Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

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K. K. L. Mak and S. Y. Chan
Epidermal Growth Factor as a Biologic Switch in Hair Growth Cycle
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K. L. Schwertfeger, J. L. McManaman, C. A. Palmer, M. C. Neville, and S. M. Anderson
Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation
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R.-A. Wang, R. K. Vadlamudi, R. Bagheri-Yarmand, I. Beuvink, N. E. Hynes, and R. Kumar
Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands
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R. Iwamoto, S. Yamazaki, M. Asakura, S. Takashima, H. Hasuwa, K. Miyado, S. Adachi, M. Kitakaze, K. Hashimoto, G. Raab, et al.
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function
PNAS, March 18, 2003; 100(6): 3221 - 3226.
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C. J. Ormandy, M. Naylor, J. Harris, F. Robertson, N. D. Horseman, G. J. Lindeman, J. Visvader, and P. A. Kelly
Investigation of the Transcriptional Changes Underlying Functional Defects in the Mammary Glands of Prolactin Receptor Knockout Mice
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B. D. Abbott, A. R. Buckalew, M. J. DeVito, D. Ross, P. L. Bryant, and J. E. Schmid
EGF and TGF-{alpha} Expression Influence the Developmental Toxicity of TCDD: Dose Response and AhR Phenotype in EGF, TGF-{alpha}, and EGF + TGF-{alpha} Knockout Mice
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T Marchbank, R Boulton, H Hansen, and R J Playford
Human transforming growth factor {alpha} (TGF-{alpha}) is digested to a smaller (1-43), less biologically active, form in acidic gastric juice
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				K. Britt, A. Ashworth, and M. Smalley Pregnancy and the risk of breast cancer Endocr. Relat. Cancer, December 1, 2007; 14(4): 907 - 933. [Abstract] [Full Text] [PDF]

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				M. C Farach-Carson and D. D Carson Perlecan a multifunctional extracellular proteoglycan scaffold Glycobiology, September 1, 2007; 17(9): 897 - 905. [Abstract] [Full Text] [PDF]

				N. Heldring, A. Pike, S. Andersson, J. Matthews, G. Cheng, J. Hartman, M. Tujague, A. Strom, E. Treuter, M. Warner, et al. Estrogen Receptors: How Do They Signal and What Are Their Targets Physiol Rev, July 1, 2007; 87(3): 905 - 931. [Abstract] [Full Text] [PDF]

				S. Lee, D. Medina, A. Tsimelzon, S. K. Mohsin, S. Mao, Y. Wu, and D. C. Allred Alterations of Gene Expression in the Development of Early Hyperplastic Precursors of Breast Cancer Am. J. Pathol., July 1, 2007; 171(1): 252 - 262. [Abstract] [Full Text] [PDF]

				H.-S. Kim, M. S. Kim, A. L. Hancock, J. C. P. Harper, J. Y. Park, G. Poy, A. O. Perantoni, M. Cam, K. Malik, and S. B. Lee Identification of Novel Wilms' Tumor Suppressor Gene Target Genes Implicated in Kidney Development J. Biol. Chem., June 1, 2007; 282(22): 16278 - 16287. [Abstract] [Full Text] [PDF]

				C. J. Xian Roles of Epidermal Growth Factor Family in the Regulation of Postnatal Somatic Growth Endocr. Rev., May 1, 2007; 28(3): 284 - 296. [Abstract] [Full Text] [PDF]

				D. L. Russell and R. L. Robker Molecular mechanisms of ovulation: co-ordination through the cumulus complex Hum. Reprod. Update, May 1, 2007; 13(3): 289 - 312. [Abstract] [Full Text] [PDF]

				L. Ciarloni, S. Mallepell, and C. Brisken Amphiregulin is an essential mediator of estrogen receptor {alpha} function in mammary gland development PNAS, March 27, 2007; 104(13): 5455 - 5460. [Abstract] [Full Text] [PDF]

				M. Hsieh, D. Lee, S. Panigone, K. Horner, R. Chen, A. Theologis, D. C. Lee, D. W. Threadgill, and M. Conti Luteinizing Hormone-Dependent Activation of the Epidermal Growth Factor Network Is Essential for Ovulation Mol. Cell. Biol., March 1, 2007; 27(5): 1914 - 1924. [Abstract] [Full Text] [PDF]

				J.-I. Huh, T. H. Qiu, G. V. R. Chandramouli, R. Charles, M. Wiench, G. L. Hager, R. Catena, A. Calvo, T. M. LaVallee, P.-Y. Desprez, et al. 2-Methoxyestradiol Induces Mammary Gland Differentiation through Amphiregulin-Epithelial Growth Factor Receptor-Mediated Signaling: Molecular Distinctions from the Mammary Gland of Pregnant Mice Endocrinology, March 1, 2007; 148(3): 1266 - 1277. [Abstract] [Full Text] [PDF]

				D. M. Zaiss, L. Yang, P. R. Shah, J. J. Kobie, J. F. Urban, and T. R. Mosmann Amphiregulin, a TH2 Cytokine Enhancing Resistance to Nematodes Science, December 15, 2006; 314(5806): 1746 - 1746. [Abstract] [Full Text] [PDF]

				P. J. Miettinen, J. Ustinov, P. Ormio, R. Gao, J. Palgi, E. Hakonen, L. Juntti-Berggren, P.-O. Berggren, and T. Otonkoski Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal {beta}-Cell Growth Diabetes, December 1, 2006; 55(12): 3299 - 3308. [Abstract] [Full Text] [PDF]

				J. M. Fleming, G. Desury, T. A. Polanco, and W. S. Cohick Insulin Growth Factor-I and Epidermal Growth Factor Receptors Recruit Distinct Upstream Signaling Molecules to Enhance AKT Activation in Mammary Epithelial Cells Endocrinology, December 1, 2006; 147(12): 6027 - 6035. [Abstract] [Full Text] [PDF]

				S. SH. Choi, M. A. Miller, and P. A. Harper In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Amphiregulin Gene Expression in the Developing Mouse Ureter Toxicol. Sci., November 1, 2006; 94(1): 163 - 174. [Abstract] [Full Text] [PDF]

				E.A. Campbell, L. O'Hara, R.D. Catalano, A.M. Sharkey, T.C. Freeman, and M. H. Johnson Temporal expression profiling of the uterine luminal epithelium of the pseudo-pregnant mouse suggests receptivity to the fertilized egg is associated with complex transcriptional changes Hum. Reprod., October 1, 2006; 21(10): 2495 - 2513. [Abstract] [Full Text] [PDF]

				M. Conti, M. Hsieh, J.-Y. Park, and Y.-Q. Su Role of the Epidermal Growth Factor Network in Ovarian Follicles Mol. Endocrinol., April 1, 2006; 20(4): 715 - 723. [Abstract] [Full Text] [PDF]

				L. M. Arendt, T. A. Rose-Hellekant, E. P. Sandgren, and L. A. Schuler Prolactin Potentiates Transforming Growth Factor {alpha} Induction of Mammary Neoplasia in Transgenic Mice Am. J. Pathol., April 1, 2006; 168(4): 1365 - 1374. [Abstract] [Full Text] [PDF]

				C. Hu, A. Dievart, M. Lupien, E. Calvo, G. Tremblay, and P. Jolicoeur Overexpression of Activated Murine Notch1 and Notch3 in Transgenic Mice Blocks Mammary Gland Development and Induces Mammary Tumors Am. J. Pathol., March 1, 2006; 168(3): 973 - 990. [Abstract] [Full Text] [PDF]

				X. Gao, X. Chen, M. Taglienti, B. Rumballe, M. H. Little, and J. A. Kreidberg Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa Development, December 15, 2005; 132(24): 5437 - 5449. [Abstract] [Full Text] [PDF]

				M. R. Schneider, M. Dahlhoff, N. Herbach, I. Renner-Mueller, C. Dalke, O. Puk, J. Graw, R. Wanke, and E. Wolf Betacellulin Overexpression in Transgenic Mice Causes Disproportionate Growth, Pulmonary Hemorrhage Syndrome, and Complex Eye Pathology Endocrinology, December 1, 2005; 146(12): 5237 - 5246. [Abstract] [Full Text] [PDF]

				N. Mine, R. Iwamoto, and E. Mekada HB-EGF promotes epithelial cell migration in eyelid development Development, October 1, 2005; 132(19): 4317 - 4326. [Abstract] [Full Text] [PDF]

				M. D. Sternlicht, S. W. Sunnarborg, H. Kouros-Mehr, Y. Yu, D. C. Lee, and Z. Werb Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin Development, September 1, 2005; 132(17): 3923 - 3933. [Abstract] [Full Text] [PDF]

				S. J Kimber Leukaemia inhibitory factor in implantation and uterine biology Reproduction, August 1, 2005; 130(2): 131 - 145. [Abstract] [Full Text] [PDF]

				K. Ejskjaer, B.S. Sorensen, S.S. Poulsen, O. Mogensen, A. Forman, and E. Nexo Expression of the epidermal growth factor system in human endometrium during the menstrual cycle Mol. Hum. Reprod., August 1, 2005; 11(8): 543 - 551. [Abstract] [Full Text] [PDF]

				S.-H. Chang, Y. Ai, R. M. Breyer, T. F. Lane, and T. Hla The Prostaglandin E2 Receptor EP2 Is Required for Cyclooxygenase 2-Mediated Mammary Hyperplasia Cancer Res., June 1, 2005; 65(11): 4496 - 4499. [Abstract] [Full Text] [PDF]

				Y. Shirakata, R. Kimura, D. Nanba, R. Iwamoto, S. Tokumaru, C. Morimoto, K. Yokota, M. Nakamura, K. Sayama, E. Mekada, et al. Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing J. Cell Sci., June 1, 2005; 118(11): 2363 - 2370. [Abstract] [Full Text] [PDF]

				C. Berasain, E. R. Garcia-Trevijano, J. Castillo, E. Erroba, M. Santamaria, D. C. Lee, J. Prieto, and M. A. Avila Novel Role for Amphiregulin in Protection from Liver Injury J. Biol. Chem., May 13, 2005; 280(19): 19012 - 19020. [Abstract] [Full Text] [PDF]

				E. K. Chu, J. S. Foley, J. Cheng, A. S. Patel, J. M. Drazen, and D. J. Tschumperlin Bronchial Epithelial Compression Regulates Epidermal Growth Factor Receptor Family Ligand Expression in an Autocrine Manner Am. J. Respir. Cell Mol. Biol., May 1, 2005; 32(5): 373 - 380. [Abstract] [Full Text] [PDF]

				L. Qin, J. Tamasi, L. Raggatt, X. Li, J. H. M. Feyen, D. C. Lee, E. DiCicco-Bloom, and N. C. Partridge Amphiregulin Is a Novel Growth Factor Involved in Normal Bone Development and in the Cellular Response to Parathyroid Hormone Stimulation J. Biol. Chem., February 4, 2005; 280(5): 3974 - 3981. [Abstract] [Full Text] [PDF]