Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas

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				N. Nekrep, J. Wang, T. Miyatsuka, and M. S. German Signals from the neural crest regulate beta-cell mass in the pancreas Development, June 15, 2008; 135(12): 2151 - 2160. [Abstract] [Full Text] [PDF]

				M. Y. Choi, A. I. Romer, Y. Wang, M. P. Wu, S. Ito, A. B. Leiter, and R. A. Shivdasani Requirement of the Tissue-Restricted Homeodomain Transcription Factor Nkx6.3 in Differentiation of Gastrin-Producing G Cells in the Stomach Antrum Mol. Cell. Biol., May 15, 2008; 28(10): 3208 - 3218. [Abstract] [Full Text] [PDF]

				J. C. Schisler, P. T. Fueger, D. A. Babu, H. E. Hohmeier, J. S. Tessem, D. Lu, T. C. Becker, B. Naziruddin, M. Levy, R. G. Mirmira, et al. Stimulation of Human and Rat Islet {beta}-Cell Proliferation with Retention of Function by the Homeodomain Transcription Factor Nkx6.1 Mol. Cell. Biol., May 15, 2008; 28(10): 3465 - 3476. [Abstract] [Full Text] [PDF]

				R. Klinck, P. Serup, O. D. Madsen, and M. C. Jorgensen Specificity of Four Monoclonal Anti-Nkx6-1 Antibodies J. Histochem. Cytochem., April 1, 2008; 56(4): 415 - 424. [Abstract] [Full Text] [PDF]

				M. Kodama, F. Takeshita, S. Kanegasaki, T. Ochiya, and G. Quinn Pancreatic Endocrine and Exocrine Cell Ontogeny From Renal Capsule transplanted Embryonic Stem Cells in Streptozocin-injured Mice J. Histochem. Cytochem., January 1, 2008; 56(1): 33 - 44. [Abstract] [Full Text] [PDF]

				Y. Dor and B. Z. Stanger Regeneration in Liver and Pancreas: Time to Cut the Umbilical Cord? Sci. Signal., November 27, 2007; 2007(414): pe66 - pe66. [Abstract] [Full Text] [PDF]

				M. C. Jorgensen, J. Ahnfelt-Ronne, J. Hald, O. D. Madsen, P. Serup, and J. Hecksher-Sorensen An Illustrated Review of Early Pancreas Development in the Mouse Endocr. Rev., October 1, 2007; 28(6): 685 - 705. [Abstract] [Full Text] [PDF]

				J. Ahnfelt-Ronne, M. C. Jorgensen, J. Hald, O. D. Madsen, P. Serup, and J. Hecksher-Sorensen An Improved Method for Three-dimensional Reconstruction of Protein Expression Patterns in Intact Mouse and Chicken Embryos and Organs J. Histochem. Cytochem., September 1, 2007; 55(9): 925 - 930. [Abstract] [Full Text] [PDF]

				S. B. Nelson, A. E. Schaffer, and M. Sander The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells Development, July 1, 2007; 134(13): 2491 - 2500. [Abstract] [Full Text] [PDF]

				F. C. Lynn, S. B. Smith, M. E. Wilson, K. Y. Yang, N. Nekrep, and M. S. German Sox9 coordinates a transcriptional network in pancreatic progenitor cells PNAS, June 19, 2007; 104(25): 10500 - 10505. [Abstract] [Full Text] [PDF]

				I. C. Rulifson, S. K. Karnik, P. W. Heiser, D. ten Berge, H. Chen, X. Gu, M. M. Taketo, R. Nusse, M. Hebrok, and S. K. Kim Wnt signaling regulates pancreatic beta cell proliferation PNAS, April 10, 2007; 104(15): 6247 - 6252. [Abstract] [Full Text] [PDF]

				H. T. Ku, J. Chai, Y.-J. Kim, P. White, S. Purohit-Ghelani, K. H. Kaestner, and J. S. Bromberg Insulin-Expressing Colonies Developed From Murine Embryonic Stem Cell-Derived Progenitors Diabetes, April 1, 2007; 56(4): 921 - 929. [Abstract] [Full Text] [PDF]

				I. Artner, B. Blanchi, J. C. Raum, M. Guo, T. Kaneko, S. Cordes, M. Sieweke, and R. Stein MafB is required for islet beta cell maturation PNAS, March 6, 2007; 104(10): 3853 - 3858. [Abstract] [Full Text] [PDF]

				G. O. Gillard, J. Dooley, M. Erickson, L. Peltonen, and A. G. Farr Aire-Dependent Alterations in Medullary Thymic Epithelium Indicate a Role for Aire in Thymic Epithelial Differentiation J. Immunol., March 1, 2007; 178(5): 3007 - 3015. [Abstract] [Full Text] [PDF]

				P. A. Seymour, K. K. Freude, M. N. Tran, E. E. Mayes, J. Jensen, R. Kist, G. Scherer, and M. Sander From the Cover: SOX9 is required for maintenance of the pancreatic progenitor cell pool PNAS, February 6, 2007; 104(6): 1865 - 1870. [Abstract] [Full Text] [PDF]

				A. M Ackermann and M. Gannon Molecular regulation of pancreatic {beta}-cell mass development, maintenance, and expansion J. Mol. Endocrinol., February 1, 2007; 38(2): 193 - 206. [Abstract] [Full Text] [PDF]

				L. C. Murtaugh Pancreas and beta-cell development: from the actual to the possible Development, February 1, 2007; 134(3): 427 - 438. [Abstract] [Full Text] [PDF]

				M. J. Doyle, Z. L. Loomis, and L. Sussel Nkx2.2-repressor activity is sufficient to specify {alpha}-cells and a small number of {beta}-cells in the pancreatic islet Development, February 1, 2007; 134(3): 515 - 523. [Abstract] [Full Text] [PDF]

				J. A. Moibi, D. Gupta, T. L. Jetton, M. Peshavaria, R. Desai, and J. L. Leahy Peroxisome Proliferator-Activated Receptor-{gamma} Regulates Expression of PDX-1 and NKX6.1 in INS-1 Cells Diabetes, January 1, 2007; 56(1): 88 - 95. [Abstract] [Full Text] [PDF]

				M. E Cerf Transcription factors regulating {beta}-cell function. Eur. J. Endocrinol., November 1, 2006; 155(5): 671 - 679. [Abstract] [Full Text] [PDF]

				M. S. Gierl, N. Karoulias, H. Wende, M. Strehle, and C. Birchmeier The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells Genes & Dev., September 1, 2006; 20(17): 2465 - 2478. [Abstract] [Full Text] [PDF]

				I. L. Pedersen, R. Klinck, J. Hecksher-Sorensen, S. Zahn, O. D. Madsen, P. Serup, and M. C. Jorgensen Generation and Characterization of Monoclonal Antibodies against the Transcription Factor Nkx6.1 J. Histochem. Cytochem., May 1, 2006; 54(5): 567 - 574. [Abstract] [Full Text] [PDF]

				E. A. Kim, Y. T. Noh, M.-J. Ryu, H.-T. Kim, S.-E. Lee, C.-H. Kim, C. Lee, Y. H. Kim, and C. Y. Choi Phosphorylation and Transactivation of Pax6 by Homeodomain-interacting Protein Kinase 2 J. Biol. Chem., March 17, 2006; 281(11): 7489 - 7497. [Abstract] [Full Text] [PDF]

				J. Taneera, A. Rosengren, E. Renstrom, J. M. Nygren, P. Serup, P. Rorsman, and S. E. W. Jacobsen Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic {beta}-Cell Fate Diabetes, February 1, 2006; 55(2): 290 - 296. [Abstract] [Full Text] [PDF]

				J. L. Volinic, J. H. Lee, K. Eto, V. Kaur, and M. K. Thomas Overexpression of the Coactivator Bridge-1 Results in Insulin Deficiency and Diabetes Mol. Endocrinol., January 1, 2006; 20(1): 167 - 182. [Abstract] [Full Text] [PDF]

				M. E. Wilson, K. Y. Yang, A. Kalousova, J. Lau, Y. Kosaka, F. C. Lynn, J. Wang, C. Mrejen, V. Episkopou, H. C. Clevers, et al. The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas Diabetes, December 1, 2005; 54(12): 3402 - 3409. [Abstract] [Full Text] [PDF]

				C. Kjorholt, M. C. Akerfeldt, T. J. Biden, and D. R. Laybutt Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of {beta}-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes Diabetes, September 1, 2005; 54(9): 2755 - 2763. [Abstract] [Full Text] [PDF]

				K. D. Henseleit, S. B. Nelson, K. Kuhlbrodt, J. C. Hennings, J. Ericson, and M. Sander NKX6 transcription factor activity is required for {alpha}- and {beta}-cell development in the pancreas Development, July 1, 2005; 132(13): 3139 - 3149. [Abstract] [Full Text] [PDF]

				P. Collombat, J. Hecksher-Sorensen, V. Broccoli, J. Krull, I. Ponte, T. Mundiger, J. Smith, P. Gruss, P. Serup, and A. Mansouri The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the {alpha}- and {beta}-cell lineages in the mouse endocrine pancreas Development, July 1, 2005; 132(13): 2969 - 2980. [Abstract] [Full Text] [PDF]