MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells

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Barstead, R. J. and Waterston, R (1989). The basal component of the nematode dense-body is vinculin. J. Biol. Chem 264, 10177-10185.[Abstract/Free Full Text]

Basham, S. E. and Rose, L. S (1999). Mutations in ooc-5 and ooc-3 disrupt oocyte formation and the reestablishment of asymmetric PAR protein localization in two-cell Caenorhabditis elegans embryos. Dev. Biol 215, 253-263.[Medline]

Beanan, M. and Strome, S (1992). Characterization of a germ-line proliferation mutation in C. elegans. Development 116, 755-766.[Abstract]

Boyd, L., Guo, S., Levitan, D., Stinchcomb, D. T. and Kemphues, K. J (1996). PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. Development 122, 3075-3084.[Abstract]

Brenner. S (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.[Abstract/Free Full Text]

Browning, H., Berkowitz, L., Madej, C., Paulsen, J. E., Zolan, M. E. and Strome, S (1996). Macrorestriction analysis of Caenorhabditis elegans genomic DNA. Genetics 144, 609-619.[Abstract]

Bruchner, K. and Klein, R (1998). Signalling by Eph receptors and their ephrin ligands. Curr.Opin. Neurobiol 8, 375-382.[Medline]

Cabib, E., Drgonov\207, J. and Drgon, T (1998). Role of small G proteins in yeast cell polarization and wall biosynthesis. Annu. Rev. Biochem 67, 307-333.[Medline]

Capowski, E., Martin, E., Garvin, C. and Strome, S (1991). Identification of grandchildless loci whose products are required for normal germ-line development in the nematode C. elegans. Genetics 129, 1061-1072.[Abstract]

Deppe, U., Schierenberg, E., Cole, T., Krieg, C., Schmitt, D., Yoder B. and van Ehrenstein, G (1978). Cell lineages of the embryo of the nematode Caenorhabditis elegans. Proc. Nat. Acad. Sci. USA 75, 376-380.[Abstract/Free Full Text]

Etemad-Moghadam, B., Guo, S. and Kemphues, K. J (1995). Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell 83, 743-752.[Medline]

Evans, D., Zorio, D., MacMorris, M., Winter, C. E., Lea, K. and Blumenthal, T (1997). Operons and SL2 trans-splicing exist in nematodes outside the genus Caenorhabditis. Proc. Natl. Acad. Sci. USA 94, 9751-9756.[Abstract/Free Full Text]

Faux, M.C. and Scott, J. D (1996). Molecular glue:kinase anchoring and scaffold proteins. Cell 85, 9-12.[Medline]

Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E. and Mello, C. C (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811.[Medline]

Goldstein, B (1995). Cell contacts orient some cell division axes in the Caenorhabditis elegans embryo. J. Cell. Biol 129, 1071-1080.[Abstract/Free Full Text]

Goldstein, B. and Hird, S. N (1996). Specification of the antero-posterior axis in C. elegans. Development 122, 1467-1474.[Abstract]

Guo, S. and Kemphues, K. J (1995). par-1 , a gene required for establishingpolarity in C. elegans embryos, encodes a putative ser/thr kinase that is asymmetrically distributed. Cell 81, 611-620.[Medline]

Guo, S. and Kemphues, K. J (1996). A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature 382, 455-458.[Medline]

Hawkins, N. and Garriga, G (1998). Asymmetric cell division: from A to Z. Genes Dev 12, 3625-3638.[Free Full Text]

Hill, D. P. and Strome, S (1988). An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotes. Dev. Biol 125, 75-84.[Medline]

Hill, D. and Strome, S (1990). Brief cytochalasin-induced disruption of microfilaments during a critical interval in one-cell C. elegans embryos alters the partitioning of development instructions to the two-cell embryo. Development 108, 159-172.[Abstract]

Hird, S. N., Paulsen, J. E. and Strome, S (1996). Segregation of P granules in living Caenorhabditis elegans embryos:cell-type-specific mechanisms for cytoplasmic localization. Development 122, 1303-1312.[Abstract]

Holdeman, R., Nehrt, S. and Strome, S (1998). MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans , is homologous to a Drosophila Polycomb group protein. Development 125, 2457-2467.[Abstract]

Jaglarz, M.K. and Howard, K. R (1994). The active migration of Drosophila primordial germ cells. Development 121, 3495-3503.[Abstract]

Jaglarz, M.K. and Howard, K. R (1995). Primordial germ cell migration in Drosophila melanogaster is controlled by somatic tissue. Development 120, 83-89.[Abstract]

Jan, Y.-N. and Jan, L. Y. ( (2000). Polarity in cell division: what frames thy fearful asymmetry?. Cell 100, 599-602.[Medline]

Kawasaki, I., Shim, Y.-H., J. Kirchner, J., Kaminker, J., Wood, W. B. and Strome, S (1998). PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans. Cell 94, 635-645.[Medline]

Kemphues, K. J., Priess, J. R., Morton, D. G. and Cheng, N (1988). Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52, 311-320.[Medline]

Korf, I., Fan, Y. and Strome, S (1998). The Polycomb group in Caenorhabditis elegans and maternal control of germline development. Development 125, 2469-2478.[Abstract]

Kraut, R., Chia, W., Jan, L. Y., Jan, Y. N. and Knoblich, J. A (1996). Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383, 50-55.[Medline]

Lee, L., Klee, S. K., Evangelista, M., Boone, C. and Pellman, D (1999). Control of mitotic spindle position by the Saccharomyces cerevisiae formin Bni1p. J. Cell Biol 144, 947-961.[Abstract/Free Full Text]

Lin, R., Leone, J. W., Cook, R. G. and Allis, C. D (1989). Antibodies specific to acetylated histones document the existence of deposition-and transcription-related histone acetylation in Tetrahymena. J. Cell. Biol 108, 1577-1588.[Abstract/Free Full Text]

Lin, R., Thompson, S. and Priess, J. R (1995). pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos. Cell 83, 599-609.[Medline]

Madden, K. and Snyder, M (1998). Cell polarity and morphogenesis in budding yeast. Annu. Rev. Microbiol 52, 687-744.[Medline]

Mello, C. C., Kramer, J. M., Stinchcomb, D. and Ambros, V (1991). Efficient gene transfer in C. elegans : extrachromosomal maintenance and integration of transforming sequences. EMBO J 10, 3959-3970.[Medline]

Mello, C. C., Draper, B. W., Krause, M., Weintraub, H. and Priess, J (1992). The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos. Cell 70, 163-176.[Medline]

Pawson, T (1995). Protein modules and signaling networks. Nature 373, 573-580.[Medline]

Pawson, T. and Scott, J. D (1997). Signaling through scaffold, anchoring and adaptor proteins. Science 278, 2075-2080.[Abstract/Free Full Text]

Pichler, S., Gonczy, P., Schnabel, H., Pozniakowski, A., Ashford, A., Schnabel, R. and Hyman, A. A. ( (2000). ooc-3 , a novel putativetransmembrane protein required for establishment of cortical domains and spindle orientation in the P1 blastomere of C. elegans embryos. Development, 127, 2063-2073.[Abstract]

Pinkas-Kramarski, R., Soussan, L., Waterman, H., Levkowitz, G., Alroy, I., Klapper, L., Lavi, S., Seger, R., Ratzkin, B. J., Sela, M. and Yarden, Y (1996). Diversification of Neu differentiation factor and epidermal growth factor signalling combinatorial receptor interactions. EMBO J 15, 2452-2467.[Medline]

Powell-Coffman, J.A., Knight, J. and Wood, W. B (1996). Onset of C. elegans gastrulation is blocked by inhibition of embryonic transcription with an RNA polymerase antisense RNA. Dev. Biol 178, 472-483.[Medline]

Qian, X., Decker, S. J. and Greene, M. I (1992). p185c-neuand epidermal growth factor receptor associate into a structure composed of activated kinases. Proc. Nat. Acad. Sci. USA 89, 1330-1334.[Abstract/Free Full Text]

Qian, X., Levea, C. M., Freeman, J. K., Dougall, W. C. and Greene, M. I (1994). Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient neu: a mechanism of interreceptor kinase activation and transphosphorylation. Proc. Nat.Acad. Sci. USA 91, 1500-1504.[Abstract/Free Full Text]

Rocheleau, C. E., Downs, W. D., Lin, R., Wittmann, C., Bei, Y., Cha, Y.-H., Ali, M., Preiss, J. and Mello, C. C (1997). Wnt signalling and an APC-related gene specify endoderm in early C. elegans embryos. Cell 90, 707-716.[Medline]

Rose, L. S. and Kemphues, K (1998). The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo. Development 125, 1337-1346.[Abstract]

Schierenberg, E (1987). Reversal of cellular polarity and early cell-cell interaction in the embryo of Caenorhabditis elegans. Dev. Biol 122, 452-463.[Medline]

Schweisguth, F (2000). Cell polarity: fixing cell polarity with Pins. Curr. Biol 10, 265-.

Schnabel, R., Weigner, C., Hutter, H., Feichtinger, R. and Schnabel, H (1996). mex-1 and the general partitioning of cell fate in the early C. elegans embryo. Mech. Dev 54, 133-147.[Medline]

Seydoux, G., Mello, C. C., Pettitt, J., Wood, W. B., Priess, J. R. and Fire, A (1996). Repression of gene expression in the embryonic germ lineage of C. elegans. Nature 382, 713-716.[Medline]

Shelton, C.A. and Bowerman, B (1996). Time-dependent responses to glp-1 -mediated inductions in early C. elegans embryos. Development 122, 2043-2050.[Abstract]

Shelton, C. A., Carter, J. C., Ellis, G. C. and Bowerman, B (1999). The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenohabditis elegans embryogenesis. J. Cell. Biol 146, 439-451.[Abstract/Free Full Text]

Shulman, J. M., Benton, R. and St Johnston, D (2000). The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole. Cell 101, 377-388.[Medline]

Skiba, F. and Schierenberg, E (1992). Cell lineages, developmental timing, and spatial pattern formation of free-living soil nematodes. Dev. Biol 151, 597-610.[Medline]

Spieth J., Brooke, G., Kuersten, S., Lea, K. and Blumenthal, T (1993). Operons of C. elegans : polycistronic mRNA precursors are processed by trans-splicing of SL2 to downstream coding regions. Cell 73, 521-532.[Medline]

Stearns, T (1997). Motoring to the finish:kinesin and dynein work together to orient the yeast mitotic spindle. J. Cell Biol 138, 957-960.[Free Full Text]

Strome, S. and Wood, W. B (1982). Immunofluorescence visualization of germ-line-specific cytoplasmic granules in embryos, larvae, and adults of Caenorhabditis elegans. Proc.Natl. Acad. Sci. USA 79, 1558-1562.[Abstract/Free Full Text]

Strome, S. and Wood, W. B (1983). Generation of asymmetry and segregation of germ-line granules in early Caenorhabditis elegans embryos. Cell 35, 15-25.[Medline]

Strome, S., Martin, P., Schierenberg, E. and Paulsen, J (1995). Transformation of the germ line into muscle in mes-1 mutant embryos of C. elegans. Development 121, 2961-2972.[Abstract]

Sulston, J. E., Schierenberg, E., White, J. G. and Thomson, J. N (1983). The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol 100, 64-119.[Medline]

Tabara, H., Hill, R. J., Mello, C. C., Priess, J. R. and Kohara, Y (1999). pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans. Development 126, 1-11.[Abstract]

Thaler, C. D. and Haimo, L. T (1996). Microtubules and microtubule motors: mechanisms of regulation. Int. Rev. Cytol 164, 269-327.[Medline]

Thorpe, C. J., Schlesinger, A., Carter, J. C. and Bowerman, B (1997). Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm. Cell 90, 695-705.[Medline]

Van Der Greer, P., Hunter, T. and Lindberg, R. A (1994). Receptor protein-kinases and their signal transduction pathways. Annu. Rev. Cell Biol 10, 251-337.

Wada, T., Qian, X. and Greene, M. I (1990). Intermolecular association of the p185neu proten and EGF receptor modulates EGF receptor function. Cell 61, 1339-1347.[Medline]

Watts, J. L., Etemad-Moghadam, B., Guo, S., Boyd, L., Draper, B. W., Mello, C. C., Priess, J. R. and Kemphues, K. J (1996). par-6 , a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the symmetric localization of PAR-3. Development 122, 3133-3140.[Abstract]

Warrior, R (1994). Primordial germ cell migration and the assembly of the Drosophila embryonic gonad. Dev. Biol 166, 180-194.[Medline]

Wiegner, O. and Schrienberg, S (1998). Specification of gut cell fate differs significantly between the nematodes Acrobeloides nanus and Caenorhabditis elegans. Dev Biol 204, 3-14.[Medline]

Wylie, C (1999). Germ cells. Cell 96, 165-174.[Medline]

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Articles by Strome, S.

				S. W. Leacock and V. Reinke MEG-1 and MEG-2 Are Embryo-Specific P-Granule Components Required for Germline Development in Caenorhabditis elegans Genetics, January 1, 2008; 178(1): 295 - 306. [Abstract] [Full Text] [PDF]

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				J.-Y. Lee and B. Goldstein Mechanisms of cell positioning during C. elegans gastrulation Development, March 2, 2003; 130(2): 307 - 320. [Abstract] [Full Text] [PDF]