spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    


This Article
Right arrow Summary Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Raamsdonk, C. D.
Right arrow Articles by Tilghman, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Raamsdonk, C. D.
Right arrow Articles by Tilghman, S. M.
Baldwin, C. T., Hoth, C. F., Amos, J. A., da-Silva, E. O. and Milunsky, A (1992). An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome. Nature 355, 637-638.[Medline]

Collinson, J. M., Hill, R. E. and West, J. D (2000). Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye. Development 127, 945-956.[Abstract]

Cvekl, A. and Piatigorsky, J (1996). Lens development and crystallin gene expression: many roles for Pax-6. BioEssays 18, 621-630.[Medline]

Dressler, G. R., Wilkinson, J. E., Rothenpieler, U. W., Patterson, L. T., Williams-Simons, L. and Westphal, H (1993). Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities. Nature 362, 65-67.[Medline]

Engelkamp, D. and van Heyningen, V (1996). Transcription factors in disease. Curr. Opin. Genet. Dev 6, 334-342.[Medline]

Epstein, D. J., Vekemans, M. and Gros, P (1991). Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell 67, 767-774.[Medline]

Fisher, E. and Scambler, P (1994). Human haploinsufficiency\320one for sorrow, two for joy. Nat. Genet 7, 5-7.[Medline]

Fujiwara, M., Uchida, T., Osumi-Yamashita, N. and Eto, K (1994). Uchida rat (rSey): a new mutant rat with craniofacial abnormalities resembling those of the mouse Sey mutant. Differentiation 57, 31-38.[Medline]

Furuta, Y. and Hogan, B. L. M (1998). BMP4 is essential for lens induction in the mouse embryo. Genes. Dev 12, 3764-3775.[Abstract/Free Full Text]

Gage, P. J., Suh, H. and Camper, S. A (1999). Dosage requirement of Pitx2 for development of multiple organs. Development 126, 4643-4651.[Abstract]

Glaser, T., Lane, J. and Housman, D (1990). A mouse model of the aniridia-Wilms tumor deletion syndrome. Science 250, 823-827.[Abstract/Free Full Text]

Grainger, R. M., Mannion, J. E., Cook, T. L., Jr. and Zygar, C. A (1997). Defining intermediate stages in cell determination: acquisition of a lens-forming bias in head ectoderm during lens determination. Dev. Genet 20, 246-257.[Medline]

Grindley, J. C., Davidson, D. R. and Hill, R. E (1995). The role of Pax-6 in eye and nasal development. Development 121, 1433-1442.[Abstract]

Hanson, I. M., Fletcher, J. M., Jordan, T., Brown, A., Taylor, D., Adams, R. J., Punnett, H. H. and van Heyningen, V (1994). Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly. Nat. Genet 6, 168-173.[Medline]

Hatta, K. and Takeichi, M (1986). Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. Nature 320, 447-449.[Medline]

Hendzel, M. J., Wei, Y., Mancini, M. A., Van Hooser, A., Ranalli, T., Brinkley, B. R., Bazett-Jones, D. P. and Allis, C. D (1997). Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106, 348-360.[Medline]

Herrmann, B. G., Labeit, S., Poustka, A., King, T. R. and Lehrach, H (1990). Cloning of the T gene required in mesoderm formation in the mouse. Nature 343, 617-622.[Medline]

Hill, R. E., Favor, J., Hogan, B. L., Ton, C. C., Saunders, G. F., Hanson, I. M., Prosser, J., Jordan, T., Hastie, N. D. and van Heyningen, V (1991). Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature 354, 522-525.[Medline]

Hogan, B. L., Horsburgh, G., Cohen, J., Hetherington, C. M., Fisher, G. and Lyon, M. F (1986). Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. J. Embryol. Exp. Morphol 97, 95-110.[Medline]

Johnson, C. V., Singer, R. H. and Lawrence, J. B (1991). Fluorescent detection of nuclear RNA and DNA: implications for genome organization. Methods Cell Biol 35, 73-99.[Medline]

Jordan, T., Hanson, I., Zaletayev, D., Hodgson, S., Prosser, J., Seawright, A., Hastie, N. and van Heyningen, V (1992). The human PAX6 gene is mutated in two patients with aniridia. Nat. Genet 1, 328-332.[Medline]

Kamachi, Y., Uchikawa, M., Collignon, J., Lovell-Badge, R. and Kondoh, H (1998). Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction. Development 125, 2521-2532.[Abstract]

Keller, S. A., Jones, J. M., Boyle, A., Barrow, L. L., Killen, P. D., Green, D. G., Kapousta, N. V., Hitchcock, P. F., Swank, R. T. and Meisler, M. H (1994). Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus. Genomics 23, 309-320.[Medline]

Macchia, P. E., Lapi, P., Krude, H., Pirro, M. T., Missero, C., Chiovato, L., Souabni, A., Baserga, M., Tassi, V., Pinchera, A., Fenzi, G., Gruters, A., Busslinger, M. and Di Lauro, R (1998). PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Nat. Genet 19, 83-86.[Medline]

Makarenkova, H. P., Ito, M., Govindarajan, V., Faber, S. C., Sun, L., McMahon, G., Overbeek, P. A. and Lang, R. A (2000). FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127, 2563-2572.[Abstract]

Mannervik, M., Nibu, Y., Zhang, H. and Levine, M (1999). Transcriptional coregulators in development. Science 284, 606-609.[Abstract/Free Full Text]

Mansouri, A., Goudreau, G. and Gruss, P (1999). Pax genes and their role in organogenesis. Cancer Res 59, 1707-1710.

Nishiguchi, S., Wood, H., Kondoh, H., Lovell-Badge, R. and Episkopou, V (1998). Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev 12, 776-781.[Abstract/Free Full Text]

Nutt, S. L. and Busslinger, M (1999). Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?. Biol. Chem 380, 601-611.

Nutt, S. L., Vambrie, S., Steinlein, P., Kozmik, Z., Rolink, A., Weith, A. and Busslinger, M (1999). Independent regulation of the two Pax5 alleles during B-cell development. Nat. Genet 21, 390-395.[Medline]

Ostrom, L., Tang, M. J., Gruss, P. and Dressler, G. R (2000). Reduced Pax2 Gene Dosage Increases Apoptosis and Slows the Progression of Renal Cystic Disease. Dev. Biol 219, 250-258.[Medline]

Piatigorsky, J (1981). Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation 19, 134-153.[Medline]

Quinn, J. C., West, J. D. and Hill, R. E (1996). Multiple functions for Pax6 in mouse eye and nasal development. Genes Dev 10, 435-446.[Abstract/Free Full Text]

Rhoades, K. L., Singh, N., Simon, I., Glidden, B., Cedar, H. and Chess, A (2000). Allele-specific expression patterns of interleukin-2 and Pax-5 revealed by a sensitive single-cell RT-PCR analysis. Curr. Biol 10, 789-792.[Medline]

Sanyanusin, P., Schimmenti, L. A., McNoe, L. A., Ward, T. A., Pierpont, M. E., Sullivan, M. J., Dobyns, W. B. and Eccles, M. R (1995). Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux. Nat. Genet 9, 358-364.[Medline]

Schedl, A., Ross, A., Lee, M., Engelkamp, D., Rashbass, P., van Heyningen, V. and Hastie, N. D (1996). Influence of PAX6 gene dosage ondevelopment: overexpression causes severe eye abnormalities. Cell 86, 71-82.[Medline]

Silver, J. and Hughes, A. F. W (1973). The role of cell death during morphogenesis of the mammalian eye. J. Morph 140, 159-170.[Medline]

Stockton, D. W., Das, P., Goldenberg, M., D'Souza, R. N. and Patel, P. I (2000). Mutation of PAX9 is associated with oligodontia. Nat. Genet 24, 18-19.[Medline]

Stoykova, A., Gotz, M., Gruss, P. and Prince, J (1997). Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain. Development 124, 3765-3777.[Abstract]

Stuart, E. T., Haffner, R., Oren, M. and Gruss, P (1995). Loss of p53 function through PAX-mediated transcriptional repression. EMBO J 14, 5638-45.[Medline]

Takeichi, M (1988). The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development 102, 639-655.[Abstract/Free Full Text]

Theiler, K., Varnum, D. S. and Stevens, L. C (1978). Development of Dickie's small eye, a mutation in the house mouse. Anat. Embryol. (Berl.) 155, 81-86.[Medline]

Ton, C. C., Hirvonen, H., Miwa, H., Weil, M. M., Monaghan, P., Jordan, T., van Heyningen, V., Hastie, N. D., Meijers-Heijboer, H., Drechsler, M. and et al. ( (1991). Positional cloning and characterization of a paired box-and homeobox-containing gene from the aniridia region. Cell 67, 1059-1074.[Medline]

Walther, C. and Gruss, P (1991). Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113, 1435-1449.[Abstract]

Wawersik, S., Purcell, P., Rauchman, M., Dudley, A. T., Robertson, E. J. and Maas, R (1999). BMP7 acts in murine lens placode development. Dev. Biol 207, 176-188.[Medline]

Weil, M., Jacobson, M. D. and Raff, M. C (1997). Is programmed cell death required for neural tube closure?. Curr. Biol 7, 281-284.[Medline]

Wilkie, A. O (1994). The molecular basis of genetic dominance. J. Med. Genet 31, 89-98.[Abstract]

Wilkinson, D. G. and Nieto, M. A (1993). Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol 225, 361-373.[Medline]

Wilm, B., Dahl, E., Peters, H., Balling, R. and Imai, K (1998). Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency. Proc. Natl. Acad. Sci. USA 95, 8692-8697.[Abstract/Free Full Text]




This article has been cited by other articles:


Home page
DevelopmentHome page
Y. Chen, Y.-q. Doughman, S. Gu, A. Jarrell, S.-i. Aota, A. Cvekl, M. Watanabe, S. L. Dunwoodie, R. S. Johnson, V. van Heyningen, et al.
Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis
Development, September 1, 2008; 135(17): 2939 - 2948.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
J. Favor, C. J. Gloeckner, A. Neuhauser-Klaus, W. Pretsch, R. Sandulache, S. Saule, and I. Zaus
Relationship of Pax6 Activity Levels to the Extent of Eye Development in the Mouse, Mus musculus
Genetics, July 1, 2008; 179(3): 1345 - 1355.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
M. Fuxa and M. Busslinger
Reporter Gene Insertions Reveal a Strictly B Lymphoid-Specific Expression Pattern of Pax5 in Support of Its B Cell Identity Function
J. Immunol., March 1, 2007; 178(5): 3031 - 3037.
[Abstract] [Full Text] [PDF]


Home page
IOVSHome page
J. Ouyang, Y.-C. Shen, L.-K. Yeh, W. Li, B. M. Coyle, C.-Y. Liu, and M. E. Fini
Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells.
Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2397 - 2407.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
A. Yoshimoto, Y. Saigou, Y. Higashi, and H. Kondoh
Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation
Development, October 15, 2005; 132(20): 4437 - 4448.
[Abstract] [Full Text] [PDF]


Home page
Hum Mol GenetHome page
N. Davis-Silberman, T. Kalich, V. Oron-Karni, T. Marquardt, M. Kroeber, E. R. Tamm, and R. Ashery-Padan
Genetic dissection of Pax6 dosage requirements in the developing mouse eye
Hum. Mol. Genet., August 1, 2005; 14(15): 2265 - 2276.
[Abstract] [Full Text] [PDF]


Home page
IOVSHome page
M. K. Duncan, L. Xie, L. L. David, M. L. Robinson, J. R. Taube, W. Cui, and L. W. Reneker
Ectopic Pax6 Expression Disturbs Lens Fiber Cell Differentiation
Invest. Ophthalmol. Vis. Sci., October 1, 2004; 45(10): 3589 - 3598.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
M. De Felice and R. Di Lauro
Thyroid Development and Its Disorders: Genetics and Molecular Mechanisms
Endocr. Rev., October 1, 2004; 25(5): 722 - 746.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
J. Davis, M. K. Duncan, W. G. Robison Jr, and J. Piatigorsky
Requirement for Pax6 in corneal morphogenesis: a role in adhesion
J. Cell Sci., June 1, 2003; 116(11): 2157 - 2167.
[Abstract] [Full Text] [PDF]


Home page
IOVSHome page
T. Ramaesh, J. M. Collinson, K. Ramaesh, M. H. Kaufman, J. D. West, and B. Dhillon
Corneal Abnormalities in Pax6+/- Small Eye Mice Mimic Human Aniridia-Related Keratopathy
Invest. Ophthalmol. Vis. Sci., May 1, 2003; 44(5): 1871 - 1878.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
L. T. Raetzman, R. Ward, and S. A. Camper
Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia
Development, March 11, 2003; 129(18): 4229 - 4239.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
D. Pineda, L. Rossi, R. Batistoni, A. Salvetti, M. Marsal, V. Gremigni, A. Falleni, J. Gonzalez-Linares, P. Deri, and E. Salo
The genetic network of prototypic planarian eye regeneration is Pax6 independent
Development, March 5, 2003; 129(6): 1423 - 1434.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
H. Suh, P. J. Gage, J. Drouin, and S. A. Camper
Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification
Development, March 3, 2003; 129(2): 329 - 337.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
R. Mishra, I. P. Gorlov, L. Y. Chao, S. Singh, and G. F. Saunders
PAX6, Paired Domain Influences Sequence Recognition by the Homeodomain
J. Biol. Chem., December 13, 2002; 277(51): 49488 - 49494.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
X. Zhang, A. Friedman, S. Heaney, P. Purcell, and R. L. Maas
Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis
Genes & Dev., August 15, 2002; 16(16): 2097 - 2107.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
J. Ferrer
A Genetic Switch in Pancreatic {beta}-Cells: Implications for Differentiation and Haploinsufficiency
Diabetes, August 1, 2002; 51(8): 2355 - 2362.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
G. Goudreau, P. Petrou, L. W. Reneker, J. Graw, J. Loster, and P. Gruss
Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype
PNAS, June 25, 2002; 99(13): 8719 - 8724.
[Abstract] [Full Text] [PDF]


Home page
Hum Mol GenetHome page
V. van Heyningen and K. A. Williamson
PAX6 in sensory development
Hum. Mol. Genet., May 15, 2002; 11(10): 1161 - 1167.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
B. K. Chauhan, N. A. Reed, W. Zhang, M. K. Duncan, M. W. Kilimann, and A. Cvekl
Identification of Genes Downstream of Pax6 in the Mouse Lens Using cDNA Microarrays
J. Biol. Chem., March 22, 2002; 277(13): 11539 - 11548.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
P. V. Dimanlig, S. C. Faber, W. Auerbach, H. P. Makarenkova, and R. A. Lang
The upstream ectoderm enhancer in Pax6 has an important role in lens induction
Development, November 15, 2001; 128(22): 4415 - 4424.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
J. M. Collinson, J. C. Quinn, M. A. Buchanan, M. H. Kaufman, S. E. Wedden, J. D. West, and R. E. Hill
Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye
PNAS, July 24, 2001; (2001) 161144098.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
Y. Kamachi, M. Uchikawa, A. Tanouchi, R. Sekido, and H. Kondoh
Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development
Genes & Dev., May 15, 2001; 15(10): 1272 - 1286.
[Abstract] [Full Text]


Home page
Nucleic Acids ResHome page
C. D. van Raamsdonk and S. M. Tilghman
Optimizing the detection of nascent transcripts by RNA fluorescence in situ hybridization
Nucleic Acids Res., April 15, 2001; 29(8): e42 - e42.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
J. M. Collinson, J. C. Quinn, M. A. Buchanan, M. H. Kaufman, S. E. Wedden, J. D. West, and R. E. Hill
Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye
PNAS, August 14, 2001; 98(17): 9688 - 9693.
[Abstract] [Full Text] [PDF]


This Article
Right arrow Summary Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Raamsdonk, C. D.
Right arrow Articles by Tilghman, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Raamsdonk, C. D.
Right arrow Articles by Tilghman, S. M.