FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Martinez, S.
	Articles by Martin, G. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Martinez, S.
	Articles by Martin, G. R.

Acampora, D., Avantaggiato, V., Tuorto, F. and Simeone, A (1997). Genetic control of brain morphogenesis through Otx gene dosage requirement. Development 124, 3639-3650.[Abstract]

Ang, S.-L., Conlon, R. A., Jin, O. and Rossant, J (1994). Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development 120, 2979-2989.[Abstract]

Ang, S.-L. and Rossant, J (1993). Anterior mesendoderm induces mouse Engrailed genes in explant cultures. Development 118, 139-149.[Abstract]

Bally-Cuif, L., Cholley, B. and Wassef, M (1995). Involvement of Wnt-1 in the formation of the mes/metencephalic boundary. Mech. Dev 53, 23-34.[Medline]

Bally-Cuif, L., Gulisano, M., Broccoli, V. and Boncinelli, E (1995). c-otx2 is expressed in two different phases of gastrulation and is sensitive to retinoic acid treatment in chick embryo. Mech. Dev 49, 49-63.[Medline]

Bally-Cuif, L. and Wassef, M (1994). Ectopic induction and reorganization of Wnt-1 expression in quail/chick chimeras. Development 120, 3379-3394.[Abstract]

Beddington, R. S. P. and Robertson, E. J (1998). Anterior patterning in mouse. Trends Genet 14, 277-284.[Medline]

Birgbauer, E. and Fraser, S. E (1994). Violation of cell lineage restriction compartments in the chick hindbrain. Development 120, 1347-1356.[Abstract]

Bloch-Gallego, E., Millet, S. and Alvarado-Mallart, R.-M (1996). Further observations on the susceptibility of diencephalic prosomeres to En-2 induction and on the resulting histogenetic capabilities. Mech. Dev 58, 51-63.[Medline]

Bouillet, P., Chazaud, C., Oulad-Abdelghani, M., Dolle, P. and Chambon, P (1995). Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells. Dev. Dynamics 204, 372-382.[Medline]

Crossley, P. H. and Martin, G. R (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439-451.[Abstract]

Crossley, P. H., Martinez, S. and Martin, G. R (1996). Midbrain development induced by FGF8 in the chick embryo. Nature 380, 66-68.[Medline]

Crossley, P. H., Minowada, G., MacArthur, C. A. and Martin, G. R (1996). Roles for FGF8 in the induction, initiation and maintenance of chick limb development. Cell 84, 127-136.[Medline]

Danielian, P. S. and McMahon, A. P (1996). Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature 383, 332-334.[Medline]

Davis, C. A., Holmyard, D. P., Millen, K. J. and Joyner, A. L (1991). Examining pattern formation in mouse, chicken and frog embryos with an En -specific antiserum. Development 111, 287-298.[Abstract]

Favor, J., Sandulache, R., Neuhauser-Klaus, A., Pretsch, W., Chatterjee, B., Senft, E., Wurst, W., Blanquet, V., Grimes, P., Sporle, R. and Schughart, K (1996). The mouse Pax2 (1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney. Proc. Natl. Acad. Sci. USA 93, 13870-13875.[Abstract/Free Full Text]

Figdor, M. C. and Stern, C. D (1993). Segmental organization of embryonic diencephalon. Nature 363, 630-634.[Medline]

Fraser, S. E., Keynes, R. and Lumsden, A (1990). Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions. Nature 344, 431-435.[Medline]

Gardner, C. A., Darnell, D. K., Poole, S. J., Ordahl, C. P. and Barald, K. F (1988). Expression of an engrailed -like gene during development of the early embryonic chick nervous system. J. Neurosci. Res 21, 426-437.[Medline]

Guthrie, S., Butcher, M. and Lumsden, A (1991). Patterns of cell division and interkinetic nuclear migration in the chick embryo hindbrain. J. Neurobiol 22, 742-754.[Medline]

Hamburger, V. and Hamilton, H (1951). A series of normal stages in the development of the chick embryos. Reprinted in. Dev. Dynamics 195, 231-272.

Heikinheimo, M., Lawshe, A., Shackleford, G. M., Wilson, D. B. and MacArthur, C. A (1994). Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs, and central nervous system. Mech. Dev 48, 129-138.[Medline]

Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J. and Ish-Horowicz, D (1995). Expression of a Delta homologue in prospective neurons in the chick. Nature 375, 787-790.[Medline]

Heyman, I., Faissner, A. and Lumsden, A (1995). Cell and matrix specialisations of rhombomere boundaries. Dev. Dynamics 204, 301-315.[Medline]

Joyner, A. L (1996). Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development. Trends Genet 12, 15-20.[Medline]

LaVail, J. H. and Cowan, W. M (1971). The development of the chick optic tectum. I. Normal morphology and cytoarchitectonic development. Brain Res 28, 391-419.[Medline]

Lee, S. M. K., Danielian, P. S., Fritzsch, B. and McMahon, A. P (1997). Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development 124, 959-969.[Abstract]

Logan, C., Hanks, M. C., Noble-Topham, S., Nallainathan, D., Provart, N. J. and Joyner, A. L (1992). Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions. Dev. Genet 13, 345-358.[Medline]

Lumsden, A. and Krumlauf, R (1996). Patterning the vertebrate neuraxis. Science 274, 1109-1115.[Abstract/Free Full Text]

Lun, K. and Brand, M (1998). A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary. Development 125, 3049-3062.[Abstract]

MacArthur, C. A., Lawshe, A., Xu, J., Santos-Ocampo, S., Heikinheimo, M., Chellaiah, A. T. and Ornitz, D. M (1995). FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. Development 121, 3603-3613.[Abstract]

Mahmood, R., Bresnick, J., Hornbruch, A., Mahony, C., Morton, N., Colquhoun, K., Martin, P., Lumsden, A., Dickson, C. and Mason, I (1995). A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr. Biol 5, 797-806.[Medline]

Marin, F. and Puelles, L (1994). Patterning of the embryonic avian midbrain after experimental inversions: a polarizing activity from the isthmus. Dev. Biol 163, 19-37.[Medline]

Martinez, S., Geijo, E., Sanchez-Vives, M. V., Puelles, L. and Gallego, R (1992). Reduced junctional permeability at interrhombomeric boundaries. Development 116, 1069-1076.[Abstract]

Martinez, S., Marin, F., Nieto, M. A. and Puelles, L (1995). Induction of ectopic engrailed expression and fate change in avian rhombomeres: intersegmental boundaries as barriers. Mech. Dev 51, 289-303.[Medline]

McMahon, A. P. and Bradley, A (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085.[Medline]

McMahon, A. P., Joyner, A. L., Bradley, A. and McMahon, J. A (1992). The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1-mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell 69, 581-595.[Medline]

Meyers, E. N., Lewandoski, M. and Martin, G. R (1998). An Fgf8 mutant allelic series generated by Cre-and Flp-mediated recombination. Nat. Genet 18, 136-141.[Medline]

Millet, S. and Alvarado-Mallart, R.-M (1995). Expression of the homeobox-containing gene En-2 during the development of the chick central nervous system. Eur. J. Neurosci 7, 777-791.[Medline]

Millet, S., Bloch-Gallego, E., Simeone, A. and Alvarado-Mallart, R.-M (1996). The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts. Development 122, 3785-3797.[Abstract]

Nusse, R. and Varmus, H. E (1992). Wnt genes. Cell 69, 1073-1087.[Medline]

Ohuchi, H., Yoshioka, H., Tanaka, A., Kawakami, Y., Nohno, T. and Noji, S (1994). Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis. Biochem. Biophys. Res. Commun 204, 882-888.[Medline]

Puelles, L. and Rubenstein, J. L. R (1993). Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization. Trends Neurosci 16, 472-479.[Medline]

Reifers, F., Bohli, H., Walsh, E. C., Crossley, P. H., Stainier, D. Y. and Brand, M (1998). Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. Development 125, 2381-2395.[Abstract]

Retaux, S. and Harris, W. A (1996). Engrailed and retinotectal topography. Trends Neurosci 19, 542-546.[Medline]

Rubenstein, J. L. R. and Beachy, P. A (1998). Patterning of the embryonic forebrain. Curr. Opin. Neurobiol 8, 18-26.[Medline]

Rubenstein, J. L. R., Martinez, S., Shimamura, K. and Puelles, L (1994). The embryonic vertebrate forebrain: the prosomeric model. Science 266, 578-580.[Free Full Text]

Rubenstein, J. L. R. and Puelles, L (1994). Homeobox gene expression during development of the vertebrate brain. Dev. Biol 29, 1-64.

Suda, Y., Matsuo, I. and Aizawa, S (1997). Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain. Mech. Dev 69, 125-141.[Medline]

Thomas, K. R. and Capecchi, M. R (1990). Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346, 847-850.[Medline]

Wassarman, K., Lewandoski, M., Campbell, K., Joyner, A. L., Rubenstein, J. L. R., Martinez, S. and Martin, G. R (1997). Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development 124, 2923-2934.[Abstract]

Wilkinson, D. G., Bailes, J. A. and McMahon, A. P (1987). Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell 50, 79-88.[Medline]

Wurst, W., Auerbach, A. B. and Joyner, A. L (1994). Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120, 2065-2075.[Abstract]

Ye, W., Shimamura, K., Rubenstein, J. L., Hynes, M. A. and Rosenthal, A (1998). FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93, 755-766.[Medline]

This article has been cited by other articles:

A. Kataoka and T. Shimogori
Fgf8 controls regional identity in the developing thalamus
Development, September 1, 2008; 135(17): 2873 - 2881.
[Abstract] [Full Text] [PDF]

A. Badde and D. Schulte
A Role for Receptor Protein Tyrosine Phosphatase {lambda} in Midbrain Development
J. Neurosci., June 11, 2008; 28(24): 6152 - 6164.
[Abstract] [Full Text] [PDF]

M. A. Basson, D. Echevarria, C. Petersen Ahn, A. Sudarov, A. L. Joyner, I. J. Mason, S. Martinez, and G. R. Martin
Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development
Development, March 1, 2008; 135(5): 889 - 898.
[Abstract] [Full Text] [PDF]

B. Carletti and F. Rossi
Neurogenesis in the Cerebellum
Neuroscientist, February 1, 2008; 14(1): 91 - 100.
[Abstract] [PDF]

E. Salero and M. E. Hatten
Differentiation of ES cells into cerebellar neurons
PNAS, February 20, 2007; 104(8): 2997 - 3002.
[Abstract] [Full Text] [PDF]

M. P. Fogarty, B. A. Emmenegger, L. L. Grasfeder, T. G. Oliver, and R. J. Wechsler-Reya
Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells
PNAS, February 20, 2007; 104(8): 2973 - 2978.
[Abstract] [Full Text] [PDF]

C. Guo, H.-Y. Qiu, Y. Huang, H. Chen, R.-Q. Yang, S.-D. Chen, R. L. Johnson, Z.-F. Chen, and Y.-Q. Ding
Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice
Development, January 15, 2007; 134(2): 317 - 325.
[Abstract] [Full Text] [PDF]

D. Morales and M. E. Hatten
Molecular Markers of Neuronal Progenitors in the Embryonic Cerebellar Anlage.
J. Neurosci., November 22, 2006; 26(47): 12226 - 12236.
[Abstract] [Full Text] [PDF]

P. Alexandre, I. Bachy, M. Marcou, and M. Wassef
Positive and negative regulations by FGF8 contribute to midbrain roof plate developmental plasticity
Development, August 1, 2006; 133(15): 2905 - 2913.
[Abstract] [Full Text] [PDF]

R. W. Koster and S. E. Fraser
FGF signaling mediates regeneration of the differentiating cerebellum through repatterning of the anterior hindbrain and reinitiation of neuronal migration.
J. Neurosci., July 5, 2006; 26(27): 7293 - 7304.
[Abstract] [Full Text] [PDF]

X. Zhang, O. A. Ibrahimi, S. K. Olsen, H. Umemori, M. Mohammadi, and D. M. Ornitz
Receptor Specificity of the Fibroblast Growth Factor Family: THE COMPLETE MAMMALIAN FGF FAMILY
J. Biol. Chem., June 9, 2006; 281(23): 15694 - 15700.
[Abstract] [Full Text] [PDF]

I. Foucher, M. Mione, A. Simeone, D. Acampora, L. Bally-Cuif, and C. Houart
Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants
Development, May 15, 2006; 133(10): 1891 - 1900.
[Abstract] [Full Text] [PDF]

E. E. Storm, S. Garel, U. Borello, J. M. Hebert, S. Martinez, S. K. McConnell, G. R. Martin, and J. L. R. Rubenstein
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
Development, May 1, 2006; 133(9): 1831 - 1844.
[Abstract] [Full Text] [PDF]

S. T. Waters and M. Lewandoski
A threshold requirement for Gbx2 levels in hindbrain development.
Development, May 1, 2006; 133(10): 1991 - 2000.
[Abstract] [Full Text] [PDF]

G. Griesel, D. Treichel, P. Collombat, J. Krull, A. Zembrzycki, W. M. R. van den Akker, P. Gruss, A. Simeone, and A. Mansouri
Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border
Development, May 1, 2006; 133(9): 1779 - 1787.
[Abstract] [Full Text] [PDF]

A. Picker and M. Brand
Fgf signals from a novel signaling center determine axial patterning of the prospective neural retina
Development, November 15, 2005; 132(22): 4951 - 4962.
[Abstract] [Full Text] [PDF]

F. P. O'Hara, E. Beck, L. K. Barr, L. L. Wong, D. S. Kessler, and R. D. Riddle
Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer
Development, July 15, 2005; 132(14): 3163 - 3173.
[Abstract] [Full Text] [PDF]

T. Langenberg and M. Brand
Lineage restriction maintains a stable organizer cell population at the zebrafish midbrain-hindbrain boundary
Development, July 15, 2005; 132(14): 3209 - 3216.
[Abstract] [Full Text] [PDF]

J. Kimura, Y. Suda, D. Kurokawa, Z. M. Hossain, M. Nakamura, M. Takahashi, A. Hara, and S. Aizawa
Emx2 and Pax6 Function in Cooperation with Otx2 and Otx1 to Develop Caudal Forebrain Primordium That Includes Future Archipallium
J. Neurosci., May 25, 2005; 25(21): 5097 - 5108.
[Abstract] [Full Text] [PDF]

J. Y. H. Li, Z. Lao, and A. L. Joyner
New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression
Development, April 15, 2005; 132(8): 1971 - 1981.
[Abstract] [Full Text] [PDF]

A. Suzuki-Hirano, T. Sato, and H. Nakamura
Regulation of isthmic Fgf8 signal by sprouty2
Development, January 15, 2005; 132(2): 257 - 265.
[Abstract] [Full Text] [PDF]

S. Hans, D. Liu, and M. Westerfield
Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors
Development, October 15, 2004; 131(20): 5091 - 5102.
[Abstract] [Full Text] [PDF]

T. Sato and H. Nakamura
The Fgf8 signal causes cerebellar differentiation by activating the Ras-ERK signaling pathway
Development, September 1, 2004; 131(17): 4275 - 4285.
[Abstract] [Full Text] [PDF]

D. Kurokawa, H. Kiyonari, R. Nakayama, C. Kimura-Yoshida, I. Matsuo, and S. Aizawa
Regulation of Otx2 expression and its functions in mouse forebrain and midbrain
Development, July 15, 2004; 131(14): 3319 - 3331.
[Abstract] [Full Text] [PDF]

T. Tabata and Y. Takei
Morphogens, their identification and regulation
Development, February 15, 2004; 131(4): 703 - 712.
[Abstract] [Full Text] [PDF]

J. Jaszai, F. Reifers, A. Picker, T. Langenberg, and M. Brand
Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity
Development, December 29, 2003; 130(26): 6611 - 6623.
[Abstract] [Full Text] [PDF]

A. Liu, J. Y. H. Li, C. Bromleigh, Z. Lao, L. A. Niswander, and A. L. Joyner
FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors
Development, December 22, 2003; 130(25): 6175 - 6185.
[Abstract] [Full Text] [PDF]

A. Louvi, P. Alexandre, C. Metin, W. Wurst, and M. Wassef
The isthmic neuroepithelium is essential for cerebellar midline fusion
Development, November 15, 2003; 130(22): 5319 - 5330.
[Abstract] [Full Text] [PDF]

P. Alexandre and M. Wassef
The isthmic organizer links anteroposterior and dorsoventral patterning in the mid/hindbrain by generating roof plate structures
Development, November 15, 2003; 130(22): 5331 - 5338.
[Abstract] [Full Text] [PDF]

A. Tallafuss and L. Bally-Cuif
Tracing of her5 progeny in zebrafish transgenics reveals the dynamics of midbrain-hindbrain neurogenesis and maintenance
Development, September 15, 2003; 130(18): 4307 - 4323.
[Abstract] [Full Text] [PDF]

J. Walshe and I. Mason
Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development
Development, September 15, 2003; 130(18): 4337 - 4349.
[Abstract] [Full Text] [PDF]

C. L. Chi, S. Martinez, W. Wurst, and G. R. Martin
The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
Development, June 15, 2003; 130(12): 2633 - 2644.
[Abstract] [Full Text] [PDF]

F. Hirth, L. Kammermeier, E. Frei, U. Walldorf, M. Noll, and H. Reichert
An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila
Development, June 1, 2003; 130(11): 2365 - 2373.
[Abstract] [Full Text] [PDF]

S. Garel, K. J. Huffman, and J. L. R. Rubenstein
Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants
Development, May 1, 2003; 130(9): 1903 - 1914.
[Abstract] [Full Text] [PDF]

R. Dono
Fibroblast growth factors as regulators of central nervous system development and function
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R867 - R881.
[Abstract] [Full Text] [PDF]

E. Matsunaga, T. Katahira, and H. Nakamura
Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development
Development, March 13, 2003; 129(22): 5269 - 5277.
[Abstract] [Full Text] [PDF]

G. Reim and M. Brand
spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development
Development, March 4, 2003; 129(4): 917 - 933.
[Abstract] [Full Text] [PDF]

S. Lutolf, F. Radtke, M. Aguet, U. Suter, and V. Taylor
Notch1 is required for neuronal and glial differentiation in the cerebellum
Development, March 3, 2003; 129(2): 373 - 385.
[Abstract] [Full Text] [PDF]

M. Ford-Perriss, S. E. Guimond, U. Greferath, M. Kita, K. Grobe, H. Habuchi, K. Kimata, J. D. Esko, M. Murphy, and J. E. Turnbull
Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling
Glycobiology, November 1, 2002; 12(11): 721 - 727.
[Abstract] [Full Text] [PDF]

C. Irving, A. Malhas, S. Guthrie, and I. Mason
Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8
Development, January 12, 2002; 129(23): 5389 - 5398.
[Abstract] [Full Text] [PDF]

A. Glavic, J. L. Gomez-Skarmeta, and R. Mayor
The homeoprotein Xiro1 is required for midbrain-hindbrain boundary formation
Development, January 4, 2002; 129(7): 1609 - 1621.
[Abstract] [Full Text] [PDF]

D. Kobayashi, M. Kobayashi, K. Matsumoto, T. Ogura, M. Nakafuku, and K. Shimamura
Early subdivisions in the neural plate define distinct competence for inductive signals
Development, January 1, 2002; 129(1): 83 - 93.
[Abstract] [Full Text] [PDF]

J. Y. H. Li and A. L. Joyner
Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
Development, December 15, 2001; 128(24): 4979 - 4991.
[Abstract] [Full Text] [PDF]

J. P. Martinez-Barbera, M. Signore, P. P. Boyl, E. Puelles, D. Acampora, R. Gogoi, F. Schubert, A. Lumsden, and A. Simeone
Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2
Development, December 1, 2001; 128(23): 4789 - 4800.
[Abstract] [Full Text] [PDF]

H.-G. Belting, G. Hauptmann, D. Meyer, S. Abdelilah-Seyfried, A. Chitnis, C. Eschbach, I. Soll, C. Thisse, B. Thisse, K. B. Artinger, et al.
spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer
Development, November 1, 2001; 128(21): 4165 - 4176.
[Abstract] [Full Text] [PDF]

E. Matsunaga, I. Araki, and H. Nakamura
Role of Pax3/7 in the tectum regionalization
Development, October 15, 2001; 128(20): 4069 - 4077.
[Abstract] [Full Text] [PDF]

R. A. Schneider, D. Hu, J. L. R. Rubenstein, M. Maden, and J. A. Helms
Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH
Development, July 15, 2001; 128(14): 2755 - 2767.
[Abstract] [Full Text] [PDF]

T. Sato, I. Araki, and H. Nakamura
Inductive signal and tissue responsiveness defining the tectum and the cerebellum
Development, July 1, 2001; 128(13): 2461 - 2469.
[Abstract] [Full Text] [PDF]

A Liu and A. Joyner
EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region
Development, January 1, 2001; 128(2): 181 - 191.
[Abstract] [PDF]

R. Raballo, J. Rhee, R. Lyn-Cook, J. F. Leckman, M. L. Schwartz, and F. M. Vaccarino
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
J. Neurosci., July 1, 2000; 20(13): 5012 - 5023.
[Abstract] [Full Text] [PDF]

N Bertrand, F Medevielle, and F Pituello
FGF signalling controls the timing of Pax6 activation in the neural tube
Development, January 11, 2000; 127(22): 4837 - 4843.
[Abstract] [PDF]

F Marin and P Charnay
Hindbrain patterning: FGFs regulate Krox20 and mafB/kr expression in the otic/preotic region
Development, January 11, 2000; 127(22): 4925 - 4935.
[Abstract] [PDF]

J. Martinez Barbera, M Clements, P Thomas, T Rodriguez, D Meloy, D Kioussis, and R. Beddington
The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation
Development, January 6, 2000; 127(11): 2433 - 2445.
[Abstract] [PDF]

				A. Badde and D. Schulte A Role for Receptor Protein Tyrosine Phosphatase {lambda} in Midbrain Development J. Neurosci., June 11, 2008; 28(24): 6152 - 6164. [Abstract] [Full Text] [PDF]

				M. A. Basson, D. Echevarria, C. Petersen Ahn, A. Sudarov, A. L. Joyner, I. J. Mason, S. Martinez, and G. R. Martin Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development Development, March 1, 2008; 135(5): 889 - 898. [Abstract] [Full Text] [PDF]

				B. Carletti and F. Rossi Neurogenesis in the Cerebellum Neuroscientist, February 1, 2008; 14(1): 91 - 100. [Abstract] [PDF]

				E. Salero and M. E. Hatten Differentiation of ES cells into cerebellar neurons PNAS, February 20, 2007; 104(8): 2997 - 3002. [Abstract] [Full Text] [PDF]

				M. P. Fogarty, B. A. Emmenegger, L. L. Grasfeder, T. G. Oliver, and R. J. Wechsler-Reya Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells PNAS, February 20, 2007; 104(8): 2973 - 2978. [Abstract] [Full Text] [PDF]

				C. Guo, H.-Y. Qiu, Y. Huang, H. Chen, R.-Q. Yang, S.-D. Chen, R. L. Johnson, Z.-F. Chen, and Y.-Q. Ding Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice Development, January 15, 2007; 134(2): 317 - 325. [Abstract] [Full Text] [PDF]

				D. Morales and M. E. Hatten Molecular Markers of Neuronal Progenitors in the Embryonic Cerebellar Anlage. J. Neurosci., November 22, 2006; 26(47): 12226 - 12236. [Abstract] [Full Text] [PDF]

				P. Alexandre, I. Bachy, M. Marcou, and M. Wassef Positive and negative regulations by FGF8 contribute to midbrain roof plate developmental plasticity Development, August 1, 2006; 133(15): 2905 - 2913. [Abstract] [Full Text] [PDF]

				R. W. Koster and S. E. Fraser FGF signaling mediates regeneration of the differentiating cerebellum through repatterning of the anterior hindbrain and reinitiation of neuronal migration. J. Neurosci., July 5, 2006; 26(27): 7293 - 7304. [Abstract] [Full Text] [PDF]

				X. Zhang, O. A. Ibrahimi, S. K. Olsen, H. Umemori, M. Mohammadi, and D. M. Ornitz Receptor Specificity of the Fibroblast Growth Factor Family: THE COMPLETE MAMMALIAN FGF FAMILY J. Biol. Chem., June 9, 2006; 281(23): 15694 - 15700. [Abstract] [Full Text] [PDF]

				I. Foucher, M. Mione, A. Simeone, D. Acampora, L. Bally-Cuif, and C. Houart Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants Development, May 15, 2006; 133(10): 1891 - 1900. [Abstract] [Full Text] [PDF]

				E. E. Storm, S. Garel, U. Borello, J. M. Hebert, S. Martinez, S. K. McConnell, G. R. Martin, and J. L. R. Rubenstein Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers Development, May 1, 2006; 133(9): 1831 - 1844. [Abstract] [Full Text] [PDF]

				S. T. Waters and M. Lewandoski A threshold requirement for Gbx2 levels in hindbrain development. Development, May 1, 2006; 133(10): 1991 - 2000. [Abstract] [Full Text] [PDF]

				G. Griesel, D. Treichel, P. Collombat, J. Krull, A. Zembrzycki, W. M. R. van den Akker, P. Gruss, A. Simeone, and A. Mansouri Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border Development, May 1, 2006; 133(9): 1779 - 1787. [Abstract] [Full Text] [PDF]

				A. Picker and M. Brand Fgf signals from a novel signaling center determine axial patterning of the prospective neural retina Development, November 15, 2005; 132(22): 4951 - 4962. [Abstract] [Full Text] [PDF]

				F. P. O'Hara, E. Beck, L. K. Barr, L. L. Wong, D. S. Kessler, and R. D. Riddle Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer Development, July 15, 2005; 132(14): 3163 - 3173. [Abstract] [Full Text] [PDF]

				T. Langenberg and M. Brand Lineage restriction maintains a stable organizer cell population at the zebrafish midbrain-hindbrain boundary Development, July 15, 2005; 132(14): 3209 - 3216. [Abstract] [Full Text] [PDF]

				J. Kimura, Y. Suda, D. Kurokawa, Z. M. Hossain, M. Nakamura, M. Takahashi, A. Hara, and S. Aizawa Emx2 and Pax6 Function in Cooperation with Otx2 and Otx1 to Develop Caudal Forebrain Primordium That Includes Future Archipallium J. Neurosci., May 25, 2005; 25(21): 5097 - 5108. [Abstract] [Full Text] [PDF]

				J. Y. H. Li, Z. Lao, and A. L. Joyner New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression Development, April 15, 2005; 132(8): 1971 - 1981. [Abstract] [Full Text] [PDF]

				A. Suzuki-Hirano, T. Sato, and H. Nakamura Regulation of isthmic Fgf8 signal by sprouty2 Development, January 15, 2005; 132(2): 257 - 265. [Abstract] [Full Text] [PDF]

				S. Hans, D. Liu, and M. Westerfield Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors Development, October 15, 2004; 131(20): 5091 - 5102. [Abstract] [Full Text] [PDF]

				T. Sato and H. Nakamura The Fgf8 signal causes cerebellar differentiation by activating the Ras-ERK signaling pathway Development, September 1, 2004; 131(17): 4275 - 4285. [Abstract] [Full Text] [PDF]

				D. Kurokawa, H. Kiyonari, R. Nakayama, C. Kimura-Yoshida, I. Matsuo, and S. Aizawa Regulation of Otx2 expression and its functions in mouse forebrain and midbrain Development, July 15, 2004; 131(14): 3319 - 3331. [Abstract] [Full Text] [PDF]

				T. Tabata and Y. Takei Morphogens, their identification and regulation Development, February 15, 2004; 131(4): 703 - 712. [Abstract] [Full Text] [PDF]

				J. Jaszai, F. Reifers, A. Picker, T. Langenberg, and M. Brand Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity Development, December 29, 2003; 130(26): 6611 - 6623. [Abstract] [Full Text] [PDF]

				A. Liu, J. Y. H. Li, C. Bromleigh, Z. Lao, L. A. Niswander, and A. L. Joyner FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors Development, December 22, 2003; 130(25): 6175 - 6185. [Abstract] [Full Text] [PDF]

				A. Louvi, P. Alexandre, C. Metin, W. Wurst, and M. Wassef The isthmic neuroepithelium is essential for cerebellar midline fusion Development, November 15, 2003; 130(22): 5319 - 5330. [Abstract] [Full Text] [PDF]

				P. Alexandre and M. Wassef The isthmic organizer links anteroposterior and dorsoventral patterning in the mid/hindbrain by generating roof plate structures Development, November 15, 2003; 130(22): 5331 - 5338. [Abstract] [Full Text] [PDF]

				A. Tallafuss and L. Bally-Cuif Tracing of her5 progeny in zebrafish transgenics reveals the dynamics of midbrain-hindbrain neurogenesis and maintenance Development, September 15, 2003; 130(18): 4307 - 4323. [Abstract] [Full Text] [PDF]

				J. Walshe and I. Mason Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development Development, September 15, 2003; 130(18): 4337 - 4349. [Abstract] [Full Text] [PDF]