Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Taraviras, S.
	Articles by Pachnis, V.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Taraviras, S.
	Articles by Pachnis, V.

Angrist, M., Bolk, S., Halushka, M., Lapchak, P. A. and Chakravarti, A (1996). Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. Nature Genet 14, 341-344.[Medline]

Avantaggiato, V., Dathan, N. A., Grieco, M., Fabien, N., Lazzaro, D., Fusco, A., Simeone, A. and Santoro, M (1994). Developmental expression of the RET protooncogene. Cell Growth Differ 5, 305-311.[Abstract]

Baetge, G. and Gershon, M. D (1989). Transient catecholaminergic (TC) cells in the vagus nerves and bowel of fetal mice: relationship to the development of enteric neurons. Dev. Biol 132, 189-211.[Medline]

Baetge, G., Pintar, J. E. and Gershon, M. D (1990). Transiently catecholaminergic (TC) cells in the bowel of the fetal rat: precursors of noncatecholaminergic enteric neurons. Dev. Biol 141, 353-380.[Medline]

Baloh, R. H., Gorodinsky, A., Golden, J. P., Tansey, M. G., Keck, C. L., Popescu, N. C., Johnson, E. M., Jr. and Milbrandt, J (1998). GFRalpha3is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. USA 95, 5801-5806.[Abstract/Free Full Text]

Baloh, R. H., Tansey, M. G., Golden, J. P., Creedon, D. J., Heuckeroth, R. O., Keck, C. L., Zimonjic, D. B., Popescu, N. C., Johnson, E. M., Jr. and Milbrandt, J (1997). TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron 18, 793-802.[Medline]

Beck, K. D., Valverde, J., Alexi, T., Poulsen, K., Moffat, B., Vandlen, R. A., Rosenthal, A. and Hefti, F (1995). Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373, 339-341.[Medline]

Blaugrund, E., Pham, T. D., Tennyson, V. M., Lo, L., Sommer, L. anderson, D. J. and Gershon, M. D (1996). Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence. Development 122, 309-320.[Abstract]

Buj-Bello, A., Buchman, V. L., Horton, A., Rosenthal, A. and Davies, A. M (1995). GDNF is an age-specific survival factor for sensory and autonomic neurons. Neuron 15, 821-828.[Medline]

Cacalano, G., Farinas, I., Wang, L. C., Hagler, K., Forgie, A., Moore, M., Armanini, M., Phillips, H., Ryan, A. M., Reichardt, L. F., Hynes, M., Davies, A. and Rosenthal, A (1998). GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron 21, 53-62.[Medline]

Chalazonitis, A., Rothman, T. P., Chen, J. and Gershon, M. D (1998). Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRalpha-1 in vitro and in vivo. Dev. Biol 204, 385-406.[Medline]

Chalazonitis, A., Rothman, T. P., Chen, J., Lamballe, F., Barbacid, M. and Gershon, M. D (1994). Neurotrophin-3 induces neural crest-derived cells from fetal rat gut to develop in vitro as neurons or glia. J. Neurosci 14, 6571-6584.[Abstract]

Choi-Lundberg, D. L., Lin, Q., Chang, Y. N., Chiang, Y. L., Hay, C. M., Mohajeri, H., Davidson, B. L. and Bohn, M. C (1997). Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science 275, 838-841.[Abstract/Free Full Text]

Creedon, D. J., Tansey, M. G., Baloh, R. H., Osborne, P. A., Lampe, P. A., Fahrner, T. J., Heuckeroth, R. O., Milbrandt, J. and Johnson, E. M., Jr (1997). Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Proc. Natl. Acad. Sci. USA 94, 7018-7023.[Abstract/Free Full Text]

Davies, A. M (1997). Neurotrophin switching: where does it stand?. Curr. Opin. Neurobiol 7, 110-8.[Medline]

DeChiara, T. M., Vejsada, R., Poueymirou, W. T., Acheson, A., Suri, C., Conover, J. C., Friedman, B., McClain, J., Pan, L., Stahl, N. et al (1995). Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83, 313-322.[Medline]

Doray, B., Salomon, R., Amiel, J., Pelet, A., Touraine, R., Billaud, M., Attie, T., Bachy, B., Munnich, A. and Lyonnet, S (1998). Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease. Hum. Mol. Genet 7, 1449-1452.[Abstract/Free Full Text]

Durbec, P., Marcos-Gutierrez, C. V., Kilkenny, C., Grigoriou, M., Wartiowaara, K., Suvanto, P., Smith, D., Ponder, B., Costantini, F., Saarma, M. et al (1996). GDNF signalling through the Ret receptor tyrosine kinase. Nature 381, 789-793.[Medline]

Durbec, P. L., Larsson-Blomberg, L. B., Schuchardt, A., Costantini, F. and Pachnis, V (1996). Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. Development 122, 349-358.[Abstract]

Edery, P., Lyonnet, S., Mulligan, L. M., Pelet, A., Dow, E., Abel, L., Holder, S., Nihoul-Fekete, C., Ponder, B. A. and Munnich, A (1994). Mutations of the RET proto-oncogene in Hirschsprung's disease. Nature 367, 378-380.[Medline]

Enokido, Y., de Sauvage, F., Hongo, J. A., Ninkina, N., Rosenthal, A., Buchman, V. L. and Davies, A. M (1998). GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Curr. Biol 8, 1019-1022.[Medline]

Enomoto, H., Araki, T., Jackman, A., Heuckeroth, R. O., Snider, W. D., Johnson, E. M., Jr. and Milbrandt, J (1998). GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron 21, 317-324.[Medline]

Epstein, M. L., Mikawa, T., Brown, A. M. and McFarlin, D. R (1994). Mapping the origin of the avian enteric nervous system with a retroviral marker. Dev. Dyn 201, 236-244.[Medline]

Gash, D. M., Zhang, Z., Ovadia, A., Cass, W. A., Yi, A., Simmerman, L., Russell, D., Martin, D., Lapchak, P. A., Collins, F., Hoffer, B. J. and Gerhardt, G. A (1996). Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380, 252-255.[Medline]

Gershon, M. D (1997). Genes and lineages in the formation of the enteric nervous system. Curr. Opin. Neurobiol 7, 101-109.[Medline]

Gershon, M. D (1998). V. Genes, lineages and tissue interactions in the development of the enteric nervous system. Am. J. Physiol 275, 869-873.

Gershon, M. D., Chalazonitis, A. and Rothman, T. P (1993). From neural crest to bowel: development of the enteric nervous system. J. Neurobiol 24, 199-214.[Medline]

Hearn, C. J., Murphy, M. and Newgreen, D (1998). GDNF and ET-3 differentially modulate the numbers of avian enteric neural crest cells and enteric neurons in vitro. Dev. Biol 197, 93-105.[Medline]

Henderson, C. E., Phillips, H. S., Pollock, R. A., Davies, A. M., Lemeulle, C., Armanini, M., Simmons, L., Moffet, B., Vandlen, R. A., Simpson, L. C. and et al (1994). GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266, 1062-1064.[Abstract/Free Full Text]

Heuckeroth, R. O., Lampe, P. A., Johnson, E. M. and Milbrandt, J (1998). Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro [In Process Citation]. Dev. Biol 200, 116-129.[Medline]

Horger, B. A., Nishimura, M. C., Armanini, M. P., Wang, L. C., Poulsen, K. T., Rosenblad, C., Kirik, D., Moffat, B., Simmons, L., Johnson, E., Jr., Milbrandt, J., Rosenthal, A., Bjorklund, A., Vandlen, R. A., Hynes, M. A. and Phillips, H. S (1998). Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons. J. Neurosci 18, 4929-4937.[Abstract/Free Full Text]

Ivanchuk, S. M., Myers, S. M., Eng, C. and Mulligan, L. M (1996). De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease. Hum. Mol. Genet 5, 2023-2026.[Abstract/Free Full Text]

Jacobs-Cohen, R. J., Payette, R. F., Gershon, M. D. and Rothman, T. P (1987). Inability of neural crest cells to colonize the presumptive aganglionic bowel of ls/ls mutant mice: requirement for a permissive microenvironment. J. Comp. Neurol 255, 425-438.[Medline]

Jing, S., Wen, D., Yu, Y., Holst, P. L., Luo, Y., Fang, M., Tamir, R., Antonio, L., Hu, Z., Cupples, R., Louis, J. C., Hu, S., Altrock, B. W. and Fox, G. M (1996). GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell 85, 1113-1124.[Medline]

Jing, S., Yu, Y., Fang, M., Hu, Z., Holst, P. L., Boone, T., Delaney, J., Schultz, H., Zhou, R. and Fox, G. M (1997). GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. J. Biol. Chem 272, 33111-33117.[Abstract/Free Full Text]

Josso, N. and di Clemente, N (1997). Serine/threonine kinase receptors and ligands. Curr. Opin. Genet. Dev 7, 371-377.[Medline]

Kapur, R. P., Yost, C. and Palmiter, R. D (1992). A transgenic model for studying development of the enteric nervous system in normal and aganglionic mice. Development 116, 167-175.[Abstract]

Klein, R. D., Sherman, D., Ho, W. H., Stone, D., Bennett, G. L., Moffat, B., Vandlen, R., Simmons, L., Gu, Q., Hongo, J. A., Devaux, B., Poulsen, K., Armanini, M., Nozaki, C., Asai, N., Goddard, A., Phillips, H., Henderson, C. E., Takahashi, M. and Rosenthal, A (1997). A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature 387, 717-721.[Medline]

Kotzbauer, P. T., Lampe, P. A., Heuckeroth, R. O., Golden, J. P., Creedon, D. J., Johnson, E. M., Jr. and Milbrandt, J (1996). Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384, 467-470.[Medline]

Le Douarin, N. M. and Teillet, M. A (1973). The migration of neural crest cells to the wall of the digestive tract in avian embryo. J. Embryol. Exp. Morphol 30, 31-48.[Medline]

Lin, L. F., Doherty, D. H., Lile, J. D., Bektesh, S. and Collins, F (1993). GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons [see comments]. Science 260, 1130-1132.[Abstract/Free Full Text]

Lo, L. and Anderson, D. J (1995). Postmigratory neural crest cells expressing c-RET display restricted developmental and proliferative capacities. Neuron 15, 527-539.[Medline]

Lo, L., Sommer, L. and Anderson, D. J (1997). MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells. Curr. Biol 7, 440-450.[Medline]

Marcos, C. and Pachnis, V (1996). The effect of the retmutation on the normal development of the central and parasympathetic nervous systems. Int. J. Dev. Biol 1, 137-.

Marcos-Gutierrez, C. V., Wilson, S. W., Holder, N. and Pachnis, V (1997). The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis. Oncogene 14, 879-889.[Medline]

Martucciello, G., Favre, A., Takahashi, M. and Jasonni, V (1995). Immunohistochemical localization of RET protein in Hirschsprung's disease. J. Pediatr. Surg 30, 433-436.[Medline]

Matheson, C. R., Carnahan, J., Urich, J. L., Bocangel, D., Zhang, T. J. and Yan, Q (1997). Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for sensory neurons: comparison with the effects of the neurotrophins. J. Neurobiol 32, 22-32.[Medline]

Milbrandt, J., de Sauvage, F. J., Fahrner, T. J., Baloh, R. H., Leitner, M. L., Tansey, M. G., Lampe, P. A., Heuckeroth, R. O., Kotzbauer, P. T., Simburger, K. S., Golden, J. P., Davies, J. A., Vejsada, R., Kato, A. C., Hynes, M., Sherman, D., Nishimura, M., Wang, L. C., Vandlen, R., Moffat, B., Klein, R. D., Poulsen, K., Gray, C., Garces, A., Johnson, E. M., Jr. et al (1998). Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron 20, 245-253.[Medline]

Moore, M. W., Klein, R. D., Farinas, I., Sauer, H., Armanini, M., Phillips, H., Reichardt, L. F., Ryan, A. M., Carver-Moore, K. and Rosenthal, A (1996). Renal and neuronal abnormalities in mice lacking GDNF. Nature 382, 76-79.[Medline]

Natarajan, D., Grigoriou, M., Marcos-Gutierrez, C. V., Atkins, C. and Pachnis, V (1999). Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development 126, 157-168.[Abstract]

Oppenheim, R. W., Houenou, L. J., Johnson, J. E., Lin, L. F., Li, L., Lo, A. C., Newsome, A. L., Prevette, D. M. and Wang, S (1995). Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF [see comments]. Nature 373, 344-346.[Medline]

Pachnis, V., Mankoo, B. and Costantini, F (1993). Expression of the c-ret proto-oncogene during mouse embryogenesis. Development 119, 1005-1017.[Abstract]

Pattyn, A., Morin, X., Cremer, H., Goridis, C. and Brunet, J. F (1997). Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Development 124, 4065-4075.[Abstract]

Peters-van der Sanden, M. J., Kirby, M. L., Gittenberger-de Groot, A., Tibboel, D., Mulder, M. P. and Meijers, C (1993). Ablation of various regions within the avian vagal neural crest has differential effects on ganglion formation in the fore-, mid-and hindgut. Dev. Dyn 196, 183-194.[Medline]

Pichel, J. G., Shen, L., Sheng, H. Z., Granholm, A. C., Drago, J., Grinberg, A., Lee, E. J., Huang, S. P., Saarma, M., Hoffer, B. J., Sariola, H. and Westphal, H (1996). Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382, 73-76.[Medline]

Poulsen, K. T., Armanini, M. P., Klein, R. D., Hynes, M. A., Phillips, H. S. and Rosenthal, A (1994). TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons. Neuron 13, 1245-1252.[Medline]

Robertson, K. and Mason, I (1995). Expression of ret in the chicken embryo suggests roles in regionalisation of the vagal neural tube and somites and in development of multiple neural crest and placodal lineages. Mech. Dev 53, 329-344.[Medline]

Robertson, K., Mason, I. and Hall, S (1997). Hirschsprung's disease: genetic mutations in mice and men. Gut 41, 436-441.[Abstract/Free Full Text]

Romeo, G., Ronchetto, P., Luo, Y., Barone, V., Seri, M., Ceccherini, I., Pasini, B., Bocciardi, R., Lerone, M., Kaariainen, H. et al (1994). Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature 367, 377-378.[Medline]

Rothman, T. P., Nilaver, G. and Gershon, M. D (1984). Colonization of the developing murine enteric nervous system and subsequent phenotypic expression by the precursors of peptidergic neurons. J. Comp. Neurol 225, 13-23.[Medline]

Sanchez, M. P., Silos-Santiago, I., Frisen, J., He, B., Lira, S. A. and Barbacid, M (1996). Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382, 70-73.[Medline]

Sanicola, M., Hession, C., Worley, D., Carmillo, P., Ehrenfels, C., Walus, L., Robinson, S., Jaworski, G., Wei, H., Tizard, R., Whitty, A., Pepinsky, R. B. and Cate, R. L (1997). Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc. Natl. Acad. Sci. USA 94, 6238-6243.[Abstract/Free Full Text]

Schaeren-Wiemers, N. and Gerfin-Moser, A (1993). A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry 100, 431-440.[Medline]

Schuchardt, A., Srinivas, S., Pachnis, V. and Costantini, F (1995). Isolation and characterization of a chicken homolog of the c-ret proto-oncogene. Oncogene 10, 641-649.[Medline]

Schuchardt, A., V, D. A., Larsson-Blomberg, L., Costantini, F. and Pachnis, V (1994). Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret [see comments]. Nature 367, 380-383.[Medline]

Schuchardt, A., V, D. A., Pachnis, V. and Costantini, F (1996). Renal agenesis and hypodysplasia in ret-kmutant mice result from defects in ureteric bud development. Development 122, 1919-1929.[Abstract]

Simons, K. and Ikonen, E (1997). Functional rafts in cell membranes. Nature 387, 569-572.[Medline]

Southard-Smith, E. M., Kos, L. and Pavan, W. J (1998). Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Nature Genet 18, 60-64.[Medline]

Takahashi, M., Buma, Y., Iwamoto, T., Inaguma, Y., Ikeda, H. and Hiai, H (1988). Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene 3, 571-578.[Medline]

Takahashi, M. and Cooper, G. M (1987). ret transforming gene encodes a fusion protein homologous to tyrosine kinases. Mol. Cell. Biol 7, 1378-1385.[Abstract/Free Full Text]

Tam, P. K., Gould, S. J., Martucciello, G., Biddolph, S., Takahashi, M. and Jasonni, V (1996). Ret protein in the human fetal rectum. J. Pediatr. Surg 31, 568-571.[Medline]

Tessarollo, L., Tsoulfas, P., Martin-Zanca, D., Gilbert, D. J., Jenkins, N. A., Copeland, N. G. and Parada, L. F (1993). trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development 118, 463-475.[Abstract]

Tomac, A., Lindqvist, E., Lin, L. F., Ogren, S. O., Young, D., Hoffer, B. J. and Olson, L (1995). Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373, 335-339.[Medline]

Treanor, J. J., Goodman, L., de Sauvage, F., Stone, D. M., Poulsen, K. T., Beck, C. D., Gray, C., Armanini, M. P., Pollock, R. A., Hefti, F., Phillips, H. S., Goddard, A., Moore, M. W., Buj-Bello, A., Davies, A. M., Asai, N., Takahashi, M., Vandlen, R., Henderson, C. E. and Rosenthal, A (1996). Characterization of a multicomponent receptor for GDNF. Nature 382, 80-83.[Medline]

Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A. S., Sieber, B. A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumae, U. and et al (1996). Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature 381, 785-788.[Medline]

Trupp, M., Belluardo, N., Funakoshi, H. and Ibanez, C. F (1997). Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. J. Neurosci 17, 3554-3567.[Abstract/Free Full Text]

Trupp, M., Ryden, M., Jornvall, H., Funakoshi, H., Timmusk, T., Arenas, E. and Ibanez, C. F (1995). Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell Biol 130, 137-148.[Abstract/Free Full Text]

Tsuzuki, T., Takahashi, M., Asai, N., Iwashita, T., Matsuyama, M. and Asai, J (1995). Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues. Oncogene 10, 191-198.[Medline]

Wartiovaara, K., Salo, M. and Sariola, H (1998). Hirschsprung's disease genes and the development of the enteric nervous system. Ann. Med 30, 66-74.[Medline]

Yan, Q., Matheson, C. and Lopez, O. T (1995). In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature 373, 341-344.[Medline]

Yntema, C. L. and Hammond, W. S (1954). The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo. J. Comp. Neurol 101, 515-542.

Young, H. M., Hearn, C. J., Ciampoli, D., Southwell, B. R., Brunet, J. and Newgreen, D. F (1998). A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of phox2b, ret and p75 and by explants grown under the kidney capsule or in organ culture. Dev. Biol 202, 67-84.[Medline]

This article has been cited by other articles:

Y. Okamura and Y. Saga
Notch signaling is required for the maintenance of enteric neural crest progenitors
Development, November 1, 2008; 135(21): 3555 - 3565.
[Abstract] [Full Text] [PDF]

S. Bogni, P. Trainor, D. Natarajan, R. Krumlauf, and V. Pachnis
Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis
Development, September 15, 2008; 135(18): 3007 - 3011.
[Abstract] [Full Text] [PDF]

B. P. S. Vohra, M. Fu, and R. O. Heuckeroth
Protein Kinase C{zeta} and Glycogen Synthase Kinase-3{beta} Control Neuronal Polarity in Developing Rodent Enteric Neurons, whereas SMAD Specific E3 Ubiquitin Protein Ligase 1 Promotes Neurite Growth But Does Not Influence Polarity
J. Neurosci., August 29, 2007; 27(35): 9458 - 9468.
[Abstract] [Full Text] [PDF]

T. Uesaka, S. Jain, S. Yonemura, Y. Uchiyama, J. Milbrandt, and H. Enomoto
Conditional ablation of GFR{alpha}1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype
Development, June 1, 2007; 134(11): 2171 - 2181.
[Abstract] [Full Text] [PDF]

D. Sjostrand, J. Carlsson, G. Paratcha, B. Persson, and C. F. Ibanez
Disruption of the GDNF Binding Site in NCAM Dissociates Ligand Binding and Homophilic Cell Adhesion
J. Biol. Chem., April 27, 2007; 282(17): 12734 - 12740.
[Abstract] [Full Text] [PDF]

N. Bondurand, D. Natarajan, A. Barlow, N. Thapar, and V. Pachnis
Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling
Development, May 15, 2006; 133(10): 2075 - 2086.
[Abstract] [Full Text] [PDF]

T. A. Heanue and V. Pachnis
From the Cover: Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes
PNAS, May 2, 2006; 103(18): 6919 - 6924.
[Abstract] [Full Text] [PDF]

A. Wong, S. Bogni, P. Kotka, E. de Graaff, V. D'Agati, F. Costantini, and V. Pachnis
Phosphotyrosine 1062 Is Critical for the In Vivo Activity of the Ret9 Receptor Tyrosine Kinase Isoform
Mol. Cell. Biol., November 1, 2005; 25(21): 9661 - 9673.
[Abstract] [Full Text] [PDF]

R. D. Read, P. J. Goodfellow, E. R. Mardis, N. Novak, J. R. Armstrong, and R. L. Cagan
A Drosophila Model of Multiple Endocrine Neoplasia Type 2
Genetics, November 1, 2005; 171(3): 1057 - 1081.
[Abstract] [Full Text] [PDF]

M. Jijiwa, T. Fukuda, K. Kawai, A. Nakamura, K. Kurokawa, Y. Murakumo, M. Ichihara, and M. Takahashi
A Targeting Mutation of Tyrosine 1062 in Ret Causes a Marked Decrease of Enteric Neurons and Renal Hypoplasia
Mol. Cell. Biol., September 15, 2004; 24(18): 8026 - 8036.
[Abstract] [Full Text] [PDF]

M. Fu, V. C. H. Lui, M. H. Sham, V. Pachnis, and P. K. H. Tam
Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut
J. Cell Biol., August 30, 2004; 166(5): 673 - 684.
[Abstract] [Full Text] [PDF]

A. Chalazonitis, F. D'Autreaux, U. Guha, T. D. Pham, C. Faure, J. J. Chen, D. Roman, L. Kan, T. P. Rothman, J. A. Kessler, et al.
Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing Neurotrophin-3-Dependent Subset
J. Neurosci., April 28, 2004; 24(17): 4266 - 4282.
[Abstract] [Full Text] [PDF]

I. T. Shepherd, J. Pietsch, S. Elworthy, R. N. Kelsh, and D. W. Raible
Roles for GFR{alpha}1 receptors in zebrafish enteric nervous system development
Development, January 1, 2004; 131(1): 241 - 249.
[Abstract] [Full Text] [PDF]

N. Bondurand, D. Natarajan, N. Thapar, C. Atkins, and V. Pachnis
Neuron and glia generating progenitors of the mammalian enteric nervous system isolated from foetal and postnatal gut cultures
Development, December 22, 2003; 130(25): 6387 - 6400.
[Abstract] [Full Text] [PDF]

T. Iwashita, G. M. Kruger, R. Pardal, M. J. Kiel, and S. J. Morrison
Hirschsprung Disease Is Linked to Defects in Neural Crest Stem Cell Function
Science, August 15, 2003; 301(5635): 972 - 976.
[Abstract] [Full Text] [PDF]

S. Gianino, J. R. Grider, J. Cresswell, H. Enomoto, and R. O. Heuckeroth
GDNF availability determines enteric neuron number by controlling precursor proliferation
Development, May 15, 2003; 130(10): 2187 - 2198.
[Abstract] [Full Text] [PDF]

A. Rothermel and P. G. Layer
GDNF Regulates Chicken Rod Photoreceptor Development and Survival in Reaggregated Histotypic Retinal Spheres
Invest. Ophthalmol. Vis. Sci., May 1, 2003; 44(5): 2221 - 2228.
[Abstract] [Full Text] [PDF]

D. Natarajan, C. Marcos-Gutierrez, V. Pachnis, and E. de Graaff
Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis
Development, March 13, 2003; 129(22): 5151 - 5160.
[Abstract] [Full Text] [PDF]

C. Paratore, C. Eichenberger, U. Suter, and L. Sommer
Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease
Hum. Mol. Genet., November 15, 2002; 11(24): 3075 - 3085.
[Abstract] [Full Text] [PDF]

B. Mograbi, R. Bocciardi, I. Bourget, T. Juhel, D. Farahi-Far, G. Romeo, I. Ceccherini, and B. Rossi
The Sensitivity of Activated Cys Ret Mutants to Glial Cell Line-Derived Neurotrophic Factor Is Mandatory To Rescue Neuroectodermic Cells from Apoptosis
Mol. Cell. Biol., October 15, 2001; 21(20): 6719 - 6730.
[Abstract] [Full Text] [PDF]

E. de Graaff, S. Srinivas, C. Kilkenny, V. D'Agati, B. S. Mankoo, F. Costantini, and V. Pachnis
Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis
Genes & Dev., September 15, 2001; 15(18): 2433 - 2444.
[Abstract] [Full Text] [PDF]

S. Doolen and N. R. Zahniser
Protein Tyrosine Kinase Inhibitors Alter Human Dopamine Transporter Activity in Xenopus Oocytes
J. Pharmacol. Exp. Ther., March 1, 2001; 296(3): 931 - 938.
[Abstract] [Full Text]

Gabriella De Vita, R. M. Melillo, F. Carlomagno, R. Visconti, M. D. Castellone, A. Bellacosa, M. Billaud, A. Fusco, P. N. Tsichlis, and M. Santoro
Tyrosine 1062 of RET-MEN2A Mediates Activation of Akt (Protein Kinase B) and Mitogen-activated Protein Kinase Pathways Leading to PC12 Cell Survival
Cancer Res., July 1, 2000; 60(14): 3727 - 3731.
[Abstract] [Full Text]

D. Worley, J. Pisano, E. Choi, L Walus, C. Hession, R. Cate, M Sanicola, and S. Birren
Developmental regulation of GDNF response and receptor expression in the enteric nervous system
Development, January 10, 2000; 127(20): 4383 - 4393.
[Abstract] [PDF]

B. Mograbi, R. Bocciardi, I. Bourget, R. Busca, N. Rochet, D. Farahi-Far, T. Juhel, and B. Rossi
Glial Cell Line-derived Neurotrophic Factor-stimulated Phosphatidylinositol 3-Kinase and Akt Activities Exert Opposing Effects on the ERK Pathway. IMPORTANCE FOR THE RESCUE OF NEUROECTODERMIC CELLS
J. Biol. Chem., November 21, 2001; 276(48): 45307 - 45319.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Taraviras, S.

Articles by Pachnis, V.

Search for Related Content

PubMed

PubMed Citation

Articles by Taraviras, S.

Articles by Pachnis, V.

				S. Bogni, P. Trainor, D. Natarajan, R. Krumlauf, and V. Pachnis Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis Development, September 15, 2008; 135(18): 3007 - 3011. [Abstract] [Full Text] [PDF]

				B. P. S. Vohra, M. Fu, and R. O. Heuckeroth Protein Kinase C{zeta} and Glycogen Synthase Kinase-3{beta} Control Neuronal Polarity in Developing Rodent Enteric Neurons, whereas SMAD Specific E3 Ubiquitin Protein Ligase 1 Promotes Neurite Growth But Does Not Influence Polarity J. Neurosci., August 29, 2007; 27(35): 9458 - 9468. [Abstract] [Full Text] [PDF]

				T. Uesaka, S. Jain, S. Yonemura, Y. Uchiyama, J. Milbrandt, and H. Enomoto Conditional ablation of GFR{alpha}1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype Development, June 1, 2007; 134(11): 2171 - 2181. [Abstract] [Full Text] [PDF]

				D. Sjostrand, J. Carlsson, G. Paratcha, B. Persson, and C. F. Ibanez Disruption of the GDNF Binding Site in NCAM Dissociates Ligand Binding and Homophilic Cell Adhesion J. Biol. Chem., April 27, 2007; 282(17): 12734 - 12740. [Abstract] [Full Text] [PDF]

				N. Bondurand, D. Natarajan, A. Barlow, N. Thapar, and V. Pachnis Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling Development, May 15, 2006; 133(10): 2075 - 2086. [Abstract] [Full Text] [PDF]

				T. A. Heanue and V. Pachnis From the Cover: Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes PNAS, May 2, 2006; 103(18): 6919 - 6924. [Abstract] [Full Text] [PDF]

				A. Wong, S. Bogni, P. Kotka, E. de Graaff, V. D'Agati, F. Costantini, and V. Pachnis Phosphotyrosine 1062 Is Critical for the In Vivo Activity of the Ret9 Receptor Tyrosine Kinase Isoform Mol. Cell. Biol., November 1, 2005; 25(21): 9661 - 9673. [Abstract] [Full Text] [PDF]

				R. D. Read, P. J. Goodfellow, E. R. Mardis, N. Novak, J. R. Armstrong, and R. L. Cagan A Drosophila Model of Multiple Endocrine Neoplasia Type 2 Genetics, November 1, 2005; 171(3): 1057 - 1081. [Abstract] [Full Text] [PDF]

				M. Jijiwa, T. Fukuda, K. Kawai, A. Nakamura, K. Kurokawa, Y. Murakumo, M. Ichihara, and M. Takahashi A Targeting Mutation of Tyrosine 1062 in Ret Causes a Marked Decrease of Enteric Neurons and Renal Hypoplasia Mol. Cell. Biol., September 15, 2004; 24(18): 8026 - 8036. [Abstract] [Full Text] [PDF]

				M. Fu, V. C. H. Lui, M. H. Sham, V. Pachnis, and P. K. H. Tam Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut J. Cell Biol., August 30, 2004; 166(5): 673 - 684. [Abstract] [Full Text] [PDF]

				A. Chalazonitis, F. D'Autreaux, U. Guha, T. D. Pham, C. Faure, J. J. Chen, D. Roman, L. Kan, T. P. Rothman, J. A. Kessler, et al. Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing Neurotrophin-3-Dependent Subset J. Neurosci., April 28, 2004; 24(17): 4266 - 4282. [Abstract] [Full Text] [PDF]

				I. T. Shepherd, J. Pietsch, S. Elworthy, R. N. Kelsh, and D. W. Raible Roles for GFR{alpha}1 receptors in zebrafish enteric nervous system development Development, January 1, 2004; 131(1): 241 - 249. [Abstract] [Full Text] [PDF]

				N. Bondurand, D. Natarajan, N. Thapar, C. Atkins, and V. Pachnis Neuron and glia generating progenitors of the mammalian enteric nervous system isolated from foetal and postnatal gut cultures Development, December 22, 2003; 130(25): 6387 - 6400. [Abstract] [Full Text] [PDF]

				T. Iwashita, G. M. Kruger, R. Pardal, M. J. Kiel, and S. J. Morrison Hirschsprung Disease Is Linked to Defects in Neural Crest Stem Cell Function Science, August 15, 2003; 301(5635): 972 - 976. [Abstract] [Full Text] [PDF]

				S. Gianino, J. R. Grider, J. Cresswell, H. Enomoto, and R. O. Heuckeroth GDNF availability determines enteric neuron number by controlling precursor proliferation Development, May 15, 2003; 130(10): 2187 - 2198. [Abstract] [Full Text] [PDF]

				A. Rothermel and P. G. Layer GDNF Regulates Chicken Rod Photoreceptor Development and Survival in Reaggregated Histotypic Retinal Spheres Invest. Ophthalmol. Vis. Sci., May 1, 2003; 44(5): 2221 - 2228. [Abstract] [Full Text] [PDF]

				D. Natarajan, C. Marcos-Gutierrez, V. Pachnis, and E. de Graaff Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis Development, March 13, 2003; 129(22): 5151 - 5160. [Abstract] [Full Text] [PDF]

				C. Paratore, C. Eichenberger, U. Suter, and L. Sommer Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease Hum. Mol. Genet., November 15, 2002; 11(24): 3075 - 3085. [Abstract] [Full Text] [PDF]

				B. Mograbi, R. Bocciardi, I. Bourget, T. Juhel, D. Farahi-Far, G. Romeo, I. Ceccherini, and B. Rossi The Sensitivity of Activated Cys Ret Mutants to Glial Cell Line-Derived Neurotrophic Factor Is Mandatory To Rescue Neuroectodermic Cells from Apoptosis Mol. Cell. Biol., October 15, 2001; 21(20): 6719 - 6730. [Abstract] [Full Text] [PDF]

				E. de Graaff, S. Srinivas, C. Kilkenny, V. D'Agati, B. S. Mankoo, F. Costantini, and V. Pachnis Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis Genes & Dev., September 15, 2001; 15(18): 2433 - 2444. [Abstract] [Full Text] [PDF]

				S. Doolen and N. R. Zahniser Protein Tyrosine Kinase Inhibitors Alter Human Dopamine Transporter Activity in Xenopus Oocytes J. Pharmacol. Exp. Ther., March 1, 2001; 296(3): 931 - 938. [Abstract] [Full Text]

				Gabriella De Vita, R. M. Melillo, F. Carlomagno, R. Visconti, M. D. Castellone, A. Bellacosa, M. Billaud, A. Fusco, P. N. Tsichlis, and M. Santoro Tyrosine 1062 of RET-MEN2A Mediates Activation of Akt (Protein Kinase B) and Mitogen-activated Protein Kinase Pathways Leading to PC12 Cell Survival Cancer Res., July 1, 2000; 60(14): 3727 - 3731. [Abstract] [Full Text]

				D. Worley, J. Pisano, E. Choi, L Walus, C. Hession, R. Cate, M Sanicola, and S. Birren Developmental regulation of GDNF response and receptor expression in the enteric nervous system Development, January 10, 2000; 127(20): 4383 - 4393. [Abstract] [PDF]

				B. Mograbi, R. Bocciardi, I. Bourget, R. Busca, N. Rochet, D. Farahi-Far, T. Juhel, and B. Rossi Glial Cell Line-derived Neurotrophic Factor-stimulated Phosphatidylinositol 3-Kinase and Akt Activities Exert Opposing Effects on the ERK Pathway. IMPORTANCE FOR THE RESCUE OF NEUROECTODERMIC CELLS J. Biol. Chem., November 21, 2001; 276(48): 45307 - 45319. [Abstract] [Full Text] [PDF]