Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

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Alpert, S., Hanahan, D. and Teitelman, G (1988). Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 53, 295-308.[Medline]

Edlund, H (1998). Transcribing pancreas. Diabetes 47, 1817-1823.[Abstract]

Falkmer, S., Dafgard, E., el-Salhy, M., Engstrom, W., Grimelius, L. and Zetterberg, A (1985). Phylogenetical aspects on islet hormone families: a minireview with particular reference to insulin as a growth factor and to the phylogeny of PYY and NPY immunoreactive cells and nerves in the endocrine and exocrine pancreas. Peptides 6, 315-320.

Gittes, G. K. and Rutter, W. J (1992). Onset of cell-specific gene expression in the developing mouse pancreas. Proc. Natl Acad. Sci. USA 89, 1128-1132.[Abstract/Free Full Text]

Gradwohl, G., Dierich, A., LeMeur, M. and Guillemot, F (2000). Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl Acad. Sci. USA 97, 1607-1611.[Abstract/Free Full Text]

Guz, Y., Montminy, M. R., Stein, R., Leonard, J., Gamer, L. W., Wright, C. V. and Teitelman, G (1995). Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121, 11-18.[Abstract]

Hanahan, D (1985). Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315, 115-122.[Medline]

Herrera, P. L., Huarte, J., Sanvito, F., Meda, P., Orci, L. and Vassalli, J. D (1991). Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 113, 1257-1265.[Abstract]

Herrera, P. L., Huarte, J., Zufferey, R., Nichols, A., Mermillod, B., Philippe, J., Muniesa, P., Sanvito, F., Orci, L. and Vassalli, J. D (1994). Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes. Proc. Natl Acad. Sci. USA 91, 12999-13003.[Abstract/Free Full Text]

Fig. 5 (2000). p48, one of the two subunits of the exocrine pancreas-specific transcription factor PTF1, is the earliest exocrine marker known to date (Krapp et al., 1998). That somatostatin-producing cells could descend from PP-expressing precursors is deduced from the cell ablation experiments in transgenic mice (Herrera et al., 1994). cpA, carboxypeptidase A; amy, amylase; GLU, glucagon; SOM, somatostatin; INS, insulin; GF, unknown growth or differentiation factor.a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes. J. Exp. Med 176, 1719-1731.[Abstract/Free Full Text]

Jackerott, M., Oster, A. and Larsson, L. I (1996). PYY in developing murine islet cells: comparisons to development of islet hormones, NPY, and BrdU incorporation. J Histochem Cytochem 44, 809-817.[Abstract]

Jacob, J. and Baltimore, D (1999). Modelling T-cell memory by genetic marking of memory T cells in vivo [see comments]. Nature 399, 593-597.[Medline]

Krapp, A., Knofler, M., Ledermann, B., Burki, K., Berney, C., Zoerkler, N., Hagenbuchle, O. and Wellauer, P (1998). The bHLH protein PTF1-p48 is essential for the formation of the exocrine and to correct the spatial organization of the endocrine pancreas. Genes Dev 12, 3752-3763.[Abstract/Free Full Text]

Lakso, M., Sauer, B., Mosinger, B., Jr., Lee, E. J., Manning, R. W., Yu, S. H., Mulder, K. L. and Westphal, H (1992). Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl Acad. Sci. USA 89, 6232-6236.[Abstract/Free Full Text]

Larsson, L. I (1998). On the development of the islets of Langerhans. Microsc. Res. Tech 43, 284-291.[Medline]

Liang, Y., Jetton, T. L., Zimmerman, E. C., Najafi, H., Berner, D. K., Matschinsky, F. M. and Magnuson, M. A (1994). Effects of glucose on insulin secretion, glucokinase activity, and transgene expression in transgenic mouse islets containing an upstream glucokinase promoter-human growth hormone fusion gene. Diabetes 43, 1138-1145.[Abstract]

Lopez, M. J., Upchurch, B. H., Rindi, G. and Leiter, A. B (1995). Studies in transgenic mice reveal potential relationships between secretin-producing cells and other endocrine cell types. J. Biol. Chem 270, 885-891.[Abstract/Free Full Text]

Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R. W., Magnuson, M. A., Hogan, B. L. and Wright, C. V (1996). PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122, 983-995.[Abstract]

Orci, L (1982). Macro-and micro-domains in the endocrine pancreas. Diabetes 31, 538-565.[Medline]

Pang, K., Mukonoweshuro, C. and Wong, G. G (1994). Beta cells arisefrom glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas. Proc. Natl Acad. Sci. USA 91, 9559-9563.[Abstract/Free Full Text]

Rall, L. B., Pictet, R. L., Williams, R. H. and Rutter, W. J (1973). Early differentiation of glucagon-producing cells in embryonic pancreas: a possible developmental role for glucagon. Proc. Natl Acad. Sci. USA 70, 3478-3482.[Abstract/Free Full Text]

Roth, K. A., Hertz, J. M. and Gordon, J. I (1990). Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract. J. Cell Biol 110, 1791-1801.[Abstract/Free Full Text]

Sanvito, F., Nichols, A., Herrera, P. L., Huarte, J., Wohlwend, A., Vassalli, J. D. and Orci, L (1995). TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes. Biochem. Biophys. Res. Commun 217, 1279-1286.[Medline]

Sauer, B (1993). Manipulation of transgenes by site-specific recombination: use of Cre recombinase. Methods Enzymol 225, 890-900.[Medline]

Sauer, B (1994). Site-specific recombination: developments and applications. Curr Opin. Biotechnol 5, 521-527.[Medline]

Sauer, B (1998). Inducible gene targeting in mice using the Cre/lox system. Methods 14, 381-392.[Medline]

Szabo, M., Butz, M. R., Banerjee, S. A., Chikaraishi, D. M. and Frohman, L. A (1995). Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5-flanking sequences to the hypothalamus. Endocrinology 136, 4044-4048.[Abstract]

Teitelman, G., Alpert, S., Polak, J. M., Martinez, A. and Hanahan, D (1993). Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118, 1031-1039.[Abstract]

Tsien, J. Z., Chen, D. F., Gerber, D., Tom, C., Mercer, E. H., Anderson, D. J., Mayford, M., Kandel, E. R. and Tonegawa, S (1996). Subregion-and cell type-restricted gene knockout in mouse brain [see comments]. Cell 87, 1317-1326.[Medline]

Yamaizumi, M., Mekada, E., Uchida, T. and Okada, Y (1978). One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell 15, 245-250.[Medline]

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				V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF]

				M. Attali, V. Stetsyuk, A. Basmaciogullari, V. Aiello, M. A. Zanta-Boussif, B. Duvillie, and R. Scharfmann Control of {beta}-Cell Differentiation by the Pancreatic Mesenchyme Diabetes, May 1, 2007; 56(5): 1248 - 1258. [Abstract] [Full Text] [PDF]

				A. M Ackermann and M. Gannon Molecular regulation of pancreatic {beta}-cell mass development, maintenance, and expansion J. Mol. Endocrinol., February 1, 2007; 38(2): 193 - 206. [Abstract] [Full Text] [PDF]

				L. C. Murtaugh Pancreas and beta-cell development: from the actual to the possible Development, February 1, 2007; 134(3): 427 - 438. [Abstract] [Full Text] [PDF]

				M. J. Doyle, Z. L. Loomis, and L. Sussel Nkx2.2-repressor activity is sufficient to specify {alpha}-cells and a small number of {beta}-cells in the pancreatic islet Development, February 1, 2007; 134(3): 515 - 523. [Abstract] [Full Text] [PDF]

				M. S. Gierl, N. Karoulias, H. Wende, M. Strehle, and C. Birchmeier The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells Genes & Dev., September 1, 2006; 20(17): 2465 - 2478. [Abstract] [Full Text] [PDF]

				P. W. Heiser, J. Lau, M. M. Taketo, P. L. Herrera, and M. Hebrok Stabilization of {beta}-catenin impacts pancreas growth Development, May 15, 2006; 133(10): 2023 - 2032. [Abstract] [Full Text] [PDF]

				S. Thyssen, E. Arany, and D. J. Hill Ontogeny of Regeneration of {beta}-Cells in the Neonatal Rat after Treatment with Streptozotocin Endocrinology, May 1, 2006; 147(5): 2346 - 2356. [Abstract] [Full Text] [PDF]

				S. Vignali, V. Leiss, R. Karl, F. Hofmann, and A. Welling Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells J. Physiol., May 1, 2006; 572(3): 691 - 706. [Abstract] [Full Text] [PDF]

				K. Minami, M. Okuno, K. Miyawaki, A. Okumachi, K. Ishizaki, K. Oyama, M. Kawaguchi, N. Ishizuka, T. Iwanaga, and S. Seino Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells PNAS, October 18, 2005; 102(42): 15116 - 15121. [Abstract] [Full Text] [PDF]

				B. Soria, F. J. Bedoya, and F. Martin Gastrointestinal Stem Cells I. Pancreatic stem cells Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G177 - G180. [Abstract] [Full Text] [PDF]

				K. D. Henseleit, S. B. Nelson, K. Kuhlbrodt, J. C. Hennings, J. Ericson, and M. Sander NKX6 transcription factor activity is required for {alpha}- and {beta}-cell development in the pancreas Development, July 1, 2005; 132(13): 3139 - 3149. [Abstract] [Full Text] [PDF]

				S. Schonhoff, L. Baggio, C. Ratineau, S. K. Ray, J. Lindner, M. A. Magnuson, D. J. Drucker, and A. B. Leiter Energy Homeostasis and Gastrointestinal Endocrine Differentiation Do Not Require the Anorectic Hormone Peptide YY Mol. Cell. Biol., May 15, 2005; 25(10): 4189 - 4199. [Abstract] [Full Text] [PDF]

				B. Ritz-Laser, A. Mamin, T. Brun, I. Avril, V. M. Schwitzgebel, and J. Philippe The Zinc Finger-Containing Transcription Factor Gata-4 Is Expressed in the Developing Endocrine Pancreas and Activates Glucagon Gene Expression Mol. Endocrinol., March 1, 2005; 19(3): 759 - 770. [Abstract] [Full Text] [PDF]

				Y. Lu, P. L. Herrera, Y. Guo, D. Sun, Z. Tang, D. LeRoith, and J.-L. Liu Pancreatic-Specific Inactivation of IGF-I Gene Causes Enlarged Pancreatic Islets and Significant Resistance to Diabetes Diabetes, December 1, 2004; 53(12): 3131 - 3141. [Abstract] [Full Text] [PDF]

				H. T. Ku, N. Zhang, A. Kubo, R. O'Connor, M. Mao, G. Keller, and J. S. Bromberg Committing Embryonic Stem Cells to Early Endocrine Pancreas In Vitro Stem Cells, December 1, 2004; 22(7): 1205 - 1217. [Abstract] [Full Text] [PDF]

				T. Ogata, L. Li, S. Yamada, Y. Yamamoto, Y. Tanaka, I. Takei, K. Umezawa, and I. Kojima Promotion of {beta}-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas Diabetes, October 1, 2004; 53(10): 2596 - 2602. [Abstract] [Full Text] [PDF]

				E. Gesina, F. Tronche, P. Herrera, B. Duchene, W. Tales, P. Czernichow, and B. Breant Dissecting the Role of Glucocorticoids on Pancreas Development Diabetes, September 1, 2004; 53(9): 2322 - 2329. [Abstract] [Full Text] [PDF]

				K. A. Matthews, W. B. Rhoten, H. K. Driscoll, and B. S. Chertow Vitamin A Deficiency Impairs Fetal Islet Development and Causes Subsequent Glucose Intolerance in Adult Rats J. Nutr., August 1, 2004; 134(8): 1958 - 1963. [Abstract] [Full Text] [PDF]

				H. Segev, B. Fishman, A. Ziskind, M. Shulman, and J. Itskovitz-Eldor Differentiation of Human Embryonic Stem Cells into Insulin-Producing Clusters Stem Cells, May 1, 2004; 22(3): 265 - 274. [Abstract] [Full Text] [PDF]

				H. Yoshitomi and K. S. Zaret Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a Development, February 15, 2004; 131(4): 807 - 817. [Abstract] [Full Text] [PDF]

				G. Gu, J. M. Wells, D. Dombkowski, F. Preffer, B. Aronow, and D. A. Melton Global expression analysis of gene regulatory pathways during endocrine pancreatic development Development, January 1, 2004; 131(1): 165 - 179. [Abstract] [Full Text] [PDF]