A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1

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R. Martin, R. Lahlil, A. Damert, L. Miquerol, A. Nagy, G. Keller, and T. Hoang
SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis
Development, February 1, 2004; 131(3): 693 - 702.
[Abstract] [Full Text] [PDF]

Z. Wang, K. Cohen, Y. Shao, P. Mole, D. Dombkowski, and D. T. Scadden
Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels
Blood, January 1, 2004; 103(1): 100 - 109.
[Abstract] [Full Text] [PDF]

M. Gering, Y. Yamada, T. H. Rabbitts, and R. K. Patient
Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1
Development, December 22, 2003; 130(25): 6187 - 6199.
[Abstract] [Full Text] [PDF]

J. Palis
Putting a Hex on blood and endothelium
Blood, October 1, 2003; 102(7): 2315 - 2316.
[Full Text] [PDF]

Y. Guo, R. Chan, H. Ramsey, W. Li, X. Xie, W. C. Shelley, J. P. Martinez-Barbera, B. Bort, K. Zaret, M. Yoder, et al.
The homeoprotein Hex is required for hemangioblast differentiation
Blood, October 1, 2003; 102(7): 2428 - 2435.
[Abstract] [Full Text] [PDF]

				M. T. Kassouf, H. Chagraoui, P. Vyas, and C. Porcher Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis Blood, August 15, 2008; 112(4): 1056 - 1067. [Abstract] [Full Text] [PDF]

				J.-R. Landry, S. Kinston, K. Knezevic, M. F.T.R. de Bruijn, N. Wilson, W. T. Nottingham, M. Peitz, F. Edenhofer, J. E. Pimanda, K. Ottersbach, et al. Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver Blood, March 15, 2008; 111(6): 3005 - 3014. [Abstract] [Full Text] [PDF]

				A. J. K. Williamson, D. L. Smith, D. Blinco, R. D. Unwin, S. Pearson, C. Wilson, C. Miller, L. Lancashire, G. Lacaud, V. Kouskoff, et al. Quantitative Proteomics Analysis Demonstrates Post-transcriptional Regulation of Embryonic Stem Cell Differentiation to Hematopoiesis Mol. Cell. Proteomics, March 1, 2008; 7(3): 459 - 472. [Abstract] [Full Text] [PDF]

				C. Wang, P. W. Faloon, Z. Tan, Y. Lv, P. Zhang, Y. Ge, H. Deng, and J.-W. Xiong Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation Blood, November 15, 2007; 110(10): 3601 - 3609. [Abstract] [Full Text] [PDF]

				M. Pick, L. Azzola, A. Mossman, E. G. Stanley, and A. G. Elefanty Differentiation of Human Embryonic Stem Cells in Serum-Free Medium Reveals Distinct Roles for Bone Morphogenetic Protein 4, Vascular Endothelial Growth Factor, Stem Cell Factor, and Fibroblast Growth Factor 2 in Hematopoiesis Stem Cells, September 1, 2007; 25(9): 2206 - 2214. [Abstract] [Full Text] [PDF]

				R. C. R. Perlingeiro Endoglin is required for hemangioblast and early hematopoietic development Development, August 15, 2007; 134(16): 3041 - 3048. [Abstract] [Full Text] [PDF]

				T. Haremaki, S. T. Fraser, Y.-M. Kuo, M. H. Baron, and D. C. Weinstein Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation PNAS, July 17, 2007; 104(29): 12029 - 12034. [Abstract] [Full Text] [PDF]

				H. Yao, B. Liu, X. Wang, Y. Lan, N. Hou, X. Yang, and N. Mao Identification of High Proliferative Potential Precursors with Hemangioblastic Activity in the Mouse Aorta-Gonad- Mesonephros Region Stem Cells, June 1, 2007; 25(6): 1423 - 1430. [Abstract] [Full Text] [PDF]

				H. K. Bone and M. J. Welham Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis J. Cell Sci., May 15, 2007; 120(10): 1752 - 1762. [Abstract] [Full Text] [PDF]

				M. Kennedy, S. L. D'Souza, M. Lynch-Kattman, S. Schwantz, and G. Keller Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures Blood, April 1, 2007; 109(7): 2679 - 2687. [Abstract] [Full Text] [PDF]

				D. Rajesh, N. Chinnasamy, S. M. Mitalipov, D. P. Wolf, I. Slukvin, J. A. Thomson, and A. F. Shaaban Differential Requirements for Hematopoietic Commitment Between Human and Rhesus Embryonic Stem Cells Stem Cells, February 1, 2007; 25(2): 490 - 499. [Abstract] [Full Text] [PDF]

				B. T. Zafonte, S. Liu, M. Lynch-Kattman, I. Torregroza, L. Benvenuto, M. Kennedy, G. Keller, and T. Evans Smad1 expands the hemangioblast population within a limited developmental window Blood, January 15, 2007; 109(2): 516 - 523. [Abstract] [Full Text] [PDF]

				S. T. Fraser, J. Isern, and M. H. Baron Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression Blood, January 1, 2007; 109(1): 343 - 352. [Abstract] [Full Text] [PDF]

				C. Rolny, I. Nilsson, P. Magnusson, A. Armulik, L. Jakobsson, P. Wentzel, P. Lindblom, J. Norlin, C. Betsholtz, R. Heuchel, et al. Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation Blood, September 15, 2006; 108(6): 1877 - 1886. [Abstract] [Full Text] [PDF]

				V. Camara-Clayette, F. Le Pesteur, W. Vainchenker, and F. Sainteny Quantitative Oct4 Overproduction in Mouse Embryonic Stem Cells Results in Prolonged Mesoderm Commitment During Hematopoietic Differentiation In Vitro Stem Cells, August 1, 2006; 24(8): 1937 - 1945. [Abstract] [Full Text] [PDF]

				M. Abe and Y. Sato Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is required for the development of vascular as well as hematopoietic system in embryoid bodies. Genes Cells, July 1, 2006; 11(7): 719 - 729. [Abstract] [Full Text] [PDF]

				H. Wang, P. C. Charles, Y. Wu, R. Ren, X. Pi, M. Moser, M. Barshishat-Kupper, J. S. Rubin, C. Perou, V. Bautch, et al. Gene Expression Profile Signatures Indicate a Role for Wnt Signaling in Endothelial Commitment From Embryonic Stem Cells Circ. Res., May 26, 2006; 98(10): 1331 - 1339. [Abstract] [Full Text] [PDF]

				K. M. Bowles, L. Vallier, J. R. Smith, M. R. J. Alexander, and R. A. Pedersen HOXB4 Overexpression Promotes Hematopoietic Development by Human Embryonic Stem Cells Stem Cells, May 1, 2006; 24(5): 1359 - 1369. [Abstract] [Full Text] [PDF]

				S. Willey, A. Ayuso-Sacido, H. Zhang, S. T. Fraser, K. E. Sahr, M. J. Adlam, M. Kyba, G. Q. Daley, G. Keller, and M. H. Baron Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor Blood, April 15, 2006; 107(8): 3122 - 3130. [Abstract] [Full Text] [PDF]

				J. E. Pimanda, L. Silberstein, M. Dominici, B. Dekel, M. Bowen, S. Oldham, A. Kallianpur, S. J. Brandt, D. Tannahill, B. Gottgens, et al. Transcriptional Link between Blood and Bone: the Stem Cell Leukemia Gene and Its +19 Stem Cell Enhancer Are Active in Bone Cells. Mol. Cell. Biol., April 1, 2006; 26(7): 2615 - 2625. [Abstract] [Full Text] [PDF]

				A. L. Olsen, D. L. Stachura, and M. J. Weiss Designer blood: creating hematopoietic lineages from embryonic stem cells Blood, February 15, 2006; 107(4): 1265 - 1275. [Abstract] [Full Text] [PDF]

				H. Zhang, K. Saeki, A. Kimura, K. Saeki, M. Nakahara, M. Doshi, Y. Kondo, T. Nakano, and A. Yuo Efficient and Repetitive Production of Hematopoietic and Endothelial Cells from Feeder-Free Monolayer Culture System of Primate Embryonic Stem Cells Biol Reprod, February 1, 2006; 74(2): 295 - 306. [Abstract] [Full Text] [PDF]

				A. H. Schuh, A. J. Tipping, A. J. Clark, I. Hamlett, B. Guyot, F. J. Iborra, P. Rodriguez, J. Strouboulis, T. Enver, P. Vyas, et al. ETO-2 Associates with SCL in Erythroid Cells and Megakaryocytes and Provides Repressor Functions in Erythropoiesis Mol. Cell. Biol., December 1, 2005; 25(23): 10235 - 10250. [Abstract] [Full Text] [PDF]

				J.E. Ferguson III, R. W. Kelley, and C. Patterson Mechanisms of Endothelial Differentiation in Embryonic Vasculogenesis Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2246 - 2254. [Abstract] [Full Text] [PDF]

				E. S. Ng, R. P. Davis, L. Azzola, E. G. Stanley, and A. G. Elefanty Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation Blood, September 1, 2005; 106(5): 1601 - 1603. [Abstract] [Full Text] [PDF]

				M. A. Hall, N. J. Slater, C. G. Begley, J. M. Salmon, L. J. Van Stekelenburg, M. P. McCormack, S. M. Jane, and D. J. Curtis Functional but Abnormal Adult Erythropoiesis in the Absence of the Stem Cell Leukemia Gene Mol. Cell. Biol., August 1, 2005; 25(15): 6355 - 6362. [Abstract] [Full Text] [PDF]

				E. T. Zambidis, B. Peault, T. S. Park, F. Bunz, and C. I. Civin Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development Blood, August 1, 2005; 106(3): 860 - 870. [Abstract] [Full Text] [PDF]

				E. Delabesse, S. Ogilvy, M. A. Chapman, S. G. Piltz, B. Gottgens, and A. R. Green Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In Vivo Mol. Cell. Biol., June 15, 2005; 25(12): 5215 - 5225. [Abstract] [Full Text] [PDF]

				A. Kubo, V. Chen, M. Kennedy, E. Zahradka, G. Q. Daley, and G. Keller The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation Blood, June 15, 2005; 105(12): 4590 - 4597. [Abstract] [Full Text] [PDF]

				G. Keller Embryonic stem cell differentiation: emergence of a new era in biology and medicine Genes & Dev., May 15, 2005; 19(10): 1129 - 1155. [Abstract] [Full Text] [PDF]