S. B. Greene, E. N. Olson, and B. L. Black
HRC Is a Direct Transcriptional Target of MEF2 during Cardiac, Skeletal, and Arterial Smooth Muscle Development In Vivo
Mol. Cell. Biol., May 1, 2004; 24(9): 3757 - 3768.
[Abstract] [Full Text] [PDF]

Y. Morikawa and P. Cserjesi
Extra-embryonic vasculature development is regulated by the transcription factor HAND1
Development, May 1, 2004; 131(9): 2195 - 2204.
[Abstract] [Full Text] [PDF]

C. Huang, F. Sheikh, M. Hollander, C. Cai, D. Becker, P.-H. Chu, S. Evans, and J. Chen
Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis
Development, December 15, 2003; 130(24): 6111 - 6119.
[Abstract] [Full Text] [PDF]

E. N. Olson
Coronary Artery Disease and the MEF2A Transcription Factor
Sci. Aging Knowl. Environ., December 3, 2003; 2003(48): pe33 - 33.
[Abstract] [Full Text]

V. Compernolle, K. Brusselmans, D. Franco, A. Moorman, M. Dewerchin, D. Collen, and P. Carmeliet
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1{alpha}
Cardiovasc Res, December 1, 2003; 60(3): 569 - 579.
[Abstract] [Full Text] [PDF]

S. Li, D.-Z. Wang, Z. Wang, J. A. Richardson, and E. N. Olson
The serum response factor coactivator myocardin is required for vascular smooth muscle development
PNAS, August 5, 2003; 100(16): 9366 - 9370.
[Abstract] [Full Text] [PDF]

M. S. Kumar and G. K. Owens
Combinatorial Control of Smooth Muscle-Specific Gene Expression
Arterioscler. Thromb. Vasc. Biol., May 1, 2003; 23(5): 737 - 747.
[Abstract] [Full Text] [PDF]

J. Chagraoui, A. Lepage-Noll, A. Anjo, G. Uzan, and P. Charbord
Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition
Blood, April 15, 2003; 101(8): 2973 - 2982.
[Abstract] [Full Text] [PDF]

K. E. McGrath, A. D. Koniski, J. Malik, and J. Palis
Circulation is established in a stepwise pattern in the mammalian embryo
Blood, March 1, 2003; 101(5): 1669 - 1675.
[Abstract] [Full Text] [PDF]

Z. Yan, S. Choi, X. Liu, M. Zhang, J. J. Schageman, S. Y. Lee, R. Hart, L. Lin, F. A. Thurmond, and R. S. Williams
Highly Coordinated Gene Regulation in Mouse Skeletal Muscle Regeneration
J. Biol. Chem., February 28, 2003; 278(10): 8826 - 8836.
[Abstract] [Full Text] [PDF]

J. D. Hildebrand and P. Soriano
Overlapping and Unique Roles for C-Terminal Binding Protein 1 (CtBP1) and CtBP2 during Mouse Development.
Mol. Cell. Biol., August 1, 2002; 22(15): 5296 - 5307.
[Abstract] [Full Text] [PDF]

C. P. Regan, W. Li, D. M. Boucher, S. Spatz, M. S. Su, and K. Kuida
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
PNAS, July 9, 2002; 99(14): 9248 - 9253.
[Abstract] [Full Text] [PDF]

E. Suzuki, H. Nishimatsu, H. Satonaka, K. Walsh, A. Goto, M. Omata, T. Fujita, R. Nagai, and Y. Hirata
Angiotensin II Induces Myocyte Enhancer Factor 2- and Calcineurin/Nuclear Factor of Activated T Cell-Dependent Transcriptional Activation in Vascular Myocytes
Circ. Res., May 17, 2002; 90(9): 1004 - 1011.
[Abstract] [Full Text] [PDF]

J. E. Dennis and P. Charbord
Origin and Differentiation of Human and Murine Stroma
Stem Cells, May 1, 2002; 20(3): 205 - 214.
[Abstract] [Full Text] [PDF]

M. D. Layne, S.-F. Yet, K. Maemura, C.-M. Hsieh, X. Liu, B. Ith, M.-E. Lee, and M. A. Perrella
Characterization of the Mouse Aortic Carboxypeptidase-Like Protein Promoter Reveals Activity in Differentiated and Dedifferentiated Vascular Smooth Muscle Cells
Circ. Res., April 5, 2002; 90(6): 728 - 736.
[Abstract] [Full Text] [PDF]

S. Borghi, S. Molinari, G. Razzini, F. Parise, R. Battini, and S. Ferrari
The nuclear localization domain of the MEF2 family of transcription factors shows member-specific features and mediates the nuclear import of histone deacetylase 4
J. Cell Sci., March 14, 2002; 114(24): 4477 - 4483.
[Abstract] [Full Text] [PDF]

				K. K. Schnoes, I. Z. Jaffe, L. Iyer, A. Dabreo, M. Aronovitz, B. Newfell, U. Hansen, G. Rosano, and M. E. Mendelsohn Research Resource: Rapid Recruitment of Temporally Distinct Vascular Gene Sets by Estrogen Mol. Endocrinol., November 1, 2008; 22(11): 2544 - 2556. [Abstract] [Full Text] [PDF]

				D. Maiti, Z. Xu, and E. J. Duh Vascular Endothelial Growth Factor Induces MEF2C and MEF2-Dependent Activity in Endothelial Cells Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3640 - 3648. [Abstract] [Full Text] [PDF]

				C. H. Ha, W. Wang, B. S. Jhun, C. Wong, A. Hausser, K. Pfizenmaier, T. A. McKinsey, E. N. Olson, and Z.-G. Jin Protein Kinase D-dependent Phosphorylation and Nuclear Export of Histone Deacetylase 5 Mediates Vascular Endothelial Growth Factor-induced Gene Expression and Angiogenesis J. Biol. Chem., May 23, 2008; 283(21): 14590 - 14599. [Abstract] [Full Text] [PDF]

				M. Du, R. L. S. Perry, N. B. Nowacki, J. W. Gordon, J. Salma, J. Zhao, A. Aziz, J. Chan, K. W. M. Siu, and J. C. McDermott Protein Kinase A Represses Skeletal Myogenesis by Targeting Myocyte Enhancer Factor 2D Mol. Cell. Biol., May 1, 2008; 28(9): 2952 - 2970. [Abstract] [Full Text] [PDF]

				B. Ramachandran, G. Yu, S. Li, B. Zhu, and T. Gulick Myocyte Enhancer Factor 2A Is Transcriptionally Autoregulated J. Biol. Chem., April 18, 2008; 283(16): 10318 - 10329. [Abstract] [Full Text] [PDF]

				K. K. K. Tanaka, A. L. Bryantsev, and R. M. Cripps Myocyte Enhancer Factor 2 and Chorion Factor 2 Collaborate in Activation of the Myogenic Program in Drosophila Mol. Cell. Biol., March 1, 2008; 28(5): 1616 - 1629. [Abstract] [Full Text] [PDF]

				J. Wu, C. S. Bohanan, J. C. Neumann, and J. B. Lingrel KLF2 Transcription Factor Modulates Blood Vessel Maturation through Smooth Muscle Cell Migration J. Biol. Chem., February 15, 2008; 283(7): 3942 - 3950. [Abstract] [Full Text] [PDF]

				M. J. Potthoff, M. A. Arnold, J. McAnally, J. A. Richardson, R. Bassel-Duby, and E. N. Olson Regulation of Skeletal Muscle Sarcomere Integrity and Postnatal Muscle Function by Mef2c Mol. Cell. Biol., December 1, 2007; 27(23): 8143 - 8151. [Abstract] [Full Text] [PDF]

				M. J. Potthoff and E. N. Olson MEF2: a central regulator of diverse developmental programs Development, December 1, 2007; 134(23): 4131 - 4140. [Abstract] [Full Text] [PDF]

				Y. Deng, J. Yang, M. McCarty, and B. Su MEKK3 is required for endothelium function but is not essential for tumor growth and angiogenesis Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1404 - C1411. [Abstract] [Full Text] [PDF]

				N. Imai, K. Hishikawa, T. Marumo, J. Hirahashi, T. Inowa, Y. Matsuzaki, H. Okano, T. Kitamura, D. Salant, and T. Fujita Inhibition of Histone Deacetylase Activates Side Population Cells in Kidney and Partially Reverses Chronic Renal Injury Stem Cells, October 1, 2007; 25(10): 2469 - 2475. [Abstract] [Full Text] [PDF]

				M. Haberland, M. A. Arnold, J. McAnally, D. Phan, Y. Kim, and E. N. Olson Regulation of HDAC9 Gene Expression by MEF2 Establishes a Negative-Feedback Loop in the Transcriptional Circuitry of Muscle Differentiation Mol. Cell. Biol., January 15, 2007; 27(2): 518 - 525. [Abstract] [Full Text] [PDF]

				E. E. Creemers, L. B. Sutherland, J. McAnally, J. A. Richardson, and E. N. Olson Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development Development, November 1, 2006; 133(21): 4245 - 4256. [Abstract] [Full Text] [PDF]

				C. Karamboulas, G. D. Dakubo, J. Liu, Y. De Repentigny, K. Yutzey, V. A. Wallace, R. Kothary, and I. S. Skerjanc Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis J. Cell Sci., October 15, 2006; 119(20): 4315 - 4321. [Abstract] [Full Text] [PDF]

				A. Hamik, B. Wang, and M. K. Jain Transcriptional Regulators of Angiogenesis Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 1936 - 1947. [Abstract] [Full Text] [PDF]

				J. Li, M. Stouffs, L. Serrander, B. Banfi, E. Bettiol, Y. Charnay, K. Steger, K.-H. Krause, and M. E. Jaconi The NADPH Oxidase NOX4 Drives Cardiac Differentiation: Role in Regulating Cardiac Transcription Factors and MAP Kinase Activation Mol. Biol. Cell, September 1, 2006; 17(9): 3978 - 3988. [Abstract] [Full Text] [PDF]

				J. T. Durham, O. M. Brand, M. Arnold, J. G. Reynolds, L. Muthukumar, H. Weiler, J. A. Richardson, and F. J. Naya Myospryn Is a Direct Transcriptional Target for MEF2A That Encodes a Striated Muscle, {alpha}-Actinin-interacting, Costamere-localized Protein J. Biol. Chem., March 10, 2006; 281(10): 6841 - 6849. [Abstract] [Full Text] [PDF]

				J.E. Ferguson III, R. W. Kelley, and C. Patterson Mechanisms of Endothelial Differentiation in Embryonic Vasculogenesis Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2246 - 2254. [Abstract] [Full Text] [PDF]

				S. J. Sohn, D. Li, L. K. Lee, and A. Winoto Transcriptional Regulation of Tissue-Specific Genes by the ERK5 Mitogen-Activated Protein Kinase Mol. Cell. Biol., October 1, 2005; 25(19): 8553 - 8566. [Abstract] [Full Text] [PDF]

				A. Armulik, A. Abramsson, and C. Betsholtz Endothelial/Pericyte Interactions Circ. Res., September 16, 2005; 97(6): 512 - 523. [Abstract] [Full Text] [PDF]

				S. Morin, G. Pozzulo, L. Robitaille, J. Cross, and M. Nemer MEF2-dependent Recruitment of the HAND1 Transcription Factor Results in Synergistic Activation of Target Promoters J. Biol. Chem., September 16, 2005; 280(37): 32272 - 32278. [Abstract] [Full Text] [PDF]

				R. A. Deaton, C. Su, T. G. Valencia, and S. R. Grant Transforming Growth Factor-{beta}1-induced Expression of Smooth Muscle Marker Genes Involves Activation of PKN and p38 MAPK J. Biol. Chem., September 2, 2005; 280(35): 31172 - 31181. [Abstract] [Full Text] [PDF]

				B. Zhu, B. Ramachandran, and T. Gulick Alternative Pre-mRNA Splicing Governs Expression of a Conserved Acidic Transactivation Domain in Myocyte Enhancer Factor 2 Factors of Striated Muscle and Brain J. Biol. Chem., August 5, 2005; 280(31): 28749 - 28760. [Abstract] [Full Text] [PDF]

				S. Sen-Banerjee, S. Mir, Z. Lin, A. Hamik, G. B. Atkins, H. Das, P. Banerjee, A. Kumar, and M. K. Jain Kruppel-Like Factor 2 as a Novel Mediator of Statin Effects in Endothelial Cells Circulation, August 2, 2005; 112(5): 720 - 726. [Abstract] [Full Text] [PDF]

				B. Illi, A. Scopece, S. Nanni, A. Farsetti, L. Morgante, P. Biglioli, M. C. Capogrossi, and C. Gaetano Epigenetic Histone Modification and Cardiovascular Lineage Programming in Mouse Embryonic Stem Cells Exposed to Laminar Shear Stress Circ. Res., March 18, 2005; 96(5): 501 - 508. [Abstract] [Full Text] [PDF]

				R. L. C. Carvalho, L. Jonker, M.-J. Goumans, J. Larsson, P. Bouwman, S. Karlsson, P. t. Dijke, H. M. Arthur, and C. L. Mummery Defective paracrine signalling by TGF{beta} in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia Development, December 15, 2004; 131(24): 6237 - 6247. [Abstract] [Full Text] [PDF]

				B. Zhu and T. Gulick Phosphorylation and Alternative Pre-mRNA Splicing Converge To Regulate Myocyte Enhancer Factor 2C Activity Mol. Cell. Biol., September 15, 2004; 24(18): 8264 - 8275. [Abstract] [Full Text] [PDF]

				E. Dodou, M. P. Verzi, J. P. Anderson, S.-M. Xu, and B. L. Black Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development Development, August 15, 2004; 131(16): 3931 - 3942. [Abstract] [Full Text] [PDF]

				E. Suzuki, H. Satonaka, H. Nishimatsu, S. Oba, R. Takeda, M. Omata, T. Fujita, R. Nagai, and Y. Hirata Myocyte Enhancer Factor 2 Mediates Vascular Inflammation via the p38-Dependent Pathway Circ. Res., July 9, 2004; 95(1): 42 - 49. [Abstract] [Full Text] [PDF]

				K. Kuida and D. M. Boucher Functions of MAP Kinases: Insights from Gene-Targeting Studies J. Biochem., June 1, 2004; 135(6): 653 - 656. [Abstract] [Full Text] [PDF]