Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus

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Akimaru, H., Chen, Y., Dai, P., H, D.-X., Nonaka, M., Smolik, S.M., Armstrong, S., Goodman, R. and Ishii, S (1997). Drosophila CBP is a co-activator of Cubitus interruptus in hedgehog signaling. Nature 386, 735-738.[Medline]

Alcedo, J. and Noll, M (1997). Hedgehog and its Patched-Smoothened receptor complex: a novel signaling mechanism at the cell surface. Biol. Chem 378, 583-590.

Alves, G., Limbourg-Bouchon, B., Tricoire, H., Brissard-Zahraoui, J., Lamour-Isnard, C., Busson, D (1998). Modulation of Hedgehog target gene expression by the Fused serine\320threonine kinase in wing imaginal discs. Mech. Dev 78, 17-31.[Medline]

Aza-Blanc, P., Ramirez-Weber, F. A., Laget, M. P., Schwartz, C. and Kornberg, T. B (1997). Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053.[Medline]

Aza-Blanc, P. and Kornberg, T. B (1999). Ci: a complex transducer of the hedgehog signal. Trends in Genetics 15, 458-462.[Medline]

Bhanot, P., Brink, M., Harryman Samos, C., Hsieh, J.-C., Wang, Y., Macke, J. P., Andrew, D., Nathans, J. and Nusse, R (1996). A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382, 225-230.[Medline]

Brand, A. H. and Perrimon, N (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.[Abstract]

Chen, C.-H., von Kessler, D., Park, W., Wang, B., Ma, Y. and Beachy, P. A (1999). Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 98, 305-316.[Medline]

Chen, Y., Gallaher, N., Goodman, R. H. and Smolik, S. M (1998). Protein kinase A directly regulates the activity and proteolysis of Cubitus interruptus. Proc. Natl. Acad. Sci. USA 95, 2349-2354.[Abstract/Free Full Text]

Chen, Y. and Struhl G (1996). Dual roles for Patched in sequestering and transducing Hedgehog. Cell 87, 553-563.[Medline]

Chen, Y., Cardinaux, J.-R., Goodman, R. H. and Smolik, S. M (1999). Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling. Development 126, 3607-3616.[Abstract]

Dominguez, M., Brunner, M., Hafen, E. and Basler, K (1996). Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-1625.[Abstract]

Forbes A. J., Nakano Y., Taylor A. M. and Ingham P. W (1993). Genetic analysis of hedgehog signaling in the Drosophila embryo. Development 1993, 115-124.

Hepker, J., Wang, Q.-T., Motzny, C. K., Holmgren, R. and Orenic, T. V (1997). Drosophilacubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124, 549-558.[Abstract]

Ingham, P. W (1998). Transducing Hedgehog: the story so far. EMBO J 17, 3505-3511.[Medline]

Jiang, J. and Struhl, G (1995). Protein Kinase A and Hedgehog signaling in Drosophila Limb Development. Cell 80, 563-572.[Medline]

Jiang J. and Struhl, G (1998). Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493-496.[Medline]

Lane, M. E. and Kalderon, D (1993). Genetic investigation of cAMP-dependent protein kinase function in Drosophila Development. Genes Dev 7, 1229-1243.[Abstract/Free Full Text]

Lawrence, P. A. and Struhl, G (1996). Morphogens, compartments, and pattern: lessons from Drosophila?. Cell 85, 951-961.[Medline]

Lee, J. J., von Kessler, D. P., Parks, S. and Beachy, P. A (1992). Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71, 33-50.[Medline]

Li, W., Ohlmeyer, J. T., Lane, M. E. and Kalderon, D (1995). Function of Protein Kinase A in Hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553-562.[Medline]

McMahon, A (2000). More surprises in the hedgehog signaling pathway. Cell 100, 185-188.[Medline]

Methot, N. and Basler, K (1999). Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96, 819-831.[Medline]

Monnier, V., Dussillol, F., Alves, G., Lamour-Isnard, C. and Plessis, A (1998). Molecular interactions between three members of the Drosophila Hedgehog signaling pathway: Supressor of fused links the ser-thr kinase Fused and the transcription factor Cubitus interruptus. Curr. Biol 8, 583-586.[Medline]

Neumann, C. and Cohen, S (1997). Morphogens and pattern formation. Bioessays 19, 721-729.[Medline]

Ohlmeyer, J. T. and Kalderon, D (1997). Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev 11, 2250-2258.[Abstract/Free Full Text]

Ohlmeyer, J. T. and Kalderon, D (1998). Hedgehog stimulates thematuration of Cubitus interruptus into a labile transcriptional activator. Nature 396, 749-753.[Medline]

Orenic, T. V., Slusarski, D. C., Kroll, K. L. and Holmgren, R. A (1990). Cloning and characterization of the segment polarity gene Cubitus interruptus Dominant of Drosophila. Genes Dev 4, 1053-1067.[Abstract/Free Full Text]

Price, M. A. and Kalderon, D (1999). Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by Protein Kinase A. Development 126, 4331-4339.[Abstract]

Pignoni F. and Zipursky, S. L (1997). Induction of Drosophila eye development by decapentaplegic. Development 124, 271-278.[Abstract]

Preat, T., Therond, P., Lamour-Isnard, C., Limbourg-Bouchon, B., Tricoire, H., Erk, I., Mariol, M. C. and Busson, D (1990). A putative serine/threonine protein kinase encoded by the segment polarity fused gene of Drosophila. Nature 347, 87-89.[Medline]

Preat, T (1992). Characterization of Supressor of fused , a complete supressor of the fused segment polarity gene of Drosophila melanogaster. Genetics 132, 725-736.[Abstract]

Preat, T., Therond, P., Limbourg-Bouchon, B., Pham, A., Tricoire, H., Busson, D. and Lamour-Isnard, C (1993). Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2. Genetics 135, 1047-1062.[Abstract]

Robbins, D. J., Nybakken, K. E., Kobayashi, R., Sisson, J. C., Bishop, J. M. and Therond, P. P (1997). Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein Costal2. Cell 90, 225-234.[Medline]

Ruiz i Altaba, A (1999). Gli proteins and Hedgehog signaling in development and cancer. Trends Gen 15, 418-425.[Medline]

Sanicola, M., Sekelsky, J., Elson, S. and Gelbart, W. M (1995). Drawing a stripe in Drosophila imaginal disks: negative regulation of decapentaplegic and patched expression by engrailed. Genetics 139, 745-756.[Abstract]

Sisson, J. C., Ho, K. S., Suyama, K. and Scott, M. P (1997). Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 90, 235-245.[Medline]

Therond, P., Alves, G., Limbourg-Bouchon, B., Tricoire, H., Guillemet, E., Brissard-Zahraoui, J., Lamour-Isnard C. and Busson, D (1996). Functional domains of Fused, a serine-threonine kinase required for signaling in Drosophila. Genetics 142, 1181-1198.[Abstract]

Therond, P. P., Limbourg-Bouchon, B., Gallet, A., Dussilol, F., Pietri, T., van den Heuvel, M. and Tricoire, H (1999). Differential requirements of the Fused kinase for Hedgehog signaling in the Drosophila embryo. Development 126, 4039-4051.[Abstract]

Wang, G., Wang, B. and Jiang, J (1999). Protein Kinase A antagonized Hedgehog signaling by regulating both activator and repressor forms of Cubitus interruptus. Genes Dev 13, 2828-2837.[Abstract/Free Full Text]

Wang, Q. and Holmgren, R (1999). The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels. Development 126, 5097-5106.[Abstract]

Xu, T. and Rubin, G. M (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.[Abstract]

Zecca, M., Basler, K. and Struhl, G (1995). Sequential organizing activities of engrailed , hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265-2278.[Abstract]

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				M. Varjosalo and J. Taipale Hedgehog: functions and mechanisms Genes & Dev., September 15, 2008; 22(18): 2454 - 2472. [Abstract] [Full Text] [PDF]

				L. Ruel, A. Gallet, S. Raisin, A. Truchi, L. Staccini-Lavenant, A. Cervantes, and P. P. Therond Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling Development, October 15, 2007; 134(20): 3677 - 3689. [Abstract] [Full Text] [PDF]

				Y. Liu, X. Cao, J. Jiang, and J. Jia Fused Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation Genes & Dev., August 1, 2007; 21(15): 1949 - 1963. [Abstract] [Full Text] [PDF]

				S. L. Walthall, M. Moses, and J. I. Horabin A large complex containing Patched and Smoothened initiates Hedgehog signaling in Drosophila J. Cell Sci., March 1, 2007; 120(5): 826 - 837. [Abstract] [Full Text] [PDF]

				S. Martin-Lanneree, C. Lasbleiz, M. Sanial, S. Fouix, F. Besse, H. Tricoire, and A. Plessis Characterization of the Drosophila myeloid leukemia factor Genes Cells, December 1, 2006; 11(12): 1317 - 1335. [Abstract] [Full Text] [PDF]

				Q. Zhou, S. Apionishev, and D. Kalderon The Contributions of Protein Kinase A and Smoothened Phosphorylation to Hedgehog Signal Transduction in Drosophila melanogaster Genetics, August 1, 2006; 173(4): 2049 - 2062. [Abstract] [Full Text] [PDF]

				D. Tempe, M. Casas, S. Karaz, M.-F. Blanchet-Tournier, and J.-P. Concordet Multisite Protein Kinase A and Glycogen Synthase Kinase 3{beta} Phosphorylation Leads to Gli3 Ubiquitination by SCF{beta}TrCP. Mol. Cell. Biol., June 1, 2006; 26(11): 4316 - 4326. [Abstract] [Full Text] [PDF]

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				J. F. Reiter and W. C. Skarnes Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition Genes & Dev., January 1, 2006; 20(1): 22 - 27. [Abstract] [Full Text] [PDF]

				A. F. Cooper, K. P. Yu, M. Brueckner, L. L. Brailey, L. Johnson, J. M. McGrath, and A. E. Bale Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused Development, October 1, 2005; 132(19): 4407 - 4417. [Abstract] [Full Text] [PDF]

				M.-H. Chen, N. Gao, T. Kawakami, and P.-T. Chuang Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development Mol. Cell. Biol., August 15, 2005; 25(16): 7042 - 7053. [Abstract] [Full Text] [PDF]

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				K. S. Ho, K. Suyama, M. Fish, and M. P. Scott Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused Development, March 15, 2005; 132(6): 1401 - 1412. [Abstract] [Full Text] [PDF]

				C. Zhang, E. H. Williams, Y. Guo, L. Lum, and P. A. Beachy Inaugural Article: Extensive phosphorylation of Smoothened in Hedgehog pathway activation PNAS, December 28, 2004; 101(52): 17900 - 17907. [Abstract] [Full Text] [PDF]

				M. Ascano Jr. and D. J. Robbins An Intramolecular Association between Two Domains of the Protein Kinase Fused Is Necessary for Hedgehog Signaling Mol. Cell. Biol., December 1, 2004; 24(23): 10397 - 10405. [Abstract] [Full Text] [PDF]

				M. Merchant, F. F. Vajdos, M. Ultsch, H. R. Maun, U. Wendt, J. Cannon, W. Desmarais, R. A. Lazarus, A. M. de Vos, and F. J. de Sauvage Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism Mol. Cell. Biol., October 1, 2004; 24(19): 8627 - 8641. [Abstract] [Full Text] [PDF]

				L. Lum and P. A. Beachy The Hedgehog Response Network: Sensors, Switches, and Routers Science, June 18, 2004; 304(5678): 1755 - 1759. [Abstract] [Full Text] [PDF]

				K. Sekimizu, N. Nishioka, H. Sasaki, H. Takeda, R. O. Karlstrom, and A. Kawakami The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling Development, June 1, 2004; 131(11): 2521 - 2532. [Abstract] [Full Text] [PDF]

				C. Kwon, R. Hays, J. Fetting, and T. V. Orenic Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc Development, June 1, 2004; 131(11): 2681 - 2692. [Abstract] [Full Text] [PDF]

				M. A. Stegman, J. A. Goetz, M. Ascano Jr., S. K. Ogden, K. E. Nybakken, and D. J. Robbins The Kinesin-related Protein Costal2 Associates with Membranes in a Hedgehog-sensitive, Smoothened-independent Manner J. Biol. Chem., February 20, 2004; 279(8): 7064 - 7071. [Abstract] [Full Text] [PDF]

				J. I. Horabin, S. Walthall, C. Vied, and M. Moses A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch Development, December 15, 2003; 130(24): 6101 - 6109. [Abstract] [Full Text] [PDF]

				J. Jia, C. Tong, and J. Jiang Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail Genes & Dev., November 1, 2003; 17(21): 2709 - 2720. [Abstract] [Full Text] [PDF]

				J. E. Hooper Smoothened translates Hedgehog levels into distinct responses Development, September 1, 2003; 130(17): 3951 - 3963. [Abstract] [Full Text] [PDF]

				M. Dunaeva, P. Michelson, P. Kogerman, and R. Toftgard Characterization of the Physical Interaction of Gli Proteins with SUFU Proteins J. Biol. Chem., February 7, 2003; 278(7): 5116 - 5122. [Abstract] [Full Text] [PDF]

				J. Mao, P. Maye, P. Kogerman, F. J. Tejedor, R. Toftgard, W. Xie, G. Wu, and D. Wu Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1 J. Biol. Chem., September 13, 2002; 277(38): 35156 - 35161. [Abstract] [Full Text] [PDF]

				S. Y. Cheng and J. M. Bishop Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex PNAS, April 16, 2002; 99(8): 5442 - 5447. [Abstract] [Full Text] [PDF]

				M. Ascano Jr., K. E. Nybakken, J. Sosinski, M. A. Stegman, and D. J. Robbins The Carboxyl-Terminal Domain of the Protein Kinase Fused Can Function as a Dominant Inhibitor of Hedgehog Signaling Mol. Cell. Biol., March 1, 2002; 22(5): 1555 - 1566. [Abstract] [Full Text] [PDF]

				Y. Apidianakis, D. Grbavec, S. Stifani, and C. Delidakis Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch Development, November 1, 2001; 128(21): 4361 - 4370. [Abstract] [Full Text] [PDF]

				X. Meng, R. Poon, X. Zhang, A. Cheah, Q. Ding, C.-c. Hui, and B. Alman Suppressor of Fused Negatively Regulates beta -Catenin Signaling J. Biol. Chem., October 19, 2001; 276(43): 40113 - 40119. [Abstract] [Full Text] [PDF]