Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Acampora, D.
	Articles by Simeone, A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Acampora, D.
	Articles by Simeone, A.

Acampora, D., Mazan, S., Lallemand, Y., Avantaggiato, V., Maury, M., Simeone, S. and Brulet, P (1995). Forebrain and midbrain regions are deleted Otx2/ mutants due to a defective anterior neuroectoderm specifiction during gastrulation. Development 121, 3279-3290.[Abstract]

Acampora, D., Mazan, S., Avantaggiato, V., Barone, P., Tuorto, F., Lallemand, Y., Br\236let, P. and A. Simeone, A (1996). Epilepsy and brain abnormalities in mice lacking the Otx1 mice. Nature Gen 14, 218-222.[Medline]

Acampora, D., Avantaggiato, V., Tuorto, F. and Simeone, A (1997). Genetic control of brain morphogenesis through Otx gene dosage requirement. Development 124, 3639-3650.[Abstract]

Bachiller, D., Macias, A., Duboule, D. and Morata, G (1994). Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes. EMBO J 13, 1930-1941.[Medline]

Bally-Cuif, L., Gulisano, M., Broccoli, V. and Boncinelli, E (1995). c-otx2 is expressed in two different phases of gastrulation and is sensitive to retinoic acid treatment in chick embryo. Mech. Dev 49, 49-63.[Medline]

Bulfone, A., Puelles, L., Porteus, M. H., Frohman, M. A., Martin, G. R. and Rubenstein, J. L. R (1993). Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J. Neurosci 13, 3155-3172.[Abstract]

Callaerts, P., Halder, G. and Gehring, W. J (1997). Pax-6 in development and evolution. Annu. Rev. Neurosci 20, 483-532.[Medline]

Cohen, S. M. and Jurgens, G (1991). Drosophila headlines. Trends Genet 7, 267-272.[Medline]

Crossley, P. H. and Martin, G. R (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryos. Development 121, 439-451.[Abstract]

Crossley, P. H., Martinez, S. and Martin, G. R (1996). Midbrain development induced by FGF8 in the chick embryo. Nature 380, 66-68.[Medline]

Duboule, D. and Dolle, P (1989). The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J 8, 1497-1505.[Medline]

Finkelstein, R. and Perrimon, N (1990). The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development. Nature 346, 485-488.[Medline]

Finkelstein R., Smouse, D., Capaci, T. M., Spradling, A. C. and Perrimon, N (1990). The orthodenticle gene encodes a novel homeodmain protein involved in the development the Drosophila nervous system and ocellar visual structures. Genes Dev 4, 1516-1527.[Abstract/Free Full Text]

Finkelstein, R. and Boncinelli, E (1994). From fly head to mammalian forebrain: the story of otd and Otx. Trends Genet 10, 310-315.[Medline]

Frantz, G. D., Weimann, J. M., Levin, M. E. and McConnell, S. K (1994). Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. J. Neurosci 14, 5725-5740.[Abstract]

Gans, C. and Northcutt, R. G (1983). Neural crest and the origin of vertebrates: A new head. Science 220, 268-274.[Abstract/Free Full Text]

Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol 119, 493-501.[Abstract/Free Full Text]

Graham, A., Papalopulu, N. and Krumlauf, M (1989). The murine and Drosophila homeobox clusters have common features of organization and expression. Cell 57, 367-378.[Medline]

Haddon, C. M. and Lewis, J. H (1991). Hyaluronan as a propellant for epithelial movement: the development of semiciruclar canals in the inner ear of Xenopus. Development 112, 541-550.[Abstract]

Hirth, F., Therianos, S., Loop, T., Gehring, W. J., Reichert, H. and Furukubo-Tokunaga, K (1995). Developmental defects in brain segmentation caused by mutations of the homeobox gene orthodenticle and empy spiracles in Drosophila. Neuron 15, 1-20.[Medline]

Holland, P., Ingham, P. and Krauss, S (1992). Mice and flies head to head. Nature 358, 627-628.[Medline]

Joyner, A. L (1996). Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development. Trends Genet 12, 15-20.[Medline]

Krumlauf, R (1994). Hox genes in vertebrate development. Cell 78, 191-201.[Medline]

Leuzinger, S., Hirth, F., Gehrlich, D., Acampora, D., Simeone, A., Gehring, W. J., Finkelstein, R., Furukubo-Tokunaga, K. and Reichert, H (1998). Functional equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila. Development 125, 1703-1710.[Abstract]

Lewis, E. B (1978). A gene complex controlling segmentation in Drosophila. Nature 276, 565-570.[Medline]

Matsuo, I., Kuratani, S., Kimura, C., Takeda, N. and Aizawa, S (1995). Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev 9, 2646-2658.[Abstract/Free Full Text]

McGinnis, W. and Krumlauf, R (1992). Homeobox genes and axial patterning. Cell 68, 283-302.[Medline]

McMahon, A. P., Joyner, A. L., Bradley, A. and McMahon, J. A (1992). The midbrain-hindbrain phenotype of Wnt-1/Wnt-1 mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell 69, 581-595.[Medline]

Mercier, P., Simeone, A., Cotelli, F. and Boncinelli, E (1995). Expression pattern of two Otx genes suggests a role in specifying anterior body structures in zebrafish. Int. J. Dev. Biol 39, 559-573.[Medline]

Pannese, M., Polo, C., Abdreazzoli, M., Vignali, R., Kablar, B., Barsacchi, G. and Boncinelli, E (1995). The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior structures in frog embryos. Development 121, 707-720.[Abstract]

Reichert H., and Boyan G (1997). Building a brain: developmental insights in insects. Trends Neurosci 20, 258-264.[Medline]

Royet, J. and Finkelstein, R (1995). Pattern formation in Drosophila head development: the role of the orthodenticle homeobox gene. Development 121, 3561-3572.[Abstract]

Rubenstein, J. L. R., Martinez, S., Shimamura, K. and Puelles, L (1994). The embryonic vertebrate forebrain: the prosomeric model. Science 266, 578-580.[Free Full Text]

Schmidt-Ott, U., Gonzales-Gaitan, M., J\212ckle, H., and Technau, G. M (1994). Number, identity, and sequence of the Drosophila head segments as revealed by neural elements and their deletion patterns in mutants. Proc. Natl. Acad. Sci. USA 91, 8363-8367.[Abstract/Free Full Text]

Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A. and Boncinelli,E (1992). Nested expression domains of four homeobox genes in developing rostral brain. Nature 358, 687-690.[Medline]

Simeone, A.,Acampora, D., Mallamaci, A., Stornaiuolo, A., D'Apice, M. R., Nigro, V. and Boncinelli, E (1993). A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J 12, 2735-2747.[Medline]

Thor, S (1995). The genetics of brain development: conserved programs in flies and mice. Neuron 15, 975-977.[Medline]

van der Hoeven, F., Zakany, J. and Duboule, D (1996). Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. Cell 85, 1025-1035.[Medline]

Wada, S., Katsuyama, Y., Sato, Y., Itoh, C. and Saiga, H (1996). Hroth an orthodenticle-related homeobox gene of the ascidian, Halocynthia roretzi: its expression and putative roles in the axis formation during embryogenesis. Mech. Dev 60, 59-71.[Medline]

Wassarman, K. M., Lewandoski, M., Campbell, K., Joyner, A. L., Rubenstein, J. L. R., Martinez, S. and Martin, G. R (1997). Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development 124, 2923-2934.[Abstract]

Williams, N. A. and Holland, P. W. H (1996). Old head on young shoulders. Nature 383, 490-.

Wray, G. A., Levinton, J. S. and Shapiro, L. H (1996). Molecular evidence for deep precambrian divergences among metazoan phyla. Science 274, 568-573.[Abstract/Free Full Text]

Xuan, S., Baptista, C. A., Balas, G., Tao, W., Soares, V. C. and Lai, E (1995). Winged helix transcription factor BF-1 is essential for the development of the verebral hemispheres. Neuron 14, 1141-1152.[Medline]

Younossi-Hartenstein, A., Green, P., Liaw, G. J., Rudolph, K., Lengyel, J. and Hartenstein, V (1997). Control of early neurogenesis of the Drosophila brain by the head gap genes tll, otd, ems and btd. Dev. Biol 182, 270-283.[Medline]

This article has been cited by other articles:

B.-Y. Liao and J. Zhang
Null mutations in human and mouse orthologs frequently result in different phenotypes
PNAS, May 13, 2008; 105(19): 6987 - 6992.
[Abstract] [Full Text] [PDF]

J. Aronowicz and C. J. Lowe
Hox gene expression in the hemichordate Saccoglossus kowalevskii and the evolution of deuterostome nervous systems
Integr. Comp. Biol., December 1, 2006; 46(6): 890 - 901.
[Abstract] [Full Text] [PDF]

S. L. Whitaker and B. E. Knox
Conserved Transcriptional Activators of the Xenopus Rhodopsin Gene
J. Biol. Chem., November 19, 2004; 279(47): 49010 - 49018.
[Abstract] [Full Text] [PDF]

A. S. Viczian, R. Vignali, M. E. Zuber, G. Barsacchi, and W. A. Harris
XOtx5b and XOtx2 regulate photoreceptor and bipolar fates in the Xenopus retina
Development, April 1, 2003; 130(7): 1281 - 1294.
[Abstract] [Full Text] [PDF]

D. H. Erwin and E. H. Davidson
The last common bilaterian ancestor
Development, January 7, 2002; 129(13): 3021 - 3032.
[Abstract] [Full Text] [PDF]

D. Acampora, P. P. Boyl, M. Signore, J. P. Martinez-Barbera, C. Ilengo, E. Puelles, A. Annino, H. Reichert, G. Corte, and A. Simeone
OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation
Development, December 1, 2001; 128(23): 4801 - 4813.
[Abstract] [Full Text] [PDF]

J. J. Westmoreland, J. McEwen, B. A. Moore, Y. Jin, and B. G. Condie
Conserved Function of Caenorhabditis elegans UNC-30 and Mouse Pitx2 in Controlling GABAergic Neuron Differentiation
J. Neurosci., September 1, 2001; 21(17): 6810 - 6819.
[Abstract] [Full Text] [PDF]

P. P. Boyl, M. Signore, D. Acampora, J. P. Martinez-Barbera, C. Ilengo, A. Annino, G. Corte, and A. Simeone
Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR
Development, August 1, 2001; 128(15): 2989 - 3000.
[Abstract] [Full Text] [PDF]

J. V. Brigande, A. E. Kiernan, X. Gao, L. E. Iten, and D. M. Fekete
Molecular genetics of pattern formation in the inner ear: Do compartment boundaries play a role?
PNAS, October 24, 2000; 97(22): 11700 - 11706.
[Abstract] [Full Text] [PDF]

R. Cantos, L. K. Cole, D. Acampora, A. Simeone, and D. K. Wu
Patterning of the mammalian cochlea
PNAS, October 24, 2000; 97(22): 11707 - 11713.
[Abstract] [Full Text] [PDF]

D Arendt and K Nubler-Jung
Comparison of early nerve cord development in insects and vertebrates
Development, January 6, 1999; 126(11): 2309 - 2325.
[Abstract] [PDF]

H Morsli, F Tuorto, D Choo, M. Postiglione, A Simeone, and D. Wu
Otx1 and Otx2 activities are required for the normal development of the mouse inner ear
Development, January 6, 1999; 126(11): 2335 - 2343.
[Abstract] [PDF]

D Acampora, V Avantaggiato, F Tuorto, P Barone, M Perera, D Choo, D Wu, G Corte, and A Simeone
Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes
Development, January 4, 1999; 126(7): 1417 - 1426.
[Abstract] [PDF]

Y Suda, J Nakabayashi, I Matsuo, and S Aizawa
Functional equivalency between Otx2 and Otx1 in development of the rostral head
Development, January 2, 1999; 126(4): 743 - 757.
[Abstract] [PDF]

M. Hanks, C. Loomis, E Harris, C. Tong, L Anson-Cartwright, A Auerbach, and A Joyner
Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development
Development, January 11, 1998; 125(22): 4521 - 4530.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Acampora, D.

Articles by Simeone, A.

Search for Related Content

PubMed

PubMed Citation

Articles by Acampora, D.

Articles by Simeone, A.

				J. Aronowicz and C. J. Lowe Hox gene expression in the hemichordate Saccoglossus kowalevskii and the evolution of deuterostome nervous systems Integr. Comp. Biol., December 1, 2006; 46(6): 890 - 901. [Abstract] [Full Text] [PDF]

				S. L. Whitaker and B. E. Knox Conserved Transcriptional Activators of the Xenopus Rhodopsin Gene J. Biol. Chem., November 19, 2004; 279(47): 49010 - 49018. [Abstract] [Full Text] [PDF]

				A. S. Viczian, R. Vignali, M. E. Zuber, G. Barsacchi, and W. A. Harris XOtx5b and XOtx2 regulate photoreceptor and bipolar fates in the Xenopus retina Development, April 1, 2003; 130(7): 1281 - 1294. [Abstract] [Full Text] [PDF]

				D. H. Erwin and E. H. Davidson The last common bilaterian ancestor Development, January 7, 2002; 129(13): 3021 - 3032. [Abstract] [Full Text] [PDF]

				D. Acampora, P. P. Boyl, M. Signore, J. P. Martinez-Barbera, C. Ilengo, E. Puelles, A. Annino, H. Reichert, G. Corte, and A. Simeone OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation Development, December 1, 2001; 128(23): 4801 - 4813. [Abstract] [Full Text] [PDF]

				J. J. Westmoreland, J. McEwen, B. A. Moore, Y. Jin, and B. G. Condie Conserved Function of Caenorhabditis elegans UNC-30 and Mouse Pitx2 in Controlling GABAergic Neuron Differentiation J. Neurosci., September 1, 2001; 21(17): 6810 - 6819. [Abstract] [Full Text] [PDF]

				P. P. Boyl, M. Signore, D. Acampora, J. P. Martinez-Barbera, C. Ilengo, A. Annino, G. Corte, and A. Simeone Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR Development, August 1, 2001; 128(15): 2989 - 3000. [Abstract] [Full Text] [PDF]

				J. V. Brigande, A. E. Kiernan, X. Gao, L. E. Iten, and D. M. Fekete Molecular genetics of pattern formation in the inner ear: Do compartment boundaries play a role? PNAS, October 24, 2000; 97(22): 11700 - 11706. [Abstract] [Full Text] [PDF]

				R. Cantos, L. K. Cole, D. Acampora, A. Simeone, and D. K. Wu Patterning of the mammalian cochlea PNAS, October 24, 2000; 97(22): 11707 - 11713. [Abstract] [Full Text] [PDF]

				D Arendt and K Nubler-Jung Comparison of early nerve cord development in insects and vertebrates Development, January 6, 1999; 126(11): 2309 - 2325. [Abstract] [PDF]

				H Morsli, F Tuorto, D Choo, M. Postiglione, A Simeone, and D. Wu Otx1 and Otx2 activities are required for the normal development of the mouse inner ear Development, January 6, 1999; 126(11): 2335 - 2343. [Abstract] [PDF]

				D Acampora, V Avantaggiato, F Tuorto, P Barone, M Perera, D Choo, D Wu, G Corte, and A Simeone Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes Development, January 4, 1999; 126(7): 1417 - 1426. [Abstract] [PDF]

				Y Suda, J Nakabayashi, I Matsuo, and S Aizawa Functional equivalency between Otx2 and Otx1 in development of the rostral head Development, January 2, 1999; 126(4): 743 - 757. [Abstract] [PDF]

				M. Hanks, C. Loomis, E Harris, C. Tong, L Anson-Cartwright, A Auerbach, and A Joyner Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development Development, January 11, 1998; 125(22): 4521 - 4530. [Abstract] [PDF]