The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping

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				R. E. Poelmann, M. R.M. Jongbloed, and A. C. Gittenberger-de Groot Pitx2: A Challenging Teenager Circ. Res., April 11, 2008; 102(7): 749 - 751. [Full Text] [PDF]

				A. Tessari, M. Pietrobon, A. Notte, G. Cifelli, P. J. Gage, M. D. Schneider, G. Lembo, and M. Campione Myocardial Pitx2 Differentially Regulates the Left Atrial Identity and Ventricular Asymmetric Remodeling Programs Circ. Res., April 11, 2008; 102(7): 813 - 822. [Abstract] [Full Text] [PDF]

				D. Galli, J. N. Dominguez, S. Zaffran, A. Munk, N. A. Brown, and M. E. Buckingham Atrial myocardium derives from the posterior region of the second heart field, which acquires left-right identity as Pitx2c is expressed Development, March 15, 2008; 135(6): 1157 - 1167. [Abstract] [Full Text] [PDF]

				C. V. Esguerra, L. Nelles, L. Vermeire, A. Ibrahimi, A. D. Crawford, R. Derua, E. Janssens, E. Waelkens, P. Carmeliet, D. Collen, et al. Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination Development, December 15, 2007; 134(24): 4381 - 4393. [Abstract] [Full Text] [PDF]

				S. Guioli and R. Lovell-Badge PITX2 controls asymmetric gonadal development in both sexes of the chick and can rescue the degeneration of the right ovary Development, December 1, 2007; 134(23): 4199 - 4208. [Abstract] [Full Text] [PDF]

				J. F. Martin Left Right Asymmetry, the Pulmonary Vein, and A-Fib Circ. Res., October 26, 2007; 101(9): 853 - 855. [Full Text] [PDF]

				E. N. Hilton, F. D.C. Manson, J. E. Urquhart, J. J. Johnston, A. M. Slavotinek, P. Hedera, E.-L. Stattin, A. Nordgren, L. G. Biesecker, and G. C.M. Black Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination Hum. Mol. Genet., July 15, 2007; 16(14): 1773 - 1782. [Abstract] [Full Text] [PDF]

				J. Gerhart, J. Elder, C. Neely, J. Schure, T. Kvist, K. Knudsen, and M. George-Weinstein MyoD-positive epiblast cells regulate skeletal muscle differentiation in the embryo J. Cell Biol., October 23, 2006; 175(2): 283 - 292. [Abstract] [Full Text] [PDF]

				M. D. Shapiro, M. A. Bell, and D. M. Kingsley Parallel genetic origins of pelvic reduction in vertebrates PNAS, September 12, 2006; 103(37): 13753 - 13758. [Abstract] [Full Text] [PDF]

				H. Shiratori, K. Yashiro, M. M. Shen, and H. Hamada Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs Development, August 1, 2006; 133(15): 3015 - 3025. [Abstract] [Full Text] [PDF]

				S. Nowotschin, J. Liao, P. J. Gage, J. A. Epstein, M. Campione, and B. E. Morrow Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development, April 1, 2006; 133(8): 1565 - 1573. [Abstract] [Full Text] [PDF]

				A. G. Kramer-Zucker, F. Olale, C. J. Haycraft, B. K. Yoder, A. F. Schier, and I. A. Drummond Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis Development, April 15, 2005; 132(8): 1907 - 1921. [Abstract] [Full Text] [PDF]

				J. Holmberg, C.-Y. Liu, and T. A. Hjalt PITX2 Gain-of-Function in Rieger Syndrome Eye Model Am. J. Pathol., November 1, 2004; 165(5): 1633 - 1641. [Abstract] [Full Text] [PDF]

				S. Wang, X. Yu, T. Zhang, X. Zhang, Z. Zhang, and Y. Chen Chick Pcl2 regulates the left-right asymmetry by repressing Shh expression in Hensen's node Development, September 1, 2004; 131(17): 4381 - 4391. [Abstract] [Full Text] [PDF]

				S. Horne-Badovinac, M. Rebagliati, and D. Y. R. Stainier A Cellular Framework for Gut-Looping Morphogenesis in Zebrafish Science, October 24, 2003; 302(5645): 662 - 665. [Abstract] [Full Text] [PDF]

				T. Schlange, H.-H. Arnold, and T. Brand BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo Development, March 9, 2003; 129(14): 3421 - 3429. [Abstract] [Full Text] [PDF]

				M. E. Piedra and M. A. Ros BMP signaling positively regulates Nodal expression during left right specification in the chick embryo Development, March 9, 2003; 129(14): 3431 - 3440. [Abstract] [Full Text] [PDF]

				D. P. Norris, J. Brennan, E. K. Bikoff, and E. J. Robertson The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo Development, March 9, 2003; 129(14): 3455 - 3468. [Abstract] [Full Text] [PDF]

				G. K. H. Przemeck, U. Heinzmann, J. Beckers, and M. Hrabe de Angelis Node and midline defects are associated with left-right development in Delta1 mutant embryos Development, January 1, 2003; 130(1): 3 - 13. [Abstract] [Full Text] [PDF]

				A. Marcil, E. Dumontier, M. Chamberland, S. A. Camper, and J. Drouin Pitx1 and Pitx2 are required for development of hindlimb buds Development, January 1, 2003; 130(1): 45 - 55. [Abstract] [Full Text] [PDF]

				Y Watanabe, D W Benson, S Yano, T Akagi, M Yoshino, and J C Murray Two novel frameshift mutations in NKX2.5 result in novel features including visceral inversus and sinus venosus type ASD J. Med. Genet., November 1, 2002; 39(11): 807 - 811. [Full Text] [PDF]

				C. J. Cox, H. M. Espinoza, B. McWilliams, K. Chappell, L. Morton, T. A. Hjalt, E. V. Semina, and B. A. Amendt Differential Regulation of Gene Expression by PITX2 Isoforms J. Biol. Chem., July 5, 2002; 277(28): 25001 - 25010. [Abstract] [Full Text] [PDF]

				M. A. Lines, K. Kozlowski, and M. A. Walter Molecular genetics of Axenfeld-Rieger malformations Hum. Mol. Genet., May 15, 2002; 11(10): 1177 - 1187. [Abstract] [Full Text] [PDF]

				M. Poulain and T. Lepage Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish Development, January 11, 2002; 129(21): 4901 - 4914. [Abstract] [Full Text] [PDF]

				J. E. Pitera, V. V. Smith, A. S. Woolf, and P. J. Milla Embryonic Gut Anomalies in a Mouse Model of Retinoic Acid-Induced Caudal Regression Syndrome : Delayed Gut Looping, Rudimentary Cecum, and Anorectal Anomalies Am. J. Pathol., December 1, 2001; 159(6): 2321 - 2329. [Abstract] [Full Text] [PDF]

				C. Liu, W. Liu, M.-F. Lu, N. A. Brown, and J. F. Martin Regulation of left-right asymmetry by thresholds of Pitx2c activity Development, June 1, 2001; 128(11): 2039 - 2048. [Abstract] [Full Text] [PDF]

				T. A. Hjalt, B. A. Amendt, and J. C. Murray PITX2 Regulates Procollagen Lysyl Hydroxylase (PLOD) Gene Expression: Implications for the Pathology of Rieger Syndrome J. Cell Biol., February 5, 2001; 152(3): 545 - 552. [Abstract] [Full Text] [PDF]

				L. Lowe, S Yamada, and M. Kuehn Genetic dissection of nodal function in patterning the mouse embryo Development, January 5, 2001; 128(10): 1831 - 1843. [Abstract] [PDF]

				K Niederreither, J Vermot, N Messaddeq, B Schuhbaur, P Chambon, and P Dolle Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse Development, January 4, 2001; 128(7): 1019 - 1031. [Abstract] [PDF]

				X Yu, T. St Amand, S Wang, G Li, Y Zhang, Y. Hu, L Nguyen, M. Qiu, and Y. Chen Differential expression and functional analysis of Pitx2 isoforms in regulation of heart looping in the chick Development, January 3, 2001; 128(6): 1005 - 1013. [Abstract] [PDF]