Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3

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A. Amsterdam, K. Kannan, D. Givol, Y. Yoshida, K. Tajima, and A. Dantes
Apoptosis of Granulosa Cells and Female Infertility in Achondroplastic Mice Expressing Mutant Fibroblast Growth Factor Receptor 3G374R
Mol. Endocrinol., September 1, 2001; 15(9): 1610 - 1623.
[Abstract] [Full Text] [PDF]

T. Iwata, C.-L. Li, C.-X. Deng, and C. A. Francomano
Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice
Hum. Mol. Genet., June 1, 2001; 10(12): 1255 - 1264.
[Abstract] [Full Text] [PDF]

J. S. Colvin, A. C. White, S. J. Pratt, and D. M. Ornitz
Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme
Development, June 1, 2001; 128(11): 2095 - 2106.
[Abstract] [Full Text] [PDF]

M. Sahni, R. Raz, J. D. Coffin, D. Levy, and C. Basilico
STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
Development, June 1, 2001; 128(11): 2119 - 2129.
[Abstract] [Full Text] [PDF]

L. Chen, C. Li, W. Qiao, X. Xu, and C. Deng
A Ser365{->}Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia
Hum. Mol. Genet., March 1, 2001; 10(5): 457 - 465.
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Y.-X. Zhou, X. Xu, L. Chen, C. Li, S. G. Brodie, and C.-X. Deng
A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures
Hum. Mol. Genet., August 12, 2000; 9(13): 2001 - 2008.
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M. Iwamoto, Y. Higuchi, E. Koyama, M. Enomoto-Iwamoto, K. Kurisu, H. Yeh, W. R. Abrams, J. Rosenbloom, and M. Pacifici
Transcription Factor ERG Variants and Functional Diversification of Chondrocytes during Limb Long Bone Development
J. Cell Biol., July 11, 2000; 150(1): 27 - 40.
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T. Iwata, L. Chen, C.-l. Li, D. A. Ovchinnikov, R. R. Behringer, C. A. Francomano, and C.-X. Deng
A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos
Hum. Mol. Genet., July 1, 2000; 9(11): 1603 - 1613.
[Abstract] [Full Text] [PDF]

Z. Vajo, C. A. Francomano, and D. J. Wilkin
The Molecular and Genetic Basis of Fibroblast Growth Factor Receptor 3 Disorders: The Achondroplasia Family of Skeletal Dysplasias, Muenke Craniosynostosis, and Crouzon Syndrome with Acanthosis Nigricans
Endocr. Rev., February 1, 2000; 21(1): 23 - 39.
[Abstract] [Full Text]

S. Murakami, M. Kan, W. L. McKeehan, and B. de Crombrugghe
Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway
PNAS, February 1, 2000; 97(3): 1113 - 1118.
[Abstract] [Full Text] [PDF]

O. Segev, I. Chumakov, Z. Nevo, D. Givol, L. Madar-Shapiro, Y. Sheinin, M. Weinreb, and A. Yayon
Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3G380R transgenic mice
Hum. Mol. Genet., January 22, 2000; 9(2): 249 - 258.
[Abstract] [Full Text] [PDF]

D. Thomas, A Sunters, A Gentry, and A. Grigoriadis
Inhibition of chondrocyte differentiation in vitro by constitutive and inducible overexpression of the c-fos proto-oncogene
J. Cell Sci., January 2, 2000; 113(3): 439 - 450.
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				V. L. Ruiz-Perez, H. J. Blair, M. E. Rodriguez-Andres, M. J. Blanco, A. Wilson, Y.-N. Liu, C. Miles, H. Peters, and J. A. Goodship Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia Development, August 15, 2007; 134(16): 2903 - 2912. [Abstract] [Full Text] [PDF]

				Y. Maeda, E. Nakamura, M.-T. Nguyen, L. J. Suva, F. L. Swain, M. S. Razzaque, S. Mackem, and B. Lanske Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone PNAS, April 10, 2007; 104(15): 6382 - 6387. [Abstract] [Full Text] [PDF]

				M. I. Reinhold and M. C. Naski Direct Interactions of Runx2 and Canonical Wnt Signaling Induce FGF18 J. Biol. Chem., February 9, 2007; 282(6): 3653 - 3663. [Abstract] [Full Text] [PDF]

				B. S. Yoon, R. Pogue, D. A. Ovchinnikov, I. Yoshii, Y. Mishina, R. R. Behringer, and K. M. Lyons BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways Development, December 1, 2006; 133(23): 4667 - 4678. [Abstract] [Full Text] [PDF]

				L. van der Weyden, L. Wei, J. Luo, X. Yang, D. E. Birk, D. J. Adams, A. Bradley, and Q. Chen Functional Knockout of the Matrilin-3 Gene Causes Premature Chondrocyte Maturation to Hypertrophy and Increases Bone Mineral Density and Osteoarthritis Am. J. Pathol., August 1, 2006; 169(2): 515 - 527. [Abstract] [Full Text] [PDF]

				D. Spater, T. P. Hill, R. J. O'Sullivan, M. Gruber, D. A. Conner, and C. Hartmann Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis Development, August 1, 2006; 133(15): 3039 - 3049. [Abstract] [Full Text] [PDF]

				G. Valverde-Franco, J.S. Binette, W. Li, H. Wang, S. Chai, F. Laflamme, N. Tran-Khanh, E. Quenneville, T. Meijers, A.R. Poole, et al. Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice Hum. Mol. Genet., June 1, 2006; 15(11): 1783 - 1792. [Abstract] [Full Text] [PDF]

				S. Wu, Y. Yoshiko, and F. De Luca Stanniocalcin 1 Acts as a Paracrine Regulator of Growth Plate Chondrogenesis J. Biol. Chem., February 24, 2006; 281(8): 5120 - 5127. [Abstract] [Full Text] [PDF]

				J. H. D. Bassett, R. Swinhoe, O. Chassande, J. Samarut, and G. R. Williams Thyroid Hormone Regulates Heparan Sulfate Proteoglycan Expression in the Growth Plate Endocrinology, January 1, 2006; 147(1): 295 - 305. [Abstract] [Full Text] [PDF]

				D. Davidson, A. Blanc, D. Filion, H. Wang, P. Plut, G. Pfeffer, M. D. Buschmann, and J. E. Henderson Fibroblast Growth Factor (FGF) 18 Signals through FGF Receptor 3 to Promote Chondrogenesis J. Biol. Chem., May 27, 2005; 280(21): 20509 - 20515. [Abstract] [Full Text] [PDF]

				T. Tsuji and T. Kunieda A Loss-of-Function Mutation in Natriuretic Peptide Receptor 2 (Npr2) Gene Is Responsible for Disproportionate Dwarfism in cn/cn Mouse J. Biol. Chem., April 8, 2005; 280(14): 14288 - 14292. [Abstract] [Full Text] [PDF]

				C. Colnot, L. de la Fuente, S. Huang, D. Hu, C. Lu, B. St-Jacques, and J. A. Helms Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development Development, March 1, 2005; 132(5): 1057 - 1067. [Abstract] [Full Text] [PDF]

				F. Karreth, A. Hoebertz, H. Scheuch, R. Eferl, and E. F. Wagner The AP1 transcription factor Fra2 is required for efficient cartilage development Development, November 15, 2004; 131(22): 5717 - 5725. [Abstract] [Full Text] [PDF]

				M. I. Reinhold, M. Abe, R. M. Kapadia, Z. Liao, and M. C. Naski FGF18 Represses Noggin Expression and Is Induced by Calcineurin J. Biol. Chem., September 10, 2004; 279(37): 38209 - 38219. [Abstract] [Full Text] [PDF]

				M. Horiki, T. Imamura, M. Okamoto, M. Hayashi, J. Murai, A. Myoui, T. Ochi, K. Miyazono, H. Yoshikawa, and N. Tsumaki Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia J. Cell Biol., May 10, 2004; 165(3): 433 - 445. [Abstract] [Full Text] [PDF]

				P. Smits, P. Dy, S. Mitra, and V. Lefebvre Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate J. Cell Biol., March 1, 2004; 164(5): 747 - 758. [Abstract] [Full Text] [PDF]

				G. Valverde-Franco, H. Liu, D. Davidson, S. Chai, H. Valderrama-Carvajal, D. Goltzman, D. M. Ornitz, and J. E. Henderson Defective bone mineralization and osteopenia in young adult FGFR3-/- mice Hum. Mol. Genet., February 1, 2004; 13(3): 271 - 284. [Abstract] [Full Text] [PDF]

				S. Murakami, G. Balmes, S. McKinney, Z. Zhang, D. Givol, and B. de Crombrugghe Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype Genes & Dev., February 1, 2004; 18(3): 290 - 305. [Abstract] [Full Text] [PDF]

				J. Y. Cho, C. Guo, M. Torello, G. P. Lunstrum, T. Iwata, C. Deng, and W. A. Horton Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia PNAS, January 13, 2004; 101(2): 609 - 614. [Abstract] [Full Text] [PDF]

				M. I. Reinhold, D. G. McEwen, and M. C. Naski Fibroblast Growth Factor Receptor 3 Gene: Regulation by Serum Response Factor Mol. Endocrinol., January 1, 2004; 18(1): 241 - 251. [Abstract] [Full Text] [PDF]

				K. Yu, J. Xu, Z. Liu, D. Sosic, J. Shao, E. N. Olson, D. A. Towler, and D. M. Ornitz Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth Development, July 1, 2003; 130(13): 3063 - 3074. [Abstract] [Full Text] [PDF]

				W. Yuan, Y. Rao, R. P. Babiuk, J. J. Greer, J. Y. Wu, and D. M. Ornitz A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3 PNAS, April 29, 2003; 100(9): 5217 - 5222. [Abstract] [Full Text] [PDF]

				B. Hurle, E. Ignatova, S. M. Massironi, T. Mashimo, X. Rios, I. Thalmann, R. Thalmann, and D. M. Ornitz Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1 Hum. Mol. Genet., April 1, 2003; 12(7): 777 - 789. [Abstract] [Full Text] [PDF]

				R. T. Ballock and R. J. O'Keefe The Biology of the Growth Plate J. Bone Joint Surg. Am., March 31, 2003; 85(4): 715 - 726. [Full Text] [PDF]

				V. P. Eswarakumar, E. Monsonego-Ornan, M. Pines, I. Antonopoulou, G. M. Morriss-Kay, and P. Lonai The IIIc alternative of Fgfr2 is a positive regulator of bone formation Development, March 10, 2003; 129(16): 3783 - 3793. [Abstract] [Full Text] [PDF]

				Y. Yang, L. Topol, H. Lee, and J. Wu Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation Development, March 1, 2003; 130(5): 1003 - 1015. [Abstract] [Full Text] [PDF]

				T. Kirsch, E. Koyama, M. Liu, E. E. Golub, and M. Pacifici Syndecan-3 Is a Selective Regulator of Chondrocyte Proliferation J. Biol. Chem., October 25, 2002; 277(44): 42171 - 42177. [Abstract] [Full Text] [PDF]

				S. Cormier, A.-L. Delezoide, C. Benoist-Lasselin, L. Legeai-Mallet, J. Bonaventure, and C. Silve Parathyroid Hormone Receptor Type 1/Indian Hedgehog Expression Is Preserved in the Growth Plate of Human Fetuses Affected with Fibroblast Growth Factor Receptor Type 3 Activating Mutations Am. J. Pathol., October 1, 2002; 161(4): 1325 - 1335. [Abstract] [Full Text] [PDF]

				D. M. Ornitz and P. J. Marie FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease Genes & Dev., June 15, 2002; 16(12): 1446 - 1465. [Full Text] [PDF]

				R. F. Robledo, L. Rajan, X. Li, and T. Lufkin The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development Genes & Dev., May 1, 2002; 16(9): 1089 - 1101. [Abstract] [Full Text] [PDF]