The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Chavez, V. M.
	Articles by O'Connor, M. B.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Chavez, V. M.
	Articles by O'Connor, M. B.

Aribi, N., Pitoizet, N., Quennedey, A. and Delbecque, J. P (1997). 2-Deoxyecdysone is a circulating ecdysteroid in the beetle Zophobas atratus. Biochim. Biophys. Acta 1335, 246-252.[Medline]

Ashburner, M., Chihara, C., Meltzer, P. and Richards, G (1974). Temporal control of puffing activity in polytene chromosomes. Cold Spring Harb Symp Quant Biol 38, 655-662.[Medline]

Audit-Lamour, C. and Busson, D (1981). Oogenesis defects in the ecd-1 mutant of Drosophila melanogaster , deficient in ecdysteroid at high temperature. J. Insect Physiol 27, 829-837.

Bender, M., Imam, F. B., Talbot, W. S., Ganetzky, B. and Hogness, D. S (1997). Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms. Cell 91, 777-788.[Medline]

Bilder, D. and Scott, M. P (1995). Genomic regions required for morphogenesis of the Drosophila embryonic midgut. Genetics 141, 1087-1100.[Abstract]

Birr, C. A., Fristrom, D., King, D. S. and Fristrom, J. W (1990). Ecdysone-dependent proteolysis of an apical surface glycoprotein may play a role in imaginal disc morphogenesis in Drosophila. Development 110, 239-248.[Abstract]

Bownes, M., Shirras, A., Blair, M., Collins, J. and Coulson, A (1988). Evidence that insect embryogenesis is regulated by ecdysteroids released from yolk proteins. Proc. Natl. Acad. Sci. USA 85, 1554-1557.[Abstract/Free Full Text]

Brennan, C. A., Ashburner, M. and Moses, K (1998). Ecdysone pathway is required for furrow progression in the developing Drosophila eye. Development 125, 2653-2664.[Abstract]

Buszczak, M., Freeman, M. R., Carlson, J. R., Bender, M., Cooley, L. and Segraves, W. A (1999). Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Development 126, 4581-4589.[Abstract]

Chen, K. S., Prahl, J. M. and DeLuca, H. F (1993). Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA. Proc. Natl. Acad. Sci. USA 90, 4543-4547.[Abstract/Free Full Text]

Dinan, L (1997). Ecdysteroids in adults and eggs of the house cricket, Acheta domesticus (Orthoptera: Gryllidae). Comp. Biochem. Physiol 116, 129-135.

Doctor, J., Fristrom, D. and Fristrom, J. W (1985). The pupal cuticle of Drosophila: Biphasic synthesis of pupal cuticle proteins in vivo and in vitro in response to 20-hyroxyecdysone. J. Cell Biol 101, 189-200.[Abstract/Free Full Text]

Freeman, M. R., Dobritsa, A., Gaines, P., Segraves, W. A. and Carlson, J. R (1999). The dare gene: steroid hormone production, olfactory behavior, and neural degeneration in Drosophila. Development 126, 4591-4602.[Abstract]

Fristrom, D. and Liebrich, W (1986). The hormonal coordination of cuticulin deposition and morphogenesis in Drosophila imaginal discs in vivo and in vitro. Dev. Biol 114, 1-11.[Medline]

Fristrom, J. W., Doctor, J., Fristrom, D. K., Logan, W. R. and Silvert, D. J (1982). The formation of the pupal cuticle by Drosophila imaginal disks in vivo. Dev. Biol 91, 337-350.[Medline]

Garen, A., Kauvar, L. and Lepesant, J.-A (1977). Roles of ecdysone in Drosophila development. Proc. Natl. Acad. Sci.USA 74, 5099-5103.[Abstract/Free Full Text]

Grieneisen, M. L (1994). Recent advances in our knowledge of ecdysteroid biosynthesis in insects and crustaceans. Insect Biochem. Molec. Biol 24, 115-132.

Grieneisen, M. L., Warren, J. T. and Gilbert, L. I (1993). Early steps in ecdysteroid biosynthesis: evidence for the involvement of cytochrome P-450 enzymes. Insect Biochem. Mol. Biol 23, 13-23.[Medline]

Hall, B. L. and Thummel, C. S (1998). The RXR homolog ultraspiracle is an essential component of the Drosophila ecdysone receptor. Development 125, 4709-4717.[Abstract]

Harrison, S. D., Solomon, N. and Rubin, G. M (1995). A genetic analysisof the 63E-64A genomic region of Drosophila melanogaster: identification of mutations in a replication factor C subunit. Genetics 139, 1701-1709.[Abstract]

Hillman, R. and Lesnick, L. H (1990). Cuticle formation in the embryo of Drosophila melanogaster. J. Morphol 131, 383-396.

Horner, M. A., Chen, T. and Thummel, C. S (1995). Ecdysteroid regulationand DNA binding properties of Drosophila nuclear hormone receptor superfamily members. Dev. Biol 168, 490-502.[Medline]

Kappler, C., Kabbouh, M., Durst, F. and Hoffmann, J. A (1986). Studies on the C-2 hydroxylation of 2-deoxyecdysone in Locusta migratoria. Insect Biochem 16, 25-32.

Kappler, C., Kabbouh, M., Hetru, C., Durst, F. and Hoffmann, J. A (1988). Characterization of three hydroxylases involved in the final steps of biosynthesis of the steroid hormone ecdysone in Locusta migratoria (Insecta, Orthoptera). J. Steroid Biochem 31, 891-898.[Medline]

Lagueux, M., Harry, P. and Hoffmann, J. A (1981). Ecdusterpods are bound to vitellin in newly laid eggs of Locusta. Mol. Cell. Endocrin 24, 325-338.[Medline]

Lagueux, M., Hirn, M. and Hoffmann, J. A (1977). Ecdysone during ovarian development in Locusta migratoria. J. Insect. Physiol 23, 109-119.[Medline]

Maroy, P., Kaufmann, G. and Dubendorfer, A (1988). Embryonic ecdysteroids of Drosophila melanogaster. J. Insect. Physiol 34, 633-637.

Miller, W. L (1988). Molecular biology of steroid hormone synthesis. Endocr. Rev 9, 295-318.[Medline]

Natzle, J. E (1993). Temporal regulation of Drosophila imaginal disc morphogenesis: a hierarchy of primary and secondary 20-hydroxyecdysone-responsive loci. Dev. Biol 155, 516-532.[Medline]

Natzle, J. E., Fristrom, D. K. and Fristrom, J. W (1988). Genes expressed during imaginal disc morphogenesis: IMP-E1, a gene associated with epithelial cell rearrangement. Dev. Biol 129, 428-438.[Medline]

Natzle, J. E., Hammonds, A. S. and Fristrom, J. W (1986). Isolation of genes active during hormone-induced morphogenesis in Drosophila imaginal discs. J. Biol. Chem 261, 5575-5583.[Abstract/Free Full Text]

Natzle, J. E., Robertson, J. P., Majumdar, A., Vesenka, G. D., Enlow, B. and Clark, K. E (1992). Sequence and expression of IMP-L1, an ecdysone-inducible gene expressed during Drosophila imaginal disc morphogenesis. Dev. Genet 13, 331-344.[Medline]

Omura, T. and Ito, A (1991). Biosynthesis and intracellular sorting of mitochondrial forms of cytochrome P450. Methods Enzymol 206, 75-81.[Medline]

Oro, A. E., McKeown, M. and Evans, R. M (1992). The Drosophila retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis. Development 115, 449-462.[Abstract]

Paine-Saunders, S., Fristrom, D. and Fristrom, J. W (1990). The Drosophila IMP-E2 gene encodes an apically secreted protein expressed during imaginal disc morphogenesis. Dev. Biol 140, 337-351.[Medline]

Pascual, N., Belles, X., Delbecque, J. P., Hua, Y. J. and Koolman, J (1995). Quantification of ecdysteroids by immunoassay: comparison of enzyme immunoassay and radioimmunoassay. Z. Naturforsch. [C] 50, 862-7.

Pino-Heiss, S. and Schubiger, G (1989). Extracellular protease production by Drosophila imaginal discs. Dev. Biol 132, 282-291.[Medline]

Porcheron, P., Moriniere, M., Grassi, J. and Pradelles, P (1989). Development of an enzyme immunoassay for ecdysteroids using acetylcholinesterase as label. Insect Biochem 19, 117-122.

Richards, G (1981). The radioimmune assay of ecdysteroid titres in Drosophila melanogaster. Mol. Cell. Endocrinol 21, 181-197.[Medline]

Rickoll, W. L. and Fristrom, J. W (1983). The effects of 20-hydroxyecdysone on the metabolic labeling of membrane proteins in Drosophila imaginal discs. Dev. Biol 95, 275-287.[Medline]

Sater, A. K., Woods, D. F. and Poodry, C. A (1984). Cell surface proteins of Drosophila. II. A comparison of embryonic and ecdysone-induced proteins. Dev. Biol 104, 1-8.[Medline]

Schubiger, M., Wade, A. A., Carney, G. E., Truman, J. W. and Bender, M (1998). Drosophila EcR-B ecdysone receptor isoforms are required for larval molting and for neuron remodeling during metamorphosis. Development 125, 2053-2062.[Abstract]

Schwartz, M. B., Imberski, R. B. and Kelly, T. J (1984). Analysis ofmetamorphosis in Drosophila melanogaster: characterization of giant, an ecdysteroid-deficient mutant. Dev. Biol 103, 85-95.[Medline]

Sliter, T. J. and Gilbert, L. I (1992). Developmental arrest and ecdysteroid deficiency resulting from mutations at the dre4 locus of Drosophila. Genetics 130, 555-68.[Abstract]

Talbot, W. S., Swyryd, E. A. and Hogness, D. S (1993). Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Cell 73, 1323-37.[Medline]

Tawfik, A. I., Vedrov\207, A. and Sehnal, F (1999). Ecdysteroids during ovarian development and embryogenesis in solitary and gregarious Schistocerca gregaria. Arch. Insect Biochem. Physiol 41, 134-143.[Medline]

Thummel, C. S (1995). From embryogenesis to metamorphosis: the regulation and function of Drosophila nuclear receptor superfamily members. Cell 83, 871-877.[Medline]

Truman, J. W (1996). Steroid receptors and nervous system metamorphosis in insects. Dev. Neurosci 18, 87-101.[Medline]

Walker, V. K., Watson, K. L., Holden, J. A. and Steel, C. H (1987). Vitellogenesis and fertility in Drosophila females with low ecdysteroid titres: The l(3)3DTS mutation. J. Insect Physiol 33, 137-142.

Warren, J. T., Bachmann, J. S., Dai, J. D. and Gilbert, L. I (1996). Differential incorporation of cholesterol and cholesterol derivatives into ecdysteroids by the larval ring glands and adult ovaries of Drosophila melanogaster: a putative explanation for the l(3)ecd1 mutation. Insect Biochem. Mol. Biol 26, 931-943.[Medline]

Winter, J., Bilbe, G., Richener, H., Sehringer, B. and Kayser, H (1999). Cloning of a cDNA encoding a novel cytochrome P450 from the insect Locusta migratoria: CYP6H1, a putative ecdysone 20-hydroxylase. Biochem. Biophys. Res. Commun 259, 305-310.[Medline]

Yao, T. P., Segraves, W. A., Oro, A. E., McKeown, M. and Evans, R. M (1992). Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. Cell 71, 63-72.[Medline]

Zho, X. X., Gfeller, H. and Lanzerin, B (1983). Ecdysteroids during oogenesis in the ovoviviparous cockroach Nauophoeta cinerea. J. Insect Physiol 29, 225-235.

This article has been cited by other articles:

A. Talamillo, J. Sanchez, R. Cantera, C. Perez, D. Martin, E. Caminero, and R. Barrio
Smt3 is required for Drosophila melanogaster metamorphosis
Development, May 1, 2008; 135(9): 1659 - 1668.
[Abstract] [Full Text] [PDF]

X. Huang, J. T. Warren, J. Buchanan, L. I. Gilbert, and M. P. Scott
Drosophila Niemann-Pick Type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease
Development, October 15, 2007; 134(20): 3733 - 3742.
[Abstract] [Full Text] [PDF]

H. Sonobe, T. Ohira, K. Ieki, S. Maeda, Y. Ito, M. Ajimura, K. Mita, H. Matsumoto, and M. N. Wilder
Purification, Kinetic Characterization, and Molecular Cloning of a Novel Enzyme, Ecdysteroid 22-Kinase
J. Biol. Chem., October 6, 2006; 281(40): 29513 - 29524.
[Abstract] [Full Text] [PDF]

L. Palanker, A. S. Necakov, H. M. Sampson, R. Ni, C. Hu, C. S. Thummel, and H. M. Krause
Dynamic regulation of Drosophila nuclear receptor activity in vivo
Development, September 15, 2006; 133(18): 3549 - 3562.
[Abstract] [Full Text] [PDF]

T. Yoshiyama, T. Namiki, K. Mita, H. Kataoka, and R. Niwa
Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth
Development, July 1, 2006; 133(13): 2565 - 2574.
[Abstract] [Full Text] [PDF]

A. Tonning, S. Helms, H. Schwarz, A. E. Uv, and B. Moussian
Hormonal regulation of mummy is needed for apical extracellular matrix formation and epithelial morphogenesis in Drosophila
Development, January 15, 2006; 133(2): 331 - 341.
[Abstract] [Full Text] [PDF]

J. Colombani, L. Bianchini, S. Layalle, E. Pondeville, C. Dauphin-Villemant, C. Antoniewski, C. Carre, S. Noselli, and P. Leopold
Antagonistic Actions of Ecdysone and Insulins Determine Final Size in Drosophila
Science, October 28, 2005; 310(5748): 667 - 670.
[Abstract] [Full Text] [PDF]

R. Niwa, T. Matsuda, T. Yoshiyama, T. Namiki, K. Mita, Y. Fujimoto, and H. Kataoka
CYP306A1, a Cytochrome P450 Enzyme, Is Essential for Ecdysteroid Biosynthesis in the Prothoracic Glands of Bombyx and Drosophila
J. Biol. Chem., August 20, 2004; 279(34): 35942 - 35949.
[Abstract] [Full Text] [PDF]

P. Martin and S. M. Parkhurst
Parallels between tissue repair and embryo morphogenesis
Development, July 1, 2004; 131(13): 3021 - 3034.
[Abstract] [Full Text] [PDF]

I. Gaziova, P. C. Bonnette, V. C. Henrich, and M. Jindra
Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis
Development, June 1, 2004; 131(11): 2715 - 2725.
[Abstract] [Full Text] [PDF]

G. E. Roth, M. S. Gierl, L. Vollborn, M. Meise, R. Lintermann, and G. Korge
The Drosophila gene Start1: A putative cholesterol transporter and key regulator of ecdysteroid synthesis
PNAS, February 10, 2004; 101(6): 1601 - 1606.
[Abstract] [Full Text] [PDF]

A. Petryk, J. T. Warren, G. Marques, M. P. Jarcho, L. I. Gilbert, J. Kahler, J.-P. Parvy, Y. Li, C. Dauphin-Villemant, and M. B. O'Connor
Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone
PNAS, November 25, 2003; 100(24): 13773 - 13778.
[Abstract] [Full Text] [PDF]

A. A. Sullivan and C. S. Thummel
Temporal Profiles of Nuclear Receptor Gene Expression Reveal Coordinate Transcriptional Responses during Drosophila Development
Mol. Endocrinol., November 1, 2003; 17(11): 2125 - 2137.
[Abstract] [Full Text] [PDF]

R. E. Ward, J. Evans, and C. S. Thummel
Genetic Modifier Screens in Drosophila Demonstrate a Role for Rho1 Signaling in Ecdysone-Triggered Imaginal Disc Morphogenesis
Genetics, November 1, 2003; 165(3): 1397 - 1415.
[Abstract] [Full Text] [PDF]

T. Kozlova and C. S. Thummel
Essential Roles for Ecdysone Signaling During Drosophila Mid-Embryonic Development
Science, September 26, 2003; 301(5641): 1911 - 1914.
[Abstract] [Full Text] [PDF]

C. S. Thummel and J. Chory
Steroid signaling in plants and insects---common themes, different pathways
Genes & Dev., December 15, 2002; 16(24): 3113 - 3129.
[Full Text] [PDF]

J. T. Warren, A. Petryk, G. Marques, M. Jarcho, J.-P. Parvy, C. Dauphin-Villemant, M. B. O'Connor, and L. I. Gilbert
Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophilamelanogaster
PNAS, August 20, 2002; 99(17): 11043 - 11048.
[Abstract] [Full Text] [PDF]

K. P. Sem, B. Zahedi, I. Tan, M. Deak, L. Lim, and N. Harden
ACK Family Tyrosine Kinase Activity Is a Component of Dcdc42 Signaling during Dorsal Closure in Drosophila melanogaster
Mol. Cell. Biol., June 1, 2002; 22(11): 3685 - 3697.
[Abstract] [Full Text] [PDF]

T. Kozlova and C. S. Thummel
Spatial patterns of ecdysteroid receptor activation during the onset of Drosophila metamorphosis
Development, January 4, 2002; 129(7): 1739 - 1750.
[Abstract] [Full Text] [PDF]

B. S. Gim, J. M. Park, J. H. Yoon, C. Kang, and Y.-J. Kim
Drosophila Med6 Is Required for Elevated Expression of a Large but Distinct Set of Developmentally Regulated Genes
Mol. Cell. Biol., August 1, 2001; 21(15): 5242 - 5255.
[Abstract] [Full Text] [PDF]

P. V. Benos, M. K. Gatt, L. Murphy, D. Harris, B. Barrell, C. Ferraz, S. Vidal, C. Brun, J. Demaille, E. Cadieu, et al.
From First Base: The Sequence of the Tip of the X Chromosome of Drosophila melanogaster, a Comparison of Two Sequencing Strategies
Genome Res., May 1, 2001; 11(5): 710 - 730.
[Abstract] [Full Text]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Chavez, V. M.

Articles by O'Connor, M. B.

Search for Related Content

PubMed

PubMed Citation

Articles by Chavez, V. M.

Articles by O'Connor, M. B.

				X. Huang, J. T. Warren, J. Buchanan, L. I. Gilbert, and M. P. Scott Drosophila Niemann-Pick Type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease Development, October 15, 2007; 134(20): 3733 - 3742. [Abstract] [Full Text] [PDF]

				H. Sonobe, T. Ohira, K. Ieki, S. Maeda, Y. Ito, M. Ajimura, K. Mita, H. Matsumoto, and M. N. Wilder Purification, Kinetic Characterization, and Molecular Cloning of a Novel Enzyme, Ecdysteroid 22-Kinase J. Biol. Chem., October 6, 2006; 281(40): 29513 - 29524. [Abstract] [Full Text] [PDF]

				L. Palanker, A. S. Necakov, H. M. Sampson, R. Ni, C. Hu, C. S. Thummel, and H. M. Krause Dynamic regulation of Drosophila nuclear receptor activity in vivo Development, September 15, 2006; 133(18): 3549 - 3562. [Abstract] [Full Text] [PDF]

				T. Yoshiyama, T. Namiki, K. Mita, H. Kataoka, and R. Niwa Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth Development, July 1, 2006; 133(13): 2565 - 2574. [Abstract] [Full Text] [PDF]

				A. Tonning, S. Helms, H. Schwarz, A. E. Uv, and B. Moussian Hormonal regulation of mummy is needed for apical extracellular matrix formation and epithelial morphogenesis in Drosophila Development, January 15, 2006; 133(2): 331 - 341. [Abstract] [Full Text] [PDF]

				J. Colombani, L. Bianchini, S. Layalle, E. Pondeville, C. Dauphin-Villemant, C. Antoniewski, C. Carre, S. Noselli, and P. Leopold Antagonistic Actions of Ecdysone and Insulins Determine Final Size in Drosophila Science, October 28, 2005; 310(5748): 667 - 670. [Abstract] [Full Text] [PDF]

				R. Niwa, T. Matsuda, T. Yoshiyama, T. Namiki, K. Mita, Y. Fujimoto, and H. Kataoka CYP306A1, a Cytochrome P450 Enzyme, Is Essential for Ecdysteroid Biosynthesis in the Prothoracic Glands of Bombyx and Drosophila J. Biol. Chem., August 20, 2004; 279(34): 35942 - 35949. [Abstract] [Full Text] [PDF]

				P. Martin and S. M. Parkhurst Parallels between tissue repair and embryo morphogenesis Development, July 1, 2004; 131(13): 3021 - 3034. [Abstract] [Full Text] [PDF]

				I. Gaziova, P. C. Bonnette, V. C. Henrich, and M. Jindra Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis Development, June 1, 2004; 131(11): 2715 - 2725. [Abstract] [Full Text] [PDF]

				G. E. Roth, M. S. Gierl, L. Vollborn, M. Meise, R. Lintermann, and G. Korge The Drosophila gene Start1: A putative cholesterol transporter and key regulator of ecdysteroid synthesis PNAS, February 10, 2004; 101(6): 1601 - 1606. [Abstract] [Full Text] [PDF]

				A. Petryk, J. T. Warren, G. Marques, M. P. Jarcho, L. I. Gilbert, J. Kahler, J.-P. Parvy, Y. Li, C. Dauphin-Villemant, and M. B. O'Connor Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone PNAS, November 25, 2003; 100(24): 13773 - 13778. [Abstract] [Full Text] [PDF]

				A. A. Sullivan and C. S. Thummel Temporal Profiles of Nuclear Receptor Gene Expression Reveal Coordinate Transcriptional Responses during Drosophila Development Mol. Endocrinol., November 1, 2003; 17(11): 2125 - 2137. [Abstract] [Full Text] [PDF]

				R. E. Ward, J. Evans, and C. S. Thummel Genetic Modifier Screens in Drosophila Demonstrate a Role for Rho1 Signaling in Ecdysone-Triggered Imaginal Disc Morphogenesis Genetics, November 1, 2003; 165(3): 1397 - 1415. [Abstract] [Full Text] [PDF]

				T. Kozlova and C. S. Thummel Essential Roles for Ecdysone Signaling During Drosophila Mid-Embryonic Development Science, September 26, 2003; 301(5641): 1911 - 1914. [Abstract] [Full Text] [PDF]

				C. S. Thummel and J. Chory Steroid signaling in plants and insects---common themes, different pathways Genes & Dev., December 15, 2002; 16(24): 3113 - 3129. [Full Text] [PDF]

				J. T. Warren, A. Petryk, G. Marques, M. Jarcho, J.-P. Parvy, C. Dauphin-Villemant, M. B. O'Connor, and L. I. Gilbert Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophilamelanogaster PNAS, August 20, 2002; 99(17): 11043 - 11048. [Abstract] [Full Text] [PDF]

				K. P. Sem, B. Zahedi, I. Tan, M. Deak, L. Lim, and N. Harden ACK Family Tyrosine Kinase Activity Is a Component of Dcdc42 Signaling during Dorsal Closure in Drosophila melanogaster Mol. Cell. Biol., June 1, 2002; 22(11): 3685 - 3697. [Abstract] [Full Text] [PDF]

				T. Kozlova and C. S. Thummel Spatial patterns of ecdysteroid receptor activation during the onset of Drosophila metamorphosis Development, January 4, 2002; 129(7): 1739 - 1750. [Abstract] [Full Text] [PDF]

				B. S. Gim, J. M. Park, J. H. Yoon, C. Kang, and Y.-J. Kim Drosophila Med6 Is Required for Elevated Expression of a Large but Distinct Set of Developmentally Regulated Genes Mol. Cell. Biol., August 1, 2001; 21(15): 5242 - 5255. [Abstract] [Full Text] [PDF]

				P. V. Benos, M. K. Gatt, L. Murphy, D. Harris, B. Barrell, C. Ferraz, S. Vidal, C. Brun, J. Demaille, E. Cadieu, et al. From First Base: The Sequence of the Tip of the X Chromosome of Drosophila melanogaster, a Comparison of Two Sequencing Strategies Genome Res., May 1, 2001; 11(5): 710 - 730. [Abstract] [Full Text]