Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Mercader, N.
	Articles by Torres, M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Mercader, N.
	Articles by Torres, M.

Abu-Shaar, M. and Mann, R. S (1998). Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development. Development 125, 3821-3830.[Abstract]

Abu-Shaar, M., Ryoo, H. D. and Mann, R. S (1999). Control of the nuclearlocalization of extradenticle by competing nuclear import and export signals. Genes Dev 13, 935-945.[Abstract/Free Full Text]

Berggren, K., McCaffery, P., Drager, U. and Forehand, C. J (1999). Differential distribution of retinoic acid synthesis in the chicken embryo as determined by immunolocalization of the retinoic acid synthetic enzyme, RALDH-2. Dev. Biol 210, 288-304.[Medline]

Berthelsen, J., Kilstrup-Nielsen, C., Blasi, F., Mavilio, F. and Zappavigna, V (1999). The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH. Genes Dev 13, 946-953.[Abstract/Free Full Text]

Capdevila, J., Tsukui, T., Rodriguez Esteban, C., Zappavigna, V. and Izpisua Belmonte, J. C (1999). Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol. Cell 4, 839-849.

Cecconi, F., Proetzel, G., Alvarez-Bolado, G., Jay, D. and Gruss, P (1997). Expression of Meis2, a Knotted-related murine homeobox gene, indicates a role in the differentiation of the forebrain and the somitic mesoderm. Dev. Dyn 210, 184-190.[Medline]

Cohn, M. J., Izpis\234a-Belmonte, J. C., Abud, H., Heath, J. K. and Tickle, C (1995). Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80, 739-746.[Medline]

Cohn, M. J. and Tickle, C (1996). Limbs: a model for pattern formation within the vertebrate body plan. Trends Genet 12, 253-257.[Medline]

Crawford, K. and Stocum, D. L (1988). Retinoic acid coordinately proximalizes regenerate pattern and blastema differential affinity in axolotl limbs. Development 102, 687-698.[Abstract/Free Full Text]

Crossley, P. H., Minowada, G., MacArthur, C. A. and Martin, G. R (1996). Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 84, 127-136.[Medline]

de The, H., Vivanco-Ruiz, M. M., Tiollais, P., Stunnenberg, H. and Dejean, A (1990). Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature 343, 177-180.[Medline]

Dolle, P., Ruberte, E., Leroy, P., Morriss-Kay, G. and Chambon, P (1990). Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. Development 110, 1133-1151.[Abstract/Free Full Text]

Fallon, J. F., Lopez, A., Ros, M. A., Savage, M. P., Olwin, B. B. and Simandl, B. K (1994). FGF-2: apical ectodermal ridge growth signal for chick limb development. Science 264, 104-107.[Abstract/Free Full Text]

Gardiner, D. M., Blumberg, B., Komine, Y. and Bryant, S. V (1995). Regulation of HoxA expression in developing and regenerating axolotl limbs. Development 121, 1731-1741.[Abstract]

Gonz\207lez-Crespo, S., Abu-Shaar, M., Torres, M., Mart\222nez-A, C., Mann, R. S. and Morata, G (1998). Antagonism between extradenticle function and Hedgehog signalling in the developing limb. Nature 394, 196-200.[Medline]

Gonz\207lez-Crespo, S. and Morata, G (1996). Genetic evidence for the subdivision of the arthropod limb into coxopodite and telopodite. Development 122, 3921-3928.[Abstract]

Helms, J., Thaller, C. and Eichele, G (1994). Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud. Development 120, 3267-3274.[Abstract]

Helms, J. A., Kim, C. H., Eichele, G. and Thaller, C (1996). Retinoic acid signaling is required during early chick limb development. Development 122, 1385-1394.[Abstract]

Ide, H., Wada, N. and Uchiyama, K (1994). Sorting out of cells from different parts and stages of the chick limb bud. Dev. Biol 162, 71-76.[Medline]

Irving, C. and Mason, I (2000). Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression. Development 127, 177-186.[Abstract]

Izpis\234a-Belmonte, J. C., Tickle, C., Dolle, P., Wolpert, L. and Duboule, D (1991). Expression of the homeobox Hox-4 genes and the specification of position in chick wing development. Nature 350, 585-589.[Medline]

Johnson, R. L. and Tabin, C. J (1997). Molecular models for vertebrate limb development. Cell 90, 979-990.[Medline]

Kamps, M. P., Murre, C., Sun, X. and Baltimore, D (1990). A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60, 547-555.[Medline]

Kim, W. S. and Stocum, D. L (1986). Retinoic acid modifies positional memory in the anteroposterior axis of regenerating axolotl limbs. Dev. Biol 114, 170-179.[Medline]

Kochhar, D. M., Jiang, H., Penner, J. D., Johnson, A. T. and Chandraratna, R. A (1998). The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events. Int. J. Dev. Biol 42, 601-608.[Medline]

Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A. and Tabin, C (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79, 993-1003.[Medline]

Logan, M., Pagan-Westphal, S. M., Smith, D. M., Paganessi, L. and Tabin, C. J (1998). The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell 94, 307-317.[Medline]

Logan, M. and Tabin, C (1998). Targeted gene misexpression in chick limb buds using avian replication-competent retroviruses. Methods 14, 407-420.[Medline]

Maden, M (1982). Vitamin A and pattern formation in the regenerating limb. Nature 295, 672-675.[Medline]

Maden, M (1993). The homeotic transformation of tails into limbs in Rana temporaria by retinoids. Dev. Biol 159, 379-391.[Medline]

Mendelsohn, C., Ruberte, E. and Chambon, P (1992). Retinoid receptors in vertebrate limb development. Dev. Biol 152, 50-61.[Medline]

Mendelsohn, C., Ruberte, E., LeMeur, M., Morriss-Kay, G. and Chambon, P (1992). Developmental analysis of the retinoic acid-inducible RAR-beta 2 promoter in transgenic animals. Development 113, 723-734.[Abstract]

Mercader, N., Leonardo, E., Azpiazu, N., Serrano, A., Morata, G., Martinez, C. and Torres, M (1999). Conserved regulation of proximodistal limb axis development by Meis1/Hth. Nature 402, 425-429.[Medline]

Mohammadi, M., McMahon, G., Sun, L., Tang, C., Hirth, P., Yeh, B. K., Hubbard, S. R. and Schlessinger, J (1997). Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276, 955-960.[Abstract/Free Full Text]

Mohanty-Hejmadi, P., Dutta, S. K. and Mahapatra, P (1992). Limbs generated at site of tail amputation in marbled balloon frog after vitamin A treatment. Nature 355, 352-353.[Medline]

Morgan, B. A., Izpis\234a-Belmonte, J. C., Duboule, D. and Tabin, C. J (1992). Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. Nature 358, 236-239.[Medline]

Moskow, J. J., Bullrich, F., Huebner, K., Daar, I. O. and Buchberg, A. M (1995). Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol. Cell Biol 15, 5434-5443.[Abstract]

Nakamura, T., Jenkins, N. A. and Copeland, N. G (1996). Identification of a new family of Pbx-related homeobox genes. Oncogene 13, 2235-2242.[Medline]

Niederreither, K., Subbarayan, V., Dolle, P. and Chambon, P (1999). Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat. Genet 21, 444-448.[Medline]

Niederreither, K., Ward, S. J., Dolle, P. and Chambon, P (1996). Morphological and molecular characterization of retinoic acid-induced limb duplications in mice. Dev. Biol 176, 185-198.[Medline]

Niswander, L., Tickle, C., Vogel, A., Booth, I. and Martin, G. R (1993). FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75, 579-587.[Medline]

Nourse, J., Mellentin, J. D., Galili, N., Wilkinson, J., Stanbridge, E., Smith, S. D. and Cleary, M. L (1990). Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60, 535-545.[Medline]

Oulad-Abdelghani, M., Chazaud, C., Bouillet, P., Sapin, V., Chambon, P. and Dolle, P (1997). Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. Dev. Dyn 210, 173-183.[Medline]

Pecorino, L. T., Entwistle, A. and Brockes, J. P (1996). Activation of a single retinoic acid receptor isoform mediates proximodistal respecification. Curr. Biol 6, 563-569.[Medline]

Rauskolb, C., Peifer, M. and Wieschaus, E (1993). extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell 74, 1101-1112.[Medline]

Rieckhof, G. E., Casares, F., Ryoo, H. D., Abu-Shaar, M. and Mann, R. S (1997). Nuclear translocation of extradenticle requires homothorax,which encodes an extradenticle-related homeodomain protein. Cell 91, 171-183.[Medline]

Rossant, J., Zirngibl, R., Cado, D., Shago, M. and Giguere, V (1991). Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes Dev 5, 1333-1344.[Abstract/Free Full Text]

Rutledge, J. C., Shourbaji, A. G., Hughes, L. A., Polifka, J. E., Cruz, Y. P., Bishop, J. B. and Generoso, W. M (1994). Limb and lower-body duplications induced by retinoic acid in mice. Proc. Natl Acad. Sci. USA 91, 5436-5440.[Abstract/Free Full Text]

Saunders, J. W (1948). The proximodistal sequence of origin of the parts of the chick wing and the role of the ectoderm. J. Exp. Zool 108, 363-403.[Medline]

Schneider, A., Mijalski, T., Schlange, T., Dai, W., Overbeek, P., Arnold, H. H. and Brand, T (1999). The homeobox gene NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos. Curr. Biol 9, 911-914.[Medline]

Schwabe, J. W., Rodriguez-Esteban, C. and Izpis\234a Belmonte, J. C (1998). Limbs are moving: where are they going?. Trends Genet 14, 229-235.[Medline]

Simon, H. G. and Tabin, C. J (1993). Analysis of Hox-4.5 and Hox-3.6 expression during newt limb regeneration: differential regulation of paralogous Hox genes suggest different roles for members of different Hox clusters. Development 117, 1397-1407.[Abstract]

Stratford, T., Horton, C. and Maden, M (1997). Retinoic acid is required for the initiation of outgrowth in the chick limb bud. Curr. Biol 6, 1124-1133.

Sucov, H. M., Murakami, K. K. and Evans, R. M (1990). Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene. Proc. Natl Acad. Sci. USA 87, 5392-5396.[Abstract/Free Full Text]

Summerbell, D (1983). The effect of local application of retinoic acid to the anterior margin of the developing chick limb bud. J. Embryol. Exp. Morph 78, 269-289.[Medline]

Summerbell, D., Lewis, J. and Wolpert, L (1973). Positional information in chick limb morphogenesis. Nature 224, 492-496.

Swindell, E. C., Thaller, C., Sockanathan, S., Petkovich, M., Jessell, T. M. and Eichele, G (1999). Complementary domains of retinoic acid production and degradation in the early chick embryo. Dev. Biol 216, 282-296.[Medline]

Tamura, K., Yokouchi, Y., Kuroiwa, A. and Ide, H (1997). Retinoic acid changes the proximodistal developmental competence and affinity of distal cells in the developing chick limb bud. Dev. Biol 188, 224-234.[Medline]

Tickle, C., Alberts, B., Wolpert, L. and Lee, J (1982). Local application of retinoic acid to the limb bond mimics the action of the polarizing region. Nature 296, 564-566.[Medline]

Tickle, C., Crawley, A. and Farrar, J (1989). Retinoic acid application to chick wing buds leads to a dose-dependent reorganization of the apical ectodermal ridge that is mediated by the mesenchyme. Development 106, 691-705.[Abstract/Free Full Text]

Tickle, C. and Eichele, G (1994). Vertebrate limb development. Annu. Rev. Cell Biol 10, 121-152.

Tickle, C., Lee, J. and Eichele, G (1985). A quantitative analysis of the effect of all-trans-retinoic acid on the pattern of chick wing development. Dev. Biol 109, 82-95.[Medline]

Vogel, A., Rodriguez, C. and Izpis\234a-Belmonte, J. C (1996). Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122, 1737-1750.[Abstract]

Wilkinson, D. G. and Nieto, M. A (1993). Detection of messenger RNA by in situ hybridization to tissue sections and whole mount. Methods Enzymol 225, 361-373.[Medline]

This article has been cited by other articles:

J. L. Galloway and C. J. Tabin
Classic limb patterning models and the work of Dennis Summerbell
Development, August 15, 2008; 135(16): 2683 - 2687.
[Abstract] [Full Text] [PDF]

A.-M. Teichert, J. A. Scott, G. B. Robb, Y.-Q. Zhou, S.-N. Zhu, M. Lem, A. Keightley, B. M. Steer, A. C. Schuh, S. L. Adamson, et al.
Endothelial Nitric Oxide Synthase Gene Expression During Murine Embryogenesis: Commencement of Expression in the Embryo Occurs With the Establishment of a Unidirectional Circulatory System
Circ. Res., July 3, 2008; 103(1): 24 - 33.
[Abstract] [Full Text] [PDF]

P. Lu, Y. Yu, Y. Perdue, and Z. Werb
The apical ectodermal ridge is a timer for generating distal limb progenitors
Development, April 15, 2008; 135(8): 1395 - 1405.
[Abstract] [Full Text] [PDF]

Y. Ishimaru, T. Komatsu, M. Kasahara, Y. Katoh-Fukui, H. Ogawa, Y. Toyama, M. Maekawa, K. Toshimori, R. A. S. Chandraratna, K.-i. Morohashi, et al.
Mechanism of asymmetric ovarian development in chick embryos
Development, February 15, 2008; 135(4): 677 - 685.
[Abstract] [Full Text] [PDF]

S. Pascoal and I. Palmeirim
Watch-ing out for chick limb development
Integr. Comp. Biol., September 1, 2007; 47(3): 382 - 389.
[Abstract] [Full Text] [PDF]

C. Tabin and L. Wolpert
Rethinking the proximodistal axis of the vertebrate limb in the molecular era
Genes & Dev., June 15, 2007; 21(12): 1433 - 1442.
[Full Text] [PDF]

C. L. Stoick-Cooper, R. T. Moon, and G. Weidinger
Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine
Genes & Dev., June 1, 2007; 21(11): 1292 - 1315.
[Abstract] [Full Text] [PDF]

N. Mercader, E. M. Tanaka, and M. Torres
Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins
Development, September 15, 2005; 132(18): 4131 - 4142.
[Abstract] [Full Text] [PDF]

T. M. Williams, M. E. Williams, J. H. Heaton, T. D. Gelehrter, and J. W. Innis
Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability
Nucleic Acids Res., August 8, 2005; 33(14): 4475 - 4484.
[Abstract] [Full Text] [PDF]

Y. Kida, Y. Maeda, T. Shiraishi, T. Suzuki, and T. Ogura
Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis
Development, September 1, 2004; 131(17): 4179 - 4187.
[Abstract] [Full Text] [PDF]

M. Marklund, M. Sjodal, B. C. Beehler, T. M. Jessell, T. Edlund, and L. Gunhaga
Retinoic acid signalling specifies intermediate character in the developing telencephalon
Development, September 1, 2004; 131(17): 4323 - 4332.
[Abstract] [Full Text] [PDF]

J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al.
Functional Genomics of Lung Disease
Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2/S1): S1 - S81.
[Full Text] [PDF]

F. A. Mic, I. O. Sirbu, and G. Duester
Retinoic Acid Synthesis Controlled by Raldh2 Is Required Early for Limb Bud Initiation and Then Later as a Proximodistal Signal during Apical Ectodermal Ridge Formation
J. Biol. Chem., June 18, 2004; 279(25): 26698 - 26706.
[Abstract] [Full Text] [PDF]

E. Coen, A.-G. Rolland-Lagan, M. Matthews, J. A. Bangham, and P. Prusinkiewicz
Inaugural Article: The genetics of geometry
PNAS, April 6, 2004; 101(14): 4728 - 4735.
[Abstract] [Full Text] [PDF]

H. Huang, M. Paliouras, I. Rambaldi, P. Lasko, and M. Featherstone
Nonmuscle Myosin Promotes Cytoplasmic Localization of PBX
Mol. Cell. Biol., May 15, 2003; 23(10): 3636 - 3645.
[Abstract] [Full Text] [PDF]

A. Marcil, E. Dumontier, M. Chamberland, S. A. Camper, and J. Drouin
Pitx1 and Pitx2 are required for development of hindlimb buds
Development, January 1, 2003; 130(1): 45 - 55.
[Abstract] [Full Text] [PDF]

K. Niederreither, J. Vermot, B. Schuhbaur, P. Chambon, and P. Dolle
Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse
Development, August 1, 2002; 129(15): 3563 - 3574.
[Abstract] [Full Text] [PDF]

R. Maeda, A. Ishimura, K. Mood, E. K. Park, A. M. Buchberg, and I. O. Daar
Xpbx1b and Xmeis1b play a collaborative role in hindbrain and neural crest gene expression in Xenopus embryos
PNAS, April 16, 2002; 99(8): 5448 - 5453.
[Abstract] [Full Text] [PDF]

A. J. Waskiewicz, H. A. Rikhof, R. E. Hernandez, and C. B. Moens
Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning
Development, November 1, 2001; 128(21): 4139 - 4151.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Mercader, N.

Articles by Torres, M.

Search for Related Content

PubMed

PubMed Citation

Articles by Mercader, N.

Articles by Torres, M.

				A.-M. Teichert, J. A. Scott, G. B. Robb, Y.-Q. Zhou, S.-N. Zhu, M. Lem, A. Keightley, B. M. Steer, A. C. Schuh, S. L. Adamson, et al. Endothelial Nitric Oxide Synthase Gene Expression During Murine Embryogenesis: Commencement of Expression in the Embryo Occurs With the Establishment of a Unidirectional Circulatory System Circ. Res., July 3, 2008; 103(1): 24 - 33. [Abstract] [Full Text] [PDF]

				P. Lu, Y. Yu, Y. Perdue, and Z. Werb The apical ectodermal ridge is a timer for generating distal limb progenitors Development, April 15, 2008; 135(8): 1395 - 1405. [Abstract] [Full Text] [PDF]

				Y. Ishimaru, T. Komatsu, M. Kasahara, Y. Katoh-Fukui, H. Ogawa, Y. Toyama, M. Maekawa, K. Toshimori, R. A. S. Chandraratna, K.-i. Morohashi, et al. Mechanism of asymmetric ovarian development in chick embryos Development, February 15, 2008; 135(4): 677 - 685. [Abstract] [Full Text] [PDF]

				S. Pascoal and I. Palmeirim Watch-ing out for chick limb development Integr. Comp. Biol., September 1, 2007; 47(3): 382 - 389. [Abstract] [Full Text] [PDF]

				C. Tabin and L. Wolpert Rethinking the proximodistal axis of the vertebrate limb in the molecular era Genes & Dev., June 15, 2007; 21(12): 1433 - 1442. [Full Text] [PDF]

				C. L. Stoick-Cooper, R. T. Moon, and G. Weidinger Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine Genes & Dev., June 1, 2007; 21(11): 1292 - 1315. [Abstract] [Full Text] [PDF]

				N. Mercader, E. M. Tanaka, and M. Torres Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins Development, September 15, 2005; 132(18): 4131 - 4142. [Abstract] [Full Text] [PDF]

				T. M. Williams, M. E. Williams, J. H. Heaton, T. D. Gelehrter, and J. W. Innis Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability Nucleic Acids Res., August 8, 2005; 33(14): 4475 - 4484. [Abstract] [Full Text] [PDF]

				Y. Kida, Y. Maeda, T. Shiraishi, T. Suzuki, and T. Ogura Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis Development, September 1, 2004; 131(17): 4179 - 4187. [Abstract] [Full Text] [PDF]

				M. Marklund, M. Sjodal, B. C. Beehler, T. M. Jessell, T. Edlund, and L. Gunhaga Retinoic acid signalling specifies intermediate character in the developing telencephalon Development, September 1, 2004; 131(17): 4323 - 4332. [Abstract] [Full Text] [PDF]

				J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al. Functional Genomics of Lung Disease Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2/S1): S1 - S81. [Full Text] [PDF]

				F. A. Mic, I. O. Sirbu, and G. Duester Retinoic Acid Synthesis Controlled by Raldh2 Is Required Early for Limb Bud Initiation and Then Later as a Proximodistal Signal during Apical Ectodermal Ridge Formation J. Biol. Chem., June 18, 2004; 279(25): 26698 - 26706. [Abstract] [Full Text] [PDF]

				E. Coen, A.-G. Rolland-Lagan, M. Matthews, J. A. Bangham, and P. Prusinkiewicz Inaugural Article: The genetics of geometry PNAS, April 6, 2004; 101(14): 4728 - 4735. [Abstract] [Full Text] [PDF]

				H. Huang, M. Paliouras, I. Rambaldi, P. Lasko, and M. Featherstone Nonmuscle Myosin Promotes Cytoplasmic Localization of PBX Mol. Cell. Biol., May 15, 2003; 23(10): 3636 - 3645. [Abstract] [Full Text] [PDF]

				A. Marcil, E. Dumontier, M. Chamberland, S. A. Camper, and J. Drouin Pitx1 and Pitx2 are required for development of hindlimb buds Development, January 1, 2003; 130(1): 45 - 55. [Abstract] [Full Text] [PDF]

				K. Niederreither, J. Vermot, B. Schuhbaur, P. Chambon, and P. Dolle Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse Development, August 1, 2002; 129(15): 3563 - 3574. [Abstract] [Full Text] [PDF]

				R. Maeda, A. Ishimura, K. Mood, E. K. Park, A. M. Buchberg, and I. O. Daar Xpbx1b and Xmeis1b play a collaborative role in hindbrain and neural crest gene expression in Xenopus embryos PNAS, April 16, 2002; 99(8): 5448 - 5453. [Abstract] [Full Text] [PDF]

				A. J. Waskiewicz, H. A. Rikhof, R. E. Hernandez, and C. B. Moens Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning Development, November 1, 2001; 128(21): 4139 - 4151. [Abstract] [Full Text] [PDF]